{"disease":{"id":"control","name":"control"},"drugs":{"marketed":[{"drug_id":"upadacitinib","indication_name":"Refractory, moderate to severe atopic dermatitis in adults and pediatric patients 12 years of age and older not adequately controlled with other systemic therapies","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rinvoq","generic_name":"upadacitinib","company_name":"AbbVie Inc.","drug_phase":"marketed","molecular_target":"Janus kinase (JAK) enzymes, particularly JAK1 and JAK2","drug_class":"JAK inhibitor","quality_score":86,"revenue":"5300","mechanism":"JAK inhibitor that prevents STAT phosphorylation and activation in cytokine signaling pathways."},{"drug_id":"esmolol","indication_name":"Control of ventricular rate in supraventricular tachycardia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Brevibloc In Plastic Container","generic_name":"ESMOLOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Beta-1 adrenergic receptor","drug_class":"beta-Adrenergic Blocker","quality_score":63,"revenue":null,"mechanism":"Brevibloc works by blocking the beta-1 adrenergic receptor, which reduces the heart's response to stress and increases heart rate."},{"drug_id":"esmolol","indication_name":"Control of heart rate in noncompensatory sinus tachycardia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Brevibloc In Plastic Container","generic_name":"ESMOLOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Beta-1 adrenergic receptor","drug_class":"beta-Adrenergic Blocker","quality_score":63,"revenue":null,"mechanism":"Brevibloc works by blocking the beta-1 adrenergic receptor, which reduces the heart's response to stress and increases heart rate."},{"drug_id":"esmolol","indication_name":"Control of perioperative tachycardia and hypertension","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Brevibloc In Plastic Container","generic_name":"ESMOLOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Beta-1 adrenergic receptor","drug_class":"beta-Adrenergic Blocker","quality_score":63,"revenue":null,"mechanism":"Brevibloc works by blocking the beta-1 adrenergic receptor, which reduces the heart's response to stress and increases heart rate."},{"drug_id":"trihexyphenidyl-hydrochloride","indication_name":"Extrapyramidal Disorders Control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Artane","generic_name":"TRIHEXYPHENIDYL HYDROCHLORIDE","company_name":"","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"trihexyphenidyl","quality_score":49,"revenue":null,"mechanism":""},{"drug_id":"haloperidol","indication_name":"Control of Tics and Vocal Utterances in Tourette's Disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Haldol","generic_name":"haloperidol","company_name":"Johnson & Johnson (Janssen)","drug_phase":"marketed","molecular_target":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A","drug_class":"Typical Antipsychotic [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"aspart","indication_name":"Improving glycemic control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aspart","company_name":"Emory University","drug_phase":"marketed","molecular_target":"Aminoacylase-1, Argininosuccinate synthase, Aspartate aminotransferase, cytoplasmic","drug_class":"Insulin Analog [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"dapagliflozin-and-saxagliptin","indication_name":"Glycemic Control in Type 2 Diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"dapagliflozin and saxagliptin","company_name":"AstraZeneca","drug_phase":"marketed","molecular_target":"","drug_class":"Sodium-Glucose Cotransporter 2 Inhibitor [EPC]","quality_score":16,"revenue":null,"mechanism":null},{"drug_id":"ertugliflozin","indication_name":"Glycemic control in type 2 diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Steglatro","generic_name":"ERTUGLIFLOZIN","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Low affinity sodium-glucose cotransporter","drug_class":"","quality_score":54,"revenue":null,"mechanism":"Steglatro works by blocking the kidneys' ability to reabsorb glucose, allowing excess glucose to be excreted in the urine."},{"drug_id":"triprolidine","indication_name":"Cough control for sleep","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Actidil","generic_name":"TRIPROLIDINE","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"triprolidine","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"pioglitazone-and-glimepiride","indication_name":"Glycemic Control in Type 2 Diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Pioglitazone and Glimepiride","company_name":"Takeda","drug_phase":"marketed","molecular_target":"PPARγ, ATP-sensitive potassium channel","drug_class":"Sulfonylurea [EPC]","quality_score":60,"revenue":null,"mechanism":"Pioglitazone and glimepiride work together to improve glycemic control by reducing insulin resistance and stimulating insulin release."