{"disease":{"id":"dental","name":"dental"},"drugs":{"marketed":[{"drug_id":"potassium-nitrate","indication_name":"Dental Caries Prevention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Saltpeter","generic_name":"POTASSIUM NITRATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":31,"revenue":null,"mechanism":""},{"drug_id":"platinum","indication_name":"Pain relief after dental procedures","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dentastat","generic_name":"PLATINUM","company_name":"Energique, Inc.","drug_phase":"marketed","molecular_target":"","drug_class":"Non-Standardized Food Allergenic Extract [EPC]","quality_score":13,"revenue":null,"mechanism":""},{"drug_id":"multivitamins","indication_name":"Promote Bone and Dental Health","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"multivitamins","company_name":"Faculdade de Medicina do ABC","drug_phase":"marketed","molecular_target":"","drug_class":"Vitamin C [EPC]","quality_score":17,"revenue":null,"mechanism":null},{"drug_id":"chembl-chembl650","indication_name":"Dental and Oral Surgery Procedures","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"METHYLPREDNISOLONE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":45,"revenue":null,"mechanism":"Bupivacaine blocks nerve impulses by increasing the threshold for electrical excitation, slowing propagation, and reducing the rate of rise of the action potential."},{"drug_id":"mepivacaine-hydrochloride","indication_name":"Local anesthesia for dental procedures","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"MEPIVACAINE HYDROCHLORIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":25,"revenue":null,"mechanism":null},{"drug_id":"antizol","indication_name":"Accidental poisoning by methyl alcohol","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Antizol","company_name":"Amgen","drug_phase":"marketed","molecular_target":"Alcohol dehydrogenase, Alcohol dehydrogenase","drug_class":"","quality_score":16,"revenue":null,"mechanism":null},{"drug_id":"fomepizole","indication_name":"Accidental poisoning by methyl alcohol","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Antizol","generic_name":"FOMEPIZOLE","company_name":"Par Pharm Inc","drug_phase":"marketed","molecular_target":"Alcohol dehydrogenase","drug_class":"Antidote [EPC]","quality_score":10,"revenue":null,"mechanism":"Antizol works by competitively inhibiting the enzyme alcohol dehydrogenase, which is responsible for converting toxic alcohols into their more toxic metabolites."},{"drug_id":"colecalciferol","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Infuvite Adult","generic_name":"Colecalciferol","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Vitamin D3 receptor","drug_class":"Vitamin D","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"edetic-acid","indication_name":"Accidental poisoning by lead and its compounds and fumes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Calcium Disodium Versenate","generic_name":"EDETIC ACID","company_name":"Medicis","drug_phase":"marketed","molecular_target":"Amyloid beta A4 protein","drug_class":"Anti-coagulant","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"dimercaprol","indication_name":"Accidental poisoning by lead and its compounds and fumes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bal","generic_name":"DIMERCAPROL","company_name":"Provepharm Sas","drug_phase":"marketed","molecular_target":"","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"cholecalciferol","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vitamin D3","generic_name":"cholecalciferol","company_name":"","drug_phase":"marketed","molecular_target":"Vitamin D 25-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, Sterol 26-hydroxylase, mitochondrial","drug_class":"Vitamin C [EPC]","quality_score":27,"revenue":null,"mechanism":null},{"drug_id":"ergocalciferol","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Drisdol","generic_name":"ERGOCALCIFEROL","company_name":"Esjay Pharma","drug_phase":"marketed","molecular_target":"25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial","drug_class":"Provitamin D2 Compound [EPC]","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"erdosteine","indication_name":"Accidental poisoning by lead and its compounds and fumes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dithiosteine","generic_name":"ERDOSTEINE","company_name":"","drug_phase":"phase_3","molecular_target":"","drug_class":"erdosteine","quality_score":27,"revenue":null,"mechanism":"Erdosteine works by binding to heavy metals and facilitating their excretion from the body."},{"drug_id":"potassium-nitrate","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Saltpeter","generic_name":"POTASSIUM NITRATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":31,"revenue":null,"mechanism":""},{"drug_id":"delmopinol","indication_name":"Dental plaque","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Decapinol","generic_name":"DELMOPINOL","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"delmopinol","quality_score":null,"revenue":null,"mechanism":"Decapinol works by preventing the adhesion of bacteria to tooth surfaces."