{"disease":{"id":"arthroplasty","name":"arthroplasty"},"drugs":{"marketed":[{"drug_id":"cefonicid","indication_name":"Prosthetic Arthroplasty Infection Prevention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Monocid","generic_name":"CEFONICID","company_name":"","drug_phase":"marketed","molecular_target":"Matrix metalloproteinase-9","drug_class":"cefonicid","quality_score":30,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05197660","title":"Routine Surgical Procedures During COVID-19 Pandemic: a French Nationwide Cohort Study","phase":"","overall_status":"COMPLETED","enrollment_count":2000000,"lead_sponsor_name":"EPI-PHARE","has_results":false},{"nct_id":"NCT06583382","title":"Cementation of Cup and the Risk of Second Revision","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":60000,"lead_sponsor_name":"Bispebjerg Hospital","has_results":false},{"nct_id":"NCT07067060","title":"Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":40000,"lead_sponsor_name":"Copenhagen University Hospital, Hvidovre","has_results":false},{"nct_id":"NCT05530551","title":"Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Soren Overgaard","has_results":false},{"nct_id":"NCT03973320","title":"Outcomes After Hypotensive Neuraxial Anesthesia in Total Hip Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":11292,"lead_sponsor_name":"Hospital for Special Surgery, New York","has_results":true},{"nct_id":"NCT05788757","title":"Optetrak Knee System Post Market Clinical Follow-Up","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":4588,"lead_sponsor_name":"Exactech","has_results":false},{"nct_id":"NCT05044767","title":"Study to Evaluate the Performance and Safety of ATF Implants and Lapé Médical Devices Implanted During Hip Arthroplasty","phase":"","overall_status":"RECRUITING","enrollment_count":4500,"lead_sponsor_name":"ATF Implants","has_results":false},{"nct_id":"NCT03790267","title":"Functional Outcomes and Quality of Life in Hip, Knee and Shoulder Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":4260,"lead_sponsor_name":"Istituto Ortopedico Rizzoli","has_results":false},{"nct_id":"NCT07132723","title":"Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":3700,"lead_sponsor_name":"Nordsjaellands Hospital","has_results":false},{"nct_id":"NCT03570944","title":"Postoperative Outcomes Within an Enhanced Recovery After Surgery Protocol (POWER2)","phase":"","overall_status":"UNKNOWN","enrollment_count":3012,"lead_sponsor_name":"Grupo Español de Rehabilitación Multimodal","has_results":false},{"nct_id":"NCT05849961","title":"Exactech Hip Systems Post-Market Clinical Follow-up (PMCF)","phase":"","overall_status":"RECRUITING","enrollment_count":2946,"lead_sponsor_name":"Exactech","has_results":false},{"nct_id":"NCT05530174","title":"Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Soren Overgaard","has_results":false},{"nct_id":"NCT03292003","title":"Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study","phase":"","overall_status":"COMPLETED","enrollment_count":1694,"lead_sponsor_name":"Smith & Nephew, Inc.","has_results":false},{"nct_id":"NCT03132831","title":"Influence of the Operative Day on the Average Duration of Stay in Primary Hip and Knee Replacements","phase":"","overall_status":"COMPLETED","enrollment_count":1663,"lead_sponsor_name":"Centre Hospitalier Universitaire, Amiens","has_results":false},{"nct_id":"NCT04976400","title":"Men and Women With Different Designs and Semi-individual Total Knee Replacement","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1600,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT07070570","title":"HAKA: Routine Follow-up at 10 Years After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthcare?","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Reinier Haga Orthopedisch Centrum","has_results":false},{"nct_id":"NCT05399186","title":"Arthroplasty and Modifiable Risk Factors","phase":"NA","overall_status":"COMPLETED","enrollment_count":1484,"lead_sponsor_name":"Landspitali University Hospital","has_results":false},{"nct_id":"NCT03132077","title":"Analysis of Patient Outcome Questionnaire Following Primary Knee Replacement","phase":"","overall_status":"COMPLETED","enrollment_count":1301,"lead_sponsor_name":"University of Salford","has_results":false},{"nct_id":"NCT06563531","title":"Are Elastic Restraints Still Necessary in Improved Rehabilitation Programs After Hip and Knee Prosthetic Surgery?","phase":"NA","overall_status":"RECRUITING","enrollment_count":1274,"lead_sponsor_name":"Clinique Pasteur Lanroze","has_results":false},{"nct_id":"NCT07212699","title":"Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App","phase":"NA","overall_status":"RECRUITING","enrollment_count":1250,"lead_sponsor_name":"Technical University of Munich","has_results":false},{"nct_id":"NCT03891524","title":"A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":1242,"lead_sponsor_name":"Janssen Research & Development, LLC","has_results":true},{"nct_id":"NCT03411083","title":"Silkeborg Knee Replacement Cohort Study","phase":"","overall_status":"COMPLETED","enrollment_count":1225,"lead_sponsor_name":"Central Jutland Regional Hospital","has_results":false},{"nct_id":"NCT04592302","title":"The Impact of Smoking on Outcomes and Complications in Total Joint Arthroplasty: A Prospective Crossover Study","phase":"","overall_status":"UNKNOWN","enrollment_count":1200,"lead_sponsor_name":"Rothman Institute Orthopaedics","has_results":false},{"nct_id":"NCT01422304","title":"Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1198,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT04031820","title":"Dual-mobility Cups Compared to Unipolar Cups on Dislocation and Cost-effectiveness After Primary Total Hip Arthroplasty.","phase":"NA","overall_status":"RECRUITING","enrollment_count":1100,"lead_sponsor_name":"JointResearch","has_results":false},{"nct_id":"NCT04837053","title":"Implementation