{"disease":{"id":"deep-vein-thrombosis-with-pulmonary-embolism","name":"Deep Vein Thrombosis with Pulmonary Embolism","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":3,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"heparin","indication_name":"Deep Vein Thrombosis with Pulmonary Embolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Heparin Sodium In Plastic Container","generic_name":"HEPARIN","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Antithrombin-III","drug_class":"Anti-coagulant","quality_score":56,"revenue":null,"mechanism":"Heparin works by binding to Antithrombin-III, a protein that inhibits the formation of blood clots."},{"drug_id":"heparin-sodium","indication_name":"Deep Vein Thrombosis with Pulmonary Embolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Heparin Sodium In Plastic Container","generic_name":"Heparin Sodium","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"Antithrombin III, Coagulation Factors Xa and IIa","drug_class":"Anticoagulant","quality_score":63,"revenue":null,"mechanism":"Heparin enhances Antithrombin III activity to inhibit coagulation factors Xa and IIa."},{"drug_id":"warfarin","indication_name":"Deep Vein Thrombosis with Pulmonary Embolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Coumadin","generic_name":"warfarin","company_name":"Generic (originally Wisconsin Alumni Research Foundation)","drug_phase":"marketed","molecular_target":"Vitamin K epoxide reductase complex subunit 1-like protein 1, Cytochrome P450 2C9, Proprotein convertase subtilisin/kexin type 7","drug_class":"Vitamin K antagonist (anticoagulant)","quality_score":60,"revenue":null,"mechanism":"Inhibits vitamin K epoxide reductase, blocking the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) to prevent thrombosis."}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[],"total":0},"guidelines":[{"drug_id":"heparin-sodium-25-000-units-in-dextrose-5-in-plastic-container","guideline_body":"FDA label","recommendation":"Prophylaxis and treatment of venous thrombosis and pulmonary embolism","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null},{"drug_id":"heparin-sodium-10-000-units-in-dextrose-5-in-plastic-container","guideline_body":"FDA label","recommendation":"Prophylaxis and treatment of venous thrombosis and pulmonary embolism","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null},{"drug_id":"heparin-sodium-12-500-units-in-dextrose-5-in-plastic-container","guideline_body":"FDA label","recommendation":"Prophylaxis and treatment of venous thrombosis and pulmonary embolism","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null},{"drug_id":"heparin-sodium-preservative-free","guideline_body":"FDA label","recommendation":"Prophylaxis and treatment of venous thrombosis and pulmonary embolism","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null},{"drug_id":"heparin-sodium","guideline_body":"FDA label","recommendation":"Prophylaxis and treatment of venous thrombosis and pulmonary embolism","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null}],"source":"Drug Landscape verified database"}