},{"drug_id":"calciferol","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Calciferol","company_name":"Department of Medical Services Ministry of Public Health of Thailand","drug_phase":"phase_1","molecular_target":"Vitamin D 25-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, Vitamin D3 receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"xylitol","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"XYLITOL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"Non-Standardized Food Allergenic Extract [EPC]","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"retinol","indication_name":"Prevention of dental caries","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"M.V.I. Pediatric","generic_name":"RETINOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Amyloid beta A4 protein","drug_class":"Vitamin A","quality_score":25,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":18,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05935813","title":"Caries in Adolescents (Karies Hos Ungdom)","phase":"","overall_status":"UNKNOWN","enrollment_count":115000,"lead_sponsor_name":"Kompetansesenteret Tannhelse Midt (TkMidt)","has_results":false},{"nct_id":"NCT04682938","title":"The Prevalence and Characteristics of Adrenal Incidentaloma","phase":"","overall_status":"COMPLETED","enrollment_count":25356,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT05247333","title":"Implementation of a Minor Ailment Service in Community Pharmacy Practice","phase":"NA","overall_status":"COMPLETED","enrollment_count":20987,"lead_sponsor_name":"Universidad de Granada","has_results":false},{"nct_id":"NCT05906095","title":"Pragmatic Trial to Increase Quality of Care in State Veterans Homes","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":10160,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT02333227","title":"Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi","phase":"NA","overall_status":"COMPLETED","enrollment_count":10069,"lead_sponsor_name":"Baylor College of Medicine","has_results":true},{"nct_id":"NCT03147521","title":"Accidental Falls Care Bundle","phase":"NA","overall_status":"COMPLETED","enrollment_count":10000,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT03442309","title":"Comparative Effectiveness of School-based Caries Prevention","phase":"NA","overall_status":"COMPLETED","enrollment_count":7418,"lead_sponsor_name":"NYU College of Dentistry","has_results":true},{"nct_id":"NCT06714929","title":"Advancing Water Security: A Community Participatory School-Based Hydration Intervention","phase":"NA","overall_status":"RECRUITING","enrollment_count":7200,"lead_sponsor_name":"Virginia Commonwealth University","has_results":false},{"nct_id":"NCT05560945","title":"2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":6000,"lead_sponsor_name":"Colgate Palmolive","has_results":false},{"nct_id":"NCT07083453","title":"Financial Incentives to Encourage Uptake of Preventive Dental Care Services Among Adults","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5500,"lead_sponsor_name":"National University of Singapore","has_results":false},{"nct_id":"NCT05116631","title":"Evaluation of Emergency Department Visits and Activity : Study","phase":"","overall_status":"UNKNOWN","enrollment_count":5000,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT05768217","title":"Community Resiliency Collective Efficacy Intervention","phase":"NA","overall_status":"RECRUITING","enrollment_count":4600,"lead_sponsor_name":"University of Pittsburgh","has_results":false},{"nct_id":"NCT03919734","title":"Morbidity and Mortality in Autonomous Cortisol Secretion","phase":"","overall_status":"COMPLETED","enrollment_count":4596,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT06523712","title":"A Scalable, Teacher-delivered, School-based Oral Health Intervention for Pakistani Lower Secondary Schoolchildren","phase":"NA","overall_status":"COMPLETED","enrollment_count":4055,"lead_sponsor_name":"Universiti Putra Malaysia","has_results":false},{"nct_id":"NCT06304428","title":"Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":3780,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT04917757","title":"Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3656,"lead_sponsor_name":"Wuerzburg University Hospital","has_results":true},{"nct_id":"NCT07016217","title":"Evaluation of an Educational Intervention on Antibiotics in Dental Care","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3498,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT03448107","title":"Comparative Effectiveness of Treatments to Prevent Dental Caries","phase":"NA","overall_status":"COMPLETED","enrollment_count":3345,"lead_sponsor_name":"NYU College of Dentistry","has_results":true},{"nct_id":"NCT03354468","title":"The Effects of a Fall Prevention Program on Falls, Patient Safety Culture and Patient-perceived Safety","phase":"","overall_status":"COMPLETED","enrollment_count":3143,"lead_sponsor_name":"Helse Møre og Romsdal HF","has_results":false},{"nct_id":"NCT07461324","title":"Surgeons' Prediction of Dental Surgery Complications and the Influence of Patient Characteristics: Development of an AI Model","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":3000,"lead_sponsor_name":"University of Copenhagen","has_results":false},{"nct_id":"NCT06327893","title":"Patients Treated by the Danish Emergency Medical Services Following Non-drowning Water Rescues From 2016 to 2023","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Prehospital Center, Region Zealand","has_results":false},{"nct_id":"NCT05594004","title":"A Meta-analysis Comparing Toothbrushes on Plaque Removal and Gingival Health","phase":"","overall_status":"COMPLETED","enrollment_count":2929,"lead_sponsor_name":"Procter and Gamble","has_results":false},{"nct_id":"NCT05688982","title":"MOLAR: Mapping Oral Health and Local Area Resources","phase":"NA","overall_status":"RECRUITING","enrollment_count":2927,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT02835989","title":"Community Paramedicine at Home","phase":"NA","overall_status":"COMPLETED","enrollment_count":2826,"lead_sponsor_name":"McMaster University","has_results":false},{"nct_id":"NCT06815068","title":"Effect of Simplified Implant