{"disease":{"id":"cytomegalovirus","name":"cytomegalovirus"},"drugs":{"marketed":[{"drug_id":"letermovir","indication_name":"Cytomegalovirus infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prevymis","generic_name":"LETERMOVIR","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"","drug_class":"Cytomegalovirus DNA Terminase Complex Inhibitor [EPC]","quality_score":62,"revenue":"978","mechanism":"Prevymis works by inhibiting the DNA terminase complex of the cytomegalovirus, preventing the virus from replicating."},{"drug_id":"maribavir","indication_name":"Post-transplant cytomegalovirus infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Livtencity","generic_name":"MARIBAVIR","company_name":"Takeda","drug_phase":"marketed","molecular_target":"","drug_class":"Cytomegalovirus pUL97 Kinase Inhibitor [EPC]","quality_score":65,"revenue":"300","mechanism":"Livtencity works by inhibiting the pUL97 kinase enzyme, which is essential for the replication of cytomegalovirus."},{"drug_id":"valganciclovir","indication_name":"Congenital cytomegalovirus infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valcyte","generic_name":"VALGANCICLOVIR","company_name":"Cheplapharm","drug_phase":"marketed","molecular_target":"","drug_class":"Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":70,"revenue":null,"mechanism":"Valcyte works by inhibiting the replication of cytomegalovirus DNA through its action as a nucleoside analog DNA polymerase inhibitor."}],"pipeline":[{"drug_id":"valacyclovir","indication_name":"Congenital Cytomegalovirus Infection","indication_type":"pipeline","phase":"Phase 3","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"VALACYCLOVIR","company_name":"","drug_phase":"marketed","molecular_target":"Viral DNA polymerase","drug_class":"Nucleoside analogue","quality_score":80,"revenue":null,"mechanism":"Valacyclovir is an antiviral drug that inhibits viral DNA polymerase to treat herpes simplex and varicella-zoster viruses."}],"offLabel":[],"totalMarketed":3,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT07358910","title":"Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Institut Pasteur du Cambodge","has_results":false},{"nct_id":"NCT05085366","title":"A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":7454,"lead_sponsor_name":"ModernaTX, Inc.","has_results":false},{"nct_id":"NCT04879784","title":"Primary Prevention of Cytomegalovirus in Pregnancy: Addressing the Gaps (CMV GAP)","phase":"","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"University Hospital Southampton NHS Foundation Trust","has_results":false},{"nct_id":"NCT03722615","title":"Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa","phase":"","overall_status":"COMPLETED","enrollment_count":3000,"lead_sponsor_name":"University of Witwatersrand, South Africa","has_results":false},{"nct_id":"NCT05630898","title":"Congenital Cytomegalovirus: Prevalence in Buenos Aires City (cCMV Prevalence)","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Hospital de Niños R. Gutierrez de Buenos Aires","has_results":false},{"nct_id":"NCT03486834","title":"V160 2-Dose and 3-Dose Regimens in Healthy Cytomegalovirus (CMV) Seronegative Females (V160-002)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":2200,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT04412811","title":"Prospective Survey of CMV, Herpesviruses Infections and Diseases in Allo-HSCT","phase":"","overall_status":"COMPLETED","enrollment_count":1310,"lead_sponsor_name":"Gruppo Italiano Trapianto di Midollo Osseo","has_results":false},{"nct_id":"NCT05575492","title":"A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age","phase":"PHASE1, PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":873,"lead_sponsor_name":"ModernaTX, Inc.","has_results":false},{"nct_id":"NCT05958186","title":"A Study of Cytomegalovirus Disease Epidemiology in Pediatric and Adult Liver Transplant Recipients in China","phase":"","overall_status":"COMPLETED","enrollment_count":800,"lead_sponsor_name":"Lin Zhong","has_results":true},{"nct_id":"NCT00411645","title":"Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":681,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT03910478","title":"Dried Blood Spot Testing of CMV Detection in HCT Recipients","phase":"NA","overall_status":"COMPLETED","enrollment_count":622,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":true},{"nct_id":"NCT04615715","title":"Prenatal Behavioral Intervention to Prevent Maternal Cytomegalovirus (CMV) in