{"disease":{"id":"cough","name":"Cough","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":38,"pipeline_drug_count":0,"trial_count":7},"drugs":{"marketed":[{"drug_id":"triprolidine","indication_name":"Cough relief","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Actidil","generic_name":"TRIPROLIDINE","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"triprolidine","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"triprolidine","indication_name":"Cough control for sleep","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Actidil","generic_name":"TRIPROLIDINE","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"triprolidine","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"homatropine-methylbromide","indication_name":"Symptomatic relief of cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"HOMATROPINE METHYLBROMIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":15,"revenue":null,"mechanism":null},{"drug_id":"dextromethorphan-hydrobromide","indication_name":"Cough Relief","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"DEXTROMETHORPHAN HYDROBROMIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"Expectorant [EPC]","quality_score":20,"revenue":null,"mechanism":null},{"drug_id":"dextromethorphan-hydrobromide","indication_name":"Productive Cough Promotion","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"DEXTROMETHORPHAN HYDROBROMIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"Expectorant [EPC]","quality_score":20,"revenue":null,"mechanism":null},{"drug_id":"eucalyptus-oil","indication_name":"Cough relief due to common cold","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"EUCALYPTUS OIL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":9,"revenue":null,"mechanism":null},{"drug_id":"codeine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Codeine","generic_name":"codeine phosphate","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Delta-type opioid receptor, Kappa-type opioid receptor, Mu-type opioid receptor","drug_class":"Opioid analgesic, Antitussive","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"clofedanol","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlophedianol","generic_name":"clofedanol","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"clofedanol","quality_score":19,"revenue":null,"mechanism":""},{"drug_id":"syrup","indication_name":"cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Formula 3 Cough Syrup","generic_name":"SYRUP","company_name":"Vitality Works, Inc.","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"hydrocodone","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tussionex Pennkinetic","generic_name":"HYDROCODONE","company_name":"Teva","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":67,"revenue":null,"mechanism":"Tussionex Pennkinetic works by binding to opioid receptors in the brain, which helps to reduce pain and congestion."},{"drug_id":"sodium-citrate","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bss","generic_name":"SODIUM CITRATE","company_name":"B Braun","drug_phase":"marketed","molecular_target":"Calcium","drug_class":"sodium citrate","quality_score":51,"revenue":null,"mechanism":"ANTICOAGULANT CITRATE DEXTROSE SOLUTION USP (ACD) SOLUTION A prevents blood clotting by binding free calcium, a crucial co-factor in the clotting cascade."},{"drug_id":"bromazine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bromanautine","generic_name":"bromazine","company_name":"Allergan/AbbVie","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"bromazine","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"phenylpropanolamine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Propadrine","generic_name":"PHENYLPROPANOLAMINE","company_name":"Alpharma Us Pharms","drug_phase":"marketed","molecular_target":"Sodium-dependent noradrenaline transporter","drug_class":"Indirectly Acting Sympathomimetic Amines","quality_score":36,"revenue":null,"mechanism":""},{"drug_id":"dihydrocodeine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Synalgos-Dc","generic_name":"DIHYDROCODEINE","company_name":"Caraco","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Central Nervous System Stimulant [EPC]","quality_score":54,"revenue":null,"mechanism":""},{"drug_id":"glycine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aminoacetic Acid 1.5% In Plastic Container","generic_name":"GLYCINE","company_name":"Baxter","drug_phase":"marketed","molecular_target":"Olfactory receptor 51E2","drug_class":"glycine","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"hydromorphone","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dilaudid-Hp","generic_name":"HYDROMORPHONE","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"mu-opioid receptor","drug_class":"Opioid Agonist","quality_score":66,"revenue":null,"mechanism":"Hydromorphone binds primarily to mu-opioid receptors, producing analgesia without a ceiling effect."