{"disease":{"id":"anxiety","name":"anxiety","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":19,"pipeline_drug_count":0,"trial_count":130},"drugs":{"marketed":[{"drug_id":"nardil","indication_name":"Mixed Anxiety and Depression","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nardil","generic_name":"Phenelzine Sulfate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Amine oxidase [flavin-containing] B","drug_class":"Monoamine Oxidase Inhibitor","quality_score":65,"revenue":null,"mechanism":""},{"drug_id":"hydroxyzine-pamoate","indication_name":"Anxiety and tension in psychoneurosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"HYDROXYZINE PAMOATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":25,"revenue":null,"mechanism":null},{"drug_id":"hydroxyzine-pamoate","indication_name":"Adjunct in organic disease states with anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"HYDROXYZINE PAMOATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":25,"revenue":null,"mechanism":null},{"drug_id":"prochlorperazine-maleate","indication_name":"Generalized Non-Psychotic Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PROCHLORPERAZINE MALEATE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":15,"revenue":null,"mechanism":null},{"drug_id":"diazepam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valium","generic_name":"diazepam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"Adenosine receptor A3, Aldo-keto reductase family 1 member C1, Aldo-keto reductase family 1 member C2","drug_class":"Benzodiazepine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"diazepam","indication_name":"Preoperative Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valium","generic_name":"diazepam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"Adenosine receptor A3, Aldo-keto reductase family 1 member C1, Aldo-keto reductase family 1 member C2","drug_class":"Benzodiazepine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"garlic","indication_name":"anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Calm Mood","generic_name":"GARLIC","company_name":"Forces of Nature","drug_phase":"marketed","molecular_target":"","drug_class":"Non-Standardized Food Allergenic Extract [EPC]","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"midazolam-hydrochloride","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Versed","generic_name":"Midazolam Hydrochloride","company_name":"Takeda Pharmaceutical Company Limited","drug_phase":"marketed","molecular_target":"GABA A receptor alpha-5/beta-2/gamma-2","drug_class":"Benzodiazepine","quality_score":58,"revenue":null,"mechanism":""},{"drug_id":"midazolam-hydrochloride","indication_name":"Preoperative Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Versed","generic_name":"Midazolam Hydrochloride","company_name":"Takeda Pharmaceutical Company Limited","drug_phase":"marketed","molecular_target":"GABA A receptor alpha-5/beta-2/gamma-2","drug_class":"Benzodiazepine","quality_score":58,"revenue":null,"mechanism":""},{"drug_id":"chlordiazepoxide","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlordiazepoxide Hydrochloride","generic_name":"CHLORDIAZEPOXIDE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"chlordiazepoxide","indication_name":"Anxiety associated with Menopause","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlordiazepoxide Hydrochloride","generic_name":"CHLORDIAZEPOXIDE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"chlordiazepoxide","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlordiazepoxide Hydrochloride","generic_name":"CHLORDIAZEPOXIDE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"chlordiazepoxide","indication_name":"Preoperative Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlordiazepoxide Hydrochloride","generic_name":"CHLORDIAZEPOXIDE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"chlordiazepoxide","indication_name":"Severe anxiety (panic)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Chlordiazepoxide Hydrochloride","generic_name":"CHLORDIAZEPOXIDE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"duloxetine","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cymbalta","generic_name":"duloxetine","company_name":"Eli Lilly and Company","drug_phase":"marketed","molecular_target":"Serotonin and norepinephrine reuptake","drug_class":"Serotonin and norepinephrine reuptake inhibitor (SNRI)","quality_score":68,"revenue":null,"mechanism":"Potentiates serotonergic and noradrenergic activity in the CNS through unknown exact mechanisms."