{"disease":{"id":"gist","name":"gist"},"drugs":{"marketed":[{"drug_id":"sunitinib","indication_name":"Gastrointestinal Stromal Tumor (GIST)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sutent","generic_name":"sunitinib","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"3-phosphoinositide-dependent protein kinase 1","drug_class":"Moderate Risk QT Prolonging Agents","quality_score":67,"revenue":null,"mechanism":"Sunitinib is a small-molecule, multi-targeted receptor tyrosine kinase inhibitor that inhibits PDGFRα, PDGFRβ, VEGFR1, VEGFR2, and KIT."},{"drug_id":"chembl-chembl1946170","indication_name":"Locally Advanced, Unresectable or Metastatic GIST","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"REGORAFENIB","company_name":"","drug_phase":"marketed","molecular_target":"RET, VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2, DDR2, TrkA, Eph2A, RAF-1, BRAF, BRAF V600E, SAPK2, PTK5, Abl, CSF1R","drug_class":"","quality_score":55,"revenue":null,"mechanism":"Regorafenib inhibits multiple kinases involved in oncogenesis, angiogenesis, metastasis, and tumor immunity."},{"drug_id":"chembl-chembl941","indication_name":"Kit+ Unresectable/Metastatic GIST","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"IMATINIB","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":12,"revenue":null,"mechanism":null},{"drug_id":"chembl-chembl941","indication_name":"Adjuvant Treatment of Kit+ GIST","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"IMATINIB","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":12,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":4,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03733665","title":"HES and NICOR Data Linkage for Cardiac Failure Population Analysis","phase":"","overall_status":"UNKNOWN","enrollment_count":80000,"lead_sponsor_name":"King's College London","has_results":false},{"nct_id":"NCT02993965","title":"State Immunization Information Systems to Improve HPV Vaccination Rates","phase":"NA","overall_status":"COMPLETED","enrollment_count":77716,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT03130088","title":"European Registry of Cardiac Arrest Study Two","phase":"","overall_status":"COMPLETED","enrollment_count":35000,"lead_sponsor_name":"German Resuscitation Registry","has_results":false},{"nct_id":"NCT07072143","title":"An International Study on Pediatric Patients With Rare Tumors.","phase":"","overall_status":"RECRUITING","enrollment_count":6250,"lead_sponsor_name":"Azienda Ospedaliera di Padova","has_results":false},{"nct_id":"NCT03216785","title":"SNUH MICU Cohort Study of PICS","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT06697171","title":"Effectiveness of Conflict-of-interest Disclosures on Trust, Credibility and Transparency When Displayed on Social Media Posts From Registered Dietitians","phase":"NA","overall_status":"COMPLETED","enrollment_count":3409,"lead_sponsor_name":"University of Ontario Institute of Technology","has_results":false},{"nct_id":"NCT03381053","title":"Study to Compare Pathologic Type, NIH and WHO Criteria,and Mechanism of GIST Malignant Transformation","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT03050268","title":"Familial Investigations of Childhood Cancer Predisposition","phase":"","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"St. Jude Children's Research Hospital","has_results":false},{"nct_id":"NCT05400018","title":"Clinical Evaluation of Genetron D842V PCR Kit in GIST Patients","phase":"","overall_status":"COMPLETED","enrollment_count":1041,"lead_sponsor_name":"Genetron Health","has_results":false},{"nct_id":"NCT07273045","title":"A Comprehensive, Multinational GIST Registry","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Universität Duisburg-Essen","has_results":false},{"nct_id":"NCT03896958","title":"The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"SpeciCare","has_results":false},{"nct_id":"NCT04398342","title":"Characteristics of Children With Cerebral Palsy Who Develops Hip Displacement in Denmark","phase":"","overall_status":"UNKNOWN","enrollment_count":957,"lead_sponsor_name":"Mette Røn Kristensen","has_results":false},{"nct_id":"NCT03475953","title":"A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors","phase":"PHASE1, PHASE2","overall_status":"UNKNOWN","enrollment_count":747,"lead_sponsor_name":"Institut Bergonié","has_results":false},{"nct_id":"NCT04599660","title":"Study in Low Risk Gastrointestinal Stromal Tumor (GISTs)","phase":"","overall_status":"COMPLETED","enrollment_count":700,"lead_sponsor_name":"Italian Sarcoma Group","has_results":false},{"nct_id":"NCT04007419","title":"Health Promoters and Organ Donation","phase":"NA","overall_status":"COMPLETED","enrollment_count":621,"lead_sponsor_name":"Temple University","has_results":false},{"nct_id":"NCT05804331","title":"The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Western Sydney Local Health District","has_results":false},{"nct_id":"NCT03465722","title":"(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":476,"lead_sponsor_name":"Blueprint Medicines Corporation","has_results":true},{"nct_id":"NCT04466865","title":"A Communication Tool to Assist Older Adults Facing Dialysis Choices","phase":"NA","overall_status":"COMPLETED","enrollment_count":407,"lead_sponsor_name":"University of Wisconsin, Madison","has_results":false},{"nct_id":"NCT04557969","title":"Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT07125365","title":"UK Islet Autoantibody Registry","phase":"","overall_status":"RECRUITING","enrollment_count":350,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT07503054","title":"Ovarian Cancer Screening and AI","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":350,"lead_sponsor_name":"Charite University, Berlin, Germany","has_results":false},{"nct_id":"NCT07522762","title":"Long-term Survivorship Challenges of Advanced/Metastatic GIST Patients Responding to Tyrosine Kinase Inhibitor Treatment: an Observational Study","phase":"","overall_status":"RECRUITING","enrollment_count":330,"lead_sponsor_name":"The