{"disease":{"id":"general-anesthesia","name":"General anesthesia","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":57,"pipeline_drug_count":0,"trial_count":6},"drugs":{"marketed":[{"drug_id":"sevoflurane","indication_name":"Induction and maintenance of general anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"SEVOFLURANE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"General Anesthetic [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"sevoflurane","indication_name":"Induction and maintenance of general anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"SEVOFLURANE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"General Anesthetic [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"chembl-chembl526","indication_name":"Induction of General Anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PROPOFOL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"General Anesthetic [EPC]","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"chembl-chembl526","indication_name":"Maintenance of General Anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PROPOFOL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"General Anesthetic [EPC]","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"alimemazine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Temaril","generic_name":"alimemazine","company_name":"","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"trimeprazine","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"sulfentanyl","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Sulfentanyl","company_name":"Shenzhen Third People's Hospital","drug_phase":"phase_1","molecular_target":"Solute carrier family 22 member 1, Delta-type opioid receptor, Kappa-type opioid receptor","drug_class":"","quality_score":32,"revenue":null,"mechanism":null},{"drug_id":"suxamethonium","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Succinylcholine Chloride","generic_name":"SUXAMETHONIUM","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Muscle-type nicotinic acetylcholine receptor","drug_class":"Depolarizing Neuromuscular Blocker","quality_score":67,"revenue":null,"mechanism":"Succinylcholine Chloride works by mimicking the action of acetylcholine at the neuromuscular junction, causing a rapid depolarization of muscle fibers."},{"drug_id":"enflurane","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Efrane","generic_name":"ENFLURANE","company_name":"Baxter","drug_phase":"marketed","molecular_target":"Glycine receptor subunit alpha-1","drug_class":"General Anesthetic","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"acetadote","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Acetadote","company_name":"University of Texas Southwestern Medical Center","drug_phase":"marketed","molecular_target":"Cystine/glutamate transporter, Cytochrome c, Glutathione synthetase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"midazolam-hydrochloride","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Versed","generic_name":"Midazolam Hydrochloride","company_name":"Takeda Pharmaceutical Company Limited","drug_phase":"marketed","molecular_target":"GABA A receptor alpha-5/beta-2/gamma-2","drug_class":"Benzodiazepine","quality_score":58,"revenue":null,"mechanism":""},{"drug_id":"chlordiazepoxide","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlordiazepoxide Hydrochloride","generic_name":"CHLORDIAZEPOXIDE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"rocuronium","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zemuron","generic_name":"ROCURONIUM","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"Acetylcholine receptor","drug_class":"Nondepolarizing Neuromuscular Blocker","quality_score":10,"revenue":null,"mechanism":"Zemuron works by blocking the action of acetylcholine at the neuromuscular junction, preventing muscle contraction."},{"drug_id":"midazolam","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Versed","generic_name":"midazolam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"Multidrug resistance protein 1, Cytochrome P450 3A4, GABA A receptor alpha-3/beta-2/gamma-2","drug_class":"Benzodiazepine (short-acting)","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"mivacurium","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mivacron","generic_name":"MIVACURIUM","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Acetylcholine receptor","drug_class":"Nondepolarizing Neuromuscular Blocker","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"glycopyrronium-bromide","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cuvposa","generic_name":"GLYCOPYRRONIUM BROMIDE","company_name":"Shionogi","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Anticholinergic","quality_score":62,"revenue":null,"mechanism":"Cuvposa works by blocking the action of a chemical called acetylcholine, which stimulates the muscarinic receptors in the body."