{"disease":{"id":"bone-metastasis","name":"bone metastasis"},"drugs":{"marketed":[{"drug_id":"sama","indication_name":"Pain due to Osteoblastic Bone Metastasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"SAMA","company_name":"Lantheus Medical","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Sama is a small molecule that works by interacting with a specific biological target to produce a therapeutic effect."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05480189","title":"Effect of Zoledronic Acid Treatment on Bone-related Events in Breast Cancer Patients With Bone Metastases: a Prospective, Multicenter, Real-world Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Zhejiang Cancer Hospital","has_results":false},{"nct_id":"NCT06884332","title":"Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality","phase":"NA","overall_status":"RECRUITING","enrollment_count":598,"lead_sponsor_name":"Institut de Cancérologie de Lorraine","has_results":false},{"nct_id":"NCT07030569","title":"RADIomics to Predict HER2 Status And T-DXd Efficacy in Metastatic Breast Cancer: the RADIOSPHER2 Study","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","has_results":false},{"nct_id":"NCT06430411","title":"Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT06703944","title":"Risk Model for Metastasis Detection of Neuroblastoma","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":500,"lead_sponsor_name":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT01998607","title":"Survey of XGEVA® Presrcibers in Europe to Evaluate Their Knowledge of the Summary of Product Characteristics Pertaining to Osteonecrosis of the Jaw","phase":"","overall_status":"COMPLETED","enrollment_count":420,"lead_sponsor_name":"Amgen","has_results":false},{"nct_id":"NCT04307914","title":"Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients With Bone Metastases","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":216,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT06806462","title":"Biomolecular Markers of Bone Metastasis","phase":"NA","overall_status":"RECRUITING","enrollment_count":160,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT02609828","title":"Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":156,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT04494373","title":"Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of HS-20090 and Xgeva® in Healthy Adults","phase":"PHASE1","overall_status":"UNKNOWN","enrollment_count":154,"lead_sponsor_name":"Jiangsu Hansoh Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT02839291","title":"Evaluation of Medical Practice in the Management of Bone Metastases After Injectable Bone Antiresorptive Treatment, and Its Influence on Quality of Life","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":148,"lead_sponsor_name":"Centre Hospitalier Universitaire de Besancon","has_results":false},{"nct_id":"NCT07100444","title":"Spinal Metastasis as the First Presentation of Lung Malignancy: Clinical Characteristics and Postoperative Survival","phase":"","overall_status":"COMPLETED","enrollment_count":139,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT03831243","title":"A Trial to Improve Quality of Life With Stereotactic Body Radiotherapy for Patients With Painful Bone Metastases","phase":"NA","overall_status":"COMPLETED","enrollment_count":126,"lead_sponsor_name":"Cancer Research Antwerp","has_results":false},{"nct_id":"NCT07173868","title":"FDG PET-CT in Advanced Breast Cancer","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT02511678","title":"Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases","phase":"NA","overall_status":"COMPLETED","enrollment_count":73,"lead_sponsor_name":"Boston Scientific Corporation","has_results":true},{"nct_id":"NCT06957691","title":"Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Shehzad Basaria, M.D.","has_results":false},{"nct_id":"NCT02426697","title":"Pain Management With Pecfent in the Prevention of Pain Induced by Position in Radiotherapy","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"Centre Henri Becquerel","has_results":false},{"nct_id":"NCT06972628","title":"Treatment of Patients With Progressive mCRPC With 177Lu-PSMA-617","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"Ebrahim S Delpassand","has_results":false},{"nct_id":"NCT04788147","title":"Performance and Safety of Biology-Guided Radiotherapy Using the RefleXion Medical Radiotherapy System (BIOGUIDE-X)","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"RefleXion Medical","has_results":true},{"nct_id":"NCT06165419","title":"Definitive Radiation for High-Risk Spine Metastases","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":26,"lead_sponsor_name":"Stony Brook University","has_results":false},{"nct_id":"NCT04547153","title":"Infusional Fluorouracil and Weekly Docetaxel for Gastric Cancer With Bone Marrow Involvement and DIC","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Sixth Affiliated Hospital, Sun Yat-sen University","has_results":false},{"nct_id":"NCT03796767","title":"Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20,"lead_sponsor_name":"University of Utah","has_results":true},{"nct_id":"NCT02999152","title":"Validation of Radio-induced Damage Biomarkers","phase":"NA","overall_status":"TERMINATED","enrollment_count":16,"lead_sponsor_name":"Centre Hospitalier Universitaire de Saint Etienne","has_results":false},{"nct_id":"NCT06716294","title":"Effectiveness Of Radiofrequency Ablation And Stabilization In Metastatic Spine Lesions By Positron Emission Computed Tomography (PET-CT) Confirmation","phase":"","overall_status":"RECRUITING","enrollment_count":16,"lead_sponsor_name":"National and Kapodistrian University of Athens","has_results":false},{"nct_id":"NCT04310410","title":"Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT04592887","title":"Feasibility Study of FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases","phase":"NA","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Varian, a Siemens Healthineers Company","has_results":true},{"nct_id":"NCT02443103","title":"Study Evaluating the Biologic Activity of Guanabenz in Bone Metastasis","phase":"NA","overall_status":"TERMINATED","enrollment_count":4,"lead_sponsor_name":"Kathy Miller","has_results":true},{"nct_id":"NCT06872489","title":"Expanded Access Protocol for the Use of SL-28 in the Treatment of Advanced Solid Tumors","phase":"","overall_status":"AVAILABLE","enrollment_count":null,"lead_sponsor_name":"Second Life Therapeutics","has_results":false}],"total":28},"guidelines":[],"source":"Drug Landscape verified database"}