{"disease":{"id":"aortic-valve-disease","name":"aortic valve disease"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05912660","title":"Health Status of Patients After Surgically Implanted Biological and TAVI: a Population-based Retrospective Analysis","phase":"","overall_status":"COMPLETED","enrollment_count":18882,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT04900909","title":"Health Status of Patients After Surgically Implanted Biological and Mechanical Aortic Valves: a Population-based Retrospective Analysis (2010-2018)","phase":"","overall_status":"COMPLETED","enrollment_count":13993,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT07267117","title":"Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT05439863","title":"TAVR for Aortic Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT04086836","title":"Swedish Study on STroke After TAVR","phase":"","overall_status":"COMPLETED","enrollment_count":4600,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT06257043","title":"Safety and Efficacy of Post-marketing Transcatheter Aortic Valves in \"Real World\" Chinese Patients","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT03440697","title":"Pathogenetic Basis of Aortopathy and Aortic Valve Disease","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT04231461","title":"Quality of Life After Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":2925,"lead_sponsor_name":"Papworth Hospital NHS Foundation Trust","has_results":false},{"nct_id":"NCT04464655","title":"A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease","phase":"","overall_status":"RECRUITING","enrollment_count":2130,"lead_sponsor_name":"McGill University Health Centre/Research Institute of the McGill University Health Centre","has_results":false},{"nct_id":"NCT05895487","title":"Study on Efficacy, Safety and Durability of the UniLine Prosthesis in the Treatment of Aortic and Mitral Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Closed Joint-Stock Company NeoCor","has_results":false},{"nct_id":"NCT06069232","title":"Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT05998694","title":"Post-market Clinical Monitoring of the Safety and Efficacy of the Aortic Valve Bioprothesis","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Closed Joint-Stock Company NeoCor","has_results":false},{"nct_id":"NCT06789211","title":"Outcomes in Moderate Mixed Aortic Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":1900,"lead_sponsor_name":"Leiden University Medical Center","has_results":false},{"nct_id":"NCT04503655","title":"Multicenter Study Evaluating the Efficacy of an Intervention Aimed At Reducing the Length of Stay After Transfemoral Transcatheter Aortic Valve Implantation","phase":"NA","overall_status":"COMPLETED","enrollment_count":1842,"lead_sponsor_name":"University Hospital, Rouen","has_results":false},{"nct_id":"NCT06235385","title":"European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study","phase":"","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07476703","title":"Expanded Studies on the SCAPIS Stockholm Reexamination Cohort","phase":"","overall_status":"RECRUITING","enrollment_count":1400,"lead_sponsor_name":"Danderyd Hospital","has_results":false},{"nct_id":"NCT04258488","title":"Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":1300,"lead_sponsor_name":"Joon Bum Kim","has_results":false},{"nct_id":"NCT07413965","title":"TAVR vs SAVR in Severe Bicuspid Aortic Stenosis","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Cedars-Sinai Medical Center","has_results":false},{"nct_id":"NCT04491513","title":"Detection of Proximal Coronary Artery Disease in the Work-up for Transcatheter Aortic Valve Implantation Using CTA (From the DEPICT CTA Database)","phase":"","overall_status":"COMPLETED","enrollment_count":1060,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT03444259","title":"Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1001,"lead_sponsor_name":"University of Turku","has_results":false},{"nct_id":"NCT06420895","title":"Health Data Warehouse on Aortic Insufficiency","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Lille Catholic University","has_results":false},{"nct_id":"NCT04149600","title":"Identification of Genetic Causes of Calcific Aortic Valve Disease","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT05627973","title":"Health Status of < 50 Year Old Patients After Surgically Implanted Biological and Mechanical Aortic Valves: a Population-based Retrospective Analysis (2010-2020)","phase":"","overall_status":"COMPLETED","enrollment_count":991,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT06215378","title":"Antagonization of Heparin With Protamine Sulfate After TAVI","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":940,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT02673697","title":"Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement","phase":"NA","overall_status":"TERMINATED","enrollment_count":914,"lead_sponsor_name":"Corcym S.r.l","has_results":true},{"nct_id":"NCT03453567","title":"Evaluation of Effectiveness and Safety of Aortic Valve Replacement