{"disease":{"id":"embryo","name":"embryo"},"drugs":{"marketed":[{"drug_id":"estradiol","indication_name":"Hormone replacement cycle in embryo transfer","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Estrace","generic_name":"ESTRADIOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":"Estrace works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen."},{"drug_id":"estring","indication_name":"Hormone replacement cycle in embryo transfer","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Estring","generic_name":"Estradiol","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Ovulation","drug_class":"Combined Oral Contraceptive (COC)","quality_score":71,"revenue":null,"mechanism":"Prevents pregnancy primarily by suppressing ovulation."}],"pipeline":[{"drug_id":"obe001","indication_name":"Infertility (embryo transfer support)","indication_type":"pipeline","phase":"Phase 2","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"OBE001","company_name":"ObsEva SA","drug_phase":"discontinued","molecular_target":"Oxytocin receptor (OXTR)","drug_class":"Oxytocin receptor antagonist; Tocolytic agent","quality_score":null,"revenue":null,"mechanism":"OBE001 is an oxytocin receptor antagonist that inhibits uterine contractions by blocking oxytocin signaling in myometrial smooth muscle."}],"offLabel":[],"totalMarketed":2,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT03660007","title":"Incidence of Pulmonary and Venous Thromboembolism in IVF Pregnancies After Fresh and Frozen Embryo Transfer","phase":"","overall_status":"COMPLETED","enrollment_count":902891,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05364528","title":"Pregnancy Rate in Direct Versus Afterload Technique of Embryo Transfer","phase":"","overall_status":"COMPLETED","enrollment_count":8127,"lead_sponsor_name":"Istituto Clinico Humanitas","has_results":false},{"nct_id":"NCT04253470","title":"Debate on Progesterone Elevation on the Day of Triggering","phase":"","overall_status":"COMPLETED","enrollment_count":8000,"lead_sponsor_name":"Istituto Clinico Humanitas","has_results":false},{"nct_id":"NCT04949282","title":"Spanish Series of Patients Treated With the Radionuclide Lutetium177","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Sociedad Española de Medicina Nuclear e Imagen Molecular","has_results":false},{"nct_id":"NCT03382158","title":"International PPB/DICER1 Registry","phase":"","overall_status":"RECRUITING","enrollment_count":3400,"lead_sponsor_name":"Children's Hospitals and Clinics of Minnesota","has_results":false},{"nct_id":"NCT03581422","title":"Natural Cycles With Spontaneous Versus Induced Ovulation in FET","phase":"","overall_status":"COMPLETED","enrollment_count":2866,"lead_sponsor_name":"Istituto Clinico Humanitas","has_results":false},{"nct_id":"NCT05100784","title":"The Human Sperm Survival Assay (HSSA) as an Internal Quality Control for the IVF Consumables (REPROTOX 2)","phase":"","overall_status":"UNKNOWN","enrollment_count":1800,"lead_sponsor_name":"Ramsay Générale de Santé","has_results":false},{"nct_id":"NCT04725864","title":"Progesterone as Luteal Support in Frozen IVF Natural Cycles","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":1800,"lead_sponsor_name":"Vastra Gotaland Region","has_results":false},{"nct_id":"NCT03067181","title":"Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":1780,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT05259605","title":"Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification","phase":"","overall_status":"RECRUITING","enrollment_count":1650,"lead_sponsor_name":"European Organisation for Research and Treatment of Cancer - EORTC","has_results":false},{"nct_id":"NCT03959800","title":"Molecular Basis of Pediatric Liver Cancer","phase":"","overall_status":"RECRUITING","enrollment_count":1600,"lead_sponsor_name":"University of Pittsburgh","has_results":false},{"nct_id":"NCT03630848","title":"Effect of Protein Concentration on Human Embryo Development","phase":"NA","overall_status":"COMPLETED","enrollment_count":1536,"lead_sponsor_name":"Ibn Sina Hospital","has_results":false},{"nct_id":"NCT04804020","title":"Natural