{"disease":{"id":"cerebral-ischemia","name":"Cerebral ischemia","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":3,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"ethaverine","indication_name":"Cerebral ischemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Barbonin","generic_name":"ETHAVERINE","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"ethaverine","quality_score":22,"revenue":null,"mechanism":"Barbonin works by improving blood flow to the affected areas of the body."},{"drug_id":"fasudil","indication_name":"Cerebral ischemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"FASUDIL","company_name":"","drug_phase":"marketed","molecular_target":"Rho-associated protein kinase 2","drug_class":"fasudil","quality_score":24,"revenue":null,"mechanism":""},{"drug_id":"pentobarbital","indication_name":"Cerebral ischemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nembutal Sodium","generic_name":"PENTOBARBITAL","company_name":"Oak Pharms","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"pentobarbital","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05086874","title":"Using Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in Stroke Patients","phase":"","overall_status":"COMPLETED","enrollment_count":81292,"lead_sponsor_name":"Xin Huang","has_results":false},{"nct_id":"NCT03607565","title":"A New Parameter Derived From DSA to Evaluate Cerebral Perfusion","phase":"","overall_status":"RECRUITING","enrollment_count":30000,"lead_sponsor_name":"Xi'an No.3 Hospital","has_results":false},{"nct_id":"NCT03281590","title":"Stroke and Cerebrovascular Diseases Registry","phase":"","overall_status":"COMPLETED","enrollment_count":4594,"lead_sponsor_name":"University of New Mexico","has_results":false},{"nct_id":"NCT04522856","title":"Anaesthesiological Routine Care for Thrombectomy in Cerebral Ischaemia","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"European Society of Anaesthesiology","has_results":false},{"nct_id":"NCT06431711","title":"Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel Disease","phase":"","overall_status":"RECRUITING","enrollment_count":2400,"lead_sponsor_name":"Zhejiang Provincial People's Hospital","has_results":false},{"nct_id":"NCT06254755","title":"Comparison Study Between Suction Aspiration and Combination Technique in Acute Cerebral Infarction","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1132,"lead_sponsor_name":"Inje University Haeundae Paik Hospital","has_results":false},{"nct_id":"NCT06906432","title":"Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT05169450","title":"Efficacy of Diterpene Ginkgolides Meglumine Injection in Elderly Patients With Ischemic Stroke","phase":"NA","overall_status":"COMPLETED","enrollment_count":998,"lead_sponsor_name":"Dongzhimen Hospital, Beijing","has_results":false},{"nct_id":"NCT02315443","title":"Field Randomization of Nerinetide (NA-1) Therapy in Early Responders","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":532,"lead_sponsor_name":"NoNO Inc.","has_results":false},{"nct_id":"NCT06614972","title":"Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry)","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":520,"lead_sponsor_name":"RenJi Hospital","has_results":false},{"nct_id":"NCT06954610","title":"Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT04998370","title":"Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury","phase":"","overall_status":"COMPLETED","enrollment_count":366,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT06834490","title":"Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":318,"lead_sponsor_name":"Pharmasoft","has_results":true},{"nct_id":"NCT04238260","title":"Enhancing Physical Therapy Best Practice for Improving Walking After Stroke","phase":"NA","overall_status":"COMPLETED","enrollment_count":306,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT04463563","title":"Cerebral Oximetry in Cardiac Surgery to Reduce Neurological Impairment and Hospital Length-of-stay","phase":"NA","overall_status":"COMPLETED","enrollment_count":182,"lead_sponsor_name":"Hull University Teaching Hospitals NHS Trust","has_results":false},{"nct_id":"NCT04696523","title":"Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":160,"lead_sponsor_name":"Turku University Hospital","has_results":false},{"nct_id":"NCT04047563","title":"Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":158,"lead_sponsor_name":"Pharmazz, Inc.","has_results":false},{"nct_id":"NCT04821726","title":"DEB for Symptomatic Intracranial Atherosclerosis Stenosis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":155,"lead_sponsor_name":"Yinyi(Liaoning) Biotech Co., Ltd.","has_results":false},{"nct_id":"NCT03032471","title":"Swiss SOS MoCA - DCI Study","phase":"","overall_status":"TERMINATED","enrollment_count":128,"lead_sponsor_name":"Swiss SOS Study Group","has_results":false},{"nct_id":"NCT04437862","title":"A Study to Evaluate the Q Revascularization System for Neurointervention in Acute Ischemic Stroke","phase":"NA","overall_status":"COMPLETED","enrollment_count":121,"lead_sponsor_name":"MIVI Neuroscience, Inc.","has_results":false},{"nct_id":"NCT06032533","title":"Remote Ischemic Conditioning in Aneurysmal SAH","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Aarhus University Hospital","has_results":false},{"nct_id":"NCT04507178","title":"Improving Outcome in