{"disease":{"id":"cardiac-ischemia","name":"cardiac ischemia"},"drugs":{"marketed":[{"drug_id":"heparin","indication_name":"Prevention of Cardiac Ischemia in Unstable Angina","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Heparin Sodium In Plastic Container","generic_name":"HEPARIN","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Antithrombin-III","drug_class":"Anti-coagulant","quality_score":56,"revenue":null,"mechanism":"Heparin works by binding to Antithrombin-III, a protein that inhibits the formation of blood clots."},{"drug_id":"heparin-sodium","indication_name":"Prevention of Cardiac Ischemia in Unstable Angina","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Heparin Sodium In Plastic Container","generic_name":"Heparin Sodium","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"Antithrombin III, Coagulation Factors Xa and IIa","drug_class":"Anticoagulant","quality_score":63,"revenue":null,"mechanism":"Heparin enhances Antithrombin III activity to inhibit coagulation factors Xa and IIa."}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06763549","title":"COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":15000,"lead_sponsor_name":"Peerbridge Health, Inc","has_results":false},{"nct_id":"NCT06753461","title":"Intrahepatic Blood Flow Occlusion and Cardiac Injury Risk in Partial Hepatectomy","phase":"","overall_status":"COMPLETED","enrollment_count":2600,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT05279651","title":"Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2146,"lead_sponsor_name":"Jagiellonian University","has_results":false},{"nct_id":"NCT04217551","title":"Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1158,"lead_sponsor_name":"University of Michigan","has_results":false},{"nct_id":"NCT06906432","title":"Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Beijing Tiantan Hospital","has_results":false},{"nct_id":"NCT05376267","title":"Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)","phase":"NA","overall_status":"RECRUITING","enrollment_count":900,"lead_sponsor_name":"University of Michigan","has_results":false},{"nct_id":"NCT04198792","title":"Predictors for Survival and Good Neurological Outcome in E-CPR and Non CPR Treated Patients","phase":"","overall_status":"RECRUITING","enrollment_count":700,"lead_sponsor_name":"Sahlgrenska University Hospital","has_results":false},{"nct_id":"NCT06365827","title":"Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"University of Giessen","has_results":false},{"nct_id":"NCT06954610","title":"Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT04749212","title":"Perioperative Troponin I and NT Pro-BNP in Lung Resection","phase":"","overall_status":"COMPLETED","enrollment_count":475,"lead_sponsor_name":"Hospital Universitari Vall d'Hebron Research Institute","has_results":false},{"nct_id":"NCT03857503","title":"Radiographic Imaging Validation and EvALuation for Angio iFR (ReVEAL iFR)","phase":"","overall_status":"COMPLETED","enrollment_count":441,"lead_sponsor_name":"Volcano Corporation","has_results":false},{"nct_id":"NCT05453097","title":"Prognostic Value of the Selvester QRS Score for Perioperative Myocardial Injury Following Non-cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Istanbul University - Cerrahpasa","has_results":false},{"nct_id":"NCT03857711","title":"Randomized Clinical Trial PULVAB (Prophylactic Pulmonary Veins Ablation)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":280,"lead_sponsor_name":"National Research Center of Surgery, Russia","has_results":false},{"nct_id":"NCT06946589","title":"Cardiac Changes After Effective Dose Carbetocin for Elective Caesarian Section","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Jordan Leitch","has_results":false},{"nct_id":"NCT05164640","title":"Ischemia in Patients With Non-obstructive Disease (INOCA) in Italy INOCA IT Multicenter Registry\"","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"IRCCS San Raffaele","has_results":false},{"nct_id":"NCT04463563","title":"Cerebral Oximetry in Cardiac Surgery to Reduce Neurological Impairment and Hospital Length-of-stay","phase":"NA","overall_status":"COMPLETED","enrollment_count":182,"lead_sponsor_name":"Hull University Teaching Hospitals NHS Trust","has_results":false},{"nct_id":"NCT05004610","title":"Hypertonic Lactate After Cardiac Arrest","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":125,"lead_sponsor_name":"Erasme University Hospital","has_results":false},{"nct_id":"NCT06414330","title":"Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":124,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT03433963","title":"The Use of L-arginine to Mitigate the Cardiovascular Effects of Exposure to Traffic-related Air Pollution","phase":"NA","overall_status":"COMPLETED","enrollment_count":118,"lead_sponsor_name":"Peking University","has_results":false},{"nct_id":"NCT05757947","title":"Study of the No-touch Saphenous Vein Graft","phase":"NA","overall_status":"UNKNOWN","enrollment_count":106,"lead_sponsor_name":"Meshalkin Research Institute of Pathology of Circulation","has_results":false},{"nct_id":"NCT06235424","title":"Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT03800082","title":"Development and Usability Testing of a Progressive WebApp for Women With Heart Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":98,"lead_sponsor_name":"University of Toronto","has_results":false},{"nct_id":"NCT04458155","title":"Li-Hep vs. Non-Li-Hep Coated Transfer Device","phase":"","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"VieCuri Medical Centre","has_results":false},{"nct_id":"NCT03859466","title":"Safety and Efficacy of Cardiac Shockwave Therapy in Patients Undergoing Coronary Artery Bypass Grafting","phase":"NA","overall_status":"COMPLETED","enrollment_count":63,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT05159791","title":"New Patient-specific Functional Assessment of the Anomalous Aortic Origin of Coronary Arteries.","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"IRCCS Policlinico S. Donato","has_results":false},{"nct_id":"NCT03798652","title":"Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study","phase":"","overall_status":"UNKNOWN","enrollment_count":56,"lead_sponsor_name":"King's College London","has_results":false},{"nct_id":"NCT03642730","title":"Interactive Guided Ultrasound Examinations Done by Non-experts of Ultrasound Imaging","phase":"NA","overall_status":"COMPLETED","enrollment_count":55,"lead_sponsor_name":"Philips Healthcare","has_results":false},{"nct_id":"NCT03910062","title":"Lower Limb Surveillance During VA-ECLS","phase":"","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT03203057","title":"Induced Myocardial Ischemia: a Serial Troponin T and Troponin I Measurements","phase":"","overall_status":"COMPLETED","enrollment_count":34,"lead_sponsor_name":"Herlev Hospital","has_results":false},{"nct_id":"NCT03112486","title":"Out-of-hospital Cardiac Arrest (OHCA) Biomarkers","phase":"","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT03053128","title":"Implication of Cardiac Shock Wave Therapy on Coronary Artery Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Beijing Hospital","has_results":false},{"nct_id":"NCT03743584","title":"Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.","phase":"NA","overall_status":"COMPLETED","enrollment_count":26,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT05726604","title":"4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy","phase":"NA","overall_status":"UNKNOWN","enrollment_count":15,"lead_sponsor_name":"Central Hospital Saint Quentin","has_results":false},{"nct_id":"NCT05654935","title":"Telerobotic Ultrasound for Carotid Imaging - Feasibility Study","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Rush University Medical Center","has_results":false}],"total":34},"guidelines":[],"source":"Drug Landscape verified database"}