{"disease":{"id":"chronic-constipation","name":"Chronic constipation","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":1,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"prucalopride","indication_name":"Chronic Idiopathic Constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PRUCALOPRIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":15,"revenue":null,"mechanism":null},{"drug_id":"elobixibat","indication_name":"Chronic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Goofice","generic_name":"ELOBIXIBAT","company_name":"EA Pharma","drug_phase":"discontinued","molecular_target":"Ileal sodium/bile acid cotransporter","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Goofice works by inhibiting the ileal sodium/bile acid cotransporter to stimulate bowel movements."},{"drug_id":"linaclotide","indication_name":"Chronic idiopathic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Linzess","generic_name":"LINACLOTIDE","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Heat-stable enterotoxin receptor","drug_class":"Guanylate Cyclase-C Agonist [EPC]","quality_score":57,"revenue":null,"mechanism":"Linzess works by activating the heat-stable enterotoxin receptor to increase fluid secretion in the intestines."},{"drug_id":"linzess","indication_name":"Chronic idiopathic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Linzess","company_name":"TriHealth Inc.","drug_phase":"discontinued","molecular_target":"Heat-stable enterotoxin receptor, Heat-stable enterotoxin receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"lactitol","indication_name":"Chronic idiopathic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pizensy","generic_name":"LACTITOL","company_name":"Braintree Labs","drug_phase":"marketed","molecular_target":"","drug_class":"Osmotic Laxative","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"lubiprostone","indication_name":"Chronic idiopathic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Amitiza","generic_name":"LUBIPROSTONE","company_name":"Sucampo Pharma Llc","drug_phase":"marketed","molecular_target":"Chloride channel protein 2","drug_class":"Chloride Channel Activator [EPC]","quality_score":65,"revenue":null,"mechanism":"Amitiza works by activating chloride channels in the intestines, increasing fluid secretion and promoting bowel movements."},{"drug_id":"tegaserod","indication_name":"Chronic idiopathic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zelnorm","generic_name":"TEGASEROD","company_name":"","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 2B","drug_class":"Serotonin-4 Receptor Agonist","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"plecanatide","indication_name":"Chronic idiopathic constipation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Trulance","generic_name":"PLECANATIDE","company_name":"Salix","drug_phase":"marketed","molecular_target":"Tumor necrosis factor","drug_class":"Guanylate Cyclase-C Agonist [EPC]","quality_score":65,"revenue":null,"mechanism":"Trulance works by stimulating the guanylate cyclase-C receptor to increase fluid secretion in the intestines."}],"pipeline":[],"offLabel":[],"totalMarketed":8,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07261826","title":"Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics","phase":"","overall_status":"RECRUITING","enrollment_count":4000,"lead_sponsor_name":"Chen QiYi","has_results":false},{"nct_id":"NCT03471728","title":"Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases)","phase":"","overall_status":"COMPLETED","enrollment_count":2475,"lead_sponsor_name":"Astellas Pharma Inc","has_results":false},{"nct_id":"NCT06695754","title":"Comparing Manual and Automatic Colonic Massage for Chronic Constipation.","phase":"","overall_status":"COMPLETED","enrollment_count":2312,"lead_sponsor_name":"usMIMA S.L.","has_results":false},{"nct_id":"NCT00765999","title":"An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1559,"lead_sponsor_name":"Forest Laboratories","has_results":true},{"nct_id":"NCT04031469","title":"A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease","phase":"","overall_status":"SUSPENDED","enrollment_count":1000,"lead_sponsor_name":"ProgenaBiome","has_results":false},{"nct_id":"NCT02590432","title":"An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":828,"lead_sponsor_name":"Forest Laboratories","has_results":true},{"nct_id":"NCT04804267","title":"Evaluation of Clinical Equivalence Between Two Linaclotide Products in the Treatment of Chronic Idiopathic Constipation","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":750,"lead_sponsor_name":"Jiangsu