{"disease":{"id":"blood-pressure","name":"blood pressure"},"drugs":{"marketed":[{"drug_id":"angiotensinamide","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"angiotensinamide","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"angiotensinamide","quality_score":null,"revenue":null,"mechanism":"Angiotensinamide works by increasing blood pressure through a complex interaction with the renin-angiotensin system."},{"drug_id":"dopamine","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dopamine Hydrochloride","generic_name":"DOPAMINE","company_name":"","drug_phase":"marketed","molecular_target":"D(1A) dopamine receptor","drug_class":"Catecholamine","quality_score":10,"revenue":null,"mechanism":"Dopamine Hydrochloride works by stimulating dopamine receptors in the body to increase heart rate, blood pressure, and cardiac output."},{"drug_id":"metaraminol","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aramine","generic_name":"METARAMINOL","company_name":"","drug_phase":"marketed","molecular_target":"Macrophage migration inhibitory factor","drug_class":"Indirectly Acting Sympathomimetic Amines","quality_score":21,"revenue":null,"mechanism":""},{"drug_id":"prazosin-hcl","indication_name":"Lowering blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prazosin Hcl","generic_name":"prazosin-hcl","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 1D","drug_class":"prazosin","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"levophed","indication_name":"Blood pressure restoration in adult patients","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Levophed","generic_name":"Norepinephrine Bitartrate","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Alpha-adrenergic and beta-adrenergic receptors","drug_class":"Catecholamine, sympathomimetic amine","quality_score":10,"revenue":null,"mechanism":"Peripheral vasoconstrictor via alpha-adrenergic action and cardiac inotropic stimulator with coronary vasodilation via beta-adrenergic action."},{"drug_id":"epinephrine","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Epipen","generic_name":"epinephrine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Alpha-1D adrenergic receptor","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":80,"revenue":null,"mechanism":"Epipen works by stimulating the alpha-1D adrenergic receptor to rapidly increase heart rate, blood pressure, and bronchodilation."},{"drug_id":"norepinephrine","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Norepinephrine Bitartrate In 5% Dextrose","generic_name":"NOREPINEPHRINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"alpha-adrenergic receptors, beta-adrenergic receptors","drug_class":"Catecholamine","quality_score":80,"revenue":null,"mechanism":"Norepinephrine constricts blood vessels and stimulates the heart."},{"drug_id":"lidocaine-hydrochloride-and-epinephrine","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bupivacaine Hydrochloride And Epinephrine","generic_name":"Epinephrine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Alpha-1D adrenergic receptor","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":80,"revenue":null,"mechanism":"Epinephrine works by stimulating the alpha-1D adrenergic receptor to increase heart rate and blood pressure, and to constrict blood vessels."},{"drug_id":"mephentermine","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vialin","generic_name":"MEPHENTERMINE","company_name":"Baxter","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor","drug_class":"Indirectly Acting Sympathomimetic Amines","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"methoxamine","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Methoxamin","generic_name":"METHOXAMINE","company_name":"GSK","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor","drug_class":"methoxamine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"aprocitentan","indication_name":"High blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tryvio","generic_name":"APROCITENTAN","company_name":"Idorsia","drug_phase":"marketed","molecular_target":"","drug_class":"Endothelin Receptor Antagonist [EPC]","quality_score":60,"revenue":null,"mechanism":"Tryvio works by blocking the action of endothelin, a protein that constricts blood vessels and increases blood pressure."},{"drug_id":"epinephrin","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Epinephrin","company_name":"United States Naval Medical Center, San Diego","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-1D adrenergic receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"noradrenaline","indication_name":"Low blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Noradrenaline","company_name":"Tanta University","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-1D adrenergic receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":13,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03954119","title":"Blood Pressure in the Emergency Department","phase":"","overall_status":"COMPLETED","enrollment_count":300272,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT03987633","title":"EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality","phase":"","overall_status":"RECRUITING","enrollment_count":200000,"lead_sponsor_name":"Future Genetics Limited","has_results":false},{"nct_id":"NCT04226612","title":"Association