{"disease":{"id":"granulomatosis-with-polyangiitis","name":"Granulomatosis with polyangiitis","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":5,"pipeline_drug_count":0,"trial_count":3},"drugs":{"marketed":[{"drug_id":"rituxan","indication_name":"Granulomatosis with polyangiitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mabthera","generic_name":"rituxan","company_name":"Roche","drug_phase":"marketed","molecular_target":"B-lymphocyte antigen CD20","drug_class":"CD20-directed Cytolytic Antibody","quality_score":45,"revenue":"3800","mechanism":""},{"drug_id":"avacopan","indication_name":"Granulomatosis with polyangiitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tavneos","generic_name":"AVACOPAN","company_name":"Chemocentryx","drug_phase":"marketed","molecular_target":"C5a anaphylatoxin chemotactic receptor 1","drug_class":"Complement 5a Receptor Antagonist [EPC]","quality_score":62,"revenue":"400","mechanism":"Tavneos blocks the action of a chemical called C5a, which is involved in the body's inflammatory response."},{"drug_id":"avacopan","indication_name":"Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tavneos","generic_name":"AVACOPAN","company_name":"Chemocentryx","drug_phase":"marketed","molecular_target":"C5a anaphylatoxin chemotactic receptor 1","drug_class":"Complement 5a Receptor Antagonist [EPC]","quality_score":62,"revenue":"400","mechanism":"Tavneos blocks the action of a chemical called C5a, which is involved in the body's inflammatory response."},{"drug_id":"ccx168","indication_name":"Granulomatosis with polyangiitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tavneos","generic_name":"CCX168","company_name":"Chemocentryx","drug_phase":"discontinued","molecular_target":"C5a anaphylatoxin chemotactic receptor 1","drug_class":"Complement 5a Receptor Antagonist","quality_score":null,"revenue":null,"mechanism":"Tavneos blocks the action of a chemical called C5a, which is involved in inflammation and damage to blood vessels."},{"drug_id":"ruxience","indication_name":"Granulomatosis with polyangiitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mabthera","generic_name":"Rituximab-Pvvr","company_name":"Roche","drug_phase":"marketed","molecular_target":"CD20 antigen on pre-B and mature B-lymphocytes","drug_class":"Monoclonal antibody","quality_score":10,"revenue":null,"mechanism":"Monoclonal antibody targeting CD20 on B-lymphocytes, mediating cell lysis via CDC and ADCC."},{"drug_id":"rituximab","indication_name":"Granulomatosis with polyangiitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mabthera","generic_name":"rituximab","company_name":"Roche","drug_phase":"marketed","molecular_target":"B-lymphocyte antigen CD20","drug_class":"CD20-directed Cytolytic Antibody [EPC]","quality_score":10,"revenue":null,"mechanism":"Mabthera works by binding to the CD20 antigen on B-lymphocytes, triggering their destruction."},{"drug_id":"ccx168","indication_name":"Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tavneos","generic_name":"CCX168","company_name":"Chemocentryx","drug_phase":"discontinued","molecular_target":"C5a anaphylatoxin chemotactic receptor 1","drug_class":"Complement 5a Receptor Antagonist","quality_score":null,"revenue":null,"mechanism":"Tavneos blocks the action of a chemical called C5a, which is involved in inflammation and damage to blood vessels."}],"pipeline":[],"offLabel":[],"totalMarketed":7,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03557060","title":"NUCALA® Special Drug Use Investigation (EGPA, Long-term)","phase":"","overall_status":"COMPLETED","enrollment_count":4115,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT03430388","title":"Yellow Fever Vaccine in Patients With Rheumatic Diseases","phase":"NA","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT07087912","title":"Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":477,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT03410290","title":"Journey of Patients With Vasculitis From First Symptom to Diagnosis","phase":"","overall_status":"COMPLETED","enrollment_count":456,"lead_sponsor_name":"University of Pennsylvania","has_results":false},{"nct_id":"NCT04538937","title":"Prospective Registry of Eosinophilia With Respiratory Manifestations With Translational Research Identifying and Characterizing Eosinophils","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT06758271","title":"Special Drug Use-results Survey for Long-term Use（Avacopan）","phase":"","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Kissei Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT07444567","title":"Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":230,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT05716334","title":"Biosimilars