},{"drug_id":"fentanyl-f2","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Fentanyl (F2)","company_name":"Oslo University Hospital","drug_phase":"marketed","molecular_target":"D(4) dopamine receptor, Solute carrier family 22 member 1, D(2) dopamine receptor","drug_class":"Synthetic opioid","quality_score":33,"revenue":null,"mechanism":""},{"drug_id":"chloral-hydrate","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nycoton","generic_name":"CHLORAL HYDRATE","company_name":"","drug_phase":"discontinued","molecular_target":"","drug_class":"chloral hydrate","quality_score":null,"revenue":null,"mechanism":"Nycoton works by acting as a central nervous system depressant, slowing down brain activity to induce sleep or anesthesia."},{"drug_id":"fluroxene","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fluoromar","generic_name":"FLUROXENE","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"fluroxene","quality_score":null,"revenue":null,"mechanism":"Fluoromar works by inducing unconsciousness and amnesia through its effects on the central nervous system."},{"drug_id":"rocuronium-bromide","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rocuronium","generic_name":"Rocuronium Bromide","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Cholinergic receptors at the motor end-plate","drug_class":"Nondepolarizing neuromuscular blocking agent","quality_score":10,"revenue":null,"mechanism":"Rocuronium bromide competes for cholinergic receptors at the motor end-plate, antagonized by acetylcholinesterase inhibitors."},{"drug_id":"acetylcysteine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Acetadote","generic_name":"Acetylcysteine","company_name":"Bristol-Myers Squibb","drug_phase":"marketed","molecular_target":"Glutathione levels; reactive metabolite of acetaminophen","drug_class":"Antidote","quality_score":62,"revenue":null,"mechanism":"Acetylcysteine reduces liver injury from acetaminophen overdose by maintaining glutathione levels or providing alternate conjugation substrate."},{"drug_id":"pethidine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"pethidine","company_name":"","drug_phase":"unknown","molecular_target":"Solute carrier family 22 member 1, Glutamate receptor ionotropic, NMDA 3A, Kappa-type opioid receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"desflurane","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Suprane","generic_name":"DESFLURANE","company_name":"Baxter","drug_phase":"marketed","molecular_target":"GABA-A receptor; anion channel","drug_class":"General Anesthetic [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"diprivan","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Diprivan","company_name":"St. Antonius Hospital","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C9, Fatty-acid amide hydrolase 1, Transient receptor potential cation channel subfamily V member 4","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"glycopyrrolate","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Glycopyrrolate","company_name":"Yonsei University","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"acetylcystein","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Acetylcystein","company_name":"University Hospital, Strasbourg, France","drug_phase":"marketed","molecular_target":"Cystine/glutamate transporter, Cytochrome c, Glutathione synthetase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"cisatracurium","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nimbex","generic_name":"CISATRACURIUM","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Acetylcholine receptor","drug_class":"Nondepolarizing Neuromuscular Blocker","quality_score":63,"revenue":null,"mechanism":"Nimbex works by blocking the action of acetylcholine at the neuromuscular junction, preventing muscle contraction."},{"drug_id":"pecazine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"pecazine","company_name":"","drug_phase":"unknown","molecular_target":"5-hydroxytryptamine receptor 6, FAD-linked sulfhydryl oxidase ALR, 5-hydroxytryptamine receptor 2A","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"atracurium-besylate","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Atracurium","generic_name":"Atracurium Besylate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Cholinergic receptor sites on motor end-plate","drug_class":"Nondepolarizing skeletal muscle relaxant","quality_score":68,"revenue":null,"mechanism":"Nondepolarizing skeletal muscle relaxant that competitively antagonizes acetylcholine at motor end-plate cholinergic receptors."