},{"drug_id":"midazolam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Versed","generic_name":"midazolam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"Multidrug resistance protein 1, Cytochrome P450 3A4, GABA A receptor alpha-3/beta-2/gamma-2","drug_class":"Benzodiazepine (short-acting)","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"midazolam","indication_name":"Preoperative Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Versed","generic_name":"midazolam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"Multidrug resistance protein 1, Cytochrome P450 3A4, GABA A receptor alpha-3/beta-2/gamma-2","drug_class":"Benzodiazepine (short-acting)","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"alpidem","indication_name":"Anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ananxyl","generic_name":"ALPIDEM","company_name":"","drug_phase":"marketed","molecular_target":"Translocator protein","drug_class":"alpidem","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"paroxetine","indication_name":"Social Anxiety Disorder (SAD)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Paroxetine","generic_name":"paroxetine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Serotonin (5-HT) reuptake transporter","drug_class":"Selective Serotonin Reuptake Inhibitor (SSRI)","quality_score":73,"revenue":null,"mechanism":"Inhibits neuronal reuptake of serotonin in the central nervous system, presumed mechanism for treating psychiatric disorders."},{"drug_id":"paroxetine","indication_name":"Generalized Anxiety Disorder (GAD)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Paroxetine","generic_name":"paroxetine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Serotonin (5-HT) reuptake transporter","drug_class":"Selective Serotonin Reuptake Inhibitor (SSRI)","quality_score":73,"revenue":null,"mechanism":"Inhibits neuronal reuptake of serotonin in the central nervous system, presumed mechanism for treating psychiatric disorders."},{"drug_id":"bat","indication_name":"Treatment of generalized anxiety disorder in adults","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bat","generic_name":"bat","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Unknown","drug_class":"Unknown","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"lorazepam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ativan","generic_name":"lorazepam","company_name":"Generic (originally Wyeth/Pfizer)","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-3/gamma-2, Fatty acid-binding protein, liver","drug_class":"Benzodiazepine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"clorazepate","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tranxene","generic_name":"clorazepate","company_name":"Ajenat Pharms","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"Benzodiazepine","quality_score":57,"revenue":null,"mechanism":""},{"drug_id":"secbutabarbital","indication_name":"Severe anxiety (panic)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"secbutabarbital","company_name":"","drug_phase":"unknown","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"diazepam-2mg-encapsulated-tab","indication_name":"Management of anxiety disorders","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Diazepam 2Mg encapsulated Tab","company_name":"The University of Hong Kong","drug_phase":"marketed","molecular_target":"GABA-A receptor (allosteric modulator)","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"diazepam-2mg-encapsulated-tab","indication_name":"Short-term relief of symptoms of anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Diazepam 2Mg encapsulated Tab","company_name":"The University of Hong Kong","drug_phase":"marketed","molecular_target":"GABA-A receptor (allosteric modulator)","drug_class":"Benzodiazepine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"escitalopram","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lexapro","generic_name":"escitalopram","company_name":"Generic (originally Lundbeck/Forest)","drug_phase":"marketed","molecular_target":"Serotonin (5-HT) reuptake transporter","drug_class":"Selective Serotonin Reuptake Inhibitor (SSRI)","quality_score":61,"revenue":null,"mechanism":"Inhibits CNS neuronal reuptake of serotonin (5-HT), potentiating serotonergic activity."},{"drug_id":"etizolam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Depas","generic_name":"ETIZOLAM","company_name":"","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"etizolam","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"aprobarbital","indication_name":"Severe anxiety (panic)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Allonal","generic_name":"APROBARBITAL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"aprobarbital","quality_score":16,"revenue":null,"mechanism":""},{"drug_id":"methylphenobarbital","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Metylfenemal","generic_name":"methylphenobarbital","company_name":"","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-3/gamma-2","drug_class":"methylphenobarbital","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"mebicar","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Adaptol","generic_name":"mebicar","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Adaptol is thought to work by modulating neurotransmitter activity in the brain."},{"drug_id":"butobarbital","indication_name":"Severe anxiety (panic)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Butethal","generic_name":"butobarbital","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"butobarbital","quality_score":null,"revenue":null,"mechanism":"Butethal works by enhancing the activity of neurotransmitters in the brain, such as GABA, to produce sedative and anxiolytic effects."