{"disease":{"id":"decompensated-heart-failure","name":"decompensated heart failure"},"drugs":{"marketed":[{"drug_id":"milrinone-lactate-in-dextrose-5-in-plastic-container","indication_name":"Acute decompensated heart failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Primacor","generic_name":"Milrinone Lactate","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"Phosphodiesterase 3","drug_class":"Phosphodiesterase 3 Inhibitor","quality_score":51,"revenue":null,"mechanism":""},{"drug_id":"nesiritide","indication_name":"Decompensated chronic heart failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Natrecor","generic_name":"NESIRITIDE","company_name":"Scios Llc","drug_phase":"marketed","molecular_target":"Atrial natriuretic peptide receptor 1","drug_class":"Natriuretic Peptide","quality_score":31,"revenue":null,"mechanism":""},{"drug_id":"milrinone-lactate","indication_name":"Acute decompensated heart failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Milrinone Lactate","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Phosphodiesterase-3 (PDE-3) enzyme","drug_class":"Inotropic agent; Phosphodiesterase-3 inhibitor; Vasodilator","quality_score":66,"revenue":null,"mechanism":"Phosphodiesterase-3 inhibitor that increases cardiac contractility and promotes vasodilation through cAMP elevation."},{"drug_id":"milrinone-lactate","indication_name":"Acute decompensated heart failure in patients receiving digoxin","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Milrinone Lactate","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Phosphodiesterase-3 (PDE-3) enzyme","drug_class":"Inotropic agent; Phosphodiesterase-3 inhibitor; Vasodilator","quality_score":66,"revenue":null,"mechanism":"Phosphodiesterase-3 inhibitor that increases cardiac contractility and promotes vasodilation through cAMP elevation."},{"drug_id":"milrinone-lactate","indication_name":"Acute decompensated heart failure in patients receiving diuretics","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Milrinone Lactate","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Phosphodiesterase-3 (PDE-3) enzyme","drug_class":"Inotropic agent; Phosphodiesterase-3 inhibitor; Vasodilator","quality_score":66,"revenue":null,"mechanism":"Phosphodiesterase-3 inhibitor that increases cardiac contractility and promotes vasodilation through cAMP elevation."}],"pipeline":[],"offLabel":[],"totalMarketed":5,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05776043","title":"Empagliflozin and Dapagliflozin in Patients Hospitalized for Acute Decompensated Heart Failure","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":1364,"lead_sponsor_name":"Medical University of Warsaw","has_results":false},{"nct_id":"NCT06273397","title":"Acetazolamide or Metolazone in Acute Heart Failure","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1050,"lead_sponsor_name":"Clinica Alemana de Santiago","has_results":false},{"nct_id":"NCT05100836","title":"SURPASS Impella 5.5 Study","phase":"","overall_status":"COMPLETED","enrollment_count":1017,"lead_sponsor_name":"Abiomed Inc.","has_results":false},{"nct_id":"NCT06081205","title":"Study of Patients Admitted to a Cardiac Intensive Care Unit With Acute CardioVascular Disease","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University Hospital, Ioannina","has_results":false},{"nct_id":"NCT07508891","title":"Characterisation of phenotYpes in aCute Heart faiLure patiEnts","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT04740242","title":"Metabolic Alkalosis in Heart Failure","phase":"","overall_status":"COMPLETED","enrollment_count":672,"lead_sponsor_name":"Spanish Society of Internal Medicine","has_results":false},{"nct_id":"NCT07038356","title":"Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on Active SGLT2 Inhibitor Treatment Admitted for Acute Decompensated Heart Failure","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":536,"lead_sponsor_name":"Christian Schulze","has_results":false},{"nct_id":"NCT03505788","title":"Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":519,"lead_sponsor_name":"Ziekenhuis Oost-Limburg","has_results":true},{"nct_id":"NCT07023016","title":"Comparative Assessment of Efficacy & Safety of Sacubitril/Valsartan Versus Ramipril in Patients With Renal Dysfunction Hospitalized With Acute Decompensated Heart Failure","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":515,"lead_sponsor_name":"National Heart Institute, Egypt","has_results":false},{"nct_id":"NCT03157219","title":"Manipal Heart Failure Registry (MHFR)","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Manipal University","has_results":false},{"nct_id":"NCT06298825","title":"S-ADHF：Sarcopenia in Patients With ADHF","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT05327374","title":"Use of ΔIVC for Early Diagnosis of AHF in AECOPD","phase":"","overall_status":"COMPLETED","enrollment_count":401,"lead_sponsor_name":"University of Monastir","has_results":false},{"nct_id":"NCT04436718","title":"Does Ultrasound Assessment for Extravascular Lung Water and IVC Measurement Affect Outcomes in Inpatient Heart Failure Management?","phase":"NA","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Riverside University Health System Medical Center","has_results":false},{"nct_id":"NCT04390919","title":"Prognostic Factors of Patients With ADHF","phase":"","overall_status":"COMPLETED","enrollment_count":362,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT07262723","title":"Levosimendan in Acute Decompensated Heart Failure","phase":"PHASE2, PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":332,"lead_sponsor_name":"Chittagong Medical College","has_results":false},{"nct_id":"NCT07199088","title":"Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":320,"lead_sponsor_name":"University of Health Sciences Lahore","has_results":false},{"nct_id":"NCT06989580","title":"BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software","phase":"NA","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Biotronik SE & Co. KG","has_results":false},{"nct_id":"NCT03951467","title":"Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations","phase":"NA","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT07173426","title":"Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":255,"lead_sponsor_name":"Mid