{"disease":{"id":"cardiac-surgery","name":"cardiac surgery"},"drugs":{"marketed":[{"drug_id":"dobutamine-hydrochloride","indication_name":"Cardiac Decompensation Post Cardiac Surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dobutamine Hydrochloride In Dextrose 5% In Plastic Container","generic_name":"Dobutamine Hydrochloride","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Beta-receptors of the heart","drug_class":"Inotropic agent","quality_score":10,"revenue":null,"mechanism":"Direct-acting inotropic agent stimulating cardiac beta-receptors with mild chronotropic and vasodilative effects."},{"drug_id":"dobutamine","indication_name":"Cardiac Decompensation Post Cardiac Surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dobutamine Hydrochloride In Dextrose 5% In Plastic Container","generic_name":"DOBUTAMINE","company_name":"","drug_phase":"marketed","molecular_target":"Beta-2 adrenergic receptor","drug_class":"beta-Adrenergic Agonist","quality_score":49,"revenue":null,"mechanism":""},{"drug_id":"dobutamin","indication_name":"Cardiac Decompensation Post Cardiac Surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Dobutamin","company_name":"Competence Network for Congenital Heart Defects","drug_phase":"discontinued","molecular_target":"Solute carrier family 22 member 1, Alpha-1D adrenergic receptor, Alpha-2B adrenergic receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04053335","title":"Smarter Care Virginia, Examining Low-Value Care in Virginia","phase":"","overall_status":"COMPLETED","enrollment_count":5000000,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT07249164","title":"Perioperative Dexmedetomidine and 30-Day Outcomes After Adult Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":408153,"lead_sponsor_name":"China Medical University Hospital","has_results":false},{"nct_id":"NCT04389008","title":"The Study of Anesthesia-related Risk Factors for Postoperative Death in Elderly Non-cardiac Surgery Patients in China","phase":"","overall_status":"UNKNOWN","enrollment_count":300000,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT06792578","title":"Surgical Start Time and Prognosis","phase":"","overall_status":"COMPLETED","enrollment_count":291051,"lead_sponsor_name":"Asan Medical Center","has_results":false},{"nct_id":"NCT06821139","title":"Cohort Study of Intraoperative Lung Protective Ventilation Trends in a Large Canadian Health Authority","phase":"","overall_status":"COMPLETED","enrollment_count":28700,"lead_sponsor_name":"Perseus Missirlis","has_results":false},{"nct_id":"NCT04527094","title":"Machine Learning Model to Predict Postoperative Respiratory Failure","phase":"","overall_status":"COMPLETED","enrollment_count":22250,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT05285098","title":"Leipzig FAST-TRACK Over 15 Years for Cardiac Surgical Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":20000,"lead_sponsor_name":"Heart Center Leipzig - University Hospital","has_results":false},{"nct_id":"NCT03928236","title":"Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":15886,"lead_sponsor_name":"Population Health Research Institute","has_results":false},{"nct_id":"NCT03016936","title":"MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR)","phase":"","overall_status":"COMPLETED","enrollment_count":15000,"lead_sponsor_name":"European Society of Anaesthesiology","has_results":false},{"nct_id":"NCT06882759","title":"Relationship of Point-of-care Coagulation Assays with Clinical Outcomes in Cardiac Surgery: a Retrospective Cohort Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":15000,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT07092683","title":"Mediation Analysis in Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":13683,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT07085208","title":"Derivation and Validation of Hemodynamic Phenotypes of Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":10847,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT02783781","title":"Contribution of Preoperative Biological Data in Risk Assessment in Cardiac Surgery in Addition to the EuroSCORE (EuroSCOREbio)","phase":"","overall_status":"COMPLETED","enrollment_count":9500,"lead_sponsor_name":"University Hospital Center of Martinique","has_results":false},{"nct_id":"NCT06495840","title":"Postoperative Anxiety and Depression Among Older Chinese Patients","phase":"","overall_status":"COMPLETED","enrollment_count":8590,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT07094321","title":"Study on the Correlation Between Intraoperative Hypotension and Postoperative Myocardial Injury","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":8000,"lead_sponsor_name":"China-Japan Friendship Hospital","has_results":false},{"nct_id":"NCT04762446","title":"Pre-operative Risk Assessment of Surgical Site Infection After Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":6379,"lead_sponsor_name":"Barts & The London NHS Trust","has_results":false},{"nct_id":"NCT04978636","title":"Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5502,"lead_sponsor_name":"The Cleveland Clinic","has_results":false},{"nct_id":"NCT02042898","title":"Transfusion Requirements in Cardiac Surgery III","phase":"NA","overall_status":"COMPLETED","enrollment_count":5028,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT05225246","title":"Readmissions After Cardiac Surgical Procedures","phase":"","overall_status":"COMPLETED","enrollment_count":4882,"lead_sponsor_name":"University Hospital, Basel, Switzerland","has_results":false},{"nct_id":"NCT07237243","title":"Ulinastatin Reduces Postoperative Pulmonary Complications in Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":4540,"lead_sponsor_name":"Qin Zhang","has_results":false},{"nct_id":"NCT06702553","title":"Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":3650,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT05914090","title":"The Application of Enhanced Recovery After Surgery (ERAS) for Cardiovascular Surgery in