{"disease":{"id":"dialysis","name":"dialysis"},"drugs":{"marketed":[{"drug_id":"etelcalcetide","indication_name":"Secondary Hyperparathyroidism in CKD on Hemodialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Parsabiv","generic_name":"ETELCALCETIDE","company_name":"Kai Pharms Inc","drug_phase":"marketed","molecular_target":"CaSR","drug_class":"Calcium-sensing Receptor Agonist","quality_score":70,"revenue":null,"mechanism":"Etelcalcetide enhances calcium-sensing receptor activation, reducing PTH secretion."},{"drug_id":"calcitriol-capsules","indication_name":"Secondary Hyperparathyroidism in Predialysis Patients","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Calcitriol capsules","company_name":"Indonesia University","drug_phase":"marketed","molecular_target":"","drug_class":"Vitamin D3 Analog [EPC]","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"calcitriol-capsules","indication_name":"Hypocalcemia in Chronic Renal Dialysis Patients","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Calcitriol capsules","company_name":"Indonesia University","drug_phase":"marketed","molecular_target":"","drug_class":"Vitamin D3 Analog [EPC]","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"sucrose","indication_name":"Iron Deficiency Anemia in CKD on Hemodialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"SUCROSE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"Parenteral Iron Replacement [EPC]","quality_score":15,"revenue":null,"mechanism":null},{"drug_id":"enoxaparin-sodium","indication_name":"Prevention of clot formation during haemodialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lovenox (Preservative Free)","generic_name":"ENOXAPARIN SODIUM","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"Antithrombin-III","drug_class":"Low Molecular Weight Heparin","quality_score":10,"revenue":null,"mechanism":"Lovenox works by enhancing the activity of antithrombin-III to inhibit blood clotting."},{"drug_id":"sevelamer-carbonate","indication_name":"Renal dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Renvela","generic_name":"SEVELAMER CARBONATE","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"","drug_class":"Phosphate Binder","quality_score":60,"revenue":null,"mechanism":"Renvela works by binding to dietary phosphate in the gut, preventing its absorption into the bloodstream."},{"drug_id":"ergocalciferol","indication_name":"Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Drisdol","generic_name":"ERGOCALCIFEROL","company_name":"Esjay Pharma","drug_phase":"marketed","molecular_target":"25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial","drug_class":"Provitamin D2 Compound [EPC]","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"cinacalcet","indication_name":"Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sensipar","generic_name":"CINACALCET","company_name":"Amgen","drug_phase":"marketed","molecular_target":"Extracellular calcium-sensing receptor","drug_class":"Calcium-sensing Receptor Agonist","quality_score":65,"revenue":null,"mechanism":"Sensipar works by activating the calcium-sensing receptor, which helps regulate calcium levels in the blood."},{"drug_id":"calciferol","indication_name":"Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Calciferol","company_name":"Department of Medical Services Ministry of Public Health of Thailand","drug_phase":"phase_1","molecular_target":"Vitamin D 25-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, Vitamin D3 receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"renvela","indication_name":"Renal dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Renvela","company_name":"Ardelyx","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":12,"revenue":null,"mechanism":null},{"drug_id":"doxercalciferol","indication_name":"Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Hectorol","generic_name":"DOXERCALCIFEROL","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"Vitamin D3 receptor","drug_class":"Vitamin D2 Analog [EPC]","quality_score":70,"revenue":null,"mechanism":"Hectorol works by activating the Vitamin D receptor, which helps regulate calcium levels in the body."},{"drug_id":"calcitriol","indication_name":"Hypocalcemia from End-Stage Renal Disease with Dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Calcijex","generic_name":"CALCITRIOL","company_name":"Esjay Pharma","drug_phase":"marketed","molecular_target":"Vitamin D3 receptor","drug_class":"Vitamin D3 Analog [EPC]","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"lovenox","indication_name":"Prevention of clot formation during haemodialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Lovenox","company_name":"University of Monastir","drug_phase":"marketed","molecular_target":"Antithrombin-III","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"enoxaparin","indication_name":"Prevention of clot formation during haemodialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Enoxaparin","company_name":"Dana-Farber Cancer Institute","drug_phase":"marketed","molecular_target":"Antithrombin-III","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"rocaltrol","indication_name":"Hypocalcemia from End-Stage Renal Disease with Dialysis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Rocaltrol","company_name":"Shandong University","drug_phase":"marketed","molecular_target":"Vitamin D 25-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, Vitamin D-binding protein","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[{"drug_id":"phytonadione","indication_name":"Coronary artery calcification in hemodialysis patients","indication_type":"pipeline","phase":"Phase 2","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PHYTONADIONE","company_name":"","drug_phase":"marketed","molecular_target":"Vitamin