{"disease":{"id":"coronary-artery-disease-cad","name":"coronary artery disease cad"},"drugs":{"marketed":[{"drug_id":"caduet","indication_name":"Coronary Artery Disease (CAD)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Caduet","generic_name":"Amlodipine Besylate","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"L-type calcium channel","drug_class":"Dihydropyridine calcium channel blocker","quality_score":76,"revenue":null,"mechanism":"Calcium channel antagonist inhibiting transmembrane calcium influx into vascular and cardiac muscle."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT01813435","title":"GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":15991,"lead_sponsor_name":"ECRI bv","has_results":true},{"nct_id":"NCT07353762","title":"Coronary Imaging and Metabolic Indicators-Based Risk Prediction Model for Coronary Artery Disease(CMI-RiskCAD)","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":10960,"lead_sponsor_name":"Beijing Anzhen Hospital","has_results":false},{"nct_id":"NCT01866904","title":"Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients","phase":"","overall_status":"TERMINATED","enrollment_count":9284,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT06743672","title":"Development of a Novel Risk Prediction Tool for Emergency Department Patients Symptoms of Coronary Artery Disease","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":6500,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT07479433","title":"The NAVIGATE-PCI Registry: A New Approach to VIew CT-derived Guidance Ahead of Stenting To Plan Efficient PCI","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"HeartFlow, Inc.","has_results":false},{"nct_id":"NCT04936438","title":"Clinical Cohort Study - INTERCATH","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5000,"lead_sponsor_name":"University of Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT07349875","title":"Colchicine Treatment for Non-Flow-Limiting Coronary Plaque by Coronary CTA: A Randomized Controlled Trial","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":3826,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT07354828","title":"Optimization and Validation of Quality Control Indicators for Coronary Revascularization Based on Antiplatelet Therapy","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":3500,"lead_sponsor_name":"Shenyang Northern Hospital","has_results":false},{"nct_id":"NCT06843005","title":"Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":3100,"lead_sponsor_name":"Zhang longjiang,MD","has_results":false},{"nct_id":"NCT07158307","title":"Safety and Efficacy of GENOSS® DCB With a Shellac Plus Vitamin E Excipient in Patients With De Novo Lesion","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":3000,"lead_sponsor_name":"Genoss Co., Ltd.","has_results":false},{"nct_id":"NCT07231835","title":"Registry of Coronary Disease Outcomes Revascularizing With Drug-Coated Balloons","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT05698732","title":"Coroflex® ISAR NEO PMCF Study","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Fundación EPIC","has_results":false},{"nct_id":"NCT06659367","title":"Dedinje FFR/QFR Registry","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Institute for Cardiovascular Diseases Dedinje","has_results":false},{"nct_id":"NCT04347200","title":"REGistry of Long-term AnTithrombotic TherApy-1","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"National Medical Research Center for Cardiology, Ministry of Health of Russian Federation","has_results":false},{"nct_id":"NCT07491107","title":"Brazilian Prospective Registry of the Inspiron EVO Drug-Eluting Stent in Complex Coronary Lesions","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Scitech Produtos Medicos SA","has_results":false},{"nct_id":"NCT07195149","title":"Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":1703,"lead_sponsor_name":"Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o.","has_results":false},{"nct_id":"NCT06880133","title":"Expansion of SCG/GCG-Based CAD Sceering: Inclusion of Healthy Controls and CCTA Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":1600,"lead_sponsor_name":"Heart Force Medical Inc.","has_results":false},{"nct_id":"NCT06880120","title":"Diagnostic Accuracy Of Seismocardiography for Coronary Artery Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":1534,"lead_sponsor_name":"Heart Force Medical Inc.","has_results":false},{"nct_id":"NCT07277686","title":"AI Facial Analysis Algorithm to Screening Coronary Artery Disease in High-Risk Community Population","phase":"","overall_status":"RECRUITING","enrollment_count":1392,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT07341932","title":"Helium-free Magnetocardiography Guided Therapy for Stable Coronary Artery Disease - A Randomized Controlled Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":1312,"lead_sponsor_name":"Beijing Anzhen Hospital","has_results":false},{"nct_id":"NCT07477405","title":"Drug-coatEd Balloon Multicentric Registry in Spain and PORTugal","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Portuguese Association of Interventional Cardiology","has_results":false},{"nct_id":"NCT07193693","title":"Barriers Limiting OCT Penetration in Clinical Practice","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Consorzio Futuro in Ricerca","has_results":false},{"nct_id":"NCT07237685","title":"Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT07375810","title":"Analysis of ECGio to Predict Coronary Stenosis Against a Mixed Reference Standard","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":978,"lead_sponsor_name":"Heart Input Output Inc","has_results":false},{"nct_id":"NCT03354273","title":"An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":730,"lead_sponsor_name":"GE