},{"drug_id":"pioglitazone-and-glimepiride","indication_name":"Combination Therapy for Glycemic Control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Pioglitazone and Glimepiride","company_name":"Takeda","drug_phase":"marketed","molecular_target":"PPARγ, ATP-sensitive potassium channel","drug_class":"Sulfonylurea [EPC]","quality_score":60,"revenue":null,"mechanism":"Pioglitazone and glimepiride work together to improve glycemic control by reducing insulin resistance and stimulating insulin release."},{"drug_id":"factor-ix","indication_name":"On-demand treatment and control of bleeding episodes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"factor ix","company_name":"National Heart, Lung, and Blood Institute (NHLBI)","drug_phase":"marketed","molecular_target":"coagulation Factor IX","drug_class":"","quality_score":55,"revenue":null,"mechanism":"REBINYN replaces missing coagulation Factor IX and slows its removal from circulation through PEGylation."},{"drug_id":"salmeterol","indication_name":"Asthma Not Adequately Controlled","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"SALMETEROL","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor, beta2-adrenoceptors","drug_class":"","quality_score":60,"revenue":null,"mechanism":"Fluticasone propionate reduces inflammation, while salmeterol relaxes bronchial muscles and inhibits mediator release."},{"drug_id":"tezepelumab","indication_name":"Inadequately Controlled Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tezspire","generic_name":"TEZEPELUMAB","company_name":"AstraZeneca / Amgen","drug_phase":"marketed","molecular_target":"","drug_class":"Thymic Stromal Lymphopoietin Blocker [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"mouth-rinse","indication_name":"Control of plaque leading to bleeding gums","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"mouth rinse","company_name":"Ministry of Higher Education, Malaysia","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":20,"revenue":null,"mechanism":null},{"drug_id":"prochlorperazine-maleate","indication_name":"Severe Nausea and Vomiting Control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PROCHLORPERAZINE MALEATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":15,"revenue":null,"mechanism":null},{"drug_id":"methylergonovine-maleate","indication_name":"Control of uterine hemorrhage in second stage of labor","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"METHYLERGONOVINE MALEATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"clomifene","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Clomid","generic_name":"clomifene","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase","drug_class":"Estrogen Agonist/Antagonist","quality_score":49,"revenue":null,"mechanism":""},{"drug_id":"norethisterone","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Micronor","generic_name":"norethisterone","company_name":"Johnson & Johnson","drug_phase":"marketed","molecular_target":"GnRH receptors","drug_class":"Progestin","quality_score":63,"revenue":null,"mechanism":"ORIAHNN combines elagolix, which suppresses LH and FSH to reduce ovarian sex hormones, with estradiol and norethindrone acetate to mitigate side effects."},{"drug_id":"cetrorelix","indication_name":"Prevention of premature ovulation during controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cetrotide","generic_name":"CETRORELIX","company_name":"Merck KGaA","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor","drug_class":"Gonadotropin Releasing Hormone Receptor Antagonist","quality_score":49,"revenue":null,"mechanism":""},{"drug_id":"estradiol","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Estrace","generic_name":"ESTRADIOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":"Estrace works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen."},{"drug_id":"medroxyprogesterone","indication_name":"Prevention of premature ovulation during controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Depo-Provera","generic_name":"medroxyprogesterone","company_name":"Pfizer","drug_phase":"discontinued","molecular_target":"Progesterone receptor","drug_class":"Progestin","quality_score":null,"revenue":null,"mechanism":"Depo-Provera works by binding to the progesterone receptor in the body, which helps to regulate the menstrual cycle and prevent pregnancy."},{"drug_id":"formoterol","indication_name":"Adjunct Therapy to Achieve Long-term Asthma Control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Foradil","generic_name":"FORMOTEROL","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Beta-2 adrenergic receptor","drug_class":"beta2-Adrenergic Agonist","quality_score":56,"revenue":null,"mechanism":"Foradil works by stimulating the beta-2 adrenergic receptor to relax airway muscles and improve breathing."