{"disease":{"id":"birth","name":"birth"},"drugs":{"marketed":[{"drug_id":"rsvpref-vaccine","indication_name":"Prevention of severe lower respiratory tract disease caused by respiratory syncytial virus (RSV) in young children with a history of premature birth or bronchopulmonary dysplasia.","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"RSVpreF Vaccine","generic_name":"rsvpref-vaccine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"RSV","drug_class":"vaccine","quality_score":22,"revenue":null,"mechanism":""},{"drug_id":"fragmin","indication_name":"Treatment of symptomatic venous thromboembolism to reduce recurrence in pediatric patients from birth (gestational age at least 35 weeks)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fragmin","generic_name":"Dalteparin Sodium","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Factor Xa and thrombin","drug_class":"Low molecular weight heparin (LMWH)","quality_score":68,"revenue":null,"mechanism":"Dalteparin enhances inhibition of Factor Xa and thrombin by antithrombin."}],"pipeline":[{"drug_id":"obe001","indication_name":"Preterm labor (delay of preterm birth)","indication_type":"pipeline","phase":"Phase 2","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"OBE001","company_name":"ObsEva SA","drug_phase":"discontinued","molecular_target":"Oxytocin receptor (OXTR)","drug_class":"Oxytocin receptor antagonist; Tocolytic agent","quality_score":null,"revenue":null,"mechanism":"OBE001 is an oxytocin receptor antagonist that inhibits uterine contractions by blocking oxytocin signaling in myometrial smooth muscle."}],"offLabel":[],"totalMarketed":2,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT06406998","title":"Maternal and Offspring Outcomes in Pregnant Women With Pre-existing ASCVD","phase":"","overall_status":"RECRUITING","enrollment_count":5461222,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT01777022","title":"Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial.","phase":"NA","overall_status":"COMPLETED","enrollment_count":430830,"lead_sponsor_name":"University of Edinburgh","has_results":false},{"nct_id":"NCT06420453","title":"How Long Can Labor Last? Person Centred Care During Labor to Increase Safety for Women and Newborn","phase":"","overall_status":"COMPLETED","enrollment_count":300000,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT05810545","title":"Drinking Water PFAS, Pregnancy Outcome and Maternal Morbidity","phase":"","overall_status":"COMPLETED","enrollment_count":256659,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT06284044","title":"Facilitating Safe Transition to Home for Preterm Infants - a National Database Study","phase":"","overall_status":"COMPLETED","enrollment_count":250000,"lead_sponsor_name":"University Hospitals of Derby and Burton NHS Foundation Trust","has_results":false},{"nct_id":"NCT03330301","title":"D-tecting Disease - From Exposure to Vitamin D During Critical Periods of Life","phase":"","overall_status":"COMPLETED","enrollment_count":222776,"lead_sponsor_name":"Bispebjerg Hospital","has_results":false},{"nct_id":"NCT06048276","title":"Miscarriage Preventing Herbal Medicines and the Risk of Birth Defects: a Population-based Cohort Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":200000,"lead_sponsor_name":"West China Hospital","has_results":false},{"nct_id":"NCT06340971","title":"Air Pollution and Pregnancy","phase":"","overall_status":"RECRUITING","enrollment_count":200000,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT04360564","title":"RPL: Interval to Live Birth and Adverse Perinatal Outcomes","phase":"","overall_status":"UNKNOWN","enrollment_count":140000,"lead_sponsor_name":"Children's & Women's Health Centre of British Columbia","has_results":false},{"nct_id":"NCT03112018","title":"Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda","phase":"NA","overall_status":"COMPLETED","enrollment_count":102988,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT06028555","title":"International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study","phase":"","overall_status":"RECRUITING","enrollment_count":101000,"lead_sponsor_name":"Center for Epidemiology and Health Research, Germany","has_results":false},{"nct_id":"NCT06461429","title":"PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol]","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"University