Pregnancy","phase":"NA","overall_status":"COMPLETED","enrollment_count":582,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT03915366","title":"Empirical Treatment Against Cytomegalovirus and Tuberculosis in HIV-infected Infants With Severe Pneumonia","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":563,"lead_sponsor_name":"Hospital Universitario 12 de Octubre","has_results":false},{"nct_id":"NCT02927067","title":"A Study of Maribavir Compared to Valganciclovir to Treat Cytomegalovirus Infections in People Who Have Received Stem Cell Transplants","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":553,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT01877655","title":"A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic, Hematopoietic Cell Transplant (HCT)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":514,"lead_sponsor_name":"Astellas Pharma Global Development, Inc.","has_results":true},{"nct_id":"NCT06694428","title":"Evaluation of Software for Interpreting Virological Results Indicated for the Diagnosis of Cytomegalovirus (CMV) Infection During Pregnancy and Intended for Health Professionals","phase":"","overall_status":"RECRUITING","enrollment_count":491,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05754879","title":"Diagnosis of Congenital Cytomegalovirus Infection in Newborn With Particular Risk","phase":"","overall_status":"COMPLETED","enrollment_count":479,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT05305040","title":"Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant","phase":"PHASE2, PHASE3","overall_status":"TERMINATED","enrollment_count":451,"lead_sponsor_name":"AlloVir","has_results":true},{"nct_id":"NCT04690933","title":"AntiCMV molécules Monitoring in Real-life in Stem Cell Recipients","phase":"","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"University Hospital, Limoges","has_results":false},{"nct_id":"NCT04067869","title":"Cytomegalovirus Infection in Patients With HIV-1 Infection","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":392,"lead_sponsor_name":"University Hospital, Bordeaux","has_results":false},{"nct_id":"NCT03806764","title":"Cytomegalovirus (CMV) Reactivation in Allogeneic HSCT Recipient","phase":"NA","overall_status":"UNKNOWN","enrollment_count":370,"lead_sponsor_name":"Melbourne Health","has_results":false},{"nct_id":"NCT01691820","title":"A Study in Adolescent Females to Explore Cytomegalovirus Infection","phase":"NA","overall_status":"COMPLETED","enrollment_count":369,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT06798909","title":"Kidney Transplant Preemptive Therapy or Prophylaxis for CMV Prevention in D+R Recipients","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":360,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT02931539","title":"Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment With Ganciclovir, Valganciclovir, Foscarnet, or Cidofovir","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":352,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT05089630","title":"A Study of Safety and Immune Response to Different Doses of a Cytomegalovirus Vaccine in Healthy Adults","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":339,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT06812598","title":"Efficacy of Extended Letermovir Prophylaxis to Prevent CMV Reactivation in High-Risk Chinese Adults Undergoing Allogeneic HSCT","phase":"NA","overall_status":"RECRUITING","enrollment_count":330,"lead_sponsor_name":"The First Affiliated Hospital of Soochow University","has_results":false},{"nct_id":"NCT06568055","title":"A Study of Cytomegalovirus (CMV) Infection After Kidney Transplant in Adults in the United Kingdom","phase":"","overall_status":"COMPLETED","enrollment_count":330,"lead_sponsor_name":"Takeda","has_results":false},{"nct_id":"NCT00294515","title":"IMPACT Study: A Study of Valcyte (Valganciclovir) for Prevention of Cytomegalovirus Disease (CMV) in Kidney Allograft Recipients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":326,"lead_sponsor_name":"Hoffmann-La Roche","has_results":true},{"nct_id":"NCT00023036","title":"Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts","phase":"","overall_status":"COMPLETED","enrollment_count":324,"lead_sponsor_name":"National Institute on Deafness and Other Communication Disorders (NIDCD)","has_results":false},{"nct_id":"NCT04232280","title":"Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647 in Healthy Adults","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":315,"lead_sponsor_name":"ModernaTX, Inc.","has_results":false},{"nct_id":"NCT05397223","title":"A