},{"drug_id":"captodiame","indication_name":"Anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Captodiam","generic_name":"CAPTODIAME","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"captodiame","quality_score":null,"revenue":null,"mechanism":"Captodiam works by modulating the activity of certain neurotransmitters in the brain."},{"drug_id":"ethyl-loflazepate","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Meilax","generic_name":"ETHYL LOFLAZEPATE","company_name":"","drug_phase":"phase_2","molecular_target":"","drug_class":"ethyl loflazepate","quality_score":null,"revenue":null,"mechanism":"Meilax works by enhancing the activity of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps to calm the brain and reduce anxiety."},{"drug_id":"venlafaxine","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Effexor","generic_name":"venlafaxine","company_name":"Generic (originally Wyeth/Pfizer)","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C","drug_class":"SNRI (Serotonin-norepinephrine reuptake inhibitor)","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"maprotiline","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"MAPROTILINE","company_name":"","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor","drug_class":"maprotiline","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"perphenazine","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Trilafon","generic_name":"PERPHENAZINE","company_name":"","drug_phase":"marketed","molecular_target":"D(3) dopamine receptor","drug_class":"Phenothiazine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"prochlorperazine","indication_name":"Nonpsychotic Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Compazine","generic_name":"PROCHLORPERAZINE","company_name":"GSK","drug_phase":"marketed","molecular_target":"D(2) dopamine receptor","drug_class":"Phenothiazine","quality_score":65,"revenue":null,"mechanism":""},{"drug_id":"effexor-xr","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Effexor","generic_name":"Venlafaxine Hydrochloride","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Serotonin and norepinephrine reuptake transporters","drug_class":"Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)","quality_score":70,"revenue":null,"mechanism":"Potentiates serotonin and norepinephrine in CNS through reuptake inhibition."},{"drug_id":"oxymorphone","indication_name":"Anxiety due to Cardiac Asthma","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Opana Er","generic_name":"OXYMORPHONE","company_name":"Endo","drug_phase":"marketed","molecular_target":"Mu-type opioid receptor","drug_class":"Opioid Agonist","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"citalopram","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Celexa","generic_name":"CITALOPRAM","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Sodium-dependent serotonin transporter","drug_class":"Serotonin Reuptake Inhibitor","quality_score":80,"revenue":null,"mechanism":"Celexa works by blocking the reabsorption of serotonin in the brain, allowing more of this neurotransmitter to be available for communication between nerve cells."},{"drug_id":"doxepin","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zonalon","generic_name":"DOXEPIN","company_name":"","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Tricyclic Antidepressant","quality_score":80,"revenue":null,"mechanism":"Zonalon works by blocking histamine H1 receptors in the brain, which helps to reduce anxiety and itching, and improve mood."},{"drug_id":"chlormezanone","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Phenarol","generic_name":"CHLORMEZANONE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"chlormezanone","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"amobarbital","indication_name":"Severe anxiety (panic)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Amobarbitone","generic_name":"AMOBARBITAL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"amobarbital","quality_score":28,"revenue":null,"mechanism":""},{"drug_id":"pentobarbital","indication_name":"Severe anxiety (panic)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nembutal Sodium","generic_name":"PENTOBARBITAL","company_name":"Oak Pharms","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"pentobarbital","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"halazepam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Paxipam","generic_name":"HALAZEPAM","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"GABA-A receptor; anion channel","drug_class":"halazepam","quality_score":23,"revenue":null,"mechanism":""},{"drug_id":"trifluoperazine","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Stelazine","generic_name":"TRIFLUOPERAZINE","company_name":"","drug_phase":"marketed","molecular_target":"D(3) dopamine receptor","drug_class":"Phenothiazine","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"buspirone","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Buspar","generic_name":"BUSPIRONE","company_name":"","drug_phase":"marketed","molecular_target":"D(2) dopamine