{"disease":{"id":"heart-failure-with-reduced-ejection-fraction","name":"heart failure with reduced ejection fraction"},"drugs":{"marketed":[{"drug_id":"aldactone","indication_name":"NYHA Class III-IV heart failure with reduced ejection fraction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aldactone","generic_name":"Spironolactone","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Aldosterone receptors at aldosterone-dependent sodium-potassium exchange site in distal convoluted renal tubule","drug_class":"Potassium-sparing diuretic, aldosterone antagonist","quality_score":66,"revenue":null,"mechanism":"Aldosterone antagonist causing increased sodium and water excretion while retaining potassium."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03099889","title":"WHISH-2-Prevent Heart Failure","phase":"NA","overall_status":"UNKNOWN","enrollment_count":49936,"lead_sponsor_name":"Memorial Hospital of Rhode Island","has_results":false},{"nct_id":"NCT06671314","title":"Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction","phase":"","overall_status":"COMPLETED","enrollment_count":42494,"lead_sponsor_name":"Novartis","has_results":false},{"nct_id":"NCT04237701","title":"Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System","phase":"","overall_status":"RECRUITING","enrollment_count":40000,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT06763549","title":"COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":15000,"lead_sponsor_name":"Peerbridge Health, Inc","has_results":false},{"nct_id":"NCT07022379","title":"Sodium-Glucose Cotransporter 2 Inhibitor Use in a National Heart Failure Telemonitoring Program","phase":"","overall_status":"COMPLETED","enrollment_count":13660,"lead_sponsor_name":"Satelia","has_results":false},{"nct_id":"NCT07283666","title":"Subspecialty Ambulatory Quality Cardiology Program","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":7000,"lead_sponsor_name":"NYU Langone Health","has_results":false},{"nct_id":"NCT05093933","title":"A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":6106,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT07037459","title":"Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":5056,"lead_sponsor_name":"Amgen","has_results":false},{"nct_id":"NCT02861534","title":"A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":5050,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT06697353","title":"An Observational Study to Learn More About the Real-world Outcomes in Patients With Heart Failure Who Initiate Treatment With Vericiguat in Japan","phase":"","overall_status":"COMPLETED","enrollment_count":4936,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT03036124","title":"Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":4744,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT05990296","title":"Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":4306,"lead_sponsor_name":"Geisinger Clinic","has_results":false},{"nct_id":"NCT07332520","title":"Predicting Heart Failure Outcomes With Biomarkers and Imaging","phase":"","overall_status":"COMPLETED","enrollment_count":4000,"lead_sponsor_name":"Xinjiang Medical University","has_results":false},{"nct_id":"NCT07087613","title":"Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG","phase":"","overall_status":"RECRUITING","enrollment_count":3850,"lead_sponsor_name":"Eko Devices, Inc.","has_results":false},{"nct_id":"NCT06543446","title":"Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy","phase":"NA","overall_status":"RECRUITING","enrollment_count":3290,"lead_sponsor_name":"University of Rochester","has_results":false},{"nct_id":"NCT03480633","title":"Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT06516562","title":"Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"University Medical Center Ho Chi Minh City (UMC)","has_results":false},{"nct_id":"NCT05728502","title":"An Observational Study, Called VERI-China, to Learn More About How Well Vericiguat Works and How Safe it is in Real-world Setting in People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in China","phase":"","overall_status":"COMPLETED","enrollment_count":2400,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT03387813","title":"Hemodynamic-GUIDEd Management of Heart Failure","phase":"NA","overall_status":"COMPLETED","enrollment_count":2358,"lead_sponsor_name":"Abbott Medical Devices","has_results":true},{"nct_id":"NCT05275920","title":"Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF)","phase":"NA","overall_status":"COMPLETED","enrollment_count":2211,"lead_sponsor_name":"NYU Langone Health","has_results":true},{"nct_id":"NCT06526988","title":"Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":2200,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT05650658","title":"Left vs Left Randomized Clinical Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":2136,"lead_sponsor_name":"Baylor College of Medicine","has_results":false},{"nct_id":"NCT06964464","title":"Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"University of Rochester","has_results":false},{"nct_id":"NCT02226120","title":"Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1980,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT06068166","title":"Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction","phase":"NA","overall_status":"COMPLETED","enrollment_count":1840,"lead_sponsor_name":"First Affiliated Hospital of Harbin Medical