{"disease":{"id":"febrile","name":"febrile"},"drugs":{"marketed":[{"drug_id":"filgrastim-txid","indication_name":"Febrile Neutropenia in Nonmyeloid Malignancies","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"NYPOZI","generic_name":"FILGRASTIM-TXID","company_name":"TANVEX BIOPHARMA USA INC","drug_phase":"marketed","molecular_target":"Specific cell surface receptors on hematopoietic cells","drug_class":"Leukocyte Growth Factor [EPC]","quality_score":50,"revenue":null,"mechanism":"G-CSF binds to specific receptors on hematopoietic cells, stimulating neutrophil production and function."},{"drug_id":"chembl-chembl1200962","indication_name":"Empiric Therapy for Febrile Neutropenic Patients","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CEFEPIME HYDROCHLORIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":48,"revenue":null,"mechanism":"Cefepime is a cephalosporin antibacterial drug."},{"drug_id":"eflapegrastim-xnst","indication_name":"Febrile neutropenia caused by myelosuppressive anti-cancer drugs","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"ROLVEDON","generic_name":"EFLAPEGRASTIM-XNST","company_name":"SPECTRUM PHARMS","drug_phase":"marketed","molecular_target":"Granulocyte colony-stimulating factor receptor","drug_class":"Leukocyte Growth Factor [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"eflapegrastim","indication_name":"Febrile neutropenia caused by myelosuppressive anti-cancer drugs","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rolvedon","generic_name":"EFLAPEGRASTIM","company_name":"Spectrum Pharms","drug_phase":"marketed","molecular_target":"Granulocyte colony-stimulating factor receptor","drug_class":"Leukocyte Growth Factor [EPC]","quality_score":48,"revenue":null,"mechanism":"Rolvedon works by binding to the granulocyte colony-stimulating factor receptor, stimulating the production of white blood cells."}],"pipeline":[],"offLabel":[],"totalMarketed":4,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04478578","title":"Incidences, Causes, and Outcomes of Febrile Illness in Rural South and Southeast Asia","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT04081051","title":"Advancing Access to Diagnostic Innovation Essential for UHC and AMR Prevention","phase":"NA","overall_status":"COMPLETED","enrollment_count":17294,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT04629053","title":"Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia","phase":"","overall_status":"RECRUITING","enrollment_count":7200,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT05045547","title":"Village Malaria Worker Expansion","phase":"","overall_status":"COMPLETED","enrollment_count":7191,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT04428307","title":"Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - Kenya","phase":"NA","overall_status":"COMPLETED","enrollment_count":5696,"lead_sponsor_name":"Duke University","has_results":true},{"nct_id":"NCT06422338","title":"A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)","phase":"NA","overall_status":"RECRUITING","enrollment_count":5212,"lead_sponsor_name":"Barcelona Institute for Global Health","has_results":false},{"nct_id":"NCT02728596","title":"S1415CD, Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER)","phase":"NA","overall_status":"COMPLETED","enrollment_count":3665,"lead_sponsor_name":"SWOG Cancer Research Network","has_results":true},{"nct_id":"NCT06122259","title":"Febrile Illness in Guinea","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Centre National de Formation et de Recherche en Sante Rurale","has_results":false},{"nct_id":"NCT04428385","title":"Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - Nigeria","phase":"NA","overall_status":"COMPLETED","enrollment_count":2205,"lead_sponsor_name":"Duke University","has_results":true},{"nct_id":"NCT03047642","title":"Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics","phase":"","overall_status":"COMPLETED","enrollment_count":2000,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT03618810","title":"Prophylactic Use of PEG-rhG-CSF in Medium-high Risk of FN in Chemotherapy of Breast Cancer","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Zhejiang Cancer Hospital","has_results":false},{"nct_id":"NCT07134751","title":"Febrile Infants Swedish Study","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT06822907","title":"Immunogenicity and Safety PCV-20 of the Vaccine Administered