receptor","drug_class":"buspirone","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"amitriptyline","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Endep","generic_name":"AMITRIPTYLINE","company_name":"AstraZeneca","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Tricyclic Antidepressant","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"adinazolam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Deracyn","generic_name":"ADINAZOLAM","company_name":"","drug_phase":"phase_2","molecular_target":"Translocator protein","drug_class":"adinazolam","quality_score":null,"revenue":null,"mechanism":"Deracyn works by binding to the translocator protein, which is involved in regulating the activity of GABA, a neurotransmitter that helps calm the brain."},{"drug_id":"effexor","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Effexor","company_name":"Wyeth is now a wholly owned subsidiary of Pfizer","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"cital","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cital","company_name":"Ain Shams University","drug_phase":"marketed","molecular_target":"Solute carrier family 22 member 1, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"amitryptiline","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Amitryptiline","company_name":"Mahatma Gandhi Institute of Medical Sciences","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, 5-hydroxytryptamine receptor 6, D(1B) dopamine receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"xanax","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Xanax","company_name":"National Taiwan University Hospital","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"xanax","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Xanax","company_name":"National Taiwan University Hospital","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"xanax","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Xanax","company_name":"National Taiwan University Hospital","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"alprazolam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Xanax","generic_name":"alprazolam","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"Benzodiazepine (triazolobenzodiazepine)","quality_score":0,"revenue":null,"mechanism":"Short-acting, high-potency benzodiazepine that enhances GABA-A receptor activity, providing rapid anxiolytic relief."},{"drug_id":"alprazolam","indication_name":"Generalized anxiety disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Xanax","generic_name":"alprazolam","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"Benzodiazepine (triazolobenzodiazepine)","quality_score":0,"revenue":null,"mechanism":"Short-acting, high-potency benzodiazepine that enhances GABA-A receptor activity, providing rapid anxiolytic relief."},{"drug_id":"alprazolam","indication_name":"Mixed anxiety and depressive disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Xanax","generic_name":"alprazolam","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"Benzodiazepine (triazolobenzodiazepine)","quality_score":0,"revenue":null,"mechanism":"Short-acting, high-potency benzodiazepine that enhances GABA-A receptor activity, providing rapid anxiolytic relief."},{"drug_id":"prazepam","indication_name":"Anxiety","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prazene","generic_name":"PRAZEPAM","company_name":"Parke Davis","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":60,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04946955","title":"Adaptation of a French E-health Tool for Suicide Prevention in Young Populations","phase":"NA","overall_status":"UNKNOWN","enrollment_count":12000000,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05137977","title":"Is Invasive ICU-treatment Associated With Mental Illness?","phase":"","overall_status":"COMPLETED","enrollment_count":1048576,"lead_sponsor_name":"Uppsala University","has_results":false},{"nct_id":"NCT05813652","title":"Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1","phase":"","overall_status":"COMPLETED","enrollment_count":919928,"lead_sponsor_name":"McMaster University","has_results":false},{"nct_id":"NCT03944447","title":"Outcomes Mandate National Integration With Cannabis as Medicine","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":200000,"lead_sponsor_name":"OMNI Medical Services, LLC","has_results":false},{"nct_id":"NCT02681848","title":"What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?","phase":"","overall_status":"UNKNOWN","enrollment_count":180000,"lead_sponsor_name":"University of Bristol","has_results":false},{"nct_id":"NCT06115200","title":"Norwegian Adult Mental Health Registry","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":150000,"lead_sponsor_name":"Helse Stavanger HF","has_results":false},{"nct_id":"NCT03565562","title":"Preventing Psychological Distress and Suicidal Behaviours: a Web-based and Mobile Suicide Prevention Intervention in the General