of Melbourne","has_results":false},{"nct_id":"NCT07531134","title":"The Impact of Extreme Environmental and Security Conditions on Prematurity and Low Birth Weight Rates","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Hillel Yaffe Medical Center","has_results":false},{"nct_id":"NCT05013944","title":"AnovaOS Network Powered Patient Registry","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Anova Enterprises, Inc","has_results":false},{"nct_id":"NCT04182503","title":"Environmental Factors and Embryonic Development Project","phase":"","overall_status":"UNKNOWN","enrollment_count":100000,"lead_sponsor_name":"Jinling Hospital, China","has_results":false},{"nct_id":"NCT07514377","title":"JiGenerations Health Cohort Study：Parental Exposure and Intergenerational Health in China","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"National Research Institute for Family Planning, China","has_results":false},{"nct_id":"NCT03909737","title":"Oral Azithromycin to Prevent Stillbirths and Infant Mortality in Mali","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":99700,"lead_sponsor_name":"University of Maryland, Baltimore","has_results":false},{"nct_id":"NCT02986802","title":"Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes","phase":"","overall_status":"COMPLETED","enrollment_count":89132,"lead_sponsor_name":"Kaiser Permanente","has_results":true},{"nct_id":"NCT00063063","title":"Generic Database of Very Low Birth Weight Infants","phase":"","overall_status":"RECRUITING","enrollment_count":80000,"lead_sponsor_name":"NICHD Neonatal Research Network","has_results":false},{"nct_id":"NCT00009633","title":"Follow-up Visit of High Risk Infants","phase":"","overall_status":"RECRUITING","enrollment_count":68000,"lead_sponsor_name":"NICHD Neonatal Research Network","has_results":false},{"nct_id":"NCT04685668","title":"The PartoMa Project: Enabling Best Post Possible Childbirth Care in Tanzania.","phase":"NA","overall_status":"COMPLETED","enrollment_count":65181,"lead_sponsor_name":"University of Copenhagen","has_results":false},{"nct_id":"NCT05484804","title":"Accountability for Care Through Undoing Racism & Equity for Moms","phase":"NA","overall_status":"RECRUITING","enrollment_count":60000,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":false},{"nct_id":"NCT06126302","title":"Analyzing the Changes in Eye Axis Length and Corneal Curvature in Central China","phase":"","overall_status":"UNKNOWN","enrollment_count":60000,"lead_sponsor_name":"Min Ke","has_results":false},{"nct_id":"NCT03662178","title":"Investigating the Structured Use of Ultrasound Scanning for Fetal Growth","phase":"","overall_status":"RECRUITING","enrollment_count":56000,"lead_sponsor_name":"Oxford University Hospitals NHS Trust","has_results":false},{"nct_id":"NCT05087160","title":"Socioeconomic Inequalities Exacerbated by Mitigation Measures to COVID-19 and Differences in Prematurity Prevalence","phase":"","overall_status":"COMPLETED","enrollment_count":37323,"lead_sponsor_name":"Universidad de la Republica","has_results":false},{"nct_id":"NCT04090762","title":"Improving Perinatal Outcomes Using Conditional and Targeted Transfers","phase":"NA","overall_status":"COMPLETED","enrollment_count":36607,"lead_sponsor_name":"RAND","has_results":false},{"nct_id":"NCT00339235","title":"Establishment of a Perinatal Database and a Bank of Biological Materials","phase":"","overall_status":"COMPLETED","enrollment_count":30570,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT03154177","title":"Group Antenatal/Postnatal Care in Rwanda","phase":"NA","overall_status":"COMPLETED","enrollment_count":26381,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT06653374","title":"Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns","phase":"","overall_status":"COMPLETED","enrollment_count":26000,"lead_sponsor_name":"HOSPITAL GINECO OBSTETRICO ISIDRO AYORA","has_results":false},{"nct_id":"NCT05708183","title":"Healthy Mums, Healthy Babies: Multiple Micronutrient Supplementation in Ethiopia","phase":"","overall_status":"RECRUITING","enrollment_count":25620,"lead_sponsor_name":"London School of Hygiene and Tropical Medicine","has_results":false},{"nct_id":"NCT03799861","title":"Newborn Heart Rate as a Catalyst for Improved Survival","phase":"","overall_status":"COMPLETED","enrollment_count":24034,"lead_sponsor_name":"American