{"disease":{"id":"cardio-vascular-disease","name":"cardio vascular disease"},"drugs":{"marketed":[{"drug_id":"evolocumab","indication_name":"Cardiovascular disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Repatha","generic_name":"EVOLOCUMAB","company_name":"Repatha","drug_phase":"marketed","molecular_target":"PCSK9","drug_class":"PCSK9 Inhibitor [EPC]","quality_score":75,"revenue":"2100","mechanism":"Evolocumab, a human monoclonal IgG2, lowers LDL-C by inhibiting PCSK9 binding to LDLR, increasing LDLR availability to clear LDL."},{"drug_id":"inclisiran","indication_name":"Atherosclerotic cardiovascular disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Leqvio","generic_name":"INCLISIRAN","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Proprotein convertase subtilisin/kexin type 9","drug_class":"","quality_score":59,"revenue":"863","mechanism":"Leqvio works by binding to PCSK9, preventing it from breaking down LDL receptors."},{"drug_id":"oral-p2y12-receptor-blocker","indication_name":"Reduction of thrombotic cardiovascular events in patients with atherosclerotic disease, including those with a recent ischemic stroke or peripheral artery disease (PAD)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Oral P2Y12 receptor blocker","company_name":"Italian Society of Invasive Cardiology","drug_phase":"marketed","molecular_target":"P2Y12 adenosine diphosphate receptor on platelet surface","drug_class":"Antiplatelet agent; P2Y12 receptor antagonist; Thienopyridine or non-thienopyridine class","quality_score":22,"revenue":null,"mechanism":""},{"drug_id":"colchicine","indication_name":"Cardiovascular disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Colcrys","generic_name":"COLCHICINE","company_name":"Scilex Pharms","drug_phase":"marketed","molecular_target":"Serine/threonine-protein kinase pim-1","drug_class":"Alkaloid [EPC]","quality_score":10,"revenue":null,"mechanism":"Colcrys works by inhibiting the activity of a specific enzyme called serine/threonine-protein kinase pim-1."},{"drug_id":"sotagliflozin","indication_name":"Chronic kidney disease at increased risk of cardiovascular disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Inpefa","generic_name":"SOTAGLIFLOZIN","company_name":"Lexicon Pharms Inc","drug_phase":"marketed","molecular_target":"Sodium/glucose cotransporter 2","drug_class":"Sodium-Glucose Cotransporter 2 Inhibitor [EPC]","quality_score":70,"revenue":null,"mechanism":"Inpefa works by blocking the sodium/glucose cotransporter 2 in the kidneys, reducing glucose reabsorption and lowering blood sugar levels."},{"drug_id":"sotagliflozin","indication_name":"Diabetes mellitus type 2 at increased risk of cardiovascular disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Inpefa","generic_name":"SOTAGLIFLOZIN","company_name":"Lexicon Pharms Inc","drug_phase":"marketed","molecular_target":"Sodium/glucose cotransporter 2","drug_class":"Sodium-Glucose Cotransporter 2 Inhibitor [EPC]","quality_score":70,"revenue":null,"mechanism":"Inpefa works by blocking the sodium/glucose cotransporter 2 in the kidneys, reducing glucose reabsorption and lowering blood sugar levels."}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03259100","title":"Temperature and Mortality","phase":"","overall_status":"COMPLETED","enrollment_count":17000000,"lead_sponsor_name":"Chinese Academy of Sciences","has_results":false},{"nct_id":"NCT03243253","title":"The Association of Fast Food Densities With Mortality From Cardiovascular Disease","phase":"","overall_status":"COMPLETED","enrollment_count":17000000,"lead_sponsor_name":"Chinese Academy of Sciences","has_results":false},{"nct_id":"NCT05853536","title":"In Silico Trials of Surgical Interventions","phase":"","overall_status":"UNKNOWN","enrollment_count":13977257,"lead_sponsor_name":"University of Leicester","has_results":false},{"nct_id":"NCT06406998","title":"Maternal and Offspring Outcomes in Pregnant Women With Pre-existing ASCVD","phase":"","overall_status":"RECRUITING","enrollment_count":5461222,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT03534908","title":"Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: the Correlation Analysis and Risk Prediction Model Study","phase":"","overall_status":"UNKNOWN","enrollment_count":5000000,"lead_sponsor_name":"Wuhan University","has_results":false},{"nct_id":"NCT05221528","title":"Association Between Lipid Profiles and Cardiovascular Events","phase":"","overall_status":"UNKNOWN","enrollment_count":4234339,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT06571747","title":"Kaiser Permanente VACCination Improvement With Nudge-based CardiovAscular Targeted Engagement","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3668428,"lead_sponsor_name":"Kaiser Permanente","has_results":false},{"nct_id":"NCT06517134","title":"Prescribing Patterns of Antihypertensive