},{"drug_id":"aprobarbital","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Allonal","generic_name":"APROBARBITAL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"aprobarbital","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"flutoprazepam","indication_name":"Induction of general anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Restas","generic_name":"FLUTOPRAZEPAM","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"flutoprazepam","quality_score":null,"revenue":null,"mechanism":"Flutoprazepam works by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain."},{"drug_id":"etomidate","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Amidate","generic_name":"ETOMIDATE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Cytochrome P450 11B2, mitochondrial","drug_class":"General Anesthetic [EPC]","quality_score":46,"revenue":null,"mechanism":""},{"drug_id":"fentanyl","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Duragesic","generic_name":"fentanyl","company_name":"Johnson & Johnson (Janssen Pharmaceutica)","drug_phase":"marketed","molecular_target":"D(4) dopamine receptor, Solute carrier family 22 member 1, D(2) dopamine receptor","drug_class":"Synthetic opioid analgesic","quality_score":55,"revenue":null,"mechanism":"Synthetic opioid 50-100x more potent than morphine that binds mu-opioid receptors, providing potent analgesia and anesthesia."},{"drug_id":"levorphanol","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Levo-Dromoran","generic_name":"LEVORPHANOL","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"mu-opioid receptor","drug_class":"Opioid Agonist","quality_score":64,"revenue":null,"mechanism":"Levorphanol binds primarily to mu-opioid receptors to produce analgesia, with no ceiling effect for pain relief."},{"drug_id":"pethidin","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Pethidin","company_name":"Ain Shams University","drug_phase":"marketed","molecular_target":"Solute carrier family 22 member 1, Glutamate receptor ionotropic, NMDA 3A, Kappa-type opioid receptor","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"remifentanyl","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Remifentanyl","company_name":"Kocaeli University","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor, Mu-type opioid receptor","drug_class":"","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"morphine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"MS Contin","generic_name":"morphine sulfate","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Solute carrier family 22 member 1, Delta-type opioid receptor, Kappa-type opioid receptor","drug_class":"Opioid analgesic","quality_score":10,"revenue":null,"mechanism":"The prototypical opioid agonist that binds mu-opioid receptors in the CNS, providing potent analgesia and serving as the reference standard for all opioids."},{"drug_id":"promethazine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Phenergan","generic_name":"promethazine","company_name":"Generic (originally Wyeth/Pfizer)","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, 5-hydroxytryptamine receptor 6, FAD-linked sulfhydryl oxidase ALR","drug_class":"Phenothiazine antihistamine/antiemetic","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"l-cysteine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"L-cysteine","company_name":"Louisiana State University Health Sciences Center Shreveport","drug_phase":"marketed","molecular_target":"Cystine/glutamate transporter","drug_class":"Amino acid derivative","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"demerol","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Meperidine Hydrochloride Preservative Free","generic_name":"Meperidine Hydrochloride","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":72,"revenue":null,"mechanism":"Meperidine Hydrochloride Preservative Free works by binding to opioid receptors in the brain, altering the perception of and response to pain."},{"drug_id":"alfentanil","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Alfenta","generic_name":"ALFENTANIL","company_name":"Rising","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":50,"revenue":null,"mechanism":""},{"drug_id":"cisatracurium-besylate","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nimbex","generic_name":"Cisatracurium Besylate","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Acetylcholine receptor","drug_class":"Nondepolarizing Neuromuscular Blocker","quality_score":10,"revenue":null,"mechanism":"Nimbex works by blocking the action of acetylcholine at the neuromuscular junction, preventing muscle contraction."},{"drug_id":"morphine-sulfate","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Duramorph Pf","generic_name":"Morphine Sulfate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":80,"revenue":null,"mechanism":"Duramorph Pf works by binding to opioid receptors in the brain and spinal cord, mimicking the natural pain-relieving chemicals in the body."