Academy of Pediatrics","has_results":false},{"nct_id":"NCT03220750","title":"University Hospital Advanced Age Pregnant Cohort","phase":"","overall_status":"UNKNOWN","enrollment_count":22000,"lead_sponsor_name":"Peking University","has_results":false},{"nct_id":"NCT00340249","title":"Use of the Perinatal Database and Biologic Tissue Bank at The Perinatology Research Branch (PRB)","phase":"","overall_status":"COMPLETED","enrollment_count":20964,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT00340899","title":"Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study","phase":"","overall_status":"COMPLETED","enrollment_count":19134,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT05131282","title":"Maternal Serum Markers Predicting Preeclampsia At Early Gestations","phase":"","overall_status":"COMPLETED","enrollment_count":18000,"lead_sponsor_name":"HBI Solutions Inc.","has_results":false},{"nct_id":"NCT06664554","title":"Predictive Value of Maternal Blood Protein Signatures in Preterm Birth","phase":"","overall_status":"COMPLETED","enrollment_count":18000,"lead_sponsor_name":"HBI Solutions Inc.","has_results":false},{"nct_id":"NCT05502510","title":"Assessing the Effectiveness and Efficacy of the MyHealthyPregnancy Application","phase":"","overall_status":"COMPLETED","enrollment_count":12344,"lead_sponsor_name":"Naima Health LLC","has_results":false},{"nct_id":"NCT04102644","title":"Limiting Adverse Birth Outcomes in Resource-Limited Settings","phase":"","overall_status":"COMPLETED","enrollment_count":12020,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":false},{"nct_id":"NCT02409680","title":"Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)","phase":"NA","overall_status":"COMPLETED","enrollment_count":11976,"lead_sponsor_name":"NICHD Global Network for Women's and Children's Health","has_results":true},{"nct_id":"NCT02907242","title":"Revealed Versus Concealed Cerebroplacental Ratio","phase":"NA","overall_status":"COMPLETED","enrollment_count":11582,"lead_sponsor_name":"Hospital Clinic of Barcelona","has_results":false},{"nct_id":"NCT03923023","title":"Impact of the PREEMI Package on Neonatal Mortality","phase":"","overall_status":"COMPLETED","enrollment_count":11195,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT02333227","title":"Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi","phase":"NA","overall_status":"COMPLETED","enrollment_count":10069,"lead_sponsor_name":"Baylor College of Medicine","has_results":true},{"nct_id":"NCT06074601","title":"MIRACLE of LIFE Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Mirvie","has_results":false},{"nct_id":"NCT03223363","title":"A New Birth Weight Prediction in Chinese Population","phase":"NA","overall_status":"UNKNOWN","enrollment_count":10000,"lead_sponsor_name":"Nanfang Hospital, Southern Medical University","has_results":false},{"nct_id":"NCT04847336","title":"Improving MAternal Newborn carE In the in the WHO European Region During COVID-19 Pandemic","phase":"","overall_status":"UNKNOWN","enrollment_count":10000,"lead_sponsor_name":"WHO Collaborating Centre for Maternal and Child Health, Trieste","has_results":false},{"nct_id":"NCT03921177","title":"Micronutrient Supplementation Before and During 1st Pregnancy to Improve Birth Outcomes (JiVitA-5)","phase":"NA","overall_status":"TERMINATED","enrollment_count":9859,"lead_sponsor_name":"Johns Hopkins Bloomberg School of Public Health","has_results":false},{"nct_id":"NCT03099837","title":"Tongji Maternal and Child Health Cohort","phase":"","overall_status":"UNKNOWN","enrollment_count":8649,"lead_sponsor_name":"Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT05073978","title":"B-vitamin Levels and Adverse Pregnancy Outcomes","phase":"","overall_status":"COMPLETED","enrollment_count":7500,"lead_sponsor_name":"Westlake University","has_results":false},{"nct_id":"NCT00342277","title":"Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human Parturition","phase":"","overall_status":"COMPLETED","enrollment_count":6838,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT06125860","title":"BEP Targeting Strategies in Ethiopia","phase":"NA","overall_status":"RECRUITING","enrollment_count":6750,"lead_sponsor_name":"Harvard School of Public Health (HSPH)","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}