},{"drug_id":"cortisone","indication_name":"cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Immune Support","generic_name":"CORTISONE","company_name":"Merck","drug_phase":"marketed","molecular_target":"","drug_class":"Non-Standardized Plant Allergenic Extract [EPC]","quality_score":20,"revenue":null,"mechanism":""},{"drug_id":"ammonium-chloride","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"AMMONIUM CHLORIDE","company_name":"B Braun","drug_phase":"marketed","molecular_target":"","drug_class":"ammonium chloride","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"clobutinol","indication_name":"Non-productive cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Silomat","generic_name":"CLOBUTINOL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"clobutinol","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"gefapixant-citrate","indication_name":"Refractory chronic cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lyfnua","generic_name":"GEFAPIXANT CITRATE","company_name":"Msd K.K.","drug_phase":"marketed","molecular_target":"P2X purinoceptor 3","drug_class":"","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"dropropizine","indication_name":"Non-productive cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Catabex","generic_name":"DROPROPIZINE","company_name":"","drug_phase":"phase_3","molecular_target":"","drug_class":"dropropizine","quality_score":29,"revenue":null,"mechanism":"Dropropizine works by modulating the cough reflex through its action on the central nervous system."},{"drug_id":"piperidione","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"piperidione","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"potassium-iodide","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Potassium Iodide","generic_name":"POTASSIUM IODIDE","company_name":"Roxane","drug_phase":"marketed","molecular_target":"Carbonic anhydrase 4","drug_class":"","quality_score":23,"revenue":null,"mechanism":null},{"drug_id":"iodinated-glycerol","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Organidin","generic_name":"iodinated glycerol","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Organidin works by helping to thin and loosen mucus in the airways, making it easier to cough up."},{"drug_id":"cyclizine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Marezine","generic_name":"CYCLIZINE","company_name":"GSK","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"cyclizine","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"alloclamide","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tuselin","generic_name":"ALLOCLAMIDE","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"alloclamide","quality_score":null,"revenue":null,"mechanism":"Tuselin works by interacting with the nervous system to reduce coughing."},{"drug_id":"guaiacol","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Guaiastil","generic_name":"GUAIACOL","company_name":"","drug_phase":"marketed","molecular_target":"Carbonic anhydrase 2","drug_class":"guaiacol","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"benproperine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cofrel","generic_name":"BENPROPERINE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":13,"revenue":null,"mechanism":""},{"drug_id":"phenicarbazide","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Carbaphen","generic_name":"PHENICARBAZIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"phenicarbazide","quality_score":15,"revenue":null,"mechanism":""},{"drug_id":"phenylephrine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sudafed PE","generic_name":"phenylephrine","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-1D adrenergic receptor","drug_class":"Alpha-1 adrenergic agonist (decongestant/vasopressor)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"methylhomatropine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Hycodan","generic_name":"METHYLHOMATROPINE","company_name":"Endo","drug_phase":"marketed","molecular_target":"","drug_class":"methylhomatropine","quality_score":54,"revenue":null,"mechanism":"Hycodan works by affecting the nervous system to reduce cough and relieve symptoms of irritable bowel syndrome and peptic ulcer."},{"drug_id":"chlorcyclizine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Perazyl","generic_name":"CHLORCYCLIZINE","company_name":"","drug_phase":"marketed","molecular_target":"Apoptosis regulator Bcl-2","drug_class":"chlorcyclizine","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"benzonatate","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tessalon","generic_name":"benzonatate","company_name":"Generic (originally Pfizer)","drug_phase":"marketed","molecular_target":"Sodium channel protein type 5 subunit alpha","drug_class":"Non-narcotic Antitussive [EPC]","quality_score":21,"revenue":null,"mechanism":""},{"drug_id":"guaifenesin","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mucinex","generic_name":"guaifenesin","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Vagal gastric reflex → increased respiratory secretions","drug_class":"Expectorant [EPC]","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"phenylephrine-bitartrate","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Phenergan Vc W/ Codeine","generic_name":"PHENYLEPHRINE BITARTRATE","company_name":"ANI Pharmaceuticals","drug_phase":"marketed","molecular_target":"Alpha-1B adrenergic receptor","drug_class":"Nonsteroidal Anti-inflammatory