{"disease":{"id":"heart-surgery","name":"heart surgery"},"drugs":{"marketed":[{"drug_id":"cefuroxime","indication_name":"Open Heart Surgery Infection Prevention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zinacef","generic_name":"CEFUROXIME","company_name":"GSK","drug_phase":"marketed","molecular_target":"Carbonic anhydrase 2","drug_class":"Cephalosporin Antibacterial","quality_score":65,"revenue":null,"mechanism":"Zinacef works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT02042898","title":"Transfusion Requirements in Cardiac Surgery III","phase":"NA","overall_status":"COMPLETED","enrollment_count":5028,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT06647771","title":"Relationship Between Postoperative Tempeartive and Acute Kidney Injury","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3274,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT05914103","title":"The Application of Enhanced Recovery After Surgery (ERAS) for Cardiovascular Surgery in the Correction of Complex Congenital Heart Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":3030,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false},{"nct_id":"NCT07524998","title":"A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT06647758","title":"Association Between Post-operative Anemia and Mortality After Valvular Heart Surgery","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT03724123","title":"Machine Learning-Based Risk Profile Classification of Patients Undergoing Elective Heart Valve Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":2229,"lead_sponsor_name":"Kepler University Hospital","has_results":false},{"nct_id":"NCT05489263","title":"A Predictive Score System for AKI Following Pediatric Cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT03053778","title":"Individualised Follow-up After Valve Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":1414,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT05142046","title":"Influence of Intraoperative Fluid Balance on the Incidence of Adverse Events in Pediatric Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":1400,"lead_sponsor_name":"Brugmann University Hospital","has_results":false},{"nct_id":"NCT04562207","title":"Pre-operative Carriage of Respiratory VIRUSes, and Acute Respiratory Distress Syndrome After Heart Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":1256,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT03508505","title":"Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Turku University Hospital","has_results":false},{"nct_id":"NCT04405856","title":"Outcome of Patients Treated With IABP","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT05740397","title":"Trial to Compare Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass","phase":"NA","overall_status":"RECRUITING","enrollment_count":900,"lead_sponsor_name":"Azienda Ospedaliera Universitaria Integrata Verona","has_results":false},{"nct_id":"NCT03081052","title":"Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":519,"lead_sponsor_name":"Duke University","has_results":true},{"nct_id":"NCT04487262","title":"Timing for Removal of Chest Tubes in Adult Cardiac Surgery","phase":"NA","overall_status":"TERMINATED","enrollment_count":515,"lead_sponsor_name":"Aarhus University Hospital Skejby","has_results":false},{"nct_id":"NCT05151796","title":"Continuation of Aspirin Before Isolated Heart Valve Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"University of Liege","has_results":false},{"nct_id":"NCT04973514","title":"Perioperative Transfusion Strategies in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Brugmann University Hospital","has_results":false},{"nct_id":"NCT04094168","title":"Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":474,"lead_sponsor_name":"JESSICA GARCIA SUAREZ","has_results":false},{"nct_id":"NCT06222866","title":"Anticoagulation and Inflammation Monitoring in Patients After Heart and Vascular Interventions","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT05925634","title":"Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":320,"lead_sponsor_name":"Baystate Medical Center","has_results":false},{"nct_id":"NCT02712879","title":"Moderate Bleeding in Cardiac Surgery Post Operative","phase":"","overall_status":"COMPLETED","enrollment_count":303,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT03806413","title":"Post-surgical Delirium in Patients Undergoing Open Heart Surgery.","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"University of Alexandria","has_results":false},{"nct_id":"NCT06168799","title":"Ilofotase Alfa for Prevention of Renal Damage After Cardiac Surgery","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":271,"lead_sponsor_name":"AM-Pharma","has_results":false},{"nct_id":"NCT03295669","title":"Continuous Monitoring of Right Ventricular Function, Based on the Correlation Between the C-X Segment of the Central Venous Pressure Curve, and the Echocardiographic Evaluation of Right Ventricular Systolic Function","phase":"","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Centre Hospitalier Universitaire Dijon","has_results":false},{"nct_id":"NCT07505966","title":"Active Chest Tube Clearance Versus Standard Drainage After Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Kasr El Aini Hospital","has_results":false},{"nct_id":"NCT03513718","title":"Acute Kidney Injury After Cardiac Surgery on CPB","phase":"","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Centre Hospitalier Universitaire