Cycle vs. Modified Natural Cycle vs. Artificial Cycle Protocol for Endometrial Preparation.","phase":"NA","overall_status":"COMPLETED","enrollment_count":1428,"lead_sponsor_name":"Mỹ Đức Hospital","has_results":false},{"nct_id":"NCT00919750","title":"Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors","phase":"","overall_status":"COMPLETED","enrollment_count":1258,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT06767202","title":"Relationship Between Exposure to Phenols and Pregnancy Outcomes After Embryo Transfer","phase":"","overall_status":"COMPLETED","enrollment_count":1200,"lead_sponsor_name":"keqin liu","has_results":false},{"nct_id":"NCT05564026","title":"Molecular Epidemiology of Pediatric Germ Cell Tumors","phase":"","overall_status":"RECRUITING","enrollment_count":1151,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT03292770","title":"Mucus Removal Before Embryo Transfer","phase":"NA","overall_status":"COMPLETED","enrollment_count":1118,"lead_sponsor_name":"Fundacion Dexeus","has_results":false},{"nct_id":"NCT07050537","title":"A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology","phase":"NA","overall_status":"RECRUITING","enrollment_count":980,"lead_sponsor_name":"The First Affiliated Hospital with Nanjing Medical University","has_results":false},{"nct_id":"NCT01434355","title":"DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings","phase":"","overall_status":"COMPLETED","enrollment_count":932,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT05322278","title":"Obstetric Outcomes After Double Embryo Transfer","phase":"","overall_status":"COMPLETED","enrollment_count":927,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT07257250","title":"Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation","phase":"","overall_status":"RECRUITING","enrollment_count":900,"lead_sponsor_name":"Mỹ Đức Hospital","has_results":false},{"nct_id":"NCT03296371","title":"Genetic Mutational Analysis of Saliva or Buccal Mucosa Samples From Patients With Embryonal or Alveolar Rhabdomyosarcoma","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":900,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT07526207","title":"Estradiol 8 vs 12 mg for Endometrial Preparation in HRT-FET","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":850,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT04371783","title":"A Randomized Trial Comparing the Live Birth Rate of Immediate Versus Delayed FET Following a Freeze-all Strategy","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":828,"lead_sponsor_name":"ShangHai Ji Ai Genetics & IVF Institute","has_results":false},{"nct_id":"NCT05739019","title":"The Impact of Past Coronavirus Disease 19 (COVID-19) Infection on the Live Birth Rates of Frozen Embryo Transfer Cycles","phase":"","overall_status":"COMPLETED","enrollment_count":820,"lead_sponsor_name":"ShangHai Ji Ai Genetics & IVF Institute","has_results":false},{"nct_id":"NCT06838923","title":"Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate","phase":"NA","overall_status":"COMPLETED","enrollment_count":818,"lead_sponsor_name":"Hung Vuong Hospital","has_results":false},{"nct_id":"NCT07088640","title":"Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET","phase":"NA","overall_status":"RECRUITING","enrollment_count":816,"lead_sponsor_name":"Mỹ Đức Hospital","has_results":false},{"nct_id":"NCT03964805","title":"Oxygen Tension on Human Embryonic Development","phase":"NA","overall_status":"COMPLETED","enrollment_count":773,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT03128970","title":"Synchronizing Blastocyst in Frozen Embryo Transfer","phase":"NA","overall_status":"COMPLETED","enrollment_count":742,"lead_sponsor_name":"Al-Yasmeen Fertility and Gynecology Center","has_results":false},{"nct_id":"NCT03687567","title":"A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development","phase":"","overall_status":"COMPLETED","enrollment_count":737,"lead_sponsor_name":"Reproductive & Genetic Hospital of CITIC-Xiangya","has_results":false},{"nct_id":"NCT03201783","title":"Immediate Versus Delayed FET Following a Stimulated IVF