Drug [EPC]","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"prostacyclin","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"prostacyclin","company_name":"United Therapeutics","drug_phase":"marketed","molecular_target":"P2Y purinoceptor 12, Prostacyclin receptor, Prostaglandin E2 receptor EP1 subtype","drug_class":"","quality_score":23,"revenue":null,"mechanism":null},{"drug_id":"pentoxyverine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pentoxiverine","generic_name":"pentoxyverine","company_name":"","drug_phase":"marketed","molecular_target":"Sigma non-opioid intracellular receptor 1","drug_class":"Central Nervous System Stimulant [EPC]","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"nepinalone","indication_name":"Non-productive cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"NEPINALONE","company_name":"","drug_phase":"phase_2","molecular_target":"Sigma non-opioid intracellular receptor 1","drug_class":"nepinalone","quality_score":null,"revenue":null,"mechanism":"Nepinalone works by binding to the Sigma non-opioid intracellular receptor 1, which helps to reduce coughing."},{"drug_id":"capsicum","indication_name":"cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Allergies","generic_name":"CAPSICUM","company_name":"Newton Laboratories, Inc.","drug_phase":"marketed","molecular_target":"","drug_class":"Standardized Insect Venom Allergenic Extract [EPC]","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"sulfogaiacol","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"sulfogaiacol","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"epoprostenol","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Flolan","generic_name":"EPOPROSTENOL","company_name":"AstraZeneca","drug_phase":"marketed","molecular_target":"Prostacyclin receptor","drug_class":"Prostacycline Vasodilator [EPC]","quality_score":75,"revenue":null,"mechanism":"Flolan works by binding to the prostacyclin receptor, causing blood vessels to relax and dilate."},{"drug_id":"hydromorphone-hydrochloride","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dilaudid-Hp","generic_name":"Hydromorphone Hydrochloride","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"Mu-opioid receptor","drug_class":"Opioid agonist","quality_score":67,"revenue":null,"mechanism":"Full mu-opioid receptor agonist providing analgesia through CNS opioid receptor activation."},{"drug_id":"vaccine-candidate-5","indication_name":"Relief of symptoms of cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vaccine Support Cp","generic_name":"Vaccine Candidate #5","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"common cold virus","drug_class":"vaccine","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"homatropine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Homatropin","generic_name":"homatropine","company_name":"","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M4","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"benzocaine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Norcaine","generic_name":"BENZOCAINE","company_name":"","drug_phase":"marketed","molecular_target":"Sodium channel protein type 5 subunit alpha","drug_class":"Standardized Chemical Allergen [EPC]","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"methscopolamine","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Methylscopolamine","generic_name":"METHSCOPOLAMINE","company_name":"Fougera Pharms","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Anticholinergic","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"dextromethorphan","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Delsym","generic_name":"dextromethorphan","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"Taste receptor type 2 member 46, Solute carrier family 22 member 1, Cytochrome P450 2D6","drug_class":"Antitussive (non-opioid)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"phenylpropanol","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"phenylpropanol","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"scopolamin","indication_name":"Cough","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"scopolamin","company_name":"University Hospital, Angers","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":49,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06258057","title":"Safety of Tetanus, Diphtheria, Acellular Pertussis With 5 Acellular Pertussis Components (Tdap5) Vaccination During Pregnancy","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":365000,"lead_sponsor_name":"Sanofi","has_results":false},{"nct_id":"NCT03463577","title":"The Safety of Boostrix Following Routine Immunization of Pregnant Women","phase":"","overall_status":"COMPLETED","enrollment_count":65783,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT06560853","title":"Evaluation of a Comprehensive School Health Programme in Zambia","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":28700,"lead_sponsor_name":"London School of Economics and Political Science","has_results":false},{"nct_id":"NCT05247333","title":"Implementation of a Minor Ailment Service in Community Pharmacy Practice","phase":"NA","overall_status":"COMPLETED","enrollment_count":20987,"lead_sponsor_name":"Universidad