{"disease":{"id":"biliary-infection","name":"biliary infection"},"drugs":{"marketed":[{"drug_id":"fusidic-acid","indication_name":"Pseudomonas Aeruginosa Biliary Tract Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ramycin","generic_name":"FUSIDIC ACID","company_name":"","drug_phase":"phase_3","molecular_target":"Bile salt export pump","drug_class":"fusidic acid","quality_score":47,"revenue":null,"mechanism":"Fusidic acid works by inhibiting the function of the bacterial ribosome, preventing the production of essential proteins."},{"drug_id":"gentamicin","indication_name":"Pseudomonas Aeruginosa Biliary Tract Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Garamycin","generic_name":"GENTAMICIN","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Transient receptor potential cation channel subfamily V member 5","drug_class":"Aminoglycoside Antibacterial","quality_score":55,"revenue":null,"mechanism":""},{"drug_id":"gentamicin-sulfate","indication_name":"Pseudomonas Aeruginosa Biliary Tract Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Gentamicin","generic_name":"Gentamicin Sulfate","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Dihydrofolate reductase","drug_class":"gentamicin","quality_score":55,"revenue":null,"mechanism":""},{"drug_id":"amikacin","indication_name":"Pseudomonas Aeruginosa Biliary Tract Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Arikayce Kit","generic_name":"AMIKACIN","company_name":"Bristol-Myers Squibb","drug_phase":"marketed","molecular_target":"","drug_class":"Aminoglycoside Antibacterial","quality_score":10,"revenue":null,"mechanism":"Amikacin works by binding to bacterial ribosomes, inhibiting protein synthesis and ultimately killing the bacteria."}],"pipeline":[],"offLabel":[],"totalMarketed":4,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06314399","title":"Predictive Factors Associated to Bile Cultures and Antibiogram Resistance in Patients with Laparoscopic Cholecystectomy","phase":"","overall_status":"COMPLETED","enrollment_count":703,"lead_sponsor_name":"Hospital Universitario Mayor Méderi","has_results":false},{"nct_id":"NCT05581017","title":"Association of Cephalosporin Resistance and Surgical Site Infections in Patients Undergoing Pancreaticoduodenectomy","phase":"","overall_status":"COMPLETED","enrollment_count":376,"lead_sponsor_name":"Helsinki University Central Hospital","has_results":false},{"nct_id":"NCT07407491","title":"Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":172,"lead_sponsor_name":"National University of Malaysia","has_results":false},{"nct_id":"NCT06960486","title":"Ultrasound-guided Biliary Drainage Improving Prognosis in the Frail and High Risk Elderly Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Hebei Medical University","has_results":false},{"nct_id":"NCT04620577","title":"The Influence of Antibiotics on the Incidence of Biliary Tract Infections After PTCD for Malignant Obstructive Jaundice","phase":"","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"Xian-Jun Yu","has_results":false},{"nct_id":"NCT06141395","title":"NGS-Based Assay of Blood Samples of Sepsis Patients for Rapid Bacterial Identification","phase":"","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Hellenic Institute for the Study of Sepsis","has_results":false},{"nct_id":"NCT05481398","title":"A Randomized Controlled Trial Evaluating the Role of Negative Pressure Wound Therapy (NPWT) for Incisional Surgical Site Infections in Patients Undergoing Hepatopancreatobiliary Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"Murk Niaz","has_results":false}],"total":7},"guidelines":[],"source":"Drug Landscape verified database"}