Population","phase":"NA","overall_status":"COMPLETED","enrollment_count":100000,"lead_sponsor_name":"Institut National de la Santé Et de la Recherche Médicale, France","has_results":false},{"nct_id":"NCT07453420","title":"Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping.","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Shalvata Mental Health Center","has_results":false},{"nct_id":"NCT01088542","title":"The Community Youth Development Study: A Test of Communities That Care","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":52323,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT04239521","title":"The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata","phase":"","overall_status":"COMPLETED","enrollment_count":51955,"lead_sponsor_name":"Momentum Data","has_results":false},{"nct_id":"NCT06070766","title":"RIVER At Home Ketamine Protocols","phase":"","overall_status":"RECRUITING","enrollment_count":50000,"lead_sponsor_name":"RIVER Foundation","has_results":false},{"nct_id":"NCT04953338","title":"Mental Health Associations With Vitiligo","phase":"","overall_status":"COMPLETED","enrollment_count":36104,"lead_sponsor_name":"Momentum Data","has_results":true},{"nct_id":"NCT04393649","title":"First Level Socio-geriatric Evaluation: ESOGER Databank","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Jewish General Hospital","has_results":false},{"nct_id":"NCT04558437","title":"COVID-Impact \"Psychological IMPACT of Covid-19 on AP-HP Staff\"","phase":"","overall_status":"UNKNOWN","enrollment_count":20000,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05074901","title":"Virtual Agents-based Digital Interventions to Improve Health","phase":"NA","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"University of Bordeaux","has_results":false},{"nct_id":"NCT05455905","title":"Voice Biomarkers Predictive of Depression and Anxiety","phase":"","overall_status":"COMPLETED","enrollment_count":19533,"lead_sponsor_name":"Kintsugi Mindful Wellness, Inc.","has_results":false},{"nct_id":"NCT05206734","title":"Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health","phase":"","overall_status":"COMPLETED","enrollment_count":19469,"lead_sponsor_name":"Momentum Data","has_results":true},{"nct_id":"NCT04803812","title":"Supporting the Wellness of Ontario Physicians During COVID-19","phase":"NA","overall_status":"COMPLETED","enrollment_count":19124,"lead_sponsor_name":"Ontario Medical Association","has_results":false},{"nct_id":"NCT00024635","title":"Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers","phase":"","overall_status":"RECRUITING","enrollment_count":16000,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT05765162","title":"Safe Brain Initiative, Operationalizing Precision Anaesthesia","phase":"","overall_status":"RECRUITING","enrollment_count":15000,"lead_sponsor_name":"University of Southern Denmark","has_results":false},{"nct_id":"NCT03699488","title":"Messaging Therapy for Depression and Anxiety: A Longitudinal Effectiveness Study","phase":"","overall_status":"COMPLETED","enrollment_count":12980,"lead_sponsor_name":"Talkspace","has_results":false},{"nct_id":"NCT06692842","title":"Interactive Technological Intervention to Improve Mental Health Symptoms in Primary Health Care","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":12400,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT03994809","title":"International Study of Biofield Therapy","phase":"","overall_status":"COMPLETED","enrollment_count":12000,"lead_sponsor_name":"MOA Health Science Foundation","has_results":false},{"nct_id":"NCT04792086","title":"Disease Containment Measures Among Older Adults During the Covid-19 Pandemia","phase":"","overall_status":"UNKNOWN","enrollment_count":12000,"lead_sponsor_name":"Norwegian Centre for Ageing and Health","has_results":false},{"nct_id":"NCT04786561","title":"Depression, Anxiety and Social Relationships as Risk Factors for Dementia","phase":"","overall_status":"COMPLETED","enrollment_count":11000,"lead_sponsor_name":"Norwegian Centre for Ageing and Health","has_results":false},{"nct_id":"NCT03217058","title":"Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":10821,"lead_sponsor_name":"University of California, San Francisco","has_results":true},{"nct_id":"NCT05764213","title":"Improving Maternal Mental Health & SUD Screening and Treatment","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":10470,"lead_sponsor_name":"Medical University of South Carolina","has_results":false},{"nct_id":"NCT04356365","title":"The Mental Health Status of the General Population During the COVID-19 Pandemic and Its Association With Adherence to Government-initiated Non-pharmacological Epidemiological Interventions (NPI's)","phase":"","overall_status":"COMPLETED","enrollment_count":10084,"lead_sponsor_name":"University of Oslo","has_results":false},{"nct_id":"NCT04365881","title":"Loneliness During the NPIs for the COVID-19 Pandemic in Norway: Risk Factors and Associations With Psychopathology","phase":"","overall_status":"COMPLETED","enrollment_count":10084,"lead_sponsor_name":"Modum