{"disease":{"id":"hdl","name":"hdl"},"drugs":{"marketed":[{"drug_id":"lopid","indication_name":"Reducing risk of developing coronary heart disease in Type IIb patients without history or symptoms of existing coronary heart disease with low HDL-cholesterol, elevated LDL-cholesterol, and elevated triglycerides unresponsive to weight loss, diet, exercise, and other pharmacologic agents","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lopid","generic_name":"Gemfibrozil","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"PPAR-alpha (Peroxisome Proliferator-Activated Receptor Alpha)","drug_class":"Peroxisome Proliferator Receptor alpha Agonist [EPC]","quality_score":44,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06190834","title":"Relationship Between High-Density Lipoprotein Subtypes and Coronary Heart Disease Prognosis.","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT03528031","title":"Habitual Diet and Avocado Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1008,"lead_sponsor_name":"Wake Forest University Health Sciences","has_results":false},{"nct_id":"NCT00389896","title":"A Crossover Study to Evaluate the Efficacy of Simvastatin in Elevating HDL-C Levels in Patients With Type 2 Diabetes (0733-216)(COMPLETED)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Organon and Co","has_results":false},{"nct_id":"NCT02171104","title":"MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":149,"lead_sponsor_name":"Masonic Cancer Center, University of Minnesota","has_results":false},{"nct_id":"NCT07130188","title":"Predictors for ACS and Complexity of CAD","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":130,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT05685017","title":"Adiponectin, ICAM-1, VCAM-1 Levels and Metabolic Syndrome in Obese Adolescents","phase":"","overall_status":"COMPLETED","enrollment_count":125,"lead_sponsor_name":"Universitas Airlangga","has_results":false},{"nct_id":"NCT04330209","title":"Comparing a Low-GI Nutrigenetic and Ketogenic Diet for Weight Loss With 18 Month Follow-up","phase":"","overall_status":"COMPLETED","enrollment_count":114,"lead_sponsor_name":"Iuliu Hatieganu University of Medicine and Pharmacy","has_results":false},{"nct_id":"NCT07530575","title":"Limosilactobacillus Fermentum CRL 1446 - CONICET CASASCO","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":80,"lead_sponsor_name":"PINER Pastor Manfredi Winery","has_results":false},{"nct_id":"NCT05174663","title":"Investigating the Dose Response of an Almond-enriched Diet on Optimizing HDL-C in a Population With Hypercholesterolemia","phase":"NA","overall_status":"COMPLETED","enrollment_count":75,"lead_sponsor_name":"Almond Board of California","has_results":false},{"nct_id":"NCT07496619","title":"Effects of Diabetic Educational Intervention and Dietary Supplements on Blood Glucose, Lipid Profile Levels, Body Mass Index, and Pain Management Among Adult Individuals With Painful Diabetic Peripheral Neuropathy.","phase":"NA","overall_status":"COMPLETED","enrollment_count":62,"lead_sponsor_name":"Al-Quds University","has_results":false},{"nct_id":"NCT03805776","title":"Intermittent Fasting in Dyslipidemia","phase":"NA","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Aga Khan University","has_results":false},{"nct_id":"NCT06671769","title":"Natural Heart Health Supplement Trial","phase":"PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Efforia, Inc","has_results":false},{"nct_id":"NCT03967990","title":"Corn and Heart Health Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":58,"lead_sponsor_name":"Arizona State University","has_results":false},{"nct_id":"NCT06574711","title":"Functional Yogurt Consumption and Its Effects on the Lipid Profile of Healthy Subjects","phase":"NA","overall_status":"COMPLETED","enrollment_count":54,"lead_sponsor_name":"Pontificia Universidad Javeriana","has_results":false},{"nct_id":"NCT06757777","title":"Evaluation of Remnant Cholesterol Levels and Monocyte-to-HDL-cholesterol Ratio as Predictors of Coronary Artery Disease Severity in Patients With Acute Coronary Syndrome","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":54,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT04236518","title":"Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics)","phase":"NA","overall_status":"COMPLETED","enrollment_count":53,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT04529174","title":"Oral Nutritional Supplement Effect on HDL Function","phase":"NA","overall_status":"COMPLETED","enrollment_count":53,"lead_sponsor_name":"Metagenics, Inc.","has_results":false},{"nct_id":"NCT07350213","title":"Step-Aerobics Versus Core Exercise for Non-HDL Cholesterol Reduction in Sedentary Women","phase":"NA","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"Muğla Sıtkı Koçman University","has_results":false},{"nct_id":"NCT04841460","title":"Impact of Beef's Unique Food Matrix on Human Health","phase":"NA","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Texas A&M University","has_results":false},{"nct_id":"NCT06988462","title":"Pilot Study of \"Bottarga\" Supplementation: A Little-known, Sustainable \"Blue\" Food","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"Cambridge Health Alliance","has_results":false},{"nct_id":"NCT03052491","title":"Effects of a 10 Component Dietary Supplement on Health and the Quality of Life","phase":"NA","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Centagen, Inc.","has_results":false},{"nct_id":"NCT03205254","title":"Effects of Short-term Diet on HDL Composition and Function","phase":"NA","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"University of California, Davis","has_results":false},{"nct_id":"NCT04097119","title":"HDL Function Dietary Supplement Safety and QOL","phase":"NA","overall_status":"UNKNOWN","enrollment_count":10,"lead_sponsor_name":"Metagenics, Inc.","has_results":false},{"nct_id":"NCT05641584","title":"Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":1,"lead_sponsor_name":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","has_results":false},{"nct_id":"NCT02135913","title":"Roles of Vitamin D and HDL in Obese Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":1,"lead_sponsor_name":"Xiang-An Li","has_results":false}],"total":25},"guidelines":[],"source":"Drug Landscape verified database"}