and South Essex NHS Foundation Trust","has_results":false},{"nct_id":"NCT04733365","title":"Exercise in Patients Admitted With Recently Decompensated Heart Failure","phase":"NA","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Centro Hospitalar do Porto","has_results":false},{"nct_id":"NCT03838003","title":"Exercise in Patients Admitted With Recently Decompensated Heart Failure","phase":"NA","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Universidade do Porto","has_results":false},{"nct_id":"NCT06114498","title":"Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":240,"lead_sponsor_name":"National Medical Research Center for Therapy and Preventive Medicine","has_results":false},{"nct_id":"NCT06354426","title":"Short-term Mortality Prediction by the SOFA Score in Acute Decompensated Heart Failure","phase":"","overall_status":"COMPLETED","enrollment_count":216,"lead_sponsor_name":"Hanoi Heart Hospital","has_results":false},{"nct_id":"NCT05910437","title":"Optimizing Treatments for Heart Failure During Hospitalization","phase":"","overall_status":"COMPLETED","enrollment_count":184,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT06714409","title":"Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT03407287","title":"Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status","phase":"","overall_status":"TERMINATED","enrollment_count":180,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT05807152","title":"Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid Overload","phase":"NA","overall_status":"UNKNOWN","enrollment_count":170,"lead_sponsor_name":"Centro Cardiologico Monzino","has_results":false},{"nct_id":"NCT04223271","title":"Heart Failure Event Advance Detection Trial","phase":"","overall_status":"UNKNOWN","enrollment_count":165,"lead_sponsor_name":"Vixiar Medical, Inc.","has_results":false},{"nct_id":"NCT06586008","title":"The Association Between Visual Echocardiographic Scoring System and Clinical Outcomes in Patient With Acute Decompensated Heart Failure","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Universitas Diponegoro","has_results":false},{"nct_id":"NCT06397833","title":"A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Royal Brompton & Harefield NHS Foundation Trust","has_results":false},{"nct_id":"NCT02620384","title":"Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure (MELT-HF)--A Single Center Pilot Study.","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":147,"lead_sponsor_name":"Aultman Health Foundation","has_results":true},{"nct_id":"NCT06161987","title":"EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF","phase":"NA","overall_status":"RECRUITING","enrollment_count":140,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT05927285","title":"Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1","phase":"NA","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Hospital Civil de Guadalajara","has_results":false},{"nct_id":"NCT03388918","title":"Future Patient - Telerehabilitation of Heart Failure Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Aalborg University","has_results":false},{"nct_id":"NCT06161649","title":"Mobile Education System to Improve Disease Knowledge, Self-efficacy and Quality of Life in Patients With Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":138,"lead_sponsor_name":"Chang Gung Memorial Hospital","has_results":false},{"nct_id":"NCT07506499","title":"Cardiac Rehabilitation in Decompensated Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":135,"lead_sponsor_name":"Beni-Suef University","has_results":false},{"nct_id":"NCT07444398","title":"Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":130,"lead_sponsor_name":"Khawaja Danish Ali","has_results":false},{"nct_id":"NCT03555123","title":"Evaluate the Efficacy and Safety of Short-term Administration of SIMDAX","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":112,"lead_sponsor_name":"Yooyoung Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT06414759","title":"Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":110,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT05090930","title":"Innovative Technologies for the Treatment of Pulmonary and Heart Failure","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"National Research Center for Cardiac Surgery, Kazakhstan","has_results":false},{"nct_id":"NCT05174312","title":"Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Reprieve Cardiovascular, Inc","has_results":false},{"nct_id":"NCT03488979","title":"Effect of Providing Education and Patient's Inferior Vena Cava Ultrasound Images on Adherence to a Heart Failure Regimen","phase":"","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT06459115","title":"Adherence to Medication in Patients With Acute Decompensated Heart Failure","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Universität des Saarlandes","has_results":false},{"nct_id":"NCT06795737","title":"ExCR's Effects and Safety in Vulnerable ADHF Patients","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":88,"lead_sponsor_name":"YE Jing","has_results":false},{"nct_id":"NCT04158674","title":"Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLS","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":82,"lead_sponsor_name":"Centre Hospitalier Universitaire Dijon","has_results":false},{"nct_id":"NCT04752462","title":"Motivational Enhancement - Acute Decompensated Heart Failure and OSA","phase":"NA","overall_status":"COMPLETED","enrollment_count":75,"lead_sponsor_name":"The Cleveland Clinic","has_results":false},{"nct_id":"NCT02993601","title":"Feasibility Study of a New Peripheral Oedema Monitor for Heart Failure","phase":"","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"Heartfelt Technologies","has_results":false},{"nct_id":"NCT02157506","title":"A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":true},{"nct_id":"NCT07372040","title":"Add-on Diuretics in Acute Decompensated Heart Failure","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":66,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT06475105","title":"Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":66,"lead_sponsor_name":"Universitas Diponegoro","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}