Cycle","phase":"NA","overall_status":"COMPLETED","enrollment_count":724,"lead_sponsor_name":"ShangHai Ji Ai Genetics & IVF Institute","has_results":false},{"nct_id":"NCT03945812","title":"Platelet-Rich Plasma vs. Granulocyte Colony-Stimulating Factor vs. Placebo and Outcomes in Frozen Embryo Transfer","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":665,"lead_sponsor_name":"Wael Elbanna Clinic","has_results":false},{"nct_id":"NCT04734769","title":"Embryos With Preimplantation Genetic Testing for Aneuploidies (PGT-A) Inconclusive Result: Clinical Implications","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"IVI Vigo","has_results":false},{"nct_id":"NCT07171970","title":"IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women","phase":"NA","overall_status":"RECRUITING","enrollment_count":600,"lead_sponsor_name":"Mỹ Đức Hospital","has_results":false},{"nct_id":"NCT03740568","title":"Effect of Intervention on Progesterone Levels Before Euploid Embryo Transfer in Pregnancy Outcomes.","phase":"NA","overall_status":"COMPLETED","enrollment_count":598,"lead_sponsor_name":"Fundacion Dexeus","has_results":false},{"nct_id":"NCT04092829","title":"Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer","phase":"NA","overall_status":"TERMINATED","enrollment_count":591,"lead_sponsor_name":"Instituto Valenciano de Infertilidad, IVI VALENCIA","has_results":false},{"nct_id":"NCT03037385","title":"Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":590,"lead_sponsor_name":"Hoffmann-La Roche","has_results":true},{"nct_id":"NCT06741748","title":"Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":578,"lead_sponsor_name":"Chinese University of Hong Kong","has_results":false},{"nct_id":"NCT07088952","title":"Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle","phase":"NA","overall_status":"RECRUITING","enrollment_count":572,"lead_sponsor_name":"Vida Recoletas Sevilla","has_results":false},{"nct_id":"NCT03642665","title":"Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":554,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT06279715","title":"DFI and Aneuploidies","phase":"","overall_status":"COMPLETED","enrollment_count":537,"lead_sponsor_name":"Clinique Ovo","has_results":false},{"nct_id":"NCT07461077","title":"Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":520,"lead_sponsor_name":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","has_results":false},{"nct_id":"NCT04455191","title":"Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle","phase":"NA","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Jinan Central Hospital","has_results":false},{"nct_id":"NCT01980212","title":"Tumor Relapsed Study of Serum Trxr Activity in Advanced Non-small Cell Lung Cancer","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Hunan Province Tumor Hospital","has_results":false},{"nct_id":"NCT03630900","title":"Sequential Versus Single O2 Levels on Human Embryo Development","phase":"NA","overall_status":"COMPLETED","enrollment_count":487,"lead_sponsor_name":"Ibn Sina Hospital","has_results":false},{"nct_id":"NCT00354835","title":"Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":481,"lead_sponsor_name":"Children's Oncology Group","has_results":true},{"nct_id":"NCT07522281","title":"Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":478,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT04619524","title":"Biomarkers of Endometrial Receptivity","phase":"NA","overall_status":"RECRUITING","enrollment_count":476,"lead_sponsor_name":"The Institute of Molecular and Translational Medicine, Czech Republic","has_results":false},{"nct_id":"NCT04456478","title":"Impact of PH Values of the Embryo Culture Medium on Success of in Vitro Fertilization (IVF)","phase":"NA","overall_status":"COMPLETED","enrollment_count":429,"lead_sponsor_name":"University Hospital, Toulouse","has_results":false},{"nct_id":"NCT04114500","title":"The Association Between Serum E2 and P on the Day of FET and the Pregnancy Outcome","phase":"","overall_status":"COMPLETED","enrollment_count":402,"lead_sponsor_name":"Al Baraka Fertility Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}