Bad","has_results":false},{"nct_id":"NCT03672448","title":"The China Longitudinal Aging Study of Cognitive Impairment","phase":"","overall_status":"UNKNOWN","enrollment_count":10000,"lead_sponsor_name":"Shanghai Mental Health Center","has_results":false},{"nct_id":"NCT04905524","title":"Activity Changes in Irritable Bowel Syndrome (IBS), Anxiety, and Depression Following the Use of Viome Precision Nutrition Program (VPNP)","phase":"NA","overall_status":"COMPLETED","enrollment_count":10000,"lead_sponsor_name":"Viome","has_results":false},{"nct_id":"NCT04343664","title":"Mental Health Assessment Among Community Member During the Covid-19 Pandemic in Indonesia","phase":"","overall_status":"UNKNOWN","enrollment_count":10000,"lead_sponsor_name":"Tjhin Wiguna","has_results":false},{"nct_id":"NCT04806620","title":"Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Brain Inflammation Collaborative","has_results":false},{"nct_id":"NCT07305701","title":"Cohort Study on Medical Students' Mental Health","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Centre Hospitalier Régional d'Orléans","has_results":false},{"nct_id":"NCT04633603","title":"LázBarát™ (FeverFriend™) Projekt: Attitude Toward Fever and Its Change in the Healthcare System","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":10000,"lead_sponsor_name":"University of Pecs","has_results":false},{"nct_id":"NCT06351800","title":"The PredictPlusPrevent Study","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":9000,"lead_sponsor_name":"The Mediterranean Institute for the Advance of Biotechnology and Health Research","has_results":false},{"nct_id":"NCT04282915","title":"Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)","phase":"NA","overall_status":"COMPLETED","enrollment_count":8705,"lead_sponsor_name":"George Washington University","has_results":false},{"nct_id":"NCT07532122","title":"Postoperative Anxiety and Depression Among Chinese Elderly Patients","phase":"","overall_status":"COMPLETED","enrollment_count":8590,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT06495840","title":"Postoperative Anxiety and Depression Among Older Chinese Patients","phase":"","overall_status":"COMPLETED","enrollment_count":8590,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT04498442","title":"A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls","phase":"NA","overall_status":"COMPLETED","enrollment_count":8519,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT04377412","title":"Risk Factors for Anxiety and Depression Among Pregnant Women During the COVID-19 Pandemic","phase":"","overall_status":"UNKNOWN","enrollment_count":8500,"lead_sponsor_name":"Żelazna Medical Centre, LLC","has_results":false},{"nct_id":"NCT06122688","title":"By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Care","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":8360,"lead_sponsor_name":"University of California, Riverside","has_results":false},{"nct_id":"NCT03632122","title":"Subgroups of Older Adults With Back Pain and Multiple Chronic Conditions","phase":"","overall_status":"COMPLETED","enrollment_count":8344,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT04595123","title":"Impact of COVID-19 Pandemic in Perinatal Mental Health (RISEUP-PPD-COVID-19)","phase":"","overall_status":"COMPLETED","enrollment_count":7642,"lead_sponsor_name":"University of Minho","has_results":false},{"nct_id":"NCT07313657","title":"Improving Care and Mental Well-Being for Adults With Heart Failure","phase":"NA","overall_status":"RECRUITING","enrollment_count":7300,"lead_sponsor_name":"Bruyère Health Research Institute.","has_results":false},{"nct_id":"NCT06238869","title":"Online Mental Health Interventions for Children and Adolescents (OMHICA)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":7000,"lead_sponsor_name":"Jiangsu Province Nanjing Brain Hospital","has_results":false},{"nct_id":"NCT04542915","title":"COVID-19-Related Health and Practices Among Dental Hygienists","phase":"","overall_status":"COMPLETED","enrollment_count":6976,"lead_sponsor_name":"American Dental Association","has_results":false},{"nct_id":"NCT04385238","title":"Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic","phase":"","overall_status":"COMPLETED","enrollment_count":6894,"lead_sponsor_name":"Pregistry","has_results":true},{"nct_id":"NCT05369429","title":"My Wellbeing Guide: a Novel Tool for Managing Stress and Improving Quality of Life","phase":"NA","overall_status":"RECRUITING","enrollment_count":6516,"lead_sponsor_name":"Northwestern University","has_results":false},{"nct_id":"NCT04162847","title":"Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations","phase":"NA","overall_status":"COMPLETED","enrollment_count":6205,"lead_sponsor_name":"Washington University School of Medicine","has_results":true}],"total":50},"guidelines":[{"drug_id":"diazepam","guideline_body":"FDA label","recommendation":"Diazepam tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.","line_of_therapy":"1L","evidence_grade":"B","guideline_year":null}],"source":"Drug Landscape verified database"}