Hansoh Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT07382167","title":"A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":692,"lead_sponsor_name":"Ardelyx","has_results":false},{"nct_id":"NCT06408883","title":"Effect of Vibration Capsule on Different Subtypes of Functional Constipation","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":600,"lead_sponsor_name":"Changhai Hospital","has_results":false},{"nct_id":"NCT03097861","title":"Evaluation of the Bioequivalence of Sprinkle and Capsule Formulations of Lubiprostone, as Compared to Placebo","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":552,"lead_sponsor_name":"Sucampo Pharma Americas, LLC","has_results":true},{"nct_id":"NCT02281630","title":"Phase II Dose-Finding Study of KWA-0711 in Patients With Chronic Constipation (CC)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":388,"lead_sponsor_name":"Kissei Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT02425722","title":"A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic Constipation","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":383,"lead_sponsor_name":"Astellas Pharma Inc","has_results":false},{"nct_id":"NCT01147926","title":"Evaluation of Prucalopride in Male Subjects With Chronic Constipation.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":374,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT03879239","title":"Efficacy and Safety of Vibrant Capsule vs. Placebo for the Treatment of Chronic Idiopathic Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":349,"lead_sponsor_name":"Vibrant Ltd.","has_results":true},{"nct_id":"NCT06418685","title":"Real-World Clinical Study on the Efficacy of Vibrating Capsule (Vibrabot Capsule) for Chronic Functional Constipation","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Changhai Hospital","has_results":false},{"nct_id":"NCT03143517","title":"Fecal Calprotectin Collection Protocol","phase":"","overall_status":"COMPLETED","enrollment_count":240,"lead_sponsor_name":"DiaSorin Inc.","has_results":false},{"nct_id":"NCT02809105","title":"A Study of Oral Dosing of ASP0456 in Patients With Chronic Constipation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":186,"lead_sponsor_name":"Astellas Pharma Inc","has_results":false},{"nct_id":"NCT07388589","title":"Soluble and Osmotic Fibre (SOLOS) Diet for Constipation","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":180,"lead_sponsor_name":"Singapore Institute of Technology","has_results":false},{"nct_id":"NCT02751411","title":"Effectiveness & Safety of Promelaxin® Microenemas Against Macrogol 4000 P.O. in Chronic Constipation in Children 6-48 Months","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":158,"lead_sponsor_name":"Aboca Spa Societa' Agricola","has_results":false},{"nct_id":"NCT02695719","title":"Lubiprostone for Treatment of Chronic Idiopathic Constipation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":156,"lead_sponsor_name":"Takeda","has_results":true},{"nct_id":"NCT04869280","title":"Post-Marketing Study of Prucalopride Safety In Pregnancy","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":127,"lead_sponsor_name":"Takeda","has_results":false},{"nct_id":"NCT05652205","title":"A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":123,"lead_sponsor_name":"AbbVie","has_results":false},{"nct_id":"NCT06526767","title":"Comparative Study of Different Dosages of Vibrabot Capsule in the Treatment of Chronic Functional Constipation","phase":"NA","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT05723731","title":"Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation","phase":"NA","overall_status":"TERMINATED","enrollment_count":106,"lead_sponsor_name":"Air Force Military Medical University, China","has_results":false},{"nct_id":"NCT06349031","title":"Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Institute of Medical Sciences and SUM Hospital","has_results":false},{"nct_id":"NCT05548842","title":"The Combined Seed Extracts of Cassia Obtusifolia Linne and Foeniculum Vulgare Mill in Patients With Chronic Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Pusan National University Yangsan Hospital","has_results":false},{"nct_id":"NCT04784780","title":"Long-term Elobixibat for Chronic Constipation","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Yokohama City University","has_results":false},{"nct_id":"NCT07431957","title":"\"Efficacy and Safety of Linaclotide in Chronic Constipation\"","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":90,"lead_sponsor_name":"Md Mehedi Shahriar","has_results":false},{"nct_id":"NCT04666155","title":"MOWOOT Device Treatment for Adults With Chronic Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"usMIMA