{"disease":{"id":"bladder-dysfunction","name":"bladder dysfunction"},"drugs":{"marketed":[{"drug_id":"mirabegron","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Myrbetriq","generic_name":"MIRABEGRON","company_name":"Apgdi","drug_phase":"marketed","molecular_target":"Beta-3 adrenergic receptor","drug_class":"beta3-Adrenergic Agonist [EPC]","quality_score":71,"revenue":"1800","mechanism":"Myrbetriq works by activating the beta-3 adrenergic receptor in the bladder muscle, leading to relaxation and improved bladder control."},{"drug_id":"trospium","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sanctura","generic_name":"TROSPIUM","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":63,"revenue":null,"mechanism":"Sanctura works by blocking the action of a chemical called acetylcholine at the M3 receptor in the bladder muscle, reducing muscle contractions and urgency."},{"drug_id":"vesicare","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Vesicare","company_name":"University of California, Irvine","drug_phase":"discontinued","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"butacaine","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Butyn","generic_name":"BUTACAINE","company_name":"","drug_phase":"marketed","molecular_target":"Sodium channel alpha subunits; brain (Types I, II, III)","drug_class":"butacaine","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"imidafenacin","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Uritos","generic_name":"IMIDAFENACIN","company_name":"","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"toviaz","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Toviaz","generic_name":"Fesoterodine Fumarate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M2","drug_class":"fesoterodine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"fesoterodine","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Toviaz","generic_name":"FESOTERODINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M2","drug_class":"fesoterodine","quality_score":44,"revenue":null,"mechanism":""},{"drug_id":"solifenacin","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vesicare","generic_name":"SOLIFENACIN","company_name":"Astellas Pharma","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":80,"revenue":null,"mechanism":"Vesicare works by blocking the action of a chemical called acetylcholine at the muscarinic receptors in the bladder muscle, reducing muscle contractions and urgency."},{"drug_id":"darifenacin","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Enablex","generic_name":"DARIFENACIN","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":80,"revenue":null,"mechanism":"Enablex works by blocking the action of a chemical called acetylcholine on the bladder muscle, which helps to relax the muscle and improve bladder control."},{"drug_id":"oxybutynin","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ditropan Xl","generic_name":"OXYBUTYNIN","company_name":"Hisamitsu Pharmaceutical Co., Inc.","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":75,"revenue":null,"mechanism":"Oxybutynin works by blocking the action of a chemical called acetylcholine on the bladder muscle, reducing spasms and urgency."},{"drug_id":"tolterodine","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Detrol","generic_name":"TOLTERODINE","company_name":"Upjohn","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Cholinergic Muscarinic Antagonist","quality_score":63,"revenue":null,"mechanism":"Detrol works by blocking the action of a chemical called acetylcholine at the muscarinic receptors in the bladder muscle."},{"drug_id":"oxytrol","indication_name":"Bladder muscle dysfunction - overactive","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Oxytrol","company_name":"Jewish General Hospital","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, 5-hydroxytryptamine receptor 2B, D(3) dopamine receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":12,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05652023","title":"Noninvasive Ultrasound Assessment of Detrusor Dysfunction","phase":"","overall_status":"RECRUITING","enrollment_count":2023,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT07357714","title":"Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT06333886","title":"Use of Point-of-care Neuro-sacral Electrophysiology Following Spinal Cord Injury","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":450,"lead_sponsor_name":"Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal","has_results":false},{"nct_id":"NCT05681936","title":"Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury","phase":"","overall_status":"RECRUITING","enrollment_count":225,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT03029676","title":"The Assessment of