},{"drug_id":"ganirelix","indication_name":"Prevention of Luteinizing Hormone Surge when undergoing Controlled Ovarian Hyperstimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ganirelix Acetate","generic_name":"GANIRELIX","company_name":"Organon Usa Organon","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor","drug_class":"Gonadotropin Releasing Hormone Receptor Antagonist","quality_score":46,"revenue":null,"mechanism":""},{"drug_id":"dydrogesterone","indication_name":"Prevention of premature ovulation during controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Gynorest","generic_name":"DYDROGESTERONE","company_name":"Solvay","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"dydrogesterone","quality_score":24,"revenue":null,"mechanism":""},{"drug_id":"metformin","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Glucophage","generic_name":"metformin","company_name":"Generic (originally Merck Serono/Lipha)","drug_phase":"marketed","molecular_target":"5'-AMP-activated protein kinase subunit beta-1, Solute carrier family 22 member 1, Solute carrier family 22 member 2","drug_class":"Dipeptidyl Peptidase 4 Inhibitor [EPC]","quality_score":55,"revenue":null,"mechanism":"Activates AMP-activated protein kinase (AMPK) to reduce hepatic glucose production and improve insulin sensitivity without causing hypoglycemia."},{"drug_id":"clomid","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Clomid","company_name":"rana alaaeldin aly ibrahim nasr","drug_phase":"phase_1","molecular_target":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 5-hydroxytryptamine receptor 6, Adenosine receptor A3","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"levonorgestrel","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Jadelle","generic_name":"LEVONORGESTREL","company_name":"Fdn Consumer","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"Progestin","quality_score":10,"revenue":null,"mechanism":"Jadelle works by binding to the progesterone receptor, which helps to prevent ovulation and thicken cervical mucus to prevent sperm from reaching the egg."},{"drug_id":"verapamil-hydrochloride","indication_name":"Control of ventricular rate at rest in patients with chronic atrial flutter and/or atrial fibrillation (in association with digitalis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Verapamil Hydrochloride","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"L-type calcium channels (slow channels)","drug_class":"Calcium channel blocker","quality_score":56,"revenue":null,"mechanism":"Calcium ion influx inhibitor that modulates ionic calcium across cell membranes of arterial smooth muscle and myocardial cells."},{"drug_id":"verapamil-hydrochloride","indication_name":"Control of ventricular rate during stress in patients with chronic atrial flutter and/or atrial fibrillation (in association with digitalis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Verapamil Hydrochloride","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"L-type calcium channels (slow channels)","drug_class":"Calcium channel blocker","quality_score":56,"revenue":null,"mechanism":"Calcium ion influx inhibitor that modulates ionic calcium across cell membranes of arterial smooth muscle and myocardial cells."},{"drug_id":"ertugliflozin-15-mg","indication_name":"Treatment of type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ertugliflozin 15 mg","generic_name":"ertugliflozin-15-mg","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"SGLT2","drug_class":"SGLT2 inhibitor","quality_score":44,"revenue":null,"mechanism":""},{"drug_id":"cetrotide","indication_name":"Prevention of premature ovulation during controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cetrotide","company_name":"Wolfson Medical Center","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor, Lutropin-choriogonadotropic hormone receptor","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"glucophage","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Glucophage","company_name":"Dr. Reddy's Laboratories Limited","drug_phase":"marketed","molecular_target":"5'-AMP-activated protein kinase subunit beta-1, Solute carrier family 22 member 1, Solute carrier family 22 member 2","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"ethinylestradiol","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ortho-Novum 10/11-21","generic_name":"Ethinylestradiol","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":38,"revenue":null,"mechanism":""},{"drug_id":"estring","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Estring","generic_name":"Estradiol","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Ovulation","drug_class":"Combined Oral Contraceptive (COC)","quality_score":71,"revenue":null,"mechanism":"Prevents pregnancy primarily by suppressing ovulation."