S.L.","has_results":false},{"nct_id":"NCT05192317","title":"Administration of a Natural Molecular Complex in Functional Chronic Constipation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":86,"lead_sponsor_name":"Aboca Spa Societa' Agricola","has_results":false},{"nct_id":"NCT06847919","title":"Exploring the Potential Benefits of Probiotic Yogurt","phase":"NA","overall_status":"RECRUITING","enrollment_count":84,"lead_sponsor_name":"Wecare Probiotics Co., Ltd.","has_results":false},{"nct_id":"NCT06736912","title":"This Study Aims to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties and Food Effect of IN-114199 in Healthy Participants","phase":"PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"HK inno.N Corporation","has_results":false},{"nct_id":"NCT06621160","title":"Investigation of Spinal Posture and Anthropometric Characteristics of Women with Chronic Constipation","phase":"","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Ondokuz Mayıs University","has_results":false},{"nct_id":"NCT03569527","title":"Kiwifruit, Prunes, & Fiber for Abdominal and Bowel Symptoms in US Patients With Chronic Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":78,"lead_sponsor_name":"University of Michigan","has_results":false},{"nct_id":"NCT00256984","title":"Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":75,"lead_sponsor_name":"Ethicon Endo-Surgery","has_results":true},{"nct_id":"NCT06543979","title":"Anorectal Manometery in Pediatric Chronic Refractory Constipation","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Ain Shams University","has_results":false},{"nct_id":"NCT05202028","title":"The Efficacy of Massage and Reflexology Applications in Children With Cerebral Palsy","phase":"NA","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Halic University","has_results":false},{"nct_id":"NCT04458675","title":"Efficacy and Safety of Vibrant Capsule vs. Vibrant Placebo for the Treatment of Chronic Idiopathic Constipation (CIC)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":59,"lead_sponsor_name":"Vibrant Ltd.","has_results":true},{"nct_id":"NCT04710433","title":"Non-invasive Sacral Nerve Stimulation in Children and Adolescents With Chronic Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":59,"lead_sponsor_name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","has_results":false},{"nct_id":"NCT03054506","title":"The Effect of CSP01 on Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"Massachusetts General Hospital","has_results":true},{"nct_id":"NCT04713085","title":"Sacral Neuromodulation in Children and Adolescents","phase":"NA","overall_status":"COMPLETED","enrollment_count":48,"lead_sponsor_name":"Friedrich-Alexander-Universität Erlangen-Nürnberg","has_results":false},{"nct_id":"NCT05980988","title":"Effectiveness and Safety of Probiotic in Regulating Chronic Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"Wecare Probiotics Co., Ltd.","has_results":false},{"nct_id":"NCT06364111","title":"Comparative Study on the Efficacy of Vibrabot Capsule and Polyethylene Glycol for Chronic Functional Constipation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":45,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT03117322","title":"Synbiotic, Prebiotics and Probiotics in Children With Cerebral Palsy and Constipation","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Andrea Garcia Contreras","has_results":false},{"nct_id":"NCT05336305","title":"Polydextrose for Patients With Chronic Kidney Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Universidade Federal Fluminense","has_results":false},{"nct_id":"NCT05703464","title":"Elobixibat for Chronic Constipation Without Defecation Desire","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":40,"lead_sponsor_name":"International University of Health and Welfare","has_results":false},{"nct_id":"NCT02961556","title":"General Clinical Study of AJG555 in Pediatric Patients With Chronic Constipation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"EA Pharma Co., Ltd.","has_results":false},{"nct_id":"NCT02343978","title":"Phase II Study of KWA-0711 in Patients With Chronic Constipation (CC)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Kissei Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT05734859","title":"Drinking Effect of Electrolyzed Alkaline Reduced Water on Functional Constipation","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Wonju Severance Christian Hospital","has_results":false},{"nct_id":"NCT03508076","title":"Efficacy of Vibrating Capsule in Patients With Chronic Constipation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":27,"lead_sponsor_name":"Changhai Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}