POCD After TURBT Under Spinal Anesthesia","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Medical University of Warsaw","has_results":false},{"nct_id":"NCT04579731","title":"Development of Fecal Scoring for the Management of Fecal Impaction With Regards to Lower Urinary Tract Dysfunction","phase":"","overall_status":"COMPLETED","enrollment_count":187,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT06729151","title":"Effect of Intradetrusor onabotulinumtoxinA Injection Versus Conservative Management on Female Sexual Function in Patients With Bladder Pain Syndrome","phase":"","overall_status":"RECRUITING","enrollment_count":159,"lead_sponsor_name":"Walter Reed National Military Medical Center","has_results":false},{"nct_id":"NCT04993859","title":"Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children","phase":"","overall_status":"RECRUITING","enrollment_count":152,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT06792851","title":"ECHO-012 Kosmos Bladder Clinical Validation Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":146,"lead_sponsor_name":"EchoNous Inc.","has_results":false},{"nct_id":"NCT05337813","title":"Effects of Low-intensity Excoporeal Shock Wave Therapy (LiESWT) on Women With Pelvic Floor Dysfunction","phase":"NA","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","has_results":false},{"nct_id":"NCT04835766","title":"Urodynamic Changes Following Bladder Injury","phase":"","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT07355803","title":"Define Final Selection Choice Criteria for a Coloplast Catheter Ensuring Highest Patient Satisfaction Via Surveys (EVA).","phase":"NA","overall_status":"RECRUITING","enrollment_count":107,"lead_sponsor_name":"Coloplast NV/SA","has_results":false},{"nct_id":"NCT04738539","title":"Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies","phase":"","overall_status":"UNKNOWN","enrollment_count":105,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT05318365","title":"Bladder and Bowel Dysfunction in Children","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT03570593","title":"Removal of Urinary Catheter After Radical Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":95,"lead_sponsor_name":"Barretos Cancer Hospital","has_results":false},{"nct_id":"NCT05313984","title":"OptiLUTS Part C: the Development of a Symptom Assessment Tool in Sacral Neuromodulation.","phase":"","overall_status":"COMPLETED","enrollment_count":93,"lead_sponsor_name":"University Hospital, Ghent","has_results":false},{"nct_id":"NCT06733194","title":"Complications of Bladder Augmentation in Children","phase":"","overall_status":"COMPLETED","enrollment_count":87,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT07070687","title":"Transcutaneous Electrical Nerve Stimulation in Nerve-Sparing Radical Hysterectomy: Effects on Bladder Management and Quality of Life in Cervical Cancer","phase":"NA","overall_status":"COMPLETED","enrollment_count":78,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT07084376","title":"RElax & feeL at EASE (RELEASE)","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":64,"lead_sponsor_name":"Stefania Musco","has_results":false},{"nct_id":"NCT05380856","title":"Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT02910596","title":"Effectiveness of Bethanechol Chloride and Early Bladder Training for Prevention of Bladder Dysfunction After Radical Hysterectomy in Cervical Cancer Stage IB - IIA","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"Department of Medical Services Ministry of Public Health of Thailand","has_results":false},{"nct_id":"NCT05351138","title":"Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy","phase":"NA","overall_status":"COMPLETED","enrollment_count":54,"lead_sponsor_name":"Bahçeşehir University","has_results":false},{"nct_id":"NCT05013541","title":"Effect of Bladder Filling on Rectal Contractions During Cystometry","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Gérard Amarenco","has_results":false},{"nct_id":"NCT04490642","title":"Linguistic Validation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for 5-12 Years Old in Korean","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT04703413","title":"User Satisfaction When Catheterizing With Hydrophilic Urinary Catheters From a More Sustainable Manufacturing Process.","phase":"NA","overall_status":"TERMINATED","enrollment_count":50,"lead_sponsor_name":"Wellspect HealthCare","has_results":false},{"nct_id":"NCT05182671","title":"Relationship Between Pelvic Angle, Femoral Anteversion, and Hip Muscle Strength Ratios in Bladder-bowel Dysfunction","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Halil Tugtepe","has_results":false},{"nct_id":"NCT04635709","title":"Effect of Behavioral Therapy Versus Interferential Current