{"disease":{"id":"brain-metastases","name":"brain metastases"},"drugs":{"marketed":[{"drug_id":"lorlatinib-with-chemotherapy-2","indication_name":"Anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) with brain metastases","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lorlatinib with chemotherapy 2","generic_name":"lorlatinib-with-chemotherapy-2","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"ALK","drug_class":"ALK inhibitor","quality_score":40,"revenue":"798","mechanism":""},{"drug_id":"lorlatinib-with-chemotherapy-2","indication_name":"ALK-positive metastatic NSCLC without brain metastases","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lorlatinib with chemotherapy 2","generic_name":"lorlatinib-with-chemotherapy-2","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"ALK","drug_class":"ALK inhibitor","quality_score":40,"revenue":"798","mechanism":""},{"drug_id":"lorlatinib-with-chemotherapy-2","indication_name":"ALK-positive metastatic NSCLC with brain metastases and with or without echinoderm microtubule-associated protein-like 4 (EML4) anaplastic lymphoma kinase (ALK) fusion","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lorlatinib with chemotherapy 2","generic_name":"lorlatinib-with-chemotherapy-2","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"ALK","drug_class":"ALK inhibitor","quality_score":40,"revenue":"798","mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04654975","title":"Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT04075305","title":"The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study","phase":"","overall_status":"RECRUITING","enrollment_count":8000,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT03346655","title":"Brain Metastases in Norway - A Prospective Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT07198256","title":"AI-assisted Diagnosis of Malignant Brain Tumors","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT05616377","title":"Combination of Local Therapy and Target Therapy for Brain Metastases With EGFR Mutation","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT05609162","title":"Treatments for Brain Metastases With Poor Prognostic Factors","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT04170777","title":"Perfexion Registration Using CBCT","phase":"","overall_status":"COMPLETED","enrollment_count":1250,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT05267158","title":"The Cohort for Patient-reported Outcomes, Imaging and Trial Inclusion in Metastatic BRAin Disease (COIMBRA)","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT05270707","title":"HyperArc Registry Study","phase":"","overall_status":"COMPLETED","enrollment_count":968,"lead_sponsor_name":"Varian, a Siemens Healthineers Company","has_results":false},{"nct_id":"NCT05464992","title":"Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI","phase":"NA","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"Centre Paul Strauss","has_results":false},{"nct_id":"NCT07448662","title":"Local Treatment Strategies for Brain Metastases of Colorectal Cancer","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":700,"lead_sponsor_name":"Blokhin's Russian Cancer Research Center","has_results":false},{"nct_id":"NCT06029140","title":"Stereotactic Radiotherapy Management of Brain Metastases: the Value of a Longitudinal Multimodal Approach (POSTPONE)","phase":"","overall_status":"UNKNOWN","enrollment_count":700,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04832672","title":"Sequence of Radiation and Targeted Therapy in Brain Metastases","phase":"","overall_status":"COMPLETED","enrollment_count":570,"lead_sponsor_name":"Chinese Academy of Medical Sciences","has_results":false},{"nct_id":"NCT05573815","title":"Evaluation of Clinical Decision Support System for Brain Metastasis Using Brain MR Images","phase":"NA","overall_status":"UNKNOWN","enrollment_count":558,"lead_sponsor_name":"Heuron Inc.","has_results":false},{"nct_id":"NCT03653546","title":"First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":492,"lead_sponsor_name":"Alpha Biopharma (Jiangsu) Co., Ltd.","has_results":false},{"nct_id":"NCT05948813","title":"TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":420,"lead_sponsor_name":"TYK Medicines, Inc","has_results":false},{"nct_id":"NCT07542288","title":"Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases:","phase":"PHASE2, PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":400,"lead_sponsor_name":"The Second Affiliated Hospital of Hainan Medical University","has_results":false},{"nct_id":"NCT07373951","title":"Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":380,"lead_sponsor_name":"Ming Yang","has_results":false},{"nct_id":"NCT06869460","title":"Multicenter Retrospective Study on Patients Treated with Stereotactic Radiosurgery/Radiotherapy for Single Brain Lesions: Evaluation of Treatment Efficacy and Safety, Also Through Radiomic Analysis Methods.","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":372,"lead_sponsor_name":"Gemelli Molise Hospital","has_results":false},{"nct_id":"NCT06457906","title":"SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":340,"lead_sponsor_name":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","has_results":false},{"nct_id":"NCT06649058","title":"EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":316,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT01657799","title":"Comparison of Veliparib and Whole Brain Radiation Therapy (WBRT) Versus Placebo and WBRT in Adults With Brain Metastases From Non-Small Cell Lung