{"disease":{"id":"aortic-valve","name":"aortic valve"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05015452","title":"The Leipzig TAVI Registry","phase":"","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Helios Health Institute GmbH","has_results":false},{"nct_id":"NCT05912660","title":"Health Status of Patients After Surgically Implanted Biological and TAVI: a Population-based Retrospective Analysis","phase":"","overall_status":"COMPLETED","enrollment_count":18882,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT04227002","title":"Hamburg AoRtic Valve cOhoRt","phase":"","overall_status":"RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT04900909","title":"Health Status of Patients After Surgically Implanted Biological and Mechanical Aortic Valves: a Population-based Retrospective Analysis (2010-2018)","phase":"","overall_status":"COMPLETED","enrollment_count":13993,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT03588247","title":"Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves.","phase":"","overall_status":"COMPLETED","enrollment_count":12000,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT07267117","title":"Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT03826264","title":"Transpacific TAVR Registry","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Duk-Woo Park, MD","has_results":false},{"nct_id":"NCT05930899","title":"Translational-Omics in Aortic Stenosis (TOmAS) Biobank","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"McGill University Health Centre/Research Institute of the McGill University Health Centre","has_results":false},{"nct_id":"NCT03385915","title":"Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis: FinnValve Registry","phase":"","overall_status":"COMPLETED","enrollment_count":6463,"lead_sponsor_name":"Turku University Hospital","has_results":false},{"nct_id":"NCT05439863","title":"TAVR for Aortic Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT07489313","title":"Association of Prosthesis Types for Aortic or Mitral Valve Replacement With Long-term Risk of Mental Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":4761,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT03768180","title":"Infective Endocarditis After TAVR","phase":"","overall_status":"COMPLETED","enrollment_count":4600,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT04086836","title":"Swedish Study on STroke After TAVR","phase":"","overall_status":"COMPLETED","enrollment_count":4600,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT06782620","title":"Association Between Surgical Aortic Valve Replacement and Long-term Outcomes in 50 to 65-year-olds","phase":"","overall_status":"COMPLETED","enrollment_count":3761,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT03740425","title":"Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) Study","phase":"","overall_status":"COMPLETED","enrollment_count":3235,"lead_sponsor_name":"G. d'Annunzio University","has_results":false},{"nct_id":"NCT06257043","title":"Safety and Efficacy of Post-marketing Transcatheter Aortic Valves in \"Real World\" Chinese Patients","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT06200870","title":"ID as a Promoter of IH-induced CAVD","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Qilu Hospital of Shandong University","has_results":false},{"nct_id":"NCT03440697","title":"Pathogenetic Basis of Aortopathy and Aortic Valve Disease","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT04231461","title":"Quality of Life After Cardiac Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":2925,"lead_sponsor_name":"Papworth Hospital NHS Foundation Trust","has_results":false},{"nct_id":"NCT06168370","title":"Personalized, CT-guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Non-atrial Fibrillation Patients After Transcatheter Aortic Valve Implantation","phase":"NA","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"St. Antonius Hospital","has_results":false},{"nct_id":"NCT06000943","title":"Ischemic And Bleeding Risk Assessment After TAVR","phase":"","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Niguarda Hospital","has_results":false},{"nct_id":"NCT04579445","title":"Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing TAVI in Europe","phase":"","overall_status":"COMPLETED","enrollment_count":2408,"lead_sponsor_name":"Institut für Pharmakologie und Präventive Medizin","has_results":false},{"nct_id":"NCT05308173","title":"Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry","phase":"","overall_status":"COMPLETED","enrollment_count":2393,"lead_sponsor_name":"Nicolaus Copernicus University","has_results":false},{"nct_id":"NCT02241447","title":"Quality of Care in AS IMPULSE Study","phase":"","overall_status":"COMPLETED","enrollment_count":2173,"lead_sponsor_name":"Institut für Pharmakologie und Präventive Medizin","has_results":false},{"nct_id":"NCT04464655","title":"A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease","phase":"","overall_status":"RECRUITING","enrollment_count":2130,"lead_sponsor_name":"McGill University Health