{"disease":{"id":"chronic-rhinosinusitis-without-nasal-polyps","name":"chronic rhinosinusitis without nasal polyps"},"drugs":{"marketed":[],"pipeline":[{"drug_id":"rimegepant-75-mg","indication_name":"Acute treatment of chronic rhinosinusitis with and without nasal polyps","indication_type":"pipeline","phase":"Phase 3","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rimegepant 75 MG","generic_name":"rimegepant-75-mg","company_name":"Pfizer Inc.","drug_phase":"preclinical","molecular_target":"Calcitonin gene-related peptide (CGRP) receptor","drug_class":"CGRP receptor antagonist (gepant)","quality_score":25,"revenue":null,"mechanism":"Rimegepant selectively antagonizes the calcitonin gene-related peptide (CGRP) receptor to block migraine pain signaling."}],"offLabel":[],"totalMarketed":0,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT06970977","title":"CRS Questionnaire Validation Project","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"The European Forum for Research and Education in Allergy and Airway Diseases","has_results":false},{"nct_id":"NCT07290140","title":"Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Airiver Medical, Inc.","has_results":false},{"nct_id":"NCT06013241","title":"A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":288,"lead_sponsor_name":"Insmed Incorporated","has_results":false},{"nct_id":"NCT05248997","title":"Safety and Efficacy of BHV-3000 (Rimegepant) Orally Disintegrating Tablet for the Acute Treatment of Chronic Rhinosinusitis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":261,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT06118554","title":"3D Printing to Improve Nasal Irrigation Outcome","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Ohio State University","has_results":false},{"nct_id":"NCT06737198","title":"Correlation of Preoperative Indices (serum Vit D, Calcium, Phosphorus, FAR, PLR, SII) on Intraoperative Bleeding in CRS","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT07198607","title":"Pistacia Lentiscus Oil Nasal Drops for Preventing Recurrence of Chronic Rhinosinusitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Liaquat University of Medical & Health Sciences","has_results":false},{"nct_id":"NCT03956862","title":"GB001 in Adult Participants With Chronic Rhinosinusitis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":97,"lead_sponsor_name":"GB001, Inc, a wholly owned subsidiary of Gossamer Bio, Inc.","has_results":true},{"nct_id":"NCT05553951","title":"Adherence in Global Airways","phase":"NA","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"Christiane Haase","has_results":false},{"nct_id":"NCT05642806","title":"Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":90,"lead_sponsor_name":"St. Paul's Sinus Centre","has_results":false},{"nct_id":"NCT06850805","title":"Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":84,"lead_sponsor_name":"Optinose US Inc.","has_results":false},{"nct_id":"NCT05843019","title":"Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis","phase":"","overall_status":"UNKNOWN","enrollment_count":80,"lead_sponsor_name":"Christiane Haase","has_results":false},{"nct_id":"NCT06398873","title":"Effect of Dupilumab on Nasal Epithelial Barrier Function in Patients With CRSwNP","phase":"","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT04678856","title":"Dupilumab in CRSsNP","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":71,"lead_sponsor_name":"Sanofi","has_results":true},{"nct_id":"NCT06691113","title":"A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti--IL-33 mAb) in Participants With Chronic Rhinosinusitis Without Nasal Polyps","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Sanofi","has_results":false},{"nct_id":"NCT06069310","title":"Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":40,"lead_sponsor_name":"National and Kapodistrian University of Athens","has_results":false},{"nct_id":"NCT04158596","title":"Safety and Efficacy of SDX-3101 for the Treatment of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)","phase":"NA","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"SynDermix AG","has_results":false}],"total":17},"guidelines":[],"source":"Drug Landscape verified database"}