},{"drug_id":"femara","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Femara","company_name":"M.D. Anderson Cancer Center","drug_phase":"discontinued","molecular_target":"Cytochrome P450 11B2, mitochondrial, Aromatase, Cytochrome P450 11B1, mitochondrial","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"letrozole","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Femara","generic_name":"letrozole","company_name":"Novartis AG","drug_phase":"marketed","molecular_target":"aromatase enzyme","drug_class":"Aromatase Inhibitor [EPC]","quality_score":65,"revenue":null,"mechanism":"Letrozole reduces estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogens."},{"drug_id":"repaglinide","indication_name":"Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prandin","generic_name":"repaglinide","company_name":"Novo Nordisk","drug_phase":"marketed","molecular_target":"ATP-binding cassette sub-family C member 8","drug_class":"Glinide [EPC]","quality_score":10,"revenue":null,"mechanism":"Repaglinide lowers blood glucose levels by stimulating insulin release from the pancreas through ATP-dependent potassium channel blockade."},{"drug_id":"drospirenone","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Slynd","generic_name":"DROSPIRENONE","company_name":"Exeltis Usa Inc","drug_phase":"marketed","molecular_target":"Mineralocorticoid receptor","drug_class":"Progestin","quality_score":75,"revenue":null,"mechanism":"Slynd works by binding to the mineralocorticoid receptor, a protein that plays a role in hormone regulation."},{"drug_id":"nitroprusside","indication_name":"Controlled Hypotension","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sodium Nitroprusside","generic_name":"NITROPRUSSIDE","company_name":"Roche","drug_phase":"marketed","molecular_target":"Atrial natriuretic peptide receptor 1","drug_class":"Vasodilator","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"chorionic-gonadotrophin","indication_name":"Controlled ovarian stimulation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Choriogonadotropin","generic_name":"chorionic gonadotrophin","company_name":"Ferring","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":19,"revenue":null,"mechanism":""},{"drug_id":"ertugliflozin-5-mg","indication_name":"Treatment of type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ertugliflozin 5 mg","generic_name":"ertugliflozin-5-mg","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"SGLT2","drug_class":"SGLT2 inhibitor","quality_score":44,"revenue":null,"mechanism":""},{"drug_id":"serevent","indication_name":"Adjunct Therapy to Achieve Long-term Asthma Control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Serevent","company_name":"Fundacio Privada Mon Clinic Barcelona","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"hyoscyamine","indication_name":"Gastric Secretion Control","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"(-)-Atropine","generic_name":"Hyoscyamine","company_name":"University of Kansas Medical Center","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M4","drug_class":"hyoscyamine","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"trimetaphan","indication_name":"Controlled Hypotension","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"trimetaphan","company_name":"","drug_phase":"unknown","molecular_target":"Neuronal acetylcholine receptor subunit alpha-10, Neuronal acetylcholine receptor subunit alpha-7, Neuronal acetylcholine receptor; alpha3/beta4","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":46,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06028555","title":"International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study","phase":"","overall_status":"RECRUITING","enrollment_count":101000,"lead_sponsor_name":"Center for Epidemiology and Health Research, Germany","has_results":false},{"nct_id":"NCT03653156","title":"China Cognition and Aging Study","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Capital Medical University","has_results":false},{"nct_id":"NCT03938207","title":"Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT05376059","title":"How v. How and Why Nudges and Rewards","phase":"NA","overall_status":"COMPLETED","enrollment_count":60000,"lead_sponsor_name":"University of Pennsylvania","has_results":false},{"nct_id":"NCT01776424","title":"Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":27395,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT04529421","title":"Assocation Between In-person Instruction and COVID-19 Risk","phase":"","overall_status":"COMPLETED","enrollment_count":26754,"lead_sponsor_name":"Oslo Metropolitan University","has_results":false},{"nct_id":"NCT06633393","title":"Effect of a Myopia Prediction System on Myopia Prevention and