de Granada","has_results":false},{"nct_id":"NCT07444502","title":"Safety Monitoring of Boostagen® Vaccine in Thailand","phase":"","overall_status":"COMPLETED","enrollment_count":10727,"lead_sponsor_name":"BioNet-Asia Co., Ltd.","has_results":false},{"nct_id":"NCT03536286","title":"Asili Evaluation in the Democratic Republic of Congo","phase":"NA","overall_status":"COMPLETED","enrollment_count":9999,"lead_sponsor_name":"Stanford University","has_results":false},{"nct_id":"NCT06862362","title":"China Chronic Cough Registry: a Multicenter, Prospective, Observational Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":6000,"lead_sponsor_name":"The First Affiliated Hospital of Guangzhou Medical University","has_results":false},{"nct_id":"NCT03505216","title":"Swiss Paediatric Airway Cohort","phase":"","overall_status":"RECRUITING","enrollment_count":6000,"lead_sponsor_name":"University of Bern","has_results":false},{"nct_id":"NCT07400120","title":"Safety Monitoring of VacPertagen Vaccine in Thailand","phase":"","overall_status":"COMPLETED","enrollment_count":5414,"lead_sponsor_name":"BioNet-Asia Co., Ltd.","has_results":false},{"nct_id":"NCT03474887","title":"Digital Online Consultations - Effects on Antibiotic Prescribing and Health Care Utilization in Primary Care","phase":"","overall_status":"COMPLETED","enrollment_count":4057,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT02983487","title":"Pertussis Immunization Programs in Low Income Countries","phase":"","overall_status":"COMPLETED","enrollment_count":3587,"lead_sponsor_name":"Institut Pasteur","has_results":false},{"nct_id":"NCT03931577","title":"Effectiveness of Improving Diagnostic and Communication Skills on Antibiotic Prescribing Appropriateness in Acute Cough","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2940,"lead_sponsor_name":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","has_results":false},{"nct_id":"NCT05091619","title":"A Phase 3 Study of BIBP Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2898,"lead_sponsor_name":"China National Biotec Group Company Limited","has_results":false},{"nct_id":"NCT06888076","title":"Study Evaluating the Safety of a Recombinant Acellular Pertussis Vaccine in Pregnant Women","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2700,"lead_sponsor_name":"BioNet-Asia Co., Ltd.","has_results":false},{"nct_id":"NCT06951321","title":"Characteristics of Postinfectious Cough","phase":"","overall_status":"COMPLETED","enrollment_count":1650,"lead_sponsor_name":"Kefang Lai","has_results":false},{"nct_id":"NCT02587520","title":"Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":1363,"lead_sponsor_name":"Sanofi Pasteur, a Sanofi Company","has_results":true},{"nct_id":"NCT03449147","title":"A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1317,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT06590740","title":"Establish FeNO Cut-off Value for Predicting Budesonide-formoterol Response in Chronic Cough Suggestive of CVA Patients.","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1000,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT05600777","title":"A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":975,"lead_sponsor_name":"Bellus Health Inc. - a GSK company","has_results":false},{"nct_id":"NCT04762693","title":"Digital Acoustic Surveillance for Early Detection of Respiratory Disease Outbreaks","phase":"","overall_status":"COMPLETED","enrollment_count":930,"lead_sponsor_name":"Clinica Universidad de Navarra, Universidad de Navarra","has_results":false},{"nct_id":"NCT04807712","title":"Pediatric Pertussis in Ambulatory Settings","phase":"","overall_status":"RECRUITING","enrollment_count":898,"lead_sponsor_name":"Association Clinique Thérapeutique Infantile du val de Marne","has_results":false},{"nct_id":"NCT05599191","title":"A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":825,"lead_sponsor_name":"Bellus Health Inc. - a GSK company","has_results":false},{"nct_id":"NCT03388034","title":"Pertussis Immunization Programs in Low Income Countries - Ivory Coast","phase":"","overall_status":"COMPLETED","enrollment_count":789,"lead_sponsor_name":"Institut Pasteur","has_results":false},{"nct_id":"NCT04000997","title":"The Predictive Value of Peak Cough Flow for Endotracheal Extubation of Patients After Craniotomy","phase":"","overall_status":"COMPLETED","enrollment_count":785,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT03449134","title":"A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":732,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT04393909","title":"Improving Safety of Diagnosis and Therapy in the Inpatient Setting","phase":"NA","overall_status":"COMPLETED","enrollment_count":700,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":false},{"nct_id":"NCT05042063","title":"Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease","phase":"","overall_status":"COMPLETED","enrollment_count":616,"lead_sponsor_name":"Clinica Universidad de Navarra, Universidad de Navarra","has_results":false},{"nct_id":"NCT03169699","title":"Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"KK Women's and Children's