Subarachnoid Hemorrhage wIth Nadroparine","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT06629116","title":"Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Tingyu-Yi","has_results":false},{"nct_id":"NCT04908241","title":"Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":96,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT06953427","title":"The Impact of Age on Short-term Post-thrombectomy Outcomes in Patients Aged 70 or Beyond With Acute Ischemic Stroke","phase":"","overall_status":"COMPLETED","enrollment_count":94,"lead_sponsor_name":"Kuang Tien General Hospital","has_results":false},{"nct_id":"NCT06375889","title":"Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage","phase":"","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT04986774","title":"Rescue Intracranial Stenting in Acute Ischemic Stroke","phase":"NA","overall_status":"COMPLETED","enrollment_count":85,"lead_sponsor_name":"Can Tho Stroke International Services Hospital","has_results":false},{"nct_id":"NCT03214705","title":"Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage","phase":"","overall_status":"COMPLETED","enrollment_count":64,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT04232163","title":"Arm Boot Camp Study: Evaluation of a Program to Increase Upper Limb Recovery After Stroke","phase":"NA","overall_status":"COMPLETED","enrollment_count":62,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT06881329","title":"Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":61,"lead_sponsor_name":"Pomeranian Medical University Szczecin","has_results":false},{"nct_id":"NCT03448159","title":"Fluoxetine Opens Window to Improve Motor Recovery After Stroke","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT03393559","title":"Effect of Leg Elevation on Prevention of Intraoperative Hypotension During Beach Chair Position","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT07324421","title":"Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT","phase":"NA","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"Resolve Stroke","has_results":false},{"nct_id":"NCT01787123","title":"Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin™ in Patients With Aneurysmal Subarachnoid Hemorrhage","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Kwong Wah Hospital","has_results":false},{"nct_id":"NCT05131295","title":"Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":49,"lead_sponsor_name":"El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez","has_results":false},{"nct_id":"NCT03745092","title":"The Efficacy of Normobaric Oxygen on Chronic Cerebral Ischemia","phase":"NA","overall_status":"COMPLETED","enrollment_count":49,"lead_sponsor_name":"Capital Medical University","has_results":true},{"nct_id":"NCT06178419","title":"Remote Ischemic Conditioning for Cerebral Ischemia in Patients With Takayasu Arteritis (TARIC-1)","phase":"NA","overall_status":"RECRUITING","enrollment_count":44,"lead_sponsor_name":"Xuanwu Hospital, Beijing","has_results":false},{"nct_id":"NCT03352310","title":"Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia","phase":"PHASE1","overall_status":"UNKNOWN","enrollment_count":40,"lead_sponsor_name":"Mononuclear Therapeutics Ltd.","has_results":false},{"nct_id":"NCT04046484","title":"PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Pharmazz, Inc.","has_results":false},{"nct_id":"NCT04265664","title":"Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke","phase":"NA","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT06863480","title":"Tocilizumab-aazg for Hemorrhage: Reduction of Ischemic Vascular Events","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT05294718","title":": External Shunt Versus Internal Shunt for Off Pump Glenn","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Kasr El Aini Hospital","has_results":false},{"nct_id":"NCT05483751","title":"Micro- and Macrovascular Parameters in Delayed Cerebral Ischemia","phase":"","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Maastricht University Medical Center","has_results":false},{"nct_id":"NCT04649398","title":"Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration","phase":"","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT05514665","title":"Functional Imaging of Baby Brains","phase":"","overall_status":"UNKNOWN","enrollment_count":25,"lead_sponsor_name":"Hamilton Health Sciences Corporation","has_results":false},{"nct_id":"NCT05796349","title":"Study on Data Acquisition and Image Characteristics of Brain Multifrequency EIT in Healthy People and Patients With Brain Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Jieshi Ma","has_results":false},{"nct_id":"NCT05087836","title":"Correlation of Cerebral Oxygen Saturation Measured From 2 Sensor Sites: Forehead vs. Temporal","phase":"","overall_status":"COMPLETED","enrollment_count":21,"lead_sponsor_name":"Khon Kaen University","has_results":false},{"nct_id":"NCT04998357","title":"Autologous Mitochondrial Transplant for Cerebral Ischemia","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT03318783","title":"Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Oregon Health and Science University","has_results":true},{"nct_id":"NCT04876638","title":"Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20,"lead_sponsor_name":"University of Southern California","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}