{"disease":{"id":"cortisol","name":"cortisol"},"drugs":{"marketed":[{"drug_id":"osilodrostat","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Isturisa","generic_name":"OSILODROSTAT","company_name":"Recordati","drug_phase":"marketed","molecular_target":"Cytochrome P450 11B2, mitochondrial","drug_class":"Cortisol Synthesis Inhibitor","quality_score":70,"revenue":"200","mechanism":"Isturisa blocks the production of cortisol in the adrenal glands by inhibiting the cytochrome P450 11B2 enzyme."},{"drug_id":"pasireotide","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Signifor","generic_name":"PASIREOTIDE","company_name":"Recordati","drug_phase":"marketed","molecular_target":"Somatostatin receptor type 5","drug_class":"Somatostatin Analog [EPC]","quality_score":50,"revenue":null,"mechanism":"Signifor works by binding to somatostatin receptors on the surface of cells, mimicking the natural hormone somatostatin to reduce cortisol production."},{"drug_id":"trilostane","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Desopan","generic_name":"TRILOSTANE","company_name":"Bioenvision","drug_phase":"marketed","molecular_target":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","drug_class":"trilostane","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"ketoconazole","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nizoral","generic_name":"ketoconazole","company_name":"Johnson & Johnson (Janssen)","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Cytochrome P450 21, Sodium/nucleoside cotransporter 1","drug_class":"Azole Antifungal [EPC]","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"levoketoconazole","indication_name":"endogenous hypercortisolemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Recorlev","generic_name":"LEVOKETOCONAZOLE","company_name":"Strongbridge","drug_phase":"marketed","molecular_target":"","drug_class":"Cortisol Synthesis Inhibitor [EPC]","quality_score":50,"revenue":null,"mechanism":""},{"drug_id":"signifor","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Signifor","company_name":"University Hospital Heidelberg","drug_phase":"marketed","molecular_target":"Somatostatin receptor type 1, Somatostatin receptor type 2, Somatostatin receptor type 3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"corticorelin","indication_name":"Diagnosis of Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Corticotropin-Releasing Factor (Human)","generic_name":"CORTICORELIN","company_name":"","drug_phase":"marketed","molecular_target":"Corticotropin-releasing factor receptor 1","drug_class":"","quality_score":17,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":7,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03919734","title":"Morbidity and Mortality in Autonomous Cortisol Secretion","phase":"","overall_status":"COMPLETED","enrollment_count":4596,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT05759637","title":"Type 2 Diabetes, Obesity and Cortisol Excess","phase":"","overall_status":"RECRUITING","enrollment_count":3200,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT07296484","title":"Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Sparrow Pharmaceuticals","has_results":false},{"nct_id":"NCT06324084","title":"PATHophysiology of OSteoporosis: Role of Hidden Cortisol Excess and Its Predictors in Bone Fragility","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT06829537","title":"Study of the Prevalence of Endogenous Hypercortisolism in Patients With Resistant Hypertension (MOMENTUM)","phase":"","overall_status":"COMPLETED","enrollment_count":1143,"lead_sponsor_name":"Corcept Therapeutics","has_results":false},{"nct_id":"NCT05772169","title":"Study to Determine the Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Treatment With Korlym® (Mifepristone) (CATALYST)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1113,"lead_sponsor_name":"Corcept Therapeutics","has_results":false},{"nct_id":"NCT05762549","title":"Prevalence of Hidden Hypercortisolism in Osteoporosis","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT06443268","title":"Cerebrovascular Disease: Quality of Life (CODE: QoL)","phase":"","overall_status":"RECRUITING","enrollment_count":680,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT07156370","title":"Salivary Cortisol and Hypercortisolism in Type 2 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Shanghai 6th People's Hospital","has_results":false},{"nct_id":"NCT05503433","title":"Effect of Maternal Cortisol Levels on Fetal Heart Rate Patterns","phase":"","overall_status":"UNKNOWN","enrollment_count":392,"lead_sponsor_name":"Halic University","has_results":false},{"nct_id":"NCT04349423","title":"Daily Assessment of Mood and Social Media Behaviors Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":324,"lead_sponsor_name":"Southern Methodist University","has_results":false},{"nct_id":"NCT05766085","title":"Cortisol Secretion, Sensitivity and Activity and Hypertension","phase":"","overall_status":"UNKNOWN","enrollment_count":290,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT07350031","title":"Serum and Salivary Cortisol Assessment in Patients With Adrenal Incidentalomas and Healthy Controls","phase":"","overall_status":"COMPLETED","enrollment_count":209,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT04833192","title":"Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism","phase":"","overall_status":"UNKNOWN","enrollment_count":202,"lead_sponsor_name":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","has_results":false},{"nct_id":"NCT04433819","title":"Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Marmara University","has_results":false},{"nct_id":"NCT05743933","title":"Cohort Study of Adrenogenic Autonomic Cortisol Secretion","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT06955286","title":"Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT06833437","title":"68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)","phase":"NA","overall_status":"RECRUITING","enrollment_count":178,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT07268222","title":"Metyrapone Versus Osilodrostat in Patients With Metabolic Autonomous Cortisol Secretion (MACS)","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Laikο General