Placement Protocols on Failure Rate","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2700,"lead_sponsor_name":"Chrysalis Dental Center","has_results":false},{"nct_id":"NCT04081025","title":"Oral Health and Risk Factors for Oral Disease","phase":"","overall_status":"COMPLETED","enrollment_count":2500,"lead_sponsor_name":"Dalarna County Council, Sweden","has_results":false},{"nct_id":"NCT05689554","title":"Reducing CNS-Active Medications to Prevent Falls and Injuries in Older Adults","phase":"NA","overall_status":"COMPLETED","enrollment_count":2367,"lead_sponsor_name":"University of Washington","has_results":true},{"nct_id":"NCT04006483","title":"Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque","phase":"","overall_status":"COMPLETED","enrollment_count":2359,"lead_sponsor_name":"Procter and Gamble","has_results":false},{"nct_id":"NCT03385629","title":"Providers Against Cavities in Children's Teeth","phase":"NA","overall_status":"COMPLETED","enrollment_count":2108,"lead_sponsor_name":"Case Western Reserve University","has_results":true},{"nct_id":"NCT04001296","title":"The Impact of a 21day School Brushing Intervention on the Knowledge, Behaviour and Oral Health of School Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":2020,"lead_sponsor_name":"Unilever R&D","has_results":false},{"nct_id":"NCT04750902","title":"A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":2000,"lead_sponsor_name":"Colgate Palmolive","has_results":false},{"nct_id":"NCT07275281","title":"Incidental Findings on Coronary Computed Tomography Angiography","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Jordan Collaborating Cardiology Group","has_results":false},{"nct_id":"NCT04890444","title":"China Adrenal Disease Registry","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT03746990","title":"Presence of Enamel Fluorosis in Libyan Children","phase":"","overall_status":"COMPLETED","enrollment_count":1935,"lead_sponsor_name":"Ajman University","has_results":false},{"nct_id":"NCT03547128","title":"Iowa Fluoride Study/Iowa Bone Development Study","phase":"","overall_status":"COMPLETED","enrollment_count":1882,"lead_sponsor_name":"Steven M Levy","has_results":false},{"nct_id":"NCT05980273","title":"Effectiveness of Oral Health Education Programs Among School Children, Their Mothers and Teachers in Fayyum: Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":1800,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT03963570","title":"The Effectiveness of a Self-managed Digital Exercise Programme to Prevent Falls in Older Community-dwelling People","phase":"NA","overall_status":"COMPLETED","enrollment_count":1628,"lead_sponsor_name":"Umeå University","has_results":false},{"nct_id":"NCT03703245","title":"Pooled Analysis of Clinical Data From Six GSK Studies to Investigate the Efficacy of a Dentifrice Containing 67% Weight by Weight (w/w) Sodium Bicarbonate on Gingivitis and Plaque Accumulation","phase":"","overall_status":"COMPLETED","enrollment_count":1601,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT03474601","title":"Seoul National University Pituitary Disease Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":1600,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT03474237","title":"A Prospective Cohort Study for Patients With Adrenal Diseases","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1500,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT01707797","title":"Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings","phase":"","overall_status":"COMPLETED","enrollment_count":1326,"lead_sponsor_name":"University of Michigan","has_results":false},{"nct_id":"NCT06908603","title":"Use of Artificial Intelligence in Oral Radiology: A Multicenter Cross-Sectional Study in Egypt","phase":"","overall_status":"COMPLETED","enrollment_count":1326,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT06965660","title":"Population Cohort Set-up for the Epidemiological Assessment of Balance Disorders in Elderly People","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1300,"lead_sponsor_name":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","has_results":false},{"nct_id":"NCT06024395","title":"A Stepped Care Approach to Treating Dental Fear","phase":"NA","overall_status":"RECRUITING","enrollment_count":1250,"lead_sponsor_name":"New York University","has_results":false},{"nct_id":"NCT03596255","title":"Clinical Estimation of Dental Anxiety","phase":"","overall_status":"COMPLETED","enrollment_count":1230,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05902611","title":"The Relationship Between Body Mass Index, Dental Eruption and Dental Caries Prevalence in School Children","phase":"","overall_status":"UNKNOWN","enrollment_count":1224,"lead_sponsor_name":"Al-Azhar University","has_results":false},{"nct_id":"NCT03694496","title":"The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong","phase":"NA","overall_status":"COMPLETED","enrollment_count":1184,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT04632667","title":"CATCH Healthy Smiles:An Elementary School Oral Health Intervention Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1084,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT05025163","title":"Cost-effectiveness of Topical Fluoride in Preventing Deciduous Dental Caries in Preschool Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":1083,"lead_sponsor_name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC","has_results":false},{"nct_id":"NCT07161362","title":"Measurement of Dental Health Care Utilization","phase":"","overall_status":"COMPLETED","enrollment_count":1059,"lead_sponsor_name":"Cairo University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}