Study of Modified mRNA Vaccines in Healthy Adults","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":308,"lead_sponsor_name":"ModernaTX, Inc.","has_results":false},{"nct_id":"NCT00497796","title":"Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":307,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT07210242","title":"HCMV-miRNA Monitoring After Allogeneic Hematopoietic Stem Cell Transplantation Using PSTM-qPCR","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Ting YANG","has_results":false},{"nct_id":"NCT06615921","title":"A Study of Maribavir in Adults With Post-transplant Cytomegalovirus (CMV) Infection","phase":"","overall_status":"COMPLETED","enrollment_count":265,"lead_sponsor_name":"Takeda","has_results":false},{"nct_id":"NCT01923636","title":"Prognostic Value of Neonatal Markers for the Development of Neurosensorial Sequelae in Children Infected by Cytomegalovirus in Utero","phase":"NA","overall_status":"COMPLETED","enrollment_count":254,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06577363","title":"A Survey of Maribavir Tablets in Participants With Cytomegalovirus Infection","phase":"","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Takeda","has_results":false},{"nct_id":"NCT06058858","title":"Incidence and Risks Factors of CMV Reactivation in Patients Receiving of CAR-T Cells for Acute Leukemia and Lymphoma Relapse, a Cohort Study Analysis","phase":"","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT02139423","title":"Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening","phase":"NA","overall_status":"COMPLETED","enrollment_count":235,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06916195","title":"Burden of Cytomegalovirus Reactivation in Pediatric Patients After Allogeneic Hematopoietic Stem Cell Transplantation","phase":"","overall_status":"RECRUITING","enrollment_count":230,"lead_sponsor_name":"MSD Italia S.r.l.","has_results":false},{"nct_id":"NCT05683457","title":"A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Allogenic Hematopoietic Cell Transplantation (HCT) Participants.","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":224,"lead_sponsor_name":"ModernaTX, Inc.","has_results":false},{"nct_id":"NCT03930615","title":"Extension of Letermovir (LET) From Day 100 to Day 200 Post-transplant for the Prevention of Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant (HSCT) Participants (MK-8228-040)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":220,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT01552369","title":"CMV Antiviral Prevention Strategies in D+R-Liver Transplants (\"CAPSIL\")","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":205,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":true},{"nct_id":"NCT06793124","title":"Comparison Diagnostic Tests for the Diagnosis of CYTOmegalovirus Organ Disease in Patients With intestinalBOweL Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT04724265","title":"Cytomegalovirus (CMV) Perilymphatic Fluid","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT01986010","title":"Safety, Tolerability, and Immunogenicity of the Human Cytomegalovirus Vaccine (V160) in Healthy Adults (V160-001)","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":190,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT02328963","title":"Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":186,"lead_sponsor_name":"University Hospital, Bordeaux","has_results":false},{"nct_id":"NCT03382405","title":"Safety, Reactogenicity, and Immunogenicity of Cytomegalovirus Vaccines mRNA-1647 and mRNA-1443 in Healthy Adults","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":181,"lead_sponsor_name":"ModernaTX, Inc.","has_results":false},{"nct_id":"NCT03858907","title":"Cytomegalovirus Risk in Seropositive Kidney Transplant Recipients Stratified by Quantiferon-CMV","phase":"","overall_status":"UNKNOWN","enrollment_count":180,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT06555432","title":"A Study of LIVTENCITY (Maribavir) in Adults With Cytomegalovirus (CMV) Infection After Transplantation in South Korea","phase":"","overall_status":"RECRUITING","enrollment_count":168,"lead_sponsor_name":"Takeda","has_results":false},{"nct_id":"NCT05419206","title":"The Relationship Between CMV* Reactivation and Anti-cytokine Treatment in Critical COVID-19 Patients","phase":"","overall_status":"COMPLETED","enrollment_count":167,"lead_sponsor_name":"Ramazan Gozukucuk","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}