Hospital","has_results":false},{"nct_id":"NCT06503939","title":"Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on the Efficacy of ICS or ICS/LABA","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":600,"lead_sponsor_name":"Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT04321369","title":"Impact of Swab Site and Sample Collector on Testing Sensitivity for COVID-19 Virus in Symptomatic Individuals","phase":"","overall_status":"COMPLETED","enrollment_count":530,"lead_sponsor_name":"UnitedHealth Group","has_results":false},{"nct_id":"NCT01506583","title":"Clinical Evaluation of QFlu Combo Test","phase":"","overall_status":"COMPLETED","enrollment_count":506,"lead_sponsor_name":"Cellex, Inc.","has_results":false},{"nct_id":"NCT05888350","title":"Biomarkers for Predicting the Response to Inhaled Corticosteroid in Patients With Chronic Cough.","phase":"NA","overall_status":"COMPLETED","enrollment_count":502,"lead_sponsor_name":"The First Affiliated Hospital of Guangzhou Medical University","has_results":false},{"nct_id":"NCT03523182","title":"Spirulina Supplementation and Infant Growth, Morbidity and Motor Development","phase":"NA","overall_status":"COMPLETED","enrollment_count":501,"lead_sponsor_name":"Programme Against Malnutrition","has_results":false},{"nct_id":"NCT06082791","title":"A Clinical Validation Study to Evaluate the Diagnostic Accuracy of a Cough-based Auxiliary Diagnosis Algorithm for COPD","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Ruijin Hospital","has_results":false},{"nct_id":"NCT06640387","title":"CARE-ID: Dynamics of Respiratory Infections in Children and Transmission in Households and Schools","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"The Hospital for Sick Children","has_results":false},{"nct_id":"NCT04694963","title":"A Multi-center Study to Determine the Prevalence and Influence of Pertussis on Subacute Cough in Shenzhen","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Shenzhen People's Hospital","has_results":false},{"nct_id":"NCT05040802","title":"Effectiveness of Adacel Vaccination in Pregnancy at Preventing Pertussis in Infants < 2 Months of Age in the United States","phase":"","overall_status":"COMPLETED","enrollment_count":462,"lead_sponsor_name":"Sanofi Pasteur, a Sanofi Company","has_results":false},{"nct_id":"NCT06504446","title":"Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":455,"lead_sponsor_name":"Nocion Therapeutics","has_results":false},{"nct_id":"NCT04193202","title":"Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":419,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT06655337","title":"Efficiency of the \"Medidux\" Smartphone App for Demission Management in Patients Medicated in Acute Admission Unit (AAU)","phase":"NA","overall_status":"RECRUITING","enrollment_count":417,"lead_sponsor_name":"Mobile Health AG","has_results":false},{"nct_id":"NCT07287293","title":"Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia","phase":"NA","overall_status":"RECRUITING","enrollment_count":408,"lead_sponsor_name":"Mahidol University","has_results":false},{"nct_id":"NCT04110054","title":"Evaluation of S-600918 in Adults With Refractory Chronic Cough","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":406,"lead_sponsor_name":"Shionogi","has_results":true},{"nct_id":"NCT04078542","title":"Prevalence and Main Features of Chronic Refractory Cough.","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Campus Bio-Medico University","has_results":false},{"nct_id":"NCT04193176","title":"Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":376,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT05116241","title":"Immunogenicity and Safety of BPZE1 Intranasal Pertussis Vaccine in Healthy School-age Children","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":368,"lead_sponsor_name":"ILiAD Biotechnologies","has_results":true},{"nct_id":"NCT06773117","title":"Phase III Trial of Susu Zhike Granules in Children With Cold-cough Syndrome for Acute Cough Treatment","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":360,"lead_sponsor_name":"Tasly Pharmaceutical Group Co., Ltd","has_results":false},{"nct_id":"NCT05129761","title":"Clinical Response of Syrup Hydryllin® in Pakistani Subjects With Cough in Routine Practice","phase":"","overall_status":"COMPLETED","enrollment_count":320,"lead_sponsor_name":"The Searle Company Limited Pakistan","has_results":false},{"nct_id":"NCT02993822","title":"A Dose-ranging Study of Orvepitant in Patients With Chronic Refractory Cough","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":315,"lead_sponsor_name":"Nerre Therapeutics Ltd.","has_results":true},{"nct_id":"NCT03126851","title":"Promoting Safe Use of Children's Cough/Cold Medicines","phase":"NA","overall_status":"COMPLETED","enrollment_count":312,"lead_sponsor_name":"NYU Langone Health","has_results":false},{"nct_id":"NCT04562155","title":"Clinical Study to Evaluate the Efficacy and Safety of Three Different Doses of BAY1817080 Compared to Placebo in Patients With Chronic Cough","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":310,"lead_sponsor_name":"Bayer","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}