{"disease":{"id":"ankylosing-spondylitis","name":"Ankylosing Spondylitis","therapeutic_area":"Immunology & Inflammation","data":{"aiSummary":"The treatment landscape for ankylosing spondylitis primarily involves NSAIDs as first-line therapy to manage pain and inflammation. For patients who do not respond adequately to NSAIDs, biologic agents, particularly TNF inhibitors and IL-17 inhibitors, are commonly used. Several biosimilars are available. Research is ongoing with novel agents like JAK inhibitors and TYK2 inhibitors, which are in clinical trials. The focus is on improving symptom control, slowing disease progression, and enhancing the quality of life for patients.","drug_count":8,"description":"Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, leading to pain, stiffness, and potential fusion of the vertebrae. The disease is characterized by inflammation at the entheses (sites where tendons and ligaments attach to bone) and can cause significant disability. The pathophysiology involves a complex interplay of genetic, environmental, and immunological factors, with the HLA-B27 gene strongly associated with the disease. Current treatments aim to reduce inflammation, relieve pain, and slow disease progression.","subtype_count":9},"enrichment_level":2,"last_enriched_at":null,"visit_count":0,"created_at":"2026-03-25T12:16:34.908Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":53,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"abrilada","indication_name":"Ankylosing spondylitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Abrilada","generic_name":"Adalimumab-Afzb","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Tumor necrosis factor-alpha (TNF-alpha)","drug_class":"TNF blocker","quality_score":84,"revenue":"10191","mechanism":"Adalimumab-afzb binds TNF-alpha and blocks interaction with p55 and p75 cell surface receptors."},{"drug_id":"upadacitinib","indication_name":"Ankylosing Spondylitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rinvoq","generic_name":"upadacitinib","company_name":"AbbVie Inc.","drug_phase":"marketed","molecular_target":"Janus kinase (JAK) enzymes, particularly JAK1 and JAK2","drug_class":"JAK inhibitor","quality_score":86,"revenue":"5300","mechanism":"JAK inhibitor that prevents STAT phosphorylation and activation in cytokine signaling pathways."},{"drug_id":"upadacitinib","indication_name":"Active ankylosing spondylitis in adults with inadequate response or intolerance to TNF 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[EPC]","quality_score":73,"revenue":"4200","mechanism":"Remicade works by binding to and neutralizing tumor necrosis factor, a protein that promotes inflammation and tissue damage."},{"drug_id":"secukinumab","indication_name":"Ankylosing spondylitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cosentyx","generic_name":"secukinumab","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Interleukin-17A (IL-17A)","drug_class":"IL-17A antagonist","quality_score":89,"revenue":"3900","mechanism":"Secukinumab selectively binds IL-17A cytokine and inhibits its interaction with IL-17 receptor."},{"drug_id":"etanercept","indication_name":"Ankylosing spondylitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Enbrel","generic_name":"etanercept","company_name":"Immunex","drug_phase":"marketed","molecular_target":"Tumor necrosis factor","drug_class":"Tumor Necrosis Factor Blocker [EPC]","quality_score":77,"revenue":"3100","mechanism":"Enbrel works by binding to tumor necrosis factor, a protein that promotes inflammation, thereby reducing inflammation and alleviating symptoms."},{"drug_id":"ixekizumab","indication_name":"Ankylosing spondylitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Taltz","generic_name":"ixekizumab","company_name":"Eli Lilly","drug_phase":"marketed","molecular_target":"Interleukin 17A (IL-17A) 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