},{"drug_id":"oxymorphone","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Opana Er","generic_name":"OXYMORPHONE","company_name":"Endo","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"isoflurane","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Forane","generic_name":"ISOFLURANE","company_name":"Baxter","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 2B","drug_class":"General Anesthetic [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"atracurium","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tracrium Preservative Free","generic_name":"ATRACURIUM","company_name":"","drug_phase":"marketed","molecular_target":"Neuronal acetylcholine receptor subunit alpha-3","drug_class":"Nondepolarizing Neuromuscular Blocker","quality_score":55,"revenue":null,"mechanism":""},{"drug_id":"sufentanil","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sufenta Preservative Free","generic_name":"SUFENTANIL","company_name":"Rising","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":80,"revenue":null,"mechanism":"Sufentanil works by binding to opioid receptors in the brain, spinal cord, and other areas to produce pain relief."},{"drug_id":"amidate","indication_name":"Induction of general anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Amidate","generic_name":"Etomidate","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"GABA A receptor alpha-2/beta-2/gamma-2","drug_class":"General Anesthetic [EPC]","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"doxacurium","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bw-A938U","generic_name":"DOXACURIUM","company_name":"","drug_phase":"marketed","molecular_target":"Acetylcholine receptor","drug_class":"doxacurium","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"amobarbital","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Amobarbitone","generic_name":"AMOBARBITAL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"amobarbital","quality_score":28,"revenue":null,"mechanism":""},{"drug_id":"pentobarbital","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nembutal Sodium","generic_name":"PENTOBARBITAL","company_name":"Oak Pharms","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"pentobarbital","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"ketamine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ketalar","generic_name":"ketamine","company_name":"Ph Health","drug_phase":"marketed","molecular_target":"Glutamate [NMDA] receptor","drug_class":"General Anesthetic","quality_score":75,"revenue":null,"mechanism":"Ketamine works by blocking the action of glutamate at the NMDA receptor, which is involved in pain perception and memory formation."},{"drug_id":"cysteine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cysteine Hydrochloride","generic_name":"CYSTEINE","company_name":"Exela Pharma","drug_phase":"marketed","molecular_target":"Cystine/glutamate transporter","drug_class":"Vitamin C [EPC]","quality_score":50,"revenue":null,"mechanism":""},{"drug_id":"methohexital","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Brevital Sodium","generic_name":"METHOHEXITAL","company_name":"Ph Health","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-3/gamma-2","drug_class":"Barbiturate","quality_score":50,"revenue":null,"mechanism":""},{"drug_id":"propofol","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Diprivan","generic_name":"Propofol","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"GABA A receptors","drug_class":"General anesthetic","quality_score":10,"revenue":null,"mechanism":"Propofol produces sedative/anesthetic effects by positive modulation of inhibitory GABA function through GABA A receptors."},{"drug_id":"halothane","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Anestan","generic_name":"HALOTHANE","company_name":"","drug_phase":"marketed","molecular_target":"GABA-A receptor; anion channel","drug_class":"halothane","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"thiopental","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pentothal","generic_name":"THIOPENTAL","company_name":"Abbott","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"thiopental","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"butorphanol","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Stadol Preservative Free","generic_name":"BUTORPHANOL","company_name":"","drug_phase":"marketed","molecular_target":"Kappa-type opioid receptor","drug_class":"Opioid Agonist/Antagonist","quality_score":57,"revenue":null,"mechanism":""},{"drug_id":"desf","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"DESF","company_name":"Baxter Hlthcare","drug_phase":"marketed","molecular_target":"Potassium channel subfamily K member 10, Potassium channel subfamily K member 18, Potassium channel subfamily K member 2","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Desf works by interacting with a specific biological target to produce a therapeutic effect."