Vaudois","has_results":false},{"nct_id":"NCT07029230","title":"Blood Based Assessment of sST2, Taken During and After Surgery, for Pediatric Patients With Heart Defects to Predict Heart Failure.","phase":"","overall_status":"RECRUITING","enrollment_count":225,"lead_sponsor_name":"Martin Schweiger","has_results":false},{"nct_id":"NCT05104658","title":"Heart Rehabilitation for All","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":218,"lead_sponsor_name":"Center for Clinical Research and Prevention","has_results":false},{"nct_id":"NCT04213040","title":"Procalcitonin and Postoperative Outcome After Open-heart Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":214,"lead_sponsor_name":"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","has_results":false},{"nct_id":"NCT03799965","title":"The Effect of Advanced Improvement Program (ERAS) on Postoperative Outcomes in Patients Undergoing Open Heart Surgery","phase":"NA","overall_status":"UNKNOWN","enrollment_count":210,"lead_sponsor_name":"Kocaeli Derince Education and Research Hospital","has_results":false},{"nct_id":"NCT05853263","title":"Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":208,"lead_sponsor_name":"Erasmus Medical Center","has_results":false},{"nct_id":"NCT05320965","title":"Prospective Validation of the Model Predicting Postoperative Delirium Occurrence With Machine Learning-based Analysis of Intraoperative Biological Signals During Anesthesia in Cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT05079724","title":"Acute Kidney Injury After Cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT07477977","title":"Dose for Reversal of Heparin After Cardiopulmonary Bypass","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":195,"lead_sponsor_name":"Sohag University","has_results":false},{"nct_id":"NCT03407287","title":"Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status","phase":"","overall_status":"TERMINATED","enrollment_count":180,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT03295344","title":"Study of Diaphragm Mobility on Tissue Doppler","phase":"","overall_status":"COMPLETED","enrollment_count":170,"lead_sponsor_name":"Centre Hospitalier Universitaire Dijon","has_results":false},{"nct_id":"NCT07391683","title":"Telemedically Assisted Optimization for Heart Failure Patients Before Cardiac Surgery to Improve Perioperative Outcome","phase":"NA","overall_status":"RECRUITING","enrollment_count":162,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT05038267","title":"Femoral Venous Pulsatility and Right Heart Dysfunction in Heart Surgery: An Observational Study","phase":"","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Montreal Heart Institute","has_results":false},{"nct_id":"NCT03491163","title":"Evaluation of Damaging Factors to Endothelial Glycocalyx During Heart Surgery Pilot Study","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Tadas Cesnaitis","has_results":false},{"nct_id":"NCT05565911","title":"Postoperative Morbidity / Mortality Rates of Patients With Pulmonary Hypertension","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Baskent University","has_results":false},{"nct_id":"NCT06918600","title":"Exercises for Early Mobilization of Patients Undergoing Open Heart Surgery With Virtual Reality Application","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Istanbul University","has_results":false},{"nct_id":"NCT07068594","title":"The Application of Virtual Reality Goggles During the First Wound Dressing After Open Heart Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Aydin Adnan Menderes University","has_results":false},{"nct_id":"NCT04670367","title":"The Effects of Baduanjin Exercise on Meridian Energy and Heart Rate Variability in Patients Undergoing Cardiac Sugery","phase":"NA","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"Tzu Chi University","has_results":false},{"nct_id":"NCT06475703","title":"Using AI Within Digital Wound Monitoring of Surgical Wounds to Prioritise Non-healing Wounds for Urgent Review","phase":"NA","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Guy's and St Thomas' NHS Foundation Trust","has_results":false},{"nct_id":"NCT04833283","title":"The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.","phase":"NA","overall_status":"COMPLETED","enrollment_count":115,"lead_sponsor_name":"I.M. Sechenov First Moscow State Medical University","has_results":false},{"nct_id":"NCT06801145","title":"The Effect of Video-supported Education on Anxiety Levels and the ICU Experience","phase":"NA","overall_status":"COMPLETED","enrollment_count":110,"lead_sponsor_name":"Zeynep Turak","has_results":false},{"nct_id":"NCT05966857","title":"FAPO-X: Assisted Digital Telemonitoring With Wearables in Patients After Cardiovascular Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":108,"lead_sponsor_name":"University of Sao Paulo","has_results":false},{"nct_id":"NCT03023644","title":"Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":106,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT06373627","title":"Procedural Pain Management by Multimodal Sedation Analgesia Combining Hypnosis in Children With Congenital Heart Disease","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":104,"lead_sponsor_name":"Fondation Hôpital Saint-Joseph","has_results":false},{"nct_id":"NCT06195592","title":"Development of Delirium in Patients Undergoing Open-Heart Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Kubra Gunes","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}