K epoxide reductase complex subunit 1 (VKORC1)","drug_class":"Vitamin K [EPC]","quality_score":65,"revenue":null,"mechanism":""}],"offLabel":[],"totalMarketed":15,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT04935827","title":"Seasonal Differences in Home Dialysis Uptake and Initiating Dialysis in the Hospital","phase":"","overall_status":"COMPLETED","enrollment_count":400000,"lead_sponsor_name":"University of Southern California","has_results":false},{"nct_id":"NCT04764435","title":"The Effect of Physician Ownership on Dialysis Outcomes","phase":"","overall_status":"COMPLETED","enrollment_count":208213,"lead_sponsor_name":"University of Southern California","has_results":false},{"nct_id":"NCT07365111","title":"Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT05151003","title":"Epidemiology of In-hospital Acute Kidney Injury","phase":"","overall_status":"UNKNOWN","enrollment_count":60000,"lead_sponsor_name":"Universita degli Studi di Genova","has_results":false},{"nct_id":"NCT06521801","title":"Cardio-Renal Registry","phase":"","overall_status":"RECRUITING","enrollment_count":60000,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT03629977","title":"Timing of Renal Replacement Therapy in the Critically Ill Patients","phase":"","overall_status":"RECRUITING","enrollment_count":50000,"lead_sponsor_name":"Karolinska University Hospital","has_results":false},{"nct_id":"NCT05497518","title":"The KidneyCARE (Community Access to Research Equity) Study","phase":"","overall_status":"RECRUITING","enrollment_count":50000,"lead_sponsor_name":"Tufts Medical Center","has_results":false},{"nct_id":"NCT04054440","title":"Outpatient Office Based Endovascular Procedures","phase":"","overall_status":"COMPLETED","enrollment_count":26000,"lead_sponsor_name":"Methodist Health System","has_results":false},{"nct_id":"NCT07013175","title":"Wise Choices in the Intensive Care Unit","phase":"NA","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT07312929","title":"Machine Learning and Artificial Intelligence Algorithms to Optimize the Performance and Delivery of Acute Dialysis","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":7500,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT03571451","title":"A Multi-center Prospective Cohort Study Based on Peritoneal Dialysis Telemedicine-assisted Platform","phase":"","overall_status":"UNKNOWN","enrollment_count":7000,"lead_sponsor_name":"Peking University First Hospital","has_results":false},{"nct_id":"NCT03535922","title":"Evaluation of Routinely Measured Patient-reported Outcomes in Hemodialysis Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":3977,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT03674307","title":"Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates","phase":"NA","overall_status":"RECRUITING","enrollment_count":3306,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT04565522","title":"Transmission of COVID-19 Virus Among Patients and Staff in Dialysis Centers","phase":"","overall_status":"COMPLETED","enrollment_count":2847,"lead_sponsor_name":"Simeone Andrulli, MD","has_results":false},{"nct_id":"NCT04088526","title":"Survey and Reduction of Mortality in Peridialysis Uremic Patients Via Intervention of Risk Factors","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2500,"lead_sponsor_name":"Shanghai Changzheng Hospital","has_results":false},{"nct_id":"NCT05225298","title":"SARS-COV-2 Screening in Dialysis Facilities","phase":"NA","overall_status":"COMPLETED","enrollment_count":2389,"lead_sponsor_name":"Stanford University","has_results":true},{"nct_id":"NCT04034628","title":"Improving the Outcomes of Peritoneal Dialysis (PD) Catheter Insertion","phase":"","overall_status":"UNKNOWN","enrollment_count":2320,"lead_sponsor_name":"Sunnybrook Health Sciences Centre","has_results":false},{"nct_id":"NCT01578200","title":"Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate in Hemodialysis Patients : Landmark Study","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":2309,"lead_sponsor_name":"Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan","has_results":false},{"nct_id":"NCT01950819","title":"Advancing Renal TRANSplant eFficacy and Safety Outcomes With an eveRolimus-based regiMen (TRANSFORM)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":2037,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT04666844","title":"Predicting Transfers to Hemodialysis in Peritoneal Dialysis Patients Using the Surprise Question","phase":"","overall_status":"COMPLETED","enrollment_count":2019,"lead_sponsor_name":"Satellite Healthcare","has_results":false},{"nct_id":"NCT03969953","title":"Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1753,"lead_sponsor_name":"The George Institute","has_results":false},{"nct_id":"NCT05699447","title":"A New Risk Score for Predicting 1-year Mortality in Older r Maintenance Hemodialysis Patients.","phase":"","overall_status":"COMPLETED","enrollment_count":1500,"lead_sponsor_name":"Beijing Friendship Hospital","has_results":false},{"nct_id":"NCT03816111","title":"Targeted Education ApproaCH to Improve Peritoneal Dialysis Outcomes Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1462,"lead_sponsor_name":"The University of Queensland","has_results":false},{"nct_id":"NCT04692636","title":"BP Variability on the Outcomes of Hemodialysis Vascular Access","phase":"","overall_status":"UNKNOWN","enrollment_count":1300,"lead_sponsor_name":"National Taiwan University Hospital Hsin-Chu Branch","has_results":false},{"nct_id":"NCT05841082","title":"Coronary Revascularization in Patients On Dialysis in China-Retrospective