in Routine Clinical Practice","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":900,"lead_sponsor_name":"Seung-Jung Park","has_results":false},{"nct_id":"NCT07462624","title":"REpeat Intervention For Failed Surgical BioProsthEtic AorTic Valves (REPEAT)","phase":"NA","overall_status":"RECRUITING","enrollment_count":890,"lead_sponsor_name":"Heart Center Leipzig - University Hospital","has_results":false},{"nct_id":"NCT04142658","title":"PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":863,"lead_sponsor_name":"Artivion Inc.","has_results":true},{"nct_id":"NCT04437303","title":"Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":858,"lead_sponsor_name":"St. Antonius Hospital","has_results":false},{"nct_id":"NCT06697249","title":"Feasibility of Valve-in-Root Transcatheter Aortic Valve Implantation in 363 Patients After Aortic Root Replacement and Repair","phase":"","overall_status":"COMPLETED","enrollment_count":760,"lead_sponsor_name":"Alicja Zientara","has_results":false},{"nct_id":"NCT07107568","title":"Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":700,"lead_sponsor_name":"Medical University Innsbruck","has_results":false},{"nct_id":"NCT04647864","title":"The Coronary AccEss After Tavi Registry - A Multicenter Prospective Registry for the Coronary Access After TAVI","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"University of Padova","has_results":false},{"nct_id":"NCT05758909","title":"Evaluation of the Viability and Safety of Early Discharge Protocol After TAVI Implantation","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":585,"lead_sponsor_name":"Fundación EPIC","has_results":false},{"nct_id":"NCT05143177","title":"A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease With Mild to Moderate Aortic Stenosis (EVOID-AS)","phase":"PHASE2, PHASE3","overall_status":"SUSPENDED","enrollment_count":580,"lead_sponsor_name":"REDNVIA Co., Ltd.","has_results":false},{"nct_id":"NCT07129421","title":"Evaluation of Safety and Effectiveness of the EMBLOK EPS Compared With No Cerebral Embolic Protection During TAVR","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":560,"lead_sponsor_name":"Emblok, Inc.","has_results":false},{"nct_id":"NCT06559332","title":"Coronary Artery Disease Assessment Strategies in TAVI Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":546,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT05044377","title":"Study on Optimal Treatment Strategy for Elderly Patients With High-risk Complex Aortic Valve Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":540,"lead_sponsor_name":"Yongjian Wu","has_results":false},{"nct_id":"NCT05295628","title":"Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":532,"lead_sponsor_name":"Emblok, Inc.","has_results":false},{"nct_id":"NCT06953206","title":"Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Institut für Pharmakologie und Präventive Medizin","has_results":false},{"nct_id":"NCT05670041","title":"Re-hospitalisation After Transcatheter Aortic Valve Implantation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Ole De Backer","has_results":false},{"nct_id":"NCT05078619","title":"Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":466,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT06830499","title":"Sapien 3 Transcatheter Aortic Valve Replacement in Young Aortic Valve Stenosis Patients From China","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT03365453","title":"Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":450,"lead_sponsor_name":"University Hospital of Ferrara","has_results":false},{"nct_id":"NCT06189976","title":"Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation","phase":"NA","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"National and Kapodistrian University of Athens","has_results":false},{"nct_id":"NCT04717219","title":"Myeloid Cells in Aortic Valve Stenosis","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT05117359","title":"Transcatheter Para-Valvular Leak Closures","phase":"","overall_status":"COMPLETED","enrollment_count":366,"lead_sponsor_name":"Centre Chirurgical Marie Lannelongue","has_results":false},{"nct_id":"NCT03016169","title":"Trifecta™ GT Post Market Clinical Follow-up","phase":"NA","overall_status":"COMPLETED","enrollment_count":358,"lead_sponsor_name":"Abbott Medical Devices","has_results":true},{"nct_id":"NCT06449469","title":"The Nordic Aortic Valve Intervention Trial 4 (NOTION-4)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":352,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT04385459","title":"Severe Aortic Valve Stenosis and Concomitant Coronary Artery Disease in Patients Undergoing TAVI","phase":"","overall_status":"COMPLETED","enrollment_count":346,"lead_sponsor_name":"Örebro County Council","has_results":false},{"nct_id":"NCT06996223","title":"A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delaying the Progression of Calcified Aortic Valve Disease","phase":"EARLY_PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":316,"lead_sponsor_name":"Nanfang Hospital, Southern Medical University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}