Healthcare","has_results":true},{"nct_id":"NCT07107568","title":"Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":700,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT04753372","title":"Rivaroxaban Plus Aspirin in Patients With Chronic Coronary Syndrome and High Ischemic Risk","phase":"","overall_status":"COMPLETED","enrollment_count":645,"lead_sponsor_name":"Maatschap Cardiologie Zwolle","has_results":false},{"nct_id":"NCT07315399","title":"The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study (SLEEP-CMD)","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":560,"lead_sponsor_name":"Beijing Anzhen Hospital","has_results":false},{"nct_id":"NCT05617599","title":"SUPRAFLEX CRUZ PMCF Study ( rEpic05 )","phase":"","overall_status":"RECRUITING","enrollment_count":508,"lead_sponsor_name":"Fundación EPIC","has_results":false},{"nct_id":"NCT06822894","title":"Clinical Implications of Three-vessel Ultrasonic Flow Ratio Measurement in Patients With Coronary Artery Disease","phase":"","overall_status":"RECRUITING","enrollment_count":494,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT07172308","title":"High Risk Atherosclerosis Identified at Cardiac CT Among Patients With vs Without Family History of CAD","phase":"","overall_status":"COMPLETED","enrollment_count":480,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT07374718","title":"Safety and Efficacy of De-escalation Dual Antiplatelet Therapy After BioFreedom™ Stenting in ACS Patients With Moderate-to-high Ischemic and High Bleeding Risk","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":468,"lead_sponsor_name":"Shenyang Northern Hospital","has_results":false},{"nct_id":"NCT07449052","title":"Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":450,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT07479056","title":"Fexuprazan for Prevention of Upper Gastrointestinal Bleeding in High Bleeding Risk Patients Receiving Dual Antiplatelet Therapy","phase":"NA","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"SUK MIN SEO","has_results":false},{"nct_id":"NCT07326735","title":"MIRAGE Study: Clinical Outcomes of the Mamba Sirolimus-Eluting PTCA Balloon","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":360,"lead_sponsor_name":"Frisch Medical Device Private Limited","has_results":false},{"nct_id":"NCT00826280","title":"Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":347,"lead_sponsor_name":"Astellas Pharma Inc","has_results":true},{"nct_id":"NCT07502703","title":"Validation of Remote Photoplethysmography (rPPG)-Derived Cardiovascular Parameters Against Standard Clinical Measurements and Risk Scores in a Community","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Tarumanagara University","has_results":false},{"nct_id":"NCT06831409","title":"Using CTA Measures to Define Cardiac Risk In NFL Alumni","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"HeartFlow, Inc.","has_results":false},{"nct_id":"NCT04298567","title":"Study to Learn More About the Safety and Effectiveness of Rivaroxaban (Xarelto) When Given Together With Acetylsalicylic Acid to Indian People With Narrowing of the Arteries of the Heart (CAD) and/or With Reduced Blood Flow in the Arteries of the Legs and Arms With Symptoms (Symptomatic PAD)","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT07473596","title":"Predictors and Long-term Incidence of In-stent Restenosis After Chronic Total Occlusion Percutaneous Coronary Intervention","phase":"NA","overall_status":"COMPLETED","enrollment_count":294,"lead_sponsor_name":"Lauri Mansikkaniemi","has_results":false},{"nct_id":"NCT06052319","title":"A Study to Assess the Engagement and Usefulness of Care4Today Digital Platform for Disease Management in Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD) Population","phase":"","overall_status":"COMPLETED","enrollment_count":277,"lead_sponsor_name":"Janssen Scientific Affairs, LLC","has_results":false},{"nct_id":"NCT07172620","title":"Safety and Effectiveness of No-touch Technique for Ascending Aorta in MICS-CABG","phase":"","overall_status":"RECRUITING","enrollment_count":260,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT05138289","title":"The REVEALPLAQUE Study: A pRospEctiVe, multicEnter Study to AnaLyze PLAQUE Using CCTA","phase":"","overall_status":"COMPLETED","enrollment_count":258,"lead_sponsor_name":"HeartFlow, Inc.","has_results":true},{"nct_id":"NCT05508893","title":"Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)","phase":"NA","overall_status":"TERMINATED","enrollment_count":250,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT07314138","title":"Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Catharina Ziekenhuis Eindhoven","has_results":false},{"nct_id":"NCT07442526","title":"AGECTO Study: PCI vs. Optimal Medical Therapy for CTO in the Octogenarian Patients","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":200,"lead_sponsor_name":"San Luigi Gonzaga Hospital","has_results":false},{"nct_id":"NCT07463664","title":"Clinical Outcomes of Drug-Coated Balloons in the Treatment of Patients With Coronary De Novo Chronic Total Occlusion Lesions","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"The First Affiliated Hospital of Zhengzhou University","has_results":false},{"nct_id":"NCT02873052","title":"MyoVista Measurements in Patients With Atherosclerosis and CAD","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","has_results":false},{"nct_id":"NCT04570527","title":"Optimized Cardioprotection Therapy in Obese Subjects With CAD","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT07512206","title":"AERO CAD Study Evaluating the Shockwave C2 Aero IVL System in Coronary Artery Disease","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"OPCI Core Laboratories LLC","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}