During an Acute Febrile Illness in Adults","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":1052,"lead_sponsor_name":"Centre Hospitalier Universitaire de Saint Etienne","has_results":false},{"nct_id":"NCT04760678","title":"Febrile Illness in Kinshasa and Kimpese","phase":"","overall_status":"COMPLETED","enrollment_count":1046,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":true},{"nct_id":"NCT02178475","title":"Prospective Observational Study of Febrile Neutropenia (FN) and Pegfilgrastim Primary Prophylaxis in Breast Cancer and Non-Hodgkin's Lymphoma Patients Receiving High (>20%) FN-risk Chemotherapy","phase":"","overall_status":"COMPLETED","enrollment_count":943,"lead_sponsor_name":"Amgen","has_results":true},{"nct_id":"NCT05090969","title":"Study of Febrile Syndromes After Tick Bite","phase":"","overall_status":"UNKNOWN","enrollment_count":940,"lead_sponsor_name":"University Hospital, Strasbourg, France","has_results":false},{"nct_id":"NCT06552975","title":"Clinical Study of Transcriptome-based Diagnostic Biomarker for Acute Febrile Illness","phase":"","overall_status":"UNKNOWN","enrollment_count":900,"lead_sponsor_name":"Qilu Hospital of Shandong University","has_results":false},{"nct_id":"NCT03810014","title":"Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial AIM 1","phase":"NA","overall_status":"COMPLETED","enrollment_count":842,"lead_sponsor_name":"Duke University","has_results":true},{"nct_id":"NCT04289688","title":"Health Itinerary of Young Children With Suspected Bloodstream Infection in Kisantu General Referral Hospital, DR Congo","phase":"","overall_status":"COMPLETED","enrollment_count":784,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT06444126","title":"The Incidence And Risk Factors Of Recurrent Febrile Seizures And Epilepsy Following Febrile Seizures","phase":"","overall_status":"RECRUITING","enrollment_count":650,"lead_sponsor_name":"Pham Ngoc Thach University of Medicine","has_results":false},{"nct_id":"NCT04837963","title":"Does Hirschsprung Disease Increase the Risk of Febrile Urinary Tract Infection in Children","phase":"","overall_status":"COMPLETED","enrollment_count":630,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT06959420","title":"Knowledge, Attitudes, Perceptions and Behaviors of Healthcare Professionals and the General Population Regarding Vaccination During Febrile Illness","phase":"","overall_status":"RECRUITING","enrollment_count":630,"lead_sponsor_name":"Centre Hospitalier Universitaire de Saint Etienne","has_results":false},{"nct_id":"NCT06539325","title":"Rapid Molecular Diagnosis and Detection of Emerging Infectious Diseases in Patients With Tropical Fever (Tropifever)","phase":"NA","overall_status":"RECRUITING","enrollment_count":564,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT03740464","title":"Long-acting G-CSF for Febrile Neutropenia","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":556,"lead_sponsor_name":"Lei Li","has_results":false},{"nct_id":"NCT05206006","title":"Impact of Computerized Decision Support for ANTIBIOtic Prescription in Cancer Patients With Febrile NEutropenia in the Emergency Department on Treatment Failure.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":540,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05850013","title":"The Measurement of Vital Signs in Children by Lifelight® Software in Comparison to the Standard of Care","phase":"","overall_status":"COMPLETED","enrollment_count":504,"lead_sponsor_name":"Xim Limited","has_results":false},{"nct_id":"NCT07345286","title":"Clinical Aspects, Management and Surveillance of Febrile Illnesses in DRC","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT05050825","title":"Validation of a CDSA Strategy to Reduce Antibiotic Prescription in Senegal","phase":"NA","overall_status":"UNKNOWN","enrollment_count":470,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT07281027","title":"COMparison Between Anakinra and Tocilizumab in NORSE - \"COMBAT-NORSE\"","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":438,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT05301023","title":"Individualized Antibiotic Therapy in Children With Acute Uncomplicated Febrile Urinary Tract Infection","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":408,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT05441800","title":"Epidemiology and Clinical Characteristics of Emerging and Re-emerging Infectious