Netherlands Cancer Institute","has_results":false},{"nct_id":"NCT02611024","title":"Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":316,"lead_sponsor_name":"PharmaMar","has_results":false},{"nct_id":"NCT05114551","title":"ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure","phase":"","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT03910257","title":"Nutrition Education Module for Preschooler Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"SEAMEO Regional Centre for Food and Nutrition","has_results":false},{"nct_id":"NCT03880617","title":"Distress, Medication Adherence and Care Needs in Patients With CML and GIST Receiving Oral Targeted Therapy","phase":"","overall_status":"COMPLETED","enrollment_count":297,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT05489237","title":"First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":278,"lead_sponsor_name":"IDRX, Inc., a wholly owned subsidiary of GSK, LLC","has_results":false},{"nct_id":"NCT04751591","title":"Study On Safety Of Endoscopic Resection For 2-5cm Gastric Gastrointestinal Stromal Tumor","phase":"NA","overall_status":"UNKNOWN","enrollment_count":260,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT07379047","title":"A Multicenter, Open-label Clinical Study to Evaluate the Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)","phase":"PHASE2, PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":255,"lead_sponsor_name":"Ningbo Newbay Technology Development Co., Ltd","has_results":false},{"nct_id":"NCT06771778","title":"Advancing the Role of the Neonatal Registered Dietitian Nutritionist","phase":"","overall_status":"COMPLETED","enrollment_count":253,"lead_sponsor_name":"Florida International University","has_results":false},{"nct_id":"NCT05954936","title":"Trauma Registry in Villavicencio, Colombia","phase":"","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Hospital Departamental de Villavicencio","has_results":false},{"nct_id":"NCT03716089","title":"Comparison of Tumor Efficacy Safety in Laparoscopic Resection of Gastrointestinal Stromal Tumors Between Favorable and Unfavorable Site","phase":"","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Fujian Medical University","has_results":false},{"nct_id":"NCT04482283","title":"HF Prevalence and Evolution of HF in DM II Patients at High Risk","phase":"","overall_status":"COMPLETED","enrollment_count":245,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT06038552","title":"Comparison of Clinical Efficacy of Liver Resection, RFA, TACE, and Drug Therapy in Patients with GIST LM","phase":"","overall_status":"COMPLETED","enrollment_count":238,"lead_sponsor_name":"First Affiliated Hospital, Sun Yat-Sen University","has_results":false},{"nct_id":"NCT03114319","title":"Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors","phase":"PHASE1","overall_status":"TERMINATED","enrollment_count":227,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT03804190","title":"Work-Related Musculoskeletal Disorders Among Otorhinolarngologists","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT04855500","title":"A Single Center Registry of Coronary OCT","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Hainan People's Hospital","has_results":false},{"nct_id":"NCT07031869","title":"The Swedish Hockey League Hand and Wrist Injury Tracking Trial","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Dalarna County Council, Sweden","has_results":false},{"nct_id":"NCT06136273","title":"Penetrating Trauma Registry and Open Source Data","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Methodist Health System","has_results":false},{"nct_id":"NCT05895942","title":"Exploring the Molecular Mechanism Based on KIT Mutation","phase":"","overall_status":"UNKNOWN","enrollment_count":190,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT07520058","title":"Shortened Working Hours for Nurses in Elderly Care and Municipal Home Care - Work Environment, Work-life Balance & Well-being","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":190,"lead_sponsor_name":"University of Gavle","has_results":false},{"nct_id":"NCT07405125","title":"Safety of Robotic Surgery for GISTs at Special Anatomic Sites","phase":"NA","overall_status":"RECRUITING","enrollment_count":182,"lead_sponsor_name":"The First Affiliated Hospital with Nanjing Medical University","has_results":false},{"nct_id":"NCT07337941","title":"Menstrual Cycle Phase and Virtual Reality on Preoperative Anxiety","phase":"NA","overall_status":"COMPLETED","enrollment_count":170,"lead_sponsor_name":"Zonguldak Bulent Ecevit University","has_results":false},{"nct_id":"NCT06986473","title":"Innovating a Questionnaire to Investigate the Awareness of Dermatologists Regarding the Role of Physical Therapy","phase":"","overall_status":"COMPLETED","enrollment_count":165,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT01742299","title":"Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":155,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT03842098","title":"Korean Medicine Patient Registry of Postoperative Therapy for Musculoskeletal Disorders (KPOP-MD): A Study Protocol","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Gachon University Gil Oriental Medical Hospital","has_results":false},{"nct_id":"NCT07411118","title":"RCT of EFTR Versus STER for GIST Treatment","phase":"NA","overall_status":"RECRUITING","enrollment_count":136,"lead_sponsor_name":"Chinese University of Hong Kong","has_results":false},{"nct_id":"NCT07507773","title":"Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":135,"lead_sponsor_name":"Centre Oscar Lambret","has_results":false},{"nct_id":"NCT03864640","title":"Reliability and Validity of Mediterranean Colorectal Cancer Registry","phase":"","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Volkan Doğru","has_results":false},{"nct_id":"NCT07169344","title":"Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":110,"lead_sponsor_name":"Oslo University Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}