Drugs in Uncomplicated Hypertension","phase":"","overall_status":"COMPLETED","enrollment_count":3325032,"lead_sponsor_name":"University Hospital, Caen","has_results":false},{"nct_id":"NCT06239129","title":"The Stockholm CREAtinine Measurements Project","phase":"","overall_status":"COMPLETED","enrollment_count":3200000,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05466825","title":"The Global Cardiovascular Risk Consortium","phase":"","overall_status":"RECRUITING","enrollment_count":3000000,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT05837364","title":"Predicting Risk of Atrial Fibrillation and Association With Other Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":2159663,"lead_sponsor_name":"University of Leeds","has_results":false},{"nct_id":"NCT05285085","title":"Real World Evidence Study of Statin Use in Brazil","phase":"","overall_status":"COMPLETED","enrollment_count":2133900,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT03904732","title":"Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU","phase":"","overall_status":"COMPLETED","enrollment_count":2000000,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT07357116","title":"Alteration of the Risk of CArdiovascular DIseases After Pneumonia","phase":"","overall_status":"COMPLETED","enrollment_count":2000000,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT04506528","title":"COVID EHR COHORT at the University of Wisconsin","phase":"","overall_status":"COMPLETED","enrollment_count":1634381,"lead_sponsor_name":"University of Wisconsin, Madison","has_results":false},{"nct_id":"NCT04091035","title":"Prevalence and Risk Factors for Common Diseases","phase":"","overall_status":"UNKNOWN","enrollment_count":1000000,"lead_sponsor_name":"Anna Nordström","has_results":false},{"nct_id":"NCT07196917","title":"Prospective Cohort of Integrated Traditional Chinese and Western Medicine in China","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000000,"lead_sponsor_name":"Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT07205978","title":"Nut Consumption and Prevention of Non-communicable Diseases: A Global Individual Participant Data Meta-analysis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1000000,"lead_sponsor_name":"Institut Investigacio Sanitaria Pere Virgili","has_results":false},{"nct_id":"NCT05021575","title":"Effects of COVID-19 Pandemic on a Health Care System: Case Study of the CirculatORy System in LiThuania","phase":"","overall_status":"COMPLETED","enrollment_count":839678,"lead_sponsor_name":"Vilnius University","has_results":false},{"nct_id":"NCT07393412","title":"Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":800000,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT06409481","title":"Pharmacovigilance Assessment of Reporting of Cardiovascular Adverse Events With Antineoplastic Agents (PARCA)","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":800000,"lead_sponsor_name":"The First Affiliated Hospital of Xinxiang Medical College","has_results":false},{"nct_id":"NCT05220917","title":"Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":781430,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":false},{"nct_id":"NCT03492580","title":"A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease","phase":"","overall_status":"COMPLETED","enrollment_count":714582,"lead_sponsor_name":"Janssen Research & Development, LLC","has_results":false},{"nct_id":"NCT04834843","title":"Temporal Trends of COronary Artery Disease and PEripheral Artery Disease (COPE) in Korea","phase":"","overall_status":"COMPLETED","enrollment_count":700000,"lead_sponsor_name":"Wonju Severance Christian Hospital","has_results":false},{"nct_id":"NCT02931500","title":"Machine Learning for Identification of Future Disease Development: A Nationwide Cohort Study (MILESTONE)","phase":"","overall_status":"UNKNOWN","enrollment_count":510000,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT04067297","title":"Using Big Data to Conduct Innovative Cardiovascular Clinical Trials","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":500000,"lead_sponsor_name":"Institute for Clinical Evaluative Sciences","has_results":false},{"nct_id":"NCT04294771","title":"JOint Use of Database to Identify Risk Factors of CARDio-vascular Toxicity Induced by Immune Checkpoint Inhibitors","phase":"","overall_status":"UNKNOWN","enrollment_count":500000,"lead_sponsor_name":"Groupe Hospitalier Pitie-Salpetriere","has_results":false},{"nct_id":"NCT07465926","title":"Early Add-On Combination of GLP-1 Receptor Agonist and SGLT2 Inhibitor in People With Cardiovascular-Kidney-Metabolic Stage 2-3","phase":"","overall_status":"COMPLETED","enrollment_count":451036,"lead_sponsor_name":"Chung Shan Medical University","has_results":false},{"nct_id":"NCT02635685","title":"Clinical Decision Support for Stroke Prevention in