Cancer","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":307,"lead_sponsor_name":"AbbVie (prior sponsor, Abbott)","has_results":true},{"nct_id":"NCT07491211","title":"Osimertinib Combined With Intracranial SRT for EGFR-Mutant NSCLC With Symptomatic Brain Metastases","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT04058704","title":"A Study to Determine the Efficiency For Brain Metastasis NSCLC Patients Treated With Icotinib Alone or Combined With Radiation Therapy","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":296,"lead_sponsor_name":"Betta Pharmaceuticals Co., Ltd.","has_results":false},{"nct_id":"NCT06933199","title":"Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis","phase":"NA","overall_status":"RECRUITING","enrollment_count":260,"lead_sponsor_name":"University Hospital Ostrava","has_results":false},{"nct_id":"NCT07058428","title":"FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung Adenocarcinoma","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":258,"lead_sponsor_name":"Sun Yat-Sen University Cancer Center","has_results":false},{"nct_id":"NCT03593330","title":"Neurosurgical Transitional Care Programme","phase":"NA","overall_status":"TERMINATED","enrollment_count":242,"lead_sponsor_name":"Barts & The London NHS Trust","has_results":false},{"nct_id":"NCT05768490","title":"Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":232,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT04365374","title":"Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":230,"lead_sponsor_name":"GT Medical Technologies, Inc.","has_results":false},{"nct_id":"NCT07448493","title":"Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":230,"lead_sponsor_name":"Blokhin's Russian Cancer Research Center","has_results":false},{"nct_id":"NCT07100600","title":"Trastuzumab Rezetecan Combined With Radiotherapy Versus Trastuzumab Rezetecan in the Treatment of HER2-positive Advanced Breast Cancer With Brain Metastases","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":224,"lead_sponsor_name":"Henan Cancer Hospital","has_results":false},{"nct_id":"NCT03778541","title":"HFSRT With Concurrent TMZ for Large BMs","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":224,"lead_sponsor_name":"Chinese Academy of Medical Sciences","has_results":false},{"nct_id":"NCT07481786","title":"Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":220,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT03550391","title":"Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":206,"lead_sponsor_name":"Canadian Cancer Trials Group","has_results":false},{"nct_id":"NCT03303365","title":"Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence","phase":"NA","overall_status":"COMPLETED","enrollment_count":203,"lead_sponsor_name":"Juergen Debus","has_results":false},{"nct_id":"NCT06020066","title":"SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":202,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT03458455","title":"Improved Therapy Response Assessment in Metastatic Brain Tumors","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT04042220","title":"Glucocorticoids, Immunotherapy and Radiosurgery for Brain Metastases","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT05124236","title":"Trial of Preoperative Radiosurgery Versus Postoperative Stereotactic Radiotherapy for Resectable Brain Metastases","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Susanne Rogers","has_results":false},{"nct_id":"NCT03075072","title":"Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":196,"lead_sponsor_name":"Dana-Farber Cancer Institute","has_results":false},{"nct_id":"NCT05378633","title":"The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases?","phase":"NA","overall_status":"RECRUITING","enrollment_count":190,"lead_sponsor_name":"University Hospital Heidelberg","has_results":false},{"nct_id":"NCT04525053","title":"Dosimetric Validation of Scans Generated by GAN From Pre-therapeutic MRI in Stereotactic Cerebral Radiotherapy","phase":"","overall_status":"COMPLETED","enrollment_count":184,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04397978","title":"Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases","phase":"","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT02747303","title":"Frameless Stereotactic Radiosurgery for Intact Brain Metastases","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":166,"lead_sponsor_name":"University of Chicago","has_results":false},{"nct_id":"NCT03951142","title":"Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":165,"lead_sponsor_name":"Kyrre Eeg Emblem","has_results":false},{"nct_id":"NCT05033691","title":"A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases","phase":"NA","overall_status":"RECRUITING","enrollment_count":162,"lead_sponsor_name":"Hadassah Medical Organization","has_results":false},{"nct_id":"NCT02308020","title":"A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT03754530","title":"Icotinib Combined With Radiation Therapy For NSCLC Patients With Brain Metastases and EGFR Mutation","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":162,"lead_sponsor_name":"Betta Pharmaceuticals Co., Ltd.","has_results":false},{"nct_id":"NCT07053033","title":"Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":155,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT07197632","title":"ioMRI in the Surgery of Brain Metastases.","phase":"NA","overall_status":"RECRUITING","enrollment_count":154,"lead_sponsor_name":"Technical University of Munich","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}