},{"drug_id":"methohexitone","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Methohexitone","company_name":"St Patrick's Hospital, Ireland","drug_phase":"marketed","molecular_target":"Neuronal acetylcholine receptor; alpha2/beta2, Glycine receptor subunit alpha-1, GABA-A receptor alpha-1/beta-3/gamma-2","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"sialanar","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Sialanar","company_name":"Proveca Pharma Limited","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"sevorane","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"sevorane","company_name":"University Hospital, Ghent","drug_phase":"marketed","molecular_target":"Glycine receptor subunit alpha-1, Potassium channel subfamily K member 10, Potassium channel subfamily K member 18","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"succinylcholine","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Succinylcholine","company_name":"Charles University, Czech Republic","drug_phase":"marketed","molecular_target":"Muscle-type nicotinic acetylcholine receptor, Acetylcholinesterase","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"sulfentanil","indication_name":"General anesthesia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Sulfentanil","company_name":"Henan Provincial People's Hospital","drug_phase":"phase_1","molecular_target":"Solute carrier family 22 member 1, Delta-type opioid receptor, Kappa-type opioid receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":63,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04697732","title":"İntraoperative Awareness Under General Anesthesia","phase":"","overall_status":"UNKNOWN","enrollment_count":30000,"lead_sponsor_name":"Baskent University Ankara Hospital","has_results":false},{"nct_id":"NCT07136194","title":"Risk Factors of Postoperative Acute Kidney Injury and Mortality Among Hospitalized Patients Undergoing Major Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":21533,"lead_sponsor_name":"Peking University First Hospital","has_results":false},{"nct_id":"NCT07495436","title":"Video Versus Direct Laryngoscopy for Tracheal Intubation in Pediatric Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":5562,"lead_sponsor_name":"Hospital Clinico Universitario de Santiago","has_results":false},{"nct_id":"NCT05762237","title":"Deep Learning Models for Prediction of Intraoperative Hypotension Using Non-invasive Parameters","phase":"","overall_status":"COMPLETED","enrollment_count":5175,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT01198639","title":"One-year Mortality After Surgery and Low Bispectral Index","phase":"NA","overall_status":"COMPLETED","enrollment_count":2044,"lead_sponsor_name":"Hopital Foch","has_results":false},{"nct_id":"NCT07061548","title":"Algorithm Predicting Intraoperative Changes in Cardiac Output Using Capnography","phase":"","overall_status":"RECRUITING","enrollment_count":2005,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT01661907","title":"Anesthesia-analgesia Methods and Postoperative Delirium","phase":"NA","overall_status":"COMPLETED","enrollment_count":1800,"lead_sponsor_name":"Peking University First Hospital","has_results":false},{"nct_id":"NCT02822417","title":"Clinical and Genetic Factors on the Postoperative Recovery Time of General Anaesthesia","phase":"","overall_status":"COMPLETED","enrollment_count":1453,"lead_sponsor_name":"Yijing He","has_results":false},{"nct_id":"NCT05549791","title":"A Non-intervention Fiberoptic Bronchoscopy Study of Remazolam Toluene Sulfonate for Injection Under General Anesthesia and Fiberoptic Bronchoscopy","phase":"","overall_status":"COMPLETED","enrollment_count":1285,"lead_sponsor_name":"Jiangsu HengRui Medicine Co., Ltd.","has_results":false},{"nct_id":"NCT05223907","title":"Safety and Efficacy of Maintenance of Etomidate in General Anesthesia","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1080,"lead_sponsor_name":"Henan Provincial People's Hospital","has_results":false},{"nct_id":"NCT05857618","title":"Study to Determine if Patients Exposed to General Anesthesia Significant Numbers of Times Would Increase the Risk for Intraoperative Awareness.","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of Chicago","has_results":false},{"nct_id":"NCT05133648","title":"Anesthesia Technique in COVID-19 Positive Hip Fracture Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT04421872","title":"The Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Shengjing Hospital","has_results":false},{"nct_id":"NCT07235514","title":"Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":958,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT03215823","title":"Predictive Factors of the Difficult Intubation When Using the Videolaryngoscope","phase":"","overall_status":"COMPLETED","enrollment_count":808,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT03987789","title":"Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":707,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT03432351","title":"Multi-center