{"disease":{"id":"cardio-pulmonary-bypass","name":"cardio pulmonary bypass"},"drugs":{"marketed":[{"drug_id":"albumin-human","indication_name":"Cardiopulmonary Bypass","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ALBUMIN HUMAN","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":45,"revenue":null,"mechanism":"Human Albumin 25% contributes to plasma colloid oncotic pressure and transports various substances, stabilizing blood volume."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06882759","title":"Relationship of Point-of-care Coagulation Assays with Clinical Outcomes in Cardiac Surgery: a Retrospective Cohort Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":15000,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT06702553","title":"Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":3650,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT06332547","title":"Transfusion in Cardiac Valve Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1600,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT03372174","title":"Maintaining Mechanical Ventilation During Cardiopulmonary Bypass for Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":1401,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT05537168","title":"Bayesian Networks in Pediatric Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":1364,"lead_sponsor_name":"Brugmann University Hospital","has_results":false},{"nct_id":"NCT03050476","title":"Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":1250,"lead_sponsor_name":"Alloksys Life Sciences B.V.","has_results":false},{"nct_id":"NCT05525195","title":"Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":932,"lead_sponsor_name":"Brugmann University Hospital","has_results":false},{"nct_id":"NCT06993467","title":"Oxygen Delivery During Cardiopulmonary Bypass And Inflammatory Reaction After Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":908,"lead_sponsor_name":"Azienda Ospedaliero, Universitaria Ospedali Riuniti","has_results":false},{"nct_id":"NCT03772990","title":"Calcium Administration in Cardiac Surgery","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":818,"lead_sponsor_name":"Meshalkin Research Institute of Pathology of Circulation","has_results":false},{"nct_id":"NCT02244034","title":"Incidence and Risk Factors of Postoperative Hypothermia in Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":760,"lead_sponsor_name":"Mahidol University","has_results":false},{"nct_id":"NCT05746559","title":"ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":736,"lead_sponsor_name":"Alexion Pharmaceuticals, Inc.","has_results":false},{"nct_id":"NCT04804345","title":"AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding","phase":"","overall_status":"COMPLETED","enrollment_count":693,"lead_sponsor_name":"University Hospital, Bordeaux","has_results":false},{"nct_id":"NCT05740059","title":"Restrictive Transfusion StratEgy Adjusted by SvO2 During Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":676,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT06365827","title":"Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"University of Giessen","has_results":false},{"nct_id":"NCT06707350","title":"Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT04444362","title":"Protective Effect of Probacine Against Negative Gut Metabolism and Organ Dysfunction After Cardiovascular Surgery (PANDA IV)","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":500,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT00981474","title":"Cerebral Autoregulation Monitoring During Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":460,"lead_sponsor_name":"Northwestern University","has_results":true},{"nct_id":"NCT07343830","title":"Prediction of Acute Kidney Injury After Cardiac Surgery With Cardiopulmonary Bypass","phase":"","overall_status":"COMPLETED","enrollment_count":455,"lead_sponsor_name":"Ataturk University","has_results":false},{"nct_id":"NCT02037555","title":"Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":425,"lead_sponsor_name":"Grifols Therapeutics LLC","has_results":true},{"nct_id":"NCT03302195","title":"Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery","phase":"NA","overall_status":"RECRUITING","enrollment_count":410,"lead_sponsor_name":"Laval University","has_results":false},{"nct_id":"NCT05595187","title":"Concomitant Tricuspid Repair in Patients With Left Heart Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":400,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT06728605","title":"Protective Effect of EECP Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":400,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT03475940","title":"Coagulopathy in Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":398,"lead_sponsor_name":"Mahidol University","has_results":false},{"nct_id":"NCT07087301","title":"Vancomycin Concentration Analysis in Post-Cardiac Surgery Patients","phase":"","overall_status":"COMPLETED","enrollment_count":350,"lead_sponsor_name":"Pengqiang