{"disease":{"id":"chronic-heart-failure-with-reduced-ejection-fraction","name":"chronic heart failure with reduced ejection fraction"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05093933","title":"A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":6106,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT02861534","title":"A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":5050,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT06697353","title":"An Observational Study to Learn More About the Real-world Outcomes in Patients With Heart Failure Who Initiate Treatment With Vericiguat in Japan","phase":"","overall_status":"COMPLETED","enrollment_count":4936,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT03036124","title":"Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":4744,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT05728502","title":"An Observational Study, Called VERI-China, to Learn More About How Well Vericiguat Works and How Safe it is in Real-world Setting in People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in China","phase":"","overall_status":"COMPLETED","enrollment_count":2400,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT02226120","title":"Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1980,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT06363110","title":"An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States","phase":"","overall_status":"COMPLETED","enrollment_count":1400,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT05974189","title":"The VERIFY Study: An Observational Study Called VERIFY to Learn More About the Use of Vericiguat in People With Chronic Heart Failure With Reduced Ejection Fraction","phase":"","overall_status":"COMPLETED","enrollment_count":1391,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT06148935","title":"An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting","phase":"","overall_status":"RECRUITING","enrollment_count":1350,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT02900378","title":"randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":621,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT06632483","title":"An Observational Study to Learn More About How Safe Vericiguat is and How Well it Works in Indian People With Chronic Heart Failure With Reduced Ejection Fraction and Worsening Chronic Heart Failure Under Real World Conditions","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":604,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT07355088","title":"Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":600,"lead_sponsor_name":"Xinjiang Medical University","has_results":false},{"nct_id":"NCT06486844","title":"An Observational Study Called ROVER to Learn More About How Well Vericiguat Works in People Who Were Newly Treated With Vericiguat in Routine Medical Care in Germany","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT04983043","title":"Efficacy and Safety of QiShen YiQi Dripping Pills in Chronic Heart Failure","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":228,"lead_sponsor_name":"Tasly Pharmaceutical Group Co., Ltd","has_results":false},{"nct_id":"NCT05658458","title":"A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":205,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT06909682","title":"AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices","phase":"","overall_status":"RECRUITING","enrollment_count":205,"lead_sponsor_name":"University of Salerno","has_results":false},{"nct_id":"NCT02768298","title":"Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":201,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT07311109","title":"A Prospective, Single-center, Randomized Controlled Clinical Study Evaluating the Efficacy and Safety of Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Chronic Heart Failure","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Fujian Medical University","has_results":false},{"nct_id":"NCT05004363","title":"Lokelma for RAAS Maximisation in CKD & Heart Failure.","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":130,"lead_sponsor_name":"St George's, University of London","has_results":false},{"nct_id":"NCT06195930","title":"A Study to Learn How Safe Starting Vericiguat at a Dose of 5 Milligrams is in Participants With Chronic Heart Failure With Reduced Ejection Fraction","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":106,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT07259512","title":"Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"Evi Liliek Wulandari","has_results":false},{"nct_id":"NCT04836182","title":"A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Participants With Chronic Heart Failure With Reduced Ejection Fraction","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":72,"lead_sponsor_name":"Ionis Pharmaceuticals, Inc.","has_results":false},{"nct_id":"NCT01876433","title":"Beta 3 Agonist Treatment in Heart Failure","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"Henning Bundgaard","has_results":false},{"nct_id":"NCT04840914","title":"A Study of LY3461767 in Participants With Chronic Heart Failure With Reduced Ejection Fraction","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"Eli Lilly and Company","has_results":false},{"nct_id":"NCT05553886","title":"S086 Tablets for Chronic Heart Failure With Reduced Ejection Fraction","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":5,"lead_sponsor_name":"Shenzhen People's Hospital","has_results":false},{"nct_id":"NCT04464525","title":"Omecamtiv Mecarbil Post-trial Access Study","phase":"PHASE3","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Cytokinetics","has_results":false}],"total":26},"guidelines":[],"source":"Drug Landscape verified database"}