on Bladder Dysfunction in Patients With Multiple Sclerosis","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Taibah University","has_results":false},{"nct_id":"NCT05861011","title":"Bladder Neck Surgery in Children With Neurogenic Bladder","phase":"","overall_status":"COMPLETED","enrollment_count":48,"lead_sponsor_name":"University of Lorraine","has_results":false},{"nct_id":"NCT04315142","title":"Bladder and TranscUtaneous Tibial Nerve Stimulation for nEurogenic Lower Urinary Tract Dysfunction","phase":"NA","overall_status":"TERMINATED","enrollment_count":48,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT06734390","title":"Bladder Neck Surgery in Children with Neurogenic Bladder","phase":"","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT05613153","title":"Peppermint Oil as a Treatment for Children With Bladder and Bowel Dysfunction","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":30,"lead_sponsor_name":"Children's Hospital of Orange County","has_results":false},{"nct_id":"NCT03987126","title":"Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","has_results":false},{"nct_id":"NCT04057222","title":"Effect of Need to Void on Rectal Sensory Function in Multiple Sclerosis","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Gérard Amarenco","has_results":false},{"nct_id":"NCT03213522","title":"Comparison of Craniosacral Therapy vs Pelvic Floor Physical Therapy","phase":"NA","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"CentraState Medical Center","has_results":false},{"nct_id":"NCT05779709","title":"Reformer Pilates Exerises in Bladder and Bowel Dysfunction","phase":"NA","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Hasan Kalyoncu University","has_results":false},{"nct_id":"NCT07019597","title":"NESA Neuromodulation Versus Transcutaneous Posterior Tibial Stimulation","phase":"NA","overall_status":"RECRUITING","enrollment_count":25,"lead_sponsor_name":"Daniel David Álamo Arce","has_results":false},{"nct_id":"NCT04528784","title":"Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":23,"lead_sponsor_name":"University of Limerick","has_results":false},{"nct_id":"NCT03472599","title":"Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia","phase":"NA","overall_status":"COMPLETED","enrollment_count":17,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT05858840","title":"Urinary Artificial Sphincter in Children","phase":"","overall_status":"COMPLETED","enrollment_count":17,"lead_sponsor_name":"University of Lorraine","has_results":false},{"nct_id":"NCT05312138","title":"Multiple Sclerosis and Overactive Bladder Treatment","phase":"NA","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"Istanbul Medipol University Hospital","has_results":false},{"nct_id":"NCT06734429","title":"Urinary Artificial Sphincter in Children","phase":"","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT03574610","title":"Brain Targets in Patients With Bladder Emptying Difficulties","phase":"NA","overall_status":"COMPLETED","enrollment_count":11,"lead_sponsor_name":"The Methodist Hospital Research Institute","has_results":true},{"nct_id":"NCT07511244","title":"SCS Therapy for Patients With Bladder and Bowel Dysfunction After SCI","phase":"NA","overall_status":"RECRUITING","enrollment_count":10,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT06472193","title":"The Utility of Shanfield Implantation Technique During Creation of Mitrofanoff Procedure in Pediatric Age Group","phase":"NA","overall_status":"RECRUITING","enrollment_count":10,"lead_sponsor_name":"Sohag University","has_results":false},{"nct_id":"NCT05502614","title":"Dorsal Genital Nerve Stimulation for Bladder Management After SCI","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":10,"lead_sponsor_name":"University College, London","has_results":false},{"nct_id":"NCT03202251","title":"Deep Brain Stimulation in Patients With LUTS","phase":"","overall_status":"COMPLETED","enrollment_count":6,"lead_sponsor_name":"The Methodist Hospital Research Institute","has_results":false},{"nct_id":"NCT05462561","title":"Vascularized Composite Bladder Allograft Transplantation","phase":"NA","overall_status":"RECRUITING","enrollment_count":5,"lead_sponsor_name":"University of Southern California","has_results":false},{"nct_id":"NCT00713921","title":"Neuropathic Investigation and Anticholinergic Treatment of Bladder Dysfunction in Diabetes and Stroke Patients","phase":"EARLY_PHASE1","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Saint Thomas Health","has_results":false},{"nct_id":"NCT05968352","title":"Restoration of Bladder Function in Spinal Cord Injury","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"University of Oxford","has_results":false}],"total":49},"guidelines":[],"source":"Drug Landscape verified database"}