Hospital, Athens","has_results":false},{"nct_id":"NCT06513611","title":"Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Hospital de Clinicas José de San Martín","has_results":false},{"nct_id":"NCT04308590","title":"A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":137,"lead_sponsor_name":"Corcept Therapeutics","has_results":true},{"nct_id":"NCT07258433","title":"Effects of PeptiSleep on Sleep Quality in Healthy Adults","phase":"NA","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Nuritas Ltd","has_results":false},{"nct_id":"NCT05315388","title":"Effects of \"Vitamin N\" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":118,"lead_sponsor_name":"Jeadran N. Malagón-Rojas","has_results":false},{"nct_id":"NCT04129593","title":"Self Awakening and Snoozing Effects on the Cortisol Awakening Response","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"University of Notre Dame","has_results":false},{"nct_id":"NCT04351945","title":"Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Semmelweis University Heart and Vascular Center","has_results":false},{"nct_id":"NCT07412782","title":"REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Meyer Children's Hospital IRCCS","has_results":false},{"nct_id":"NCT06635993","title":"Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion","phase":"","overall_status":"RECRUITING","enrollment_count":97,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT06529471","title":"Effect of Massage After CABG on Pain, Sleep Quality and Serum Cortisol Level","phase":"NA","overall_status":"COMPLETED","enrollment_count":96,"lead_sponsor_name":"Kocaeli University","has_results":false},{"nct_id":"NCT02972554","title":"Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":true},{"nct_id":"NCT05607706","title":"Effect of Maternal Odor and Kangaroo Care on Serum Cortisol and Comfort Levels in Preterm Infants: a Randomised Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"Istanbul Nisantasi University","has_results":false},{"nct_id":"NCT06246357","title":"Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT06917976","title":"Evaluating the Effects of Psychological Stress on Salivary Biomarkers in Pediatric Patients Visiting Pediatric and General Dental Clinic","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"Al-Mustansiriyah University","has_results":false},{"nct_id":"NCT06809439","title":"Comparison of Saliva Biomarkers in Two Different Geographical Regions of Turkey","phase":"NA","overall_status":"COMPLETED","enrollment_count":77,"lead_sponsor_name":"Karabuk University","has_results":false},{"nct_id":"NCT07527286","title":"The Effects of a Postbiotic Supplement on Biomarkers of Gut Health","phase":"","overall_status":"COMPLETED","enrollment_count":76,"lead_sponsor_name":"Verb Biotics LLC","has_results":false},{"nct_id":"NCT07361874","title":"IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion","phase":"NA","overall_status":"RECRUITING","enrollment_count":75,"lead_sponsor_name":"University of Texas Southwestern Medical Center","has_results":false},{"nct_id":"NCT06663865","title":"Investigating the Effects of Dairy Phospholipids on Sleep and Daytime Function in Healthy Adults.","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":70,"lead_sponsor_name":"Northumbria University","has_results":false},{"nct_id":"NCT04127552","title":"Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations","phase":"","overall_status":"RECRUITING","enrollment_count":68,"lead_sponsor_name":"University of Roma La Sapienza","has_results":false},{"nct_id":"NCT07359222","title":"Vis Pre Surgery Medical Food Validation Study","phase":"EARLY_PHASE1","overall_status":"TERMINATED","enrollment_count":67,"lead_sponsor_name":"TM Nutrition LLC","has_results":false},{"nct_id":"NCT05357456","title":"Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study","phase":"","overall_status":"RECRUITING","enrollment_count":62,"lead_sponsor_name":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","has_results":false},{"nct_id":"NCT04860180","title":"Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas","phase":"NA","overall_status":"UNKNOWN","enrollment_count":61,"lead_sponsor_name":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","has_results":false},{"nct_id":"NCT03759509","title":"Effects of Aerobic Exercise Training on Nurses' Sleep Quality, Fatigue, Attention and Cortisol Profile","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Taipei Medical University","has_results":false},{"nct_id":"NCT07431905","title":"Effect of Erector Spinae Plane Block on Postoperative Analgesia and Stress Response in Laparoscopic Sleeve Gastrectomy","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Harran University","has_results":false},{"nct_id":"NCT06307782","title":"The Effect of Oral Whey Consumption on Insulin Resistance, Cortisol, Crp, Albumin Level and Healing Quality Before Total Hip Arthroplasty","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"TC Erciyes University","has_results":false},{"nct_id":"NCT05368090","title":"Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Haukeland University Hospital","has_results":false},{"nct_id":"NCT03856502","title":"Influence of Intrathecal Dexamethasone Administration for Proximal Femoral Fractures","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"General Hospital Sveti Duh","has_results":false},{"nct_id":"NCT03830437","title":"Salivary Cortisol as Stress Marker in Newborns Subjected to Double Weighing With Physiological Body Weight","phase":"","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"Fondazione Poliambulanza Istituto Ospedaliero","has_results":false},{"nct_id":"NCT01294319","title":"Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":51,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":true},{"nct_id":"NCT05021380","title":"Salivary Immune/Stress Biomarkers Among Children","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Poznan University of Medical Sciences","has_results":false},{"nct_id":"NCT02335996","title":"Hypercortisolism and Epicardial Adipose Tissue","phase":"NA","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT03830762","title":"Xanamem™ in Healthy Elderly Subjects","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"Actinogen Medical","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}