Du","has_results":false},{"nct_id":"NCT06781294","title":"SIRAKI 02 Posthoc Analysis.","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":343,"lead_sponsor_name":"Hospital Universitari de Bellvitge","has_results":false},{"nct_id":"NCT06766032","title":"Comparison of the Performance and Effectiveness of Two Transfusion-Saving Devices: Cell-Saver and SAME","phase":"","overall_status":"COMPLETED","enrollment_count":304,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT06747546","title":"Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":300,"lead_sponsor_name":"Children's Hospital of Fudan University","has_results":false},{"nct_id":"NCT06102915","title":"Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting","phase":"","overall_status":"COMPLETED","enrollment_count":289,"lead_sponsor_name":"Institut Jantung Negara","has_results":false},{"nct_id":"NCT07314138","title":"Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Catharina Ziekenhuis Eindhoven","has_results":false},{"nct_id":"NCT04871308","title":"Dexmedetomidine and Myocardial Protection","phase":"NA","overall_status":"COMPLETED","enrollment_count":224,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT05229159","title":"Bio Impedance Electrical Analysis to Predict Outcome After Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":220,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT04213040","title":"Procalcitonin and Postoperative Outcome After Open-heart Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":214,"lead_sponsor_name":"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","has_results":false},{"nct_id":"NCT07390903","title":"GLS in Difficult CPB Weaning","phase":"","overall_status":"RECRUITING","enrollment_count":213,"lead_sponsor_name":"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","has_results":false},{"nct_id":"NCT06945536","title":"Relation Between Insulinoresistance and Neutrophile to Lymphocyte Ratio in Cardiac Surgery.","phase":"","overall_status":"COMPLETED","enrollment_count":211,"lead_sponsor_name":"Centre Hospitalier Universitaire de Besancon","has_results":false},{"nct_id":"NCT03230136","title":"Protection During Cardiac Surgery.","phase":"NA","overall_status":"COMPLETED","enrollment_count":210,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT05914896","title":"Hyperosmolality and Acute Kidney Injury After Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Umeå University","has_results":false},{"nct_id":"NCT05079724","title":"Acute Kidney Injury After Cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT07094087","title":"Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"CSL Behring","has_results":false},{"nct_id":"NCT05487469","title":"Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT05033236","title":"Platelets and Complement Activation in Coronary Artery Bypass Graft Surgery (CABG)","phase":"","overall_status":"COMPLETED","enrollment_count":190,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT06159517","title":"Heart Lung Machine Registry","phase":"","overall_status":"TERMINATED","enrollment_count":184,"lead_sponsor_name":"Maquet Cardiopulmonary GmbH","has_results":false},{"nct_id":"NCT06917859","title":"Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":170,"lead_sponsor_name":"Ain Shams University","has_results":false},{"nct_id":"NCT04062396","title":"Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction","phase":"NA","overall_status":"COMPLETED","enrollment_count":154,"lead_sponsor_name":"Maria Cecilia Hospital","has_results":false},{"nct_id":"NCT04238806","title":"Desflurane,Brain Natriuretic Peptide and Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":151,"lead_sponsor_name":"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","has_results":false},{"nct_id":"NCT06535360","title":"Efficacy of Pathogen Inactivation Strategies for Platelet Transfusion","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"University of Maryland, Baltimore","has_results":false},{"nct_id":"NCT03144011","title":"Acute Kidney Injury in Children After Cardiopulmonary Bypass","phase":"","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Meshalkin Research Institute of Pathology of Circulation","has_results":false},{"nct_id":"NCT06109155","title":"The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Taichung Veterans General Hospital","has_results":false},{"nct_id":"NCT04032938","title":"Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT03305094","title":"The Effect of Remote Ischemic Preconditioning in Aortic Valve Replacement Surgery","phase":"NA","overall_status":"UNKNOWN","enrollment_count":140,"lead_sponsor_name":"Laval University","has_results":false},{"nct_id":"NCT05757557","title":"Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":136,"lead_sponsor_name":"Tomsk National Research Medical Center of the Russian Academy of Sciences","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}