Atrial Fibrillation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":442105,"lead_sponsor_name":"University Hospital, Linkoeping","has_results":false},{"nct_id":"NCT04903041","title":"A Cardiac Registry to Evaluate and Manage the hsTnI Categorical CVD Risk in Subjects Undergoing Preventive Health Checks (PHC).","phase":"","overall_status":"SUSPENDED","enrollment_count":300000,"lead_sponsor_name":"Jaime Marino","has_results":false},{"nct_id":"NCT07141914","title":"A Master Protocol for Semaglutide Effects on Cardiovascular and Obesity-related Outcomes in People With Overweight or Obesity in the Real World","phase":"","overall_status":"COMPLETED","enrollment_count":285327,"lead_sponsor_name":"Novo Nordisk A/S","has_results":false},{"nct_id":"NCT05248412","title":"The Long-term Spill-over Impact of COVID-19 on Health and Healthcare of People With Non-communicable Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":250000,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT05073692","title":"Comparison of Type 2 Diabetes Pharmacotherapy Regimens","phase":"","overall_status":"COMPLETED","enrollment_count":241981,"lead_sponsor_name":"Kaiser Permanente","has_results":true},{"nct_id":"NCT04047147","title":"Evaluation of the Million Hearts CVD Risk Reduction Model","phase":"","overall_status":"UNKNOWN","enrollment_count":210000,"lead_sponsor_name":"Mathematica Policy Research, Inc.","has_results":false},{"nct_id":"NCT05974345","title":"In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease","phase":"","overall_status":"COMPLETED","enrollment_count":204691,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT06223906","title":"A Registry Study of Biomarkers in Heart Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":200000,"lead_sponsor_name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases","has_results":false},{"nct_id":"NCT03987633","title":"EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality","phase":"","overall_status":"RECRUITING","enrollment_count":200000,"lead_sponsor_name":"Future Genetics Limited","has_results":false},{"nct_id":"NCT03958760","title":"Characteristics, Treatment, and Economic Burden of Patients With CVD,CKD or at High Cardiovascular Risk","phase":"","overall_status":"COMPLETED","enrollment_count":200000,"lead_sponsor_name":"West China Hospital","has_results":false},{"nct_id":"NCT03225586","title":"Prospective Urban Rural Epidemiology Study","phase":"","overall_status":"RECRUITING","enrollment_count":200000,"lead_sponsor_name":"Population Health Research Institute","has_results":false},{"nct_id":"NCT02681848","title":"What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?","phase":"","overall_status":"UNKNOWN","enrollment_count":180000,"lead_sponsor_name":"University of Bristol","has_results":false},{"nct_id":"NCT04541498","title":"Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease","phase":"","overall_status":"COMPLETED","enrollment_count":150000,"lead_sponsor_name":"Medical University of Bialystok","has_results":false},{"nct_id":"NCT03299010","title":"10-year Risk Prediction Models of Complications and Mortality of DM in Hong Kong","phase":"","overall_status":"COMPLETED","enrollment_count":141516,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT04302974","title":"Cohort Study on Patient Outcomes, Effectiveness and Cost-effectiveness of Intervention Programmes for DM/HT Patients","phase":"","overall_status":"COMPLETED","enrollment_count":100000,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT03285230","title":"The French E3N Prospective Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":100000,"lead_sponsor_name":"Institut National de la Santé Et de la Recherche Médicale, France","has_results":false},{"nct_id":"NCT04281823","title":"DeBakey Cardiovascular Magnetic Resonance Study","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Dipan Shah","has_results":false},{"nct_id":"NCT06420479","title":"The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05309850","title":"Primary Prevention With the Lifestyle Tool","phase":"NA","overall_status":"RECRUITING","enrollment_count":90000,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT03453073","title":"Chocolate and CVD Risk in Postmenopausal Women","phase":"","overall_status":"COMPLETED","enrollment_count":83310,"lead_sponsor_name":"Brooklyn College of the City University of New York","has_results":false},{"nct_id":"NCT05086874","title":"Using Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in Stroke Patients","phase":"","overall_status":"COMPLETED","enrollment_count":81292,"lead_sponsor_name":"Xin Huang","has_results":false},{"nct_id":"NCT04517513","title":"Shanghai Community Cohort Establishment and Follow-up","phase":"","overall_status":"UNKNOWN","enrollment_count":80000,"lead_sponsor_name":"RenJi Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}