University","has_results":false},{"nct_id":"NCT05064709","title":"Assessment of CCM in HF With Higher Ejection Fraction","phase":"NA","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Impulse Dynamics","has_results":false},{"nct_id":"NCT04514458","title":"Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure","phase":"NA","overall_status":"COMPLETED","enrollment_count":1410,"lead_sponsor_name":"Yale University","has_results":true},{"nct_id":"NCT06363110","title":"An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States","phase":"","overall_status":"COMPLETED","enrollment_count":1400,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT05974189","title":"The VERIFY Study: An Observational Study Called VERIFY to Learn More About the Use of Vericiguat in People With Chronic Heart Failure With Reduced Ejection Fraction","phase":"","overall_status":"COMPLETED","enrollment_count":1391,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT06148935","title":"An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting","phase":"","overall_status":"RECRUITING","enrollment_count":1350,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT04903717","title":"Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists","phase":"NA","overall_status":"COMPLETED","enrollment_count":1210,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT07380555","title":"The Effectiveness and Safety of Artificial Intelligence(AI)-Assisted Medical Treatment Decision Support System Compared to Conventional Care in HFrEF Patients","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT04820556","title":"Gut Microbiota in Chronic Noncommunicable Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":1084,"lead_sponsor_name":"National Medical Research Center for Therapy and Preventive Medicine","has_results":false},{"nct_id":"NCT07238452","title":"Optimising Pacing Therapy, Integrated Medical Therapy, and Catheter AbLation for Atrial Fibrillation in Heart Failure Trial","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":1056,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT04900584","title":"Optimize Heart Failure Care During TRANSitional Period in Patients With Acute Heart Failure.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1009,"lead_sponsor_name":"Wonju Severance Christian Hospital","has_results":false},{"nct_id":"NCT02661217","title":"Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1002,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT03061747","title":"Multi-centre Observational Registry on Patients With Implantable Devices Remotely Monitored","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Azienda Ospedaliera Cardinale G. Panico","has_results":false},{"nct_id":"NCT05204238","title":"Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE)","phase":"","overall_status":"UNKNOWN","enrollment_count":998,"lead_sponsor_name":"University of Siena","has_results":false},{"nct_id":"NCT06330103","title":"Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips","phase":"NA","overall_status":"COMPLETED","enrollment_count":923,"lead_sponsor_name":"Rayong Hospital","has_results":false},{"nct_id":"NCT05828719","title":"Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction","phase":"NA","overall_status":"RECRUITING","enrollment_count":900,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT03072693","title":"Daily Ambulatory Remote Monitoring System For Post-Dischage Management Of ADHF","phase":"NA","overall_status":"UNKNOWN","enrollment_count":876,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT06455878","title":"Mobile Applet for Weight Management in Obese Heart Failure Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":830,"lead_sponsor_name":"Heart Health Research Center","has_results":false},{"nct_id":"NCT07214376","title":"A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":750,"lead_sponsor_name":"Pulnovo Medical, Inc.","has_results":false},{"nct_id":"NCT07181291","title":"Pulsed Field or Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation in Heart Failure","phase":"","overall_status":"COMPLETED","enrollment_count":700,"lead_sponsor_name":"St. Josefs-Hospital Wiesbaden GmbH","has_results":false},{"nct_id":"NCT07349979","title":"PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":654,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT04249648","title":"Hyperkalaemia and Its Impact on Therapy with RAASi","phase":"","overall_status":"COMPLETED","enrollment_count":651,"lead_sponsor_name":"Portsmouth Hospitals NHS Trust","has_results":false},{"nct_id":"NCT02900378","title":"randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":621,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT06632483","title":"An Observational Study to Learn More About How Safe Vericiguat is and How Well it Works in Indian People With Chronic Heart Failure With Reduced Ejection Fraction and Worsening Chronic Heart Failure Under Real World Conditions","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":604,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT06774014","title":"Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences","phase":"","overall_status":"RECRUITING","enrollment_count":600,"lead_sponsor_name":"University of Leeds","has_results":false},{"nct_id":"NCT07355088","title":"Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":600,"lead_sponsor_name":"Xinjiang Medical University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}