of Inpatient Blood Pressure Levels With In-hospital Adverse Events(APPLE Study)","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT03521739","title":"Association of Synchronous Four-limb blOod pRessure and Pulse Wave velocIty With Cardiovascular Events","phase":"","overall_status":"UNKNOWN","enrollment_count":100000,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false},{"nct_id":"NCT05814068","title":"Active Screening of Arterial Hypertension by Community Outreach Workers in the Cayenne Metropolitan Area to Reduce the Incidence of Cardiovascular Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":50000,"lead_sponsor_name":"Centre Hospitalier de Cayenne","has_results":false},{"nct_id":"NCT05030467","title":"Leveraging Electronic Health Record (EHR) Tools to Reduce Health Disparities for Patients With Uncontrolled Hypertension","phase":"NA","overall_status":"COMPLETED","enrollment_count":49210,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":true},{"nct_id":"NCT05698433","title":"Development of a Prediction Model for Intraoperative Blood Pressure Variability","phase":"","overall_status":"COMPLETED","enrollment_count":47520,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT03840928","title":"PatientSpot Formerly Known as ArthritisPower","phase":"","overall_status":"UNKNOWN","enrollment_count":40000,"lead_sponsor_name":"Global Healthy Living Foundation","has_results":false},{"nct_id":"NCT06670677","title":"Evaluation of the Clinical Benefit of the Aktiia Blood Pressure Monitoring for Early Awareness of Hypertension and Prediction of Cardiovascular Risk","phase":"","overall_status":"RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Aktiia SA","has_results":false},{"nct_id":"NCT03147092","title":"Matão Controlling Hypertension (MatCH Study): Rationale and Design","phase":"EARLY_PHASE1","overall_status":"UNKNOWN","enrollment_count":15000,"lead_sponsor_name":"Centro Neurológico de Pesquisa e Reabiitação, Brazil","has_results":false},{"nct_id":"NCT03808311","title":"Blood Pressure Control Target in Diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":12821,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT04827615","title":"Evaluation of the Ambuja Cement Foundation Noncommunicable Disease Program in Bathinda District of Punjab, India","phase":"NA","overall_status":"COMPLETED","enrollment_count":11322,"lead_sponsor_name":"Harvard School of Public Health (HSPH)","has_results":false},{"nct_id":"NCT07406074","title":"Duke Virtual IntEgrated Workflow","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT03547856","title":"A Registry Study on the \"Action of Controlling Ambulatory Blood Pressure to Target in Ten Thousand Patients\"","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Yan Li","has_results":false},{"nct_id":"NCT05858944","title":"Home Blood Pressure Intervention in the Community Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Shanghai Institute of Hypertension","has_results":false},{"nct_id":"NCT04040634","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":9476,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT06427096","title":"Effect of Healthy Family Program on Population Blood Pressure","phase":"NA","overall_status":"COMPLETED","enrollment_count":8001,"lead_sponsor_name":"Heart Health Research Center","has_results":false},{"nct_id":"NCT05992415","title":"Know Your Pressures NYC","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":7085,"lead_sponsor_name":"Columbia University","has_results":false},{"nct_id":"NCT03379688","title":"PDMS Outcome After Intensive Care, Organdysfunction and Monitoring","phase":"","overall_status":"COMPLETED","enrollment_count":6909,"lead_sponsor_name":"Charite University, Berlin, Germany","has_results":false},{"nct_id":"NCT04934748","title":"The GUARDIAN Trial - Vasopressor Sub-Study","phase":"PHASE4","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":6254,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT04884802","title":"The GUARDIAN Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":6254,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT04212468","title":"Home Blood Pressure Monitoring Registration Study in the Elderly(HOME Study)","phase":"","overall_status":"RECRUITING","enrollment_count":6000,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT05488795","title":"Team-Based Home Blood Pressure Monitoring","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5760,"lead_sponsor_name":"University of Rochester","has_results":false},{"nct_id":"NCT05935397","title":"HanYang University Medical Center (HYUMC) Registry","phase":"","overall_status":"UNKNOWN","enrollment_count":5000,"lead_sponsor_name":"Hanyang University Seoul Hospital","has_results":false},{"nct_id":"NCT03225196","title":"Extracellular RNAs in Relation to Cardiometabolic Risk","phase":"","overall_status":"COMPLETED","enrollment_count":4495,"lead_sponsor_name":"National Heart, Lung, and Blood Institute (NHLBI)","has_results":false},{"nct_id":"NCT04036409","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":4368,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT06394934","title":"Home Blood Pressure Variability and Its Link to Arteriosclerosis and Metabolic Dysfunction in Hypertensive Patients","phase":"","overall_status":"RECRUITING","enrollment_count":4188,"lead_sponsor_name":"Korea