of Rituximab in ANCA-associated Vasculitis Compared to the Originator","phase":"","overall_status":"COMPLETED","enrollment_count":201,"lead_sponsor_name":"McGill University Health Centre/Research Institute of the McGill University Health Centre","has_results":false},{"nct_id":"NCT01731561","title":"Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":166,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05263934","title":"Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":163,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT04551989","title":"Mepolizumab Long-term Study to Assess Real World Safety and Effectiveness of Eosinophilic Granulomatosis With Polyangiitis (EGPA) in Japan","phase":"","overall_status":"COMPLETED","enrollment_count":118,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT02807103","title":"Rituximab in Eosinophilic Granulomatosis With Polyangiitis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":107,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT04280601","title":"PRagmatic Analysis of Vitamin D in ANCA-Associated Vasculitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":102,"lead_sponsor_name":"Christian Pagnoux","has_results":false},{"nct_id":"NCT01613599","title":"An Observational Study of The Safety of MabThera/Rituxan (Rituximab) in Participants With Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis","phase":"","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Genentech, Inc.","has_results":true},{"nct_id":"NCT03782870","title":"Cardiovascular Involvement in Patients With Granulomatosis With Polyangiitis","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Medical University of Warsaw","has_results":false},{"nct_id":"NCT03298061","title":"Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT03164473","title":"Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":98,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT01862068","title":"Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)","phase":"","overall_status":"COMPLETED","enrollment_count":93,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07343661","title":"Beyond EOsinophils: proteoMICS to Identify Potential Biomarker of Organ Damage and Response to MEPOLIZUMAB in EGPA","phase":"PHASE4","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":90,"lead_sponsor_name":"Azienda Ospedaliero Universitaria di Cagliari","has_results":false},{"nct_id":"NCT04944524","title":"Comparison of Tofacitinib and Methotrexate in the Maintained Treatment of GPA","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":66,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT02108860","title":"Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":65,"lead_sponsor_name":"University of South Florida","has_results":false},{"nct_id":"NCT03482479","title":"Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"University of Pennsylvania","has_results":false},{"nct_id":"NCT03895801","title":"Study of IFX-1 to Replace Steroids in Patients With Granulomatosis With Polyangiitis and Microscopic Polyangiitis.","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":57,"lead_sponsor_name":"InflaRx GmbH","has_results":true},{"nct_id":"NCT05091333","title":"FASENRA Regulatory Postmarketing Surveillance in Korea","phase":"","overall_status":"COMPLETED","enrollment_count":51,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT05703802","title":"Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"University Hospital Muenster","has_results":false},{"nct_id":"NCT01750697","title":"A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Hoffmann-La Roche","has_results":true},{"nct_id":"NCT03712345","title":"Safety and Efficacy Study of IFX-1 in add-on to Standard of Care in GPA and MPA","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":20,"lead_sponsor_name":"InflaRx GmbH","has_results":true},{"nct_id":"NCT06512883","title":"A Trial to Investigate Benralizumab in Children With Eosinophilic Diseases","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":14,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT01933724","title":"The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":12,"lead_sponsor_name":"University of South Florida","has_results":false},{"nct_id":"NCT03919435","title":"TEMPO Study: Trimethoprim-Sulfamethoxazole in Granulomatosis With Polyangiitis","phase":"PHASE1, PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":8,"lead_sponsor_name":"University of Pennsylvania","has_results":false},{"nct_id":"NCT05376319","title":"PR3-AAV Resilient Remission or PRRR","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":6,"lead_sponsor_name":"Mayo Clinic","has_results":true}],"total":31},"guidelines":[],"source":"Drug Landscape verified database"}