{"disease":{"id":"disruptive-behavior","name":"disruptive behavior"},"drugs":{"marketed":[{"drug_id":"chlorpromazine","indication_name":"Disruptive behavior disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Thorazine","generic_name":"chlorpromazine","company_name":"Generic (originally Rhône-Poulenc/Sanofi)","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Sphingomyelin phosphodiesterase, 5-hydroxytryptamine receptor 1E","drug_class":"Typical antipsychotic (first-generation, phenothiazine)","quality_score":31,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05425381","title":"Improving Social, Emotional, Behavioral, and Academic Functioning","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1208,"lead_sponsor_name":"East Carolina University","has_results":false},{"nct_id":"NCT07505381","title":"Behavioral Parent Training to Address Early Childhood Disruptive Behavior Using the Helping Our Toddlers, Developing Our Children's Skills (HOT DOCS) Program and the Developing Our Children's Skills Kindergarten-5th Grade (DOCS K-5) Program","phase":"NA","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"University of South Florida","has_results":false},{"nct_id":"NCT03906682","title":"Improving Mental Health and School Performance in Urban Eighth Graders","phase":"NA","overall_status":"COMPLETED","enrollment_count":615,"lead_sponsor_name":"Johns Hopkins Bloomberg School of Public Health","has_results":false},{"nct_id":"NCT07495683","title":"Personalizing Psychosocial Intervention for Children With Disruptive Behaviour","phase":"NA","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT04113161","title":"Navigating Resource-Constrained Systems and Communities to Promote the Behavioral Health of Black Youth","phase":"NA","overall_status":"UNKNOWN","enrollment_count":405,"lead_sponsor_name":"Washington University School of Medicine","has_results":false},{"nct_id":"NCT00001206","title":"Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)","phase":"","overall_status":"COMPLETED","enrollment_count":347,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT06346782","title":"Feasibility and Acceptability of Internet-based Parent-child Interaction Therapy (I-PCIT) in Pediatric Cancer","phase":"NA","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Johns Hopkins All Children's Hospital","has_results":false},{"nct_id":"NCT03151187","title":"Evaluation of a Teaching Curriculum on Disruptive Behaviour Disorders","phase":"NA","overall_status":"UNKNOWN","enrollment_count":278,"lead_sponsor_name":"Children's Hospital of Eastern Ontario","has_results":false},{"nct_id":"NCT05093686","title":"RUBIES in Educational Settings","phase":"NA","overall_status":"UNKNOWN","enrollment_count":240,"lead_sponsor_name":"Seattle Children's Hospital","has_results":false},{"nct_id":"NCT06902649","title":"Step-by-Step: Evaluation of a Stepped Care Model","phase":"NA","overall_status":"RECRUITING","enrollment_count":210,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT06241300","title":"Executive Function and Parenting in Childhood","phase":"NA","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"University of Illinois at Chicago","has_results":false},{"nct_id":"NCT03260816","title":"Advancing Child Competencies by Extending Supported Services (ACCESS) for Families Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Florida International University","has_results":false},{"nct_id":"NCT07515742","title":"Empowering Youth With School Discipline Referrals as Peer Coaches","phase":"NA","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"University of Southern California","has_results":false},{"nct_id":"NCT06626750","title":"Evaluating Stress Management Strategies Within the School Readiness Parenting Program","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":120,"lead_sponsor_name":"Florida International University","has_results":false},{"nct_id":"NCT04626037","title":"CLC Parent-Child Emotional Preparation Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":109,"lead_sponsor_name":"Columbia University","has_results":false},{"nct_id":"NCT00794040","title":"A Controlled Trial of Serotonin Reuptake Inhibitors Added to Stimulant Medication in Youth With Severe Mood Dysregulation","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":103,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":true},{"nct_id":"NCT01965184","title":"Cognitive-Behavioral Therapy for Disruptive Behavior in Children and Adolescents","phase":"NA","overall_status":"COMPLETED","enrollment_count":101,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT05077722","title":"Monitoring of Sleep and Behavior of Children 3-7 Years Old Receiving Parent-Child Interaction Therapy With the Help of Artificial Intelligence","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT03967509","title":"Effectiveness of Behavioral Preschool Teacher Training for Externalizing","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Uppsala University","has_results":false},{"nct_id":"NCT06447909","title":"Randomized Controlled Trial of a Behavioral Training App","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"New York University","has_results":false},{"nct_id":"NCT03927612","title":"Virtual Reality to Improve Social Perspective Taking","phase":"NA","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Indiana University","has_results":true},{"nct_id":"NCT03499600","title":"Improving Satisfaction, Engagement and Outcomes Among Traditionally Underserved Children Through Cultural Formulation","phase":"NA","overall_status":"COMPLETED","enrollment_count":89,"lead_sponsor_name":"Florida