Centre/Research Institute of the McGill University Health Centre","has_results":false},{"nct_id":"NCT06099665","title":"Addressing Under-treatment and Health Equity in AS and MR Using an Integrated EHR Platform","phase":"NA","overall_status":"COMPLETED","enrollment_count":2118,"lead_sponsor_name":"Tempus AI","has_results":false},{"nct_id":"NCT05998694","title":"Post-market Clinical Monitoring of the Safety and Efficacy of the Aortic Valve Bioprothesis","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Closed Joint-Stock Company NeoCor","has_results":false},{"nct_id":"NCT04139616","title":"Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec","has_results":false},{"nct_id":"NCT06804148","title":"MYVAL Transcatheter Heart Valve System - Prospective German Multicenter Registry","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Prof. Dr. med. Ingo Eitel","has_results":false},{"nct_id":"NCT03836521","title":"Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Cedars-Sinai Medical Center","has_results":false},{"nct_id":"NCT05895487","title":"Study on Efficacy, Safety and Durability of the UniLine Prosthesis in the Treatment of Aortic and Mitral Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Closed Joint-Stock Company NeoCor","has_results":false},{"nct_id":"NCT06069232","title":"Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT07442357","title":"The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1986,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT05454150","title":"Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis (BEST)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1960,"lead_sponsor_name":"University Hospital, Lille","has_results":false},{"nct_id":"NCT06789211","title":"Outcomes in Moderate Mixed Aortic Valve Disease","phase":"","overall_status":"RECRUITING","enrollment_count":1900,"lead_sponsor_name":"Leiden University Medical Center","has_results":false},{"nct_id":"NCT04503655","title":"Multicenter Study Evaluating the Efficacy of an Intervention Aimed At Reducing the Length of Stay After Transfemoral Transcatheter Aortic Valve Implantation","phase":"NA","overall_status":"COMPLETED","enrollment_count":1842,"lead_sponsor_name":"University Hospital, Rouen","has_results":false},{"nct_id":"NCT03972644","title":"Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis","phase":"NA","overall_status":"RECRUITING","enrollment_count":1700,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT02556203","title":"Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":1653,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT02664649","title":"Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation for Aortic Stenosis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1510,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06235385","title":"European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study","phase":"","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07476703","title":"Expanded Studies on the SCAPIS Stockholm Reexamination Cohort","phase":"","overall_status":"RECRUITING","enrollment_count":1400,"lead_sponsor_name":"Danderyd Hospital","has_results":false},{"nct_id":"NCT04258488","title":"Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":1300,"lead_sponsor_name":"Joon Bum Kim","has_results":false},{"nct_id":"NCT05487612","title":"MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)","phase":"NA","overall_status":"RECRUITING","enrollment_count":1300,"lead_sponsor_name":"Aristotle University Of Thessaloniki","has_results":false},{"nct_id":"NCT07001800","title":"Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":1276,"lead_sponsor_name":"Kardigan, Inc.","has_results":false},{"nct_id":"NCT04696185","title":"Dapagliflozin After Transcatheter Aortic Valve Implantation","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1257,"lead_sponsor_name":"Spanish Society of Cardiology","has_results":false},{"nct_id":"NCT05283356","title":"Single Antiplatelet Treatment With Ticagrelor or Aspirin After Transcatheter Aortic Valve Implantation","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":1206,"lead_sponsor_name":"Fundacin Biomedica Galicia Sur","has_results":false},{"nct_id":"NCT05927090","title":"Outcomes of Aortic Dissection Repair","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1200,"lead_sponsor_name":"Centre Cardiologique du Nord","has_results":false},{"nct_id":"NCT07413965","title":"TAVR vs SAVR in Severe Bicuspid Aortic Stenosis","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Cedars-Sinai Medical Center","has_results":false},{"nct_id":"NCT03769545","title":"Mortality Post-TAVI and Correlation With Haemodynamic Parameters.","phase":"","overall_status":"COMPLETED","enrollment_count":1200,"lead_sponsor_name":"Royal Brompton & Harefield NHS Foundation Trust","has_results":false},{"nct_id":"NCT04400513","title":"Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes","phase":"","overall_status":"COMPLETED","enrollment_count":1145,"lead_sponsor_name":"Eko Devices, Inc.","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}