of Indication Criteria for Total Knee Replacement in Osteoarthritis (Value-based TKR)","phase":"NA","overall_status":"COMPLETED","enrollment_count":1092,"lead_sponsor_name":"Technische Universität Dresden","has_results":false},{"nct_id":"NCT03690037","title":"Investigating the Effect of Intravenous and Oral Tranexamic Acid on Blood Loss After Primary Hip and Knee Arthroplasty","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1089,"lead_sponsor_name":"Belfast Health and Social Care Trust","has_results":false},{"nct_id":"NCT06971757","title":"HAKA: Routine Follow-Up at 1 Year After Hip- or Knee Arthroplasty: Wasting Resources or Appropriate Healthcare?","phase":"NA","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"JointResearch","has_results":false},{"nct_id":"NCT05653102","title":"A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Exactech","has_results":false},{"nct_id":"NCT06296108","title":"Risk Factors for Acute Kidney Injury in Patients Undergoing Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":911,"lead_sponsor_name":"Ankara University","has_results":false},{"nct_id":"NCT06984315","title":"Effects of Anesthesia Type on Inflammatory Response","phase":"","overall_status":"COMPLETED","enrollment_count":849,"lead_sponsor_name":"Tokat Gaziosmanpasa University","has_results":false},{"nct_id":"NCT03276143","title":"FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthroplasty","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":813,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT06124170","title":"Improved Pain Management in Knee Osteoarthritis-related Surgeries","phase":"","overall_status":"COMPLETED","enrollment_count":714,"lead_sponsor_name":"Peng Liu","has_results":false},{"nct_id":"NCT06203756","title":"Patient Outcomes With Robotic-Assisted Total Knee Arthroplasty","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":713,"lead_sponsor_name":"Corin","has_results":false},{"nct_id":"NCT05867264","title":"Effect of Early Postoperative Oral Carbohydrate on Postoperative Recovery of the Unilateral Knee Arthroplasty","phase":"EARLY_PHASE1","overall_status":"UNKNOWN","enrollment_count":672,"lead_sponsor_name":"Hongwei Shi","has_results":false},{"nct_id":"NCT05046600","title":"Registry of Arthrex Hand and Wrist Products","phase":"","overall_status":"RECRUITING","enrollment_count":650,"lead_sponsor_name":"Arthrex, Inc.","has_results":false},{"nct_id":"NCT03517098","title":"Enhanced Recovery After Surgery (ERAS) Pathway for Primary Hip and Knee Arthroplasty","phase":"NA","overall_status":"COMPLETED","enrollment_count":640,"lead_sponsor_name":"West China Hospital","has_results":false},{"nct_id":"NCT03549962","title":"Preoperative Nutritional Status in Patients Undergoing Elective Total Knee Arthroplasty and In-hospital Postoperative Complications","phase":"","overall_status":"COMPLETED","enrollment_count":626,"lead_sponsor_name":"Chinese University of Hong Kong","has_results":false},{"nct_id":"NCT04867772","title":"Community Based Rehabilitation After Knee Arthroplasty","phase":"NA","overall_status":"COMPLETED","enrollment_count":621,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT03984942","title":"Bypass PACU in Knee and Hip Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"Niklas Ingemann Nielsen","has_results":false},{"nct_id":"NCT03826108","title":"ARTHR-IS (Arthroplasties' Infections Due to Staphylococcus Aureus)","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","has_results":false},{"nct_id":"NCT06467721","title":"Clinical Efficacy of Self-adhesive Silicone Gel Waterproof Dressings Versus Conventional Dressings in the Healing of Incisions After Total Joint Arthroplasty","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":600,"lead_sponsor_name":"First Affiliated Hospital of Xinjiang Medical University","has_results":false},{"nct_id":"NCT03306810","title":"Recognition and Treatment of Dysglycemia. AGS - Acute Glucose Service","phase":"NA","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Joint Authority for Päijät-Häme Social and Health Care","has_results":false},{"nct_id":"NCT00288899","title":"Benefits of 'Repeat Back' Protocols Within A Computer-Based Informed Consent Program","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":575,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT04438226","title":"Surgical Approach of Hemiarthroplasty After Femoral Neck Fracture: Posterolateral or Direct Lateral","phase":"NA","overall_status":"COMPLETED","enrollment_count":555,"lead_sponsor_name":"JointResearch","has_results":false},{"nct_id":"NCT04772625","title":"Failure Analysis of Patellofemoral Arthroplasty","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":550,"lead_sponsor_name":"Anders Odgaard","has_results":false},{"nct_id":"NCT05186168","title":"Corin MiniHip and Trinity Cup Clinical Surveillance Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":546,"lead_sponsor_name":"Corin","has_results":false},{"nct_id":"NCT05014932","title":"Evaluation of Noise Induced by Ceramic-ceramic Friction Torques of Total Hip Prostheses With Customized Femoral Stem","phase":"","overall_status":"COMPLETED","enrollment_count":531,"lead_sponsor_name":"GCS Ramsay Santé pour l'Enseignement et la Recherche","has_results":false},{"nct_id":"NCT07163598","title":"PNB Anesthesia Improves Older Patients' Postoperative Early Recovery Outcomes After Total Hip Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":516,"lead_sponsor_name":"RenJi Hospital","has_results":false},{"nct_id":"NCT06052982","title":"Evaluation of Blood Loss During Knee Arthroplasty","phase":"NA","overall_status":"COMPLETED","enrollment_count":510,"lead_sponsor_name":"Groupe Hospitalier Diaconesses Croix Saint-Simon","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}