Control","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","has_results":false},{"nct_id":"NCT02765412","title":"PrOVE QUERI Project #1","phase":"","overall_status":"COMPLETED","enrollment_count":17033,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT07135115","title":"Targeting Lifestyle to Improve Colorectal Cancer Screening","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":16000,"lead_sponsor_name":"Norwegian Institute of Public Health","has_results":false},{"nct_id":"NCT07141901","title":"Life Expectancy-informed Colorectal Cancer Screening","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Kathryn Martinez","has_results":false},{"nct_id":"NCT03808311","title":"Blood Pressure Control Target in Diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":12821,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT03507231","title":"Non-integrated Costs Increase Effectiveness of Incentives","phase":"NA","overall_status":"COMPLETED","enrollment_count":12531,"lead_sponsor_name":"Carnegie Mellon University","has_results":false},{"nct_id":"NCT05854862","title":"Analysis of Relevant Influencing Factors of Glycemic Control in Patients With Diabetes","phase":"","overall_status":"UNKNOWN","enrollment_count":10000,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT05687461","title":"Construction of a National Diagnosis and Treatment Quality Control Platform for Major Respiratory Diseases","phase":"","overall_status":"UNKNOWN","enrollment_count":10000,"lead_sponsor_name":"China-Japan Friendship Hospital","has_results":false},{"nct_id":"NCT06625983","title":"Use of a Colorectal Cancer Screening Decision Support Tool in Primary Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":9205,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT06521229","title":"Clinical& Demographic Profiles of patIents With unControllEd Asthma in Russia: Multi-center oBsErvational ReGistry Study","phase":"","overall_status":"RECRUITING","enrollment_count":9000,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT06988579","title":"The Impact of AI Assistance on Radiologist Performance and Healthcare Costs in LDCT-Based Lung Cancer Screening","phase":"NA","overall_status":"RECRUITING","enrollment_count":7294,"lead_sponsor_name":"The First Affiliated Hospital of Guangzhou Medical University","has_results":false},{"nct_id":"NCT03977636","title":"Determinants of Time Required by Medical Information Technicians for Quality Control of Hospital Activity Coding","phase":"","overall_status":"COMPLETED","enrollment_count":5431,"lead_sponsor_name":"Centre Hospitalier Régional Metz-Thionville","has_results":false},{"nct_id":"NCT04891796","title":"Tobacco Control Policy-related Survey 2020","phase":"","overall_status":"COMPLETED","enrollment_count":5112,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT03182764","title":"Tobacco Control-Related Policy Survey","phase":"","overall_status":"UNKNOWN","enrollment_count":5104,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT06385457","title":"The Effects of Mindhelper.dk: a Self-guided Digital Mental Health Promotion Service Targeting Young People","phase":"NA","overall_status":"RECRUITING","enrollment_count":4910,"lead_sponsor_name":"University of Southern Denmark","has_results":false},{"nct_id":"NCT06304428","title":"Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":3780,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT06579950","title":"Assessing the Effects of Cool Roofs on Indoor Environments and Health","phase":"NA","overall_status":"RECRUITING","enrollment_count":3200,"lead_sponsor_name":"Aditi Bunker","has_results":false},{"nct_id":"NCT06926855","title":"Community Health Workers Reduce Social Barriers That Affect the Health of Patients With High Blood Pressure and Diabetes.","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3120,"lead_sponsor_name":"Morehouse School of Medicine","has_results":false},{"nct_id":"NCT03892577","title":"Real-world Study for Patients With Advanced Hepatobiliary Tumors","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT07524998","title":"A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT05718193","title":"Real-Time Artificial Intelligence Assissted Colonoscopy to Identify and Classify Polyps","phase":"NA","overall_status":"COMPLETED","enrollment_count":2868,"lead_sponsor_name":"Xiangya Hospital of Central South University","has_results":false},{"nct_id":"NCT06931782","title":"AI in Respiratory Disease Prevention, Diagnosis, and Triage","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2400,"lead_sponsor_name":"The First Affiliated Hospital of Guangzhou Medical University","has_results":false},{"nct_id":"NCT06101862","title":"Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome","phase":"NA","overall_status":"RECRUITING","enrollment_count":2300,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT06308744","title":"A