Diseases With Epidemic Potential in Mali","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"University Clinical Research Center, Mali","has_results":false},{"nct_id":"NCT05815628","title":"Next-Generation-Sequencing Approach to Neutropenic Sepsis","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Boris Böll","has_results":false},{"nct_id":"NCT07205575","title":"AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness","phase":"","overall_status":"COMPLETED","enrollment_count":394,"lead_sponsor_name":"Qilu Hospital of Shandong University","has_results":false},{"nct_id":"NCT03943654","title":"Improving Nighttime Access to Care and Treatment (Part 2)","phase":"","overall_status":"COMPLETED","enrollment_count":391,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT06056011","title":"Timmy3 Module Clinical Accuracy ISO 80601-2-56:2017 + A1 2018","phase":"NA","overall_status":"COMPLETED","enrollment_count":373,"lead_sponsor_name":"Baxter Healthcare Corporation","has_results":true},{"nct_id":"NCT04669418","title":"Host RNA Signature in Children With Cancer and Infection","phase":"","overall_status":"COMPLETED","enrollment_count":370,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT06616571","title":"Compare the Efficacy and Safety of QL0605 Injections at Different Timepoints","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":336,"lead_sponsor_name":"Qilu Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT02773407","title":"Nepal Undifferentiated Febrile Illness Trial","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":330,"lead_sponsor_name":"Oxford University Clinical Research Unit, Vietnam","has_results":false},{"nct_id":"NCT03968328","title":"Time From Onset of Fever to Administration of Antibiotics in Neutropenic Fever Patients","phase":"","overall_status":"COMPLETED","enrollment_count":315,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT03537313","title":"Vaginal Douching and Painting in Women Who Underwent Total Abdominal Hysterectomy","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Department of Medical Services Ministry of Public Health of Thailand","has_results":false},{"nct_id":"NCT05149547","title":"mNGS Versus Blood Culture in FN","phase":"","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Peking University People's Hospital","has_results":false},{"nct_id":"NCT04299607","title":"Evaluation of the DPP II Assay in Laos","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT01735084","title":"Using Pneumococcal Vaccines in Combination for Maximum Protection From Ear and Lung Infections in First 3 Years of Life","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":261,"lead_sponsor_name":"Menzies School of Health Research","has_results":false},{"nct_id":"NCT06278896","title":"Early Neutropenic Fever De-escalation of Antibiotics Study","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":260,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":false},{"nct_id":"NCT06711523","title":"Study Evaluating PEG-G-CSF Injectionin Preventing Neutropenia After Chemotherapy","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Kexing Biopharm Co., Ltd.","has_results":false},{"nct_id":"NCT06787326","title":"Effect of the BioFire FilmArray (BCID2) for the Rapid Detection of Bloodstream Infection in Haematologic Patients With Febrile Neutropenia","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":228,"lead_sponsor_name":"Hospital Universitari de Bellvitge","has_results":false},{"nct_id":"NCT03165981","title":"Fever After Simultaneous Versus Sequential Vaccination in Young Children","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":221,"lead_sponsor_name":"Duke University","has_results":true},{"nct_id":"NCT04925401","title":"Evaluation of Knowledge About Fever After Consultation in the Pediatric Emergency Department","phase":"NA","overall_status":"COMPLETED","enrollment_count":220,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05576220","title":"Remote Temperature Monitoring of Adult Subjects Undergoing Outpatient Stem Cell Transplant or CAR-T Cell Therapy","phase":"NA","overall_status":"UNKNOWN","enrollment_count":210,"lead_sponsor_name":"IDION Inc.","has_results":false},{"nct_id":"NCT04662892","title":"An Analysis to Estimate Febrile Neutropenia (FN) in Patients Receiving Udenyca","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Coherus Oncology, Inc.","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}