Adult","phase":"NA","overall_status":"UNKNOWN","enrollment_count":3600,"lead_sponsor_name":"Yan Fuxia","has_results":false},{"nct_id":"NCT07116733","title":"Desflurane vs. Propofol for Cardiac Anesthesia","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":3560,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT03709264","title":"Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":3511,"lead_sponsor_name":"Università Vita-Salute San Raffaele","has_results":false},{"nct_id":"NCT06730854","title":"Association Between Liver Function Tests and Acute Kidney Injury in Cardiac Surgery Patients","phase":"","overall_status":"COMPLETED","enrollment_count":3415,"lead_sponsor_name":"University Hospital, Ghent","has_results":false},{"nct_id":"NCT03560193","title":"Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":3316,"lead_sponsor_name":"Poitiers University Hospital","has_results":false},{"nct_id":"NCT03310125","title":"Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":3209,"lead_sponsor_name":"Population Health Research Institute","has_results":false},{"nct_id":"NCT03782350","title":"Outcome Impact of Different Tranexamic Acid Regimen in Cardiac Surgery With Cardiopulmonary Bypass","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":3079,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false},{"nct_id":"NCT07389785","title":"Age Related Chromatin Remodelling as a Therapeutic Target for Organ Protection in Cardiac Surgery","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3055,"lead_sponsor_name":"University of Leicester","has_results":false},{"nct_id":"NCT05782036","title":"Development, Validation and Clinical Application of a Recovery Scale After Cardiac Surgery: the Fuwai-CRS (Fuwai- Cardiac Recovery Scale)","phase":"","overall_status":"COMPLETED","enrollment_count":3043,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT07485101","title":"Glycemic Targets During CPB in Elderly Diabetes","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Beijing Anzhen Hospital","has_results":false},{"nct_id":"NCT04980742","title":"Perioperative Risk Factors of Outcomes for Cardiac Surgery: A Retrospective Study","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT03099057","title":"Study of Prognostic Factors in Interventional Rhythmology","phase":"","overall_status":"TERMINATED","enrollment_count":2805,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT06753461","title":"Intrahepatic Blood Flow Occlusion and Cardiac Injury Risk in Partial Hepatectomy","phase":"","overall_status":"COMPLETED","enrollment_count":2600,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT07370831","title":"Incidence and Prognostic of Cardiac Surgery-Associated Acute Kidney Injury: A Spanish Multicenter Study (SCARS-AKI)","phase":"","overall_status":"COMPLETED","enrollment_count":2500,"lead_sponsor_name":"Universidad de Oviedo","has_results":false},{"nct_id":"NCT04456751","title":"Is Redo Pediatric Cardiac Surgery a Risk Factor for Transfusion?","phase":"","overall_status":"COMPLETED","enrollment_count":2439,"lead_sponsor_name":"Brugmann University Hospital","has_results":false},{"nct_id":"NCT07157111","title":"Perioperative Outcomes for Children With Preoperative URTI Symptoms After COVID-19 Pandemic","phase":"","overall_status":"COMPLETED","enrollment_count":2392,"lead_sponsor_name":"aijun xu","has_results":false},{"nct_id":"NCT05279651","title":"Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2146,"lead_sponsor_name":"Jagiellonian University","has_results":false},{"nct_id":"NCT04172103","title":"The Association Between the Duration of Acute Kidney Injury and New-onset Chronic Kidney Disease After Cardiac or Thoracic Aortic Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":2009,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT04843202","title":"Clinical Guidelines in Premedication Visit","phase":"","overall_status":"COMPLETED","enrollment_count":2000,"lead_sponsor_name":"Technical University of Munich","has_results":false},{"nct_id":"NCT06986187","title":"Difficult Airway Incidence in Cardiovascular Surgery and a Prediction Model Development","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Diskapi Teaching and Research Hospital","has_results":false},{"nct_id":"NCT07012668","title":"Outcomes and Risk Factors of Different Treatment Strategies for Neuro-co-cardiological Diseases and Post-cardiac Surgery Cerebrovascular Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Beijing Anzhen Hospital","has_results":false},{"nct_id":"NCT04405830","title":"Outcome of Patients Treated With RRT","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT04705064","title":"Artificial Intelligence and Postoperative Acute Kidney Injury","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT03365726","title":"Intraoperative Dobutamine Stress Test With Speckle Tracking to Decrease Postoperative Mortality (ISTMO)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"McGill University Health Centre/Research Institute of the McGill University Health Centre","has_results":false},{"nct_id":"NCT06225453","title":"Individualized Versus Conventional Perioperative Blood Pressure Management","phase":"NA","overall_status":"RECRUITING","enrollment_count":1896,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT07335042","title":"Prediction Model for MINS After Major Hepatobiliary Surgery","phase":"","overall_status":"RECRUITING","enrollment_count":1800,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT04980911","title":"Iron Deficiency and Anemia in Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":1711,"lead_sponsor_name":"Centre Hospitalier Régional Metz-Thionville","has_results":false},{"nct_id":"NCT03489486","title":"Presepsin (sCD14-ST) for Prediction of Perioperative Risk - MET-REPAIR Nested Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":1695,"lead_sponsor_name":"University Hospital Heidelberg","has_results":false},{"nct_id":"NCT06332547","title":"Transfusion in Cardiac Valve Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1600,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}