Isoelectric EEG Study in Children Under General Anesthesia","phase":"","overall_status":"COMPLETED","enrollment_count":687,"lead_sponsor_name":"Children's Hospital of Philadelphia","has_results":false},{"nct_id":"NCT06462313","title":"Dobutamine for Management of Surgical Patients With Septic Shock","phase":"NA","overall_status":"COMPLETED","enrollment_count":584,"lead_sponsor_name":"First Affiliated Hospital of Zhejiang University","has_results":false},{"nct_id":"NCT05364801","title":"Impact of Anxiety on the Decision-making Processes of Anesthesiologists","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Centre Hospitalier Universitaire de Besancon","has_results":false},{"nct_id":"NCT06909227","title":"Relevance of Veinous Lactates to Predict Postoperative Complications in Children 0-1 Years","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Hôpital Armand Trousseau","has_results":false},{"nct_id":"NCT07203287","title":"Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":490,"lead_sponsor_name":"The University of Texas Medical Branch, Galveston","has_results":false},{"nct_id":"NCT06047119","title":"Respiratory and Hemodynamic Targets During General Anesthesia","phase":"NA","overall_status":"COMPLETED","enrollment_count":485,"lead_sponsor_name":"Lars Wiuff Andersen","has_results":false},{"nct_id":"NCT05486416","title":"Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":465,"lead_sponsor_name":"Haisco-USA Pharmaceuticals, Inc.","has_results":true},{"nct_id":"NCT05082896","title":"Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia","phase":"","overall_status":"COMPLETED","enrollment_count":453,"lead_sponsor_name":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","has_results":false},{"nct_id":"NCT06755853","title":"Scale for Evaluating Oral and Pharyngolaryngeal Symptoms After General Anesthesia","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Nuh Naci Yazgan University","has_results":false},{"nct_id":"NCT07020390","title":"Effect of Anesthesia Techniques on Quality of Recovery Scores in HOLEP Surgery","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"TC Erciyes University","has_results":false},{"nct_id":"NCT05411406","title":"Prediction of Difficult Mask Ventilation Using 3D-Facescan and Machine Learning","phase":"","overall_status":"COMPLETED","enrollment_count":423,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT05478174","title":"Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"Haisco-USA Pharmaceuticals, Inc.","has_results":true},{"nct_id":"NCT06982690","title":"Anesthesia Modality and Oncologic Outcomes in High-Risk NMIBC: A Randomized Trial","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":370,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT04619979","title":"Preoperative Anxiety on Postoperative Outcome and Sleep Quality in Patients Undergoing Laparoscopic Hysterectomy","phase":"","overall_status":"COMPLETED","enrollment_count":356,"lead_sponsor_name":"Shengjing Hospital","has_results":false},{"nct_id":"NCT06566469","title":"Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":340,"lead_sponsor_name":"Peking University First Hospital","has_results":false},{"nct_id":"NCT03169556","title":"Comparison of Conventional Lightwand Intubation Versus Video-laryngoscope Guided Lightwand Intubation in Simulated Cervical Spine-immobilized Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":318,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT06773351","title":"A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Feng Gao","has_results":false},{"nct_id":"NCT05817019","title":"Postoperative Sugammadex After COVID-19","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Korea University Ansan Hospital","has_results":false},{"nct_id":"NCT05173688","title":"The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Shengjing Hospital","has_results":false},{"nct_id":"NCT05493813","title":"Total Intravenous Anesthesia Versus Sevoflurane Anesthesia for Endovascular Thrombectomy in Acute Ischemic Stroke","phase":"NA","overall_status":"UNKNOWN","enrollment_count":298,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT02400931","title":"The Necessity of Routine Mask Ventilation in Adults","phase":"NA","overall_status":"COMPLETED","enrollment_count":288,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT06632067","title":"Sugammadex and Time to Extubation in Ophthalmic Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":262,"lead_sponsor_name":"China Medical University Hospital","has_results":false},{"nct_id":"NCT04204746","title":"The Affecting Factors on Airway Temperature and Moisture","phase":"","overall_status":"COMPLETED","enrollment_count":240,"lead_sponsor_name":"Selcuk University","has_results":false},{"nct_id":"NCT06969157","title":"Diagnosis