Large Multi-site Study on Self-administered Mindfulness","phase":"NA","overall_status":"COMPLETED","enrollment_count":2239,"lead_sponsor_name":"Swansea University","has_results":false},{"nct_id":"NCT04448912","title":"Meta-Analysis on Damage Control Surgery in Patients With Non-Traumatic Abdominal Emergencies","phase":"","overall_status":"COMPLETED","enrollment_count":2170,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT05441059","title":"Use of Nucala in Severe Asthma","phase":"","overall_status":"COMPLETED","enrollment_count":2100,"lead_sponsor_name":"Frisius Medisch Centrum","has_results":false},{"nct_id":"NCT04100564","title":"LITES Task Order 0005 Prehospital Airway Control Trial (PACT)","phase":"NA","overall_status":"COMPLETED","enrollment_count":2010,"lead_sponsor_name":"Jason Sperry","has_results":false},{"nct_id":"NCT04888923","title":"Natural History of the Human Biological Response to Environmental Exposure and Injury","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"National Institute of Environmental Health Sciences (NIEHS)","has_results":false},{"nct_id":"NCT05435872","title":"Gastrointestinal Endoscopy Artificial Intelligence Cloud Platform in Gastrointestinal Endoscopy Screening","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT03363360","title":"Comprehensive Awareness and Control in Diabetes Patients in China Jiangxi: A Cross-Sectional Survey","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Second Affiliated Hospital of Nanchang University","has_results":false},{"nct_id":"NCT05903443","title":"Research on the Brain Death Determination in China","phase":"","overall_status":"COMPLETED","enrollment_count":1974,"lead_sponsor_name":"Xuanwu Hospital, Beijing","has_results":false},{"nct_id":"NCT02674464","title":"Reducing Inequities in Care of Hypertension, Lifestyle Improvement for Everyone (RICH LIFE Project)","phase":"NA","overall_status":"COMPLETED","enrollment_count":1820,"lead_sponsor_name":"Johns Hopkins University","has_results":true},{"nct_id":"NCT02193737","title":"Effects of Drinking at PACU Discharge After General Anaesthesia With Airway Control on Aspiration, Vomiting and Patients Comfort","phase":"NA","overall_status":"COMPLETED","enrollment_count":1555,"lead_sponsor_name":"Poitiers University Hospital","has_results":false},{"nct_id":"NCT03868267","title":"Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Hamilton Health Sciences Corporation","has_results":false},{"nct_id":"NCT06775951","title":"Appropriateness of Colonoscopy Indication: an Evaluation of the Clinical and Economic Impact.","phase":"","overall_status":"RECRUITING","enrollment_count":1410,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT06751836","title":"Innovative Multidisciplinary Strategies for Combating Severe Dengue","phase":"","overall_status":"RECRUITING","enrollment_count":1400,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05178290","title":"Back to ECE Safely With SAGE: Reducing COVID-19 Transmission in Hispanic and Low-income Preschoolers","phase":"NA","overall_status":"COMPLETED","enrollment_count":1356,"lead_sponsor_name":"Arizona State University","has_results":false},{"nct_id":"NCT02843113","title":"Stepping Up 4 Your Child","phase":"NA","overall_status":"COMPLETED","enrollment_count":1266,"lead_sponsor_name":"University of Louisville","has_results":false},{"nct_id":"NCT07340593","title":"Helicobacter Pylori Infection and Gastric Diseases in Lao PDR: First Community-Wide Population-Based Study","phase":"","overall_status":"COMPLETED","enrollment_count":1251,"lead_sponsor_name":"Zero Helicobacter IGAN Network","has_results":false},{"nct_id":"NCT02161757","title":"A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled Asthma","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1207,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT07158593","title":"School-Based Eating Disorder Prevention","phase":"NA","overall_status":"COMPLETED","enrollment_count":1205,"lead_sponsor_name":"Villa Garda Hospital","has_results":false},{"nct_id":"NCT06900439","title":"Exploring Glycemic Responses Through Continuous Monitoring in a Healthy Population","phase":"NA","overall_status":"COMPLETED","enrollment_count":1189,"lead_sponsor_name":"Zoe Global Limited","has_results":false},{"nct_id":"NCT03722368","title":"Health and Wellness in Healthcare Providers Post-disaster","phase":"NA","overall_status":"COMPLETED","enrollment_count":1100,"lead_sponsor_name":"University of Illinois at Urbana-Champaign","has_results":false},{"nct_id":"NCT05647252","title":"General Decolonization With Octenisan® Set Before Elective Orthopedic Surgery","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1086,"lead_sponsor_name":"Balgrist University Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}