University Anam Hospital","has_results":false},{"nct_id":"NCT05106036","title":"Preventing Cognitive Decline by Reducing BP Target Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":4000,"lead_sponsor_name":"University of Texas Southwestern Medical Center","has_results":false},{"nct_id":"NCT06148142","title":"Effectiveness of a Community Pharmacy-based Health Promotion Program on Hypertension in Bangladesh and Pakistan","phase":"NA","overall_status":"COMPLETED","enrollment_count":3600,"lead_sponsor_name":"Hitotsubashi University","has_results":false},{"nct_id":"NCT06579950","title":"Assessing the Effects of Cool Roofs on Indoor Environments and Health","phase":"NA","overall_status":"RECRUITING","enrollment_count":3200,"lead_sponsor_name":"Aditi Bunker","has_results":false},{"nct_id":"NCT04295434","title":"Blood Pressure Control in ESH Excellence Centres","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Clinical Hospital Centre Zagreb","has_results":false},{"nct_id":"NCT03154203","title":"Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Shanghai 10th People's Hospital","has_results":false},{"nct_id":"NCT03404999","title":"Clinical-Decision Support to Improve Hypertension Care in Primary Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":2803,"lead_sponsor_name":"University of Texas Southwestern Medical Center","has_results":false},{"nct_id":"NCT04278378","title":"Blood Pressure Lowering Effect of B-vitamins in Adults With a Genetic Pre-disposition to Elevated Blood Pressure.","phase":"NA","overall_status":"COMPLETED","enrollment_count":2564,"lead_sponsor_name":"University of Ulster","has_results":false},{"nct_id":"NCT06988410","title":"Income Volatility and Mental Health, Full Experiment","phase":"NA","overall_status":"RECRUITING","enrollment_count":2267,"lead_sponsor_name":"Cornell University","has_results":false},{"nct_id":"NCT04723836","title":"Optimal Nutrition for Prevention of Hypertension in Pregnancy","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2250,"lead_sponsor_name":"University of Ulster","has_results":false},{"nct_id":"NCT06027424","title":"Blood Pressure and Obstructive Sleep Apnea","phase":"","overall_status":"COMPLETED","enrollment_count":2037,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT03363360","title":"Comprehensive Awareness and Control in Diabetes Patients in China Jiangxi: A Cross-Sectional Survey","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Second Affiliated Hospital of Nanchang University","has_results":false},{"nct_id":"NCT06426732","title":"The Trajectory of Blood Pressure During Pregnancy in Assisted Reproductive Females","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"The Second Hospital of Shandong University","has_results":false},{"nct_id":"NCT04135911","title":"A Prospective Study on The\"Management of Hypertension in Young and Middle-aged Subjects in Enterprises Setting\"","phase":"","overall_status":"SUSPENDED","enrollment_count":2000,"lead_sponsor_name":"Yan Li","has_results":false},{"nct_id":"NCT04342468","title":"Blood Pressure Variability and Cardiovascular Disease Events in Patients With Hypertension","phase":"","overall_status":"COMPLETED","enrollment_count":1736,"lead_sponsor_name":"University of Malaya","has_results":false},{"nct_id":"NCT05349422","title":"Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":1726,"lead_sponsor_name":"NYU Langone Health","has_results":false},{"nct_id":"NCT05668624","title":"Sustainable Household Energy Adoption in Rwanda (SHEAR)","phase":"NA","overall_status":"COMPLETED","enrollment_count":1680,"lead_sponsor_name":"Colorado State University","has_results":false},{"nct_id":"NCT03290716","title":"Diet, ExerCIse and carDiovascular hEalth (DECIDE) - Salt Reduction Strategies for the Elderly in Nursing Homes in China","phase":"NA","overall_status":"COMPLETED","enrollment_count":1612,"lead_sponsor_name":"Peking University","has_results":false},{"nct_id":"NCT05022836","title":"Four-limb Blood Pressures in Infants With High Risk of Congenital Malformation of Aorta","phase":"","overall_status":"COMPLETED","enrollment_count":1604,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT06122246","title":"PRESSURE CHECK: Find Your Path to Better Health","phase":"NA","overall_status":"RECRUITING","enrollment_count":1440,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT05656768","title":"Sleep and Circadian Contributions to Nighttime Blood Pressure","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1427,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT07386535","title":"Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention","phase":"NA","overall_status":"RECRUITING","enrollment_count":1412,"lead_sponsor_name":"Washington University School of Medicine","has_results":false},{"nct_id":"NCT07476703","title":"Expanded Studies on the SCAPIS Stockholm Reexamination Cohort","phase":"","overall_status":"RECRUITING","enrollment_count":1400,"lead_sponsor_name":"Danderyd Hospital","has_results":false},{"nct_id":"NCT04692636","title":"BP Variability on the Outcomes of Hemodialysis Vascular Access","phase":"","overall_status":"UNKNOWN","enrollment_count":1300,"lead_sponsor_name":"National Taiwan University Hospital Hsin-Chu Branch","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}