and Its Procedural Pattern Among Patients Who Underwent Surgery at Aloha Medical Mission in Dhankuta, 2018","phase":"","overall_status":"COMPLETED","enrollment_count":225,"lead_sponsor_name":"Tribhuvan University Teaching Hospital, Institute Of Medicine.","has_results":false},{"nct_id":"NCT07019805","title":"What Causes Low Blood Pressure After Anesthesia in Older Adults Having Non-Heart Surgery ?","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":220,"lead_sponsor_name":"Indonesia University","has_results":false},{"nct_id":"NCT05277064","title":"Optimal Insertion Depth of FOB for Oral FOB Intubation","phase":"","overall_status":"UNKNOWN","enrollment_count":211,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT03134287","title":"Nasogastric Tube Placement on Intubated Patient: Two-Finger Method vs Reverse Sellick's Maneuver","phase":"NA","overall_status":"COMPLETED","enrollment_count":210,"lead_sponsor_name":"Indonesia University","has_results":false},{"nct_id":"NCT04381949","title":"Interest of Tracheal Extubation in Positive Pressure on Postoperative Oxygenation in Adult Digestive Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":208,"lead_sponsor_name":"University Hospital, Rouen","has_results":false},{"nct_id":"NCT06673979","title":"Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy","phase":"","overall_status":"COMPLETED","enrollment_count":204,"lead_sponsor_name":"Istanbul University - Cerrahpasa","has_results":false},{"nct_id":"NCT07146178","title":"Long-term Follow-up of Bio-signals and Quality of Recovery Following Implementation of ERAS","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Wonju Severance Christian Hospital","has_results":false},{"nct_id":"NCT06969118","title":"RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT04744311","title":"Translation and Validation of the Turkish Version of the ObsQoR-11 Questionnaire","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Saglik Bilimleri Universitesi Gulhane Tip Fakultesi","has_results":false},{"nct_id":"NCT05708638","title":"Target-controlled Infusion Anesthesia and Post-induction Hypotension","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Acibadem University","has_results":false},{"nct_id":"NCT05179590","title":"Factors Associated With Quality of Dreams During General Anesthesia","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Beijing Friendship Hospital","has_results":false}],"total":50},"guidelines":[{"drug_id":"atracurium-besylate-preservative-free","guideline_body":"FDA label","recommendation":"Atracurium Besylate Injection, USP is indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.","line_of_therapy":"adj","evidence_grade":"B","guideline_year":null},{"drug_id":"atracurium-besylate-preservative-free","guideline_body":"FDA label","recommendation":"Atracurium Besylate Injection, USP is indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.","line_of_therapy":"adj","evidence_grade":"B","guideline_year":null},{"drug_id":"atracurium-besylate-preservative-free","guideline_body":"FDA label","recommendation":"Atracurium Besylate Injection, USP is indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.","line_of_therapy":"adj","evidence_grade":"B","guideline_year":null},{"drug_id":"propofol","guideline_body":"FDA label","recommendation":"Propofol injectable emulsion is indicated for induction of general anesthesia for patients greater than or equal to 3 years of age and maintenance of general anesthesia for patients greater than or equal to 2 months of age.","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null},{"drug_id":"midazolam-hydrochloride","guideline_body":"FDA label","recommendation":"Midazolam injection is indicated intravenously for induction of general anesthesia, before administration of other anesthetic agents.","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null},{"drug_id":"atracurium-besylate","guideline_body":"FDA label","recommendation":"Atracurium Besylate Injection, USP is indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation.","line_of_therapy":"adj","evidence_grade":"B","guideline_year":null},{"drug_id":"demerol","guideline_body":"FDA label","recommendation":"Meperidine Hydrochloride can be used as an adjunct to general anesthesia.","line_of_therapy":"adj","evidence_grade":"B","guideline_year":null},{"drug_id":"demerol","guideline_body":"FDA label","recommendation":"Meperidine Hydrochloride can be used as an adjunct to local anesthesia.","line_of_therapy":"adj","evidence_grade":"B","guideline_year":null},{"drug_id":"midazolam","guideline_body":"FDA label","recommendation":"Midazolam injection is indicated intravenously for induction of general anesthesia, before administration of other anesthetic agents.","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null}],"source":"Drug Landscape verified database"}