International University","has_results":true},{"nct_id":"NCT05056922","title":"Telehealth Rapid Intervention for Externalizing Behaviors in ASD","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT04298437","title":"Addressing Depression and Positive Parenting Techniques (ADAPT)","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Centre for Addiction and Mental Health","has_results":false},{"nct_id":"NCT02824627","title":"Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":58,"lead_sponsor_name":"University of Nebraska","has_results":true},{"nct_id":"NCT03698240","title":"Mindfulness-based Program for Children With Disruptive Behavior Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"IRCCS Fondazione Stella Maris","has_results":false},{"nct_id":"NCT03597789","title":"Tantrum Tamers 2.0: The Role of Emotion","phase":"NA","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":true},{"nct_id":"NCT03796663","title":"Mindful Parenting and Parent Training Program Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"New York University","has_results":false},{"nct_id":"NCT03260725","title":"Evaluating the Feasibility of Internet-delivered PCIT","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Florida International University","has_results":false},{"nct_id":"NCT04199533","title":"Iterative Redesign of a Behavioral Skills Training Program for Use in Educational Settings","phase":"","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT04628546","title":"The Parenting Young Children Check-up Evaluation","phase":"NA","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"Wayne State University","has_results":false},{"nct_id":"NCT03710642","title":"Prazosin for Agitation in Alzheimer's Disease","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"Alzheimer's Disease Cooperative Study (ADCS)","has_results":true},{"nct_id":"NCT05452954","title":"Psychosocial ADHD Interventions - Brief Parent Training","phase":"NA","overall_status":"COMPLETED","enrollment_count":28,"lead_sponsor_name":"Accare","has_results":false},{"nct_id":"NCT06217146","title":"A Medical Cannabis Oil for Treatment of Agitation and Disruptive Behaviors in Subjects With Dementia.","phase":"NA","overall_status":"TERMINATED","enrollment_count":24,"lead_sponsor_name":"M. H MediCane Ltd.","has_results":false},{"nct_id":"NCT02704221","title":"Enhancing the Outcomes of a Behavioral Parent Training Intervention","phase":"NA","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Christina Studts","has_results":false},{"nct_id":"NCT07109661","title":"EFFICACY OF THE RATIONAL POSITIVE PARENTING PROGRAM (rPPP) FOR DISRUPTIVE BEHAVIORS","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":24,"lead_sponsor_name":"Sadia Ramzan","has_results":false},{"nct_id":"NCT02893852","title":"Effects of CO-OP Approach on Activity and Participation of Brazilian Children With Developmental Coordination Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":23,"lead_sponsor_name":"Federal University of Minas Gerais","has_results":false},{"nct_id":"NCT06386562","title":"Pilot Study of an Internet-based Parenting Program for Child Disruptive Behavior","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05113147","title":"Disruptive Behavior in the Operating Room","phase":"","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Pontificia Universidad Catolica de Chile","has_results":false},{"nct_id":"NCT06193382","title":"Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":20,"lead_sponsor_name":"University of Miami","has_results":false},{"nct_id":"NCT03976570","title":"The Effect of Occupational Therapy on Subthreshold Attention Deficit Hyperactivity Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Erzurum Regional Training & Research Hospital","has_results":false},{"nct_id":"NCT06828302","title":"Internet-delivered Parent-Child Interaction for Parents of Children 2-7 Years With Disruptive Behaviors","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT06366620","title":"Examining the Feasibility, Acceptability, and Fidelity of Utilizing Parent Training Graduates as Peer Supports","phase":"NA","overall_status":"COMPLETED","enrollment_count":19,"lead_sponsor_name":"Seattle Children's Hospital","has_results":false},{"nct_id":"NCT03697837","title":"Digital Parent Training for Disruptive Behaviors in Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT07201090","title":"Effects and Implementation of a Brief Version of Parent-Child Interaction Therapy","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":15,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT03669289","title":"Enhanced Support for Behavioral Barriers to Learning: An Evaluation of the SCHOOL STARS Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":14,"lead_sponsor_name":"Children's Hospital Medical Center, Cincinnati","has_results":false},{"nct_id":"NCT06559813","title":"Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":10,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT06559800","title":"Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":10,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT04113304","title":"The Parenting Young Children Check-up: Proof-of-Concept Trial","phase":"","overall_status":"COMPLETED","enrollment_count":6,"lead_sponsor_name":"Wayne State University","has_results":true},{"nct_id":"NCT05725525","title":"A Study of Internet Delivered Parent Child Interaction Therapy","phase":"NA","overall_status":"COMPLETED","enrollment_count":5,"lead_sponsor_name":"Mayo Clinic","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}