Registry","phase":"","overall_status":"UNKNOWN","enrollment_count":1249,"lead_sponsor_name":"China-Japan Friendship Hospital","has_results":false},{"nct_id":"NCT03885102","title":"Dialysis Training Therapy: The DiaTT Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1211,"lead_sponsor_name":"Prof. Dr. med. Martin Halle","has_results":false},{"nct_id":"NCT02052310","title":"Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1043,"lead_sponsor_name":"Kyntra Bio","has_results":true},{"nct_id":"NCT05673239","title":"Effects of L-carnitine Therapy on the Heart of Maintenance Hemodialysis Patients","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1008,"lead_sponsor_name":"The First Affiliated Hospital of Zhejiang Chinese Medical University","has_results":false},{"nct_id":"NCT07262320","title":"Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT04897828","title":"REtrospective Analysis on the Use of COvered Stents for the Treatment of the Dysfunctional Vascular Access","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"University Hospital of Patras","has_results":false},{"nct_id":"NCT04953819","title":"Coronary Revascularization in Patients With Dialysis in China","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"China-Japan Friendship Hospital","has_results":false},{"nct_id":"NCT04502160","title":"The Northern Ireland Haemodialysis Vascular Access Database","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Belfast Health and Social Care Trust","has_results":false},{"nct_id":"NCT05161078","title":"Improving Continuous Renal Replacement Therapy Outcomes in Neonates and Infants Through Interdisciplinary Collaboration","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1000,"lead_sponsor_name":"Children's Hospital Medical Center, Cincinnati","has_results":false},{"nct_id":"NCT04944433","title":"Safety and Efficacy of the Coronavirus Disease 2019 Vaccine in Hemodialysis Patients","phase":"","overall_status":"COMPLETED","enrollment_count":950,"lead_sponsor_name":"Hospital Italiano de Buenos Aires","has_results":false},{"nct_id":"NCT04197674","title":"China Q Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":903,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT07098676","title":"Haemodialysis Alters Hypercoagulability of Blood in Dialysis Patients","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":900,"lead_sponsor_name":"Ai Peng","has_results":false},{"nct_id":"NCT07348913","title":"Impact of Regular Low-Frequency Hemoperfusion on Medium- to Long-Term Prognosis in Maintenance Dialysis Patients","phase":"","overall_status":"COMPLETED","enrollment_count":879,"lead_sponsor_name":"Yunfeng Xia","has_results":false},{"nct_id":"NCT03289520","title":"Clopidogrel Prevention of Early Arteriovenous (AV) Fistula Thrombosis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":877,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT04796558","title":"Validation of Arterio Venous Access Stage (AVAS) Classification","phase":"","overall_status":"UNKNOWN","enrollment_count":800,"lead_sponsor_name":"Vascular surgery, University hospital Královské Vinohrady, Prague","has_results":false},{"nct_id":"NCT04420338","title":"SeroCOVIDial Study: Assessment of COVID-19 Seroconversion in Patients on Chronic Hemodialysis and in Their Caregivers, a Cohort Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":800,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT03471299","title":"Association of Survival in Impact of Ultrafiltration Rates in Hemodialysis Patients","phase":"","overall_status":"COMPLETED","enrollment_count":759,"lead_sponsor_name":"University of Hyogo","has_results":false},{"nct_id":"NCT01652872","title":"Strategies Using Darbepoetin Alfa to Avoid Transfusions in Chronic Kidney Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":756,"lead_sponsor_name":"Amgen","has_results":true},{"nct_id":"NCT06150235","title":"Impact of Physical Activity on Quality of Life for Chronic Hemodialysis Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":750,"lead_sponsor_name":"Université de Reims Champagne-Ardenne","has_results":false},{"nct_id":"NCT02273726","title":"Study to Evaluate the Efficacy and Safety of Roxadustat in the Treatment of Anemia in Participants With ESRD on Stable Dialysis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":741,"lead_sponsor_name":"Kyntra Bio","has_results":true},{"nct_id":"NCT04523220","title":"Study to Investigate the Safety of a Drug Called Osocimab at Low and High Doses in Adult Patients With Kidney Failure Requiring Regular Hemodialysis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":704,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT03969225","title":"Vascular Access Outcome Measure for Function: a vaLidation Study In haemoDialysis","phase":"","overall_status":"COMPLETED","enrollment_count":702,"lead_sponsor_name":"The University of Queensland","has_results":false},{"nct_id":"NCT04064086","title":"Trial to Evaluate and Assess the Effect of Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":656,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT07412834","title":"Safely Disconnect From the Dialysis Machine in an Emergency Situation","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":620,"lead_sponsor_name":"Istanbul University","has_results":false},{"nct_id":"NCT02021318","title":"Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":616,"lead_sponsor_name":"Astellas Pharma Europe B.V.","has_results":true},{"nct_id":"NCT03251573","title":"The Cohort Study of Cognitive Impairment in Chinese Hemodialysis Patients","phase":"","overall_status":"COMPLETED","enrollment_count":613,"lead_sponsor_name":"Beijing Shijitan Hospital, Capital Medical University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}