{"disease":{"id":"amenorrhea","name":"Amenorrhea","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":2,"pipeline_drug_count":0,"trial_count":2},"drugs":{"marketed":[{"drug_id":"clomiphene","indication_name":"Amenorrhea-Galactorrhea Syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CLOMIPHENE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":40,"revenue":null,"mechanism":null},{"drug_id":"clomiphene","indication_name":"Psychogenic Amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CLOMIPHENE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":40,"revenue":null,"mechanism":null},{"drug_id":"clomiphene","indication_name":"Post-Oral-Contraceptive Amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CLOMIPHENE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":40,"revenue":null,"mechanism":null},{"drug_id":"clomiphene","indication_name":"Secondary Amenorrhea of Undetermined Etiology","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CLOMIPHENE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":40,"revenue":null,"mechanism":null},{"drug_id":"progesterone","indication_name":"Treatment of secondary amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PROGESTERONE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"Progesterone [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"norethisterone","indication_name":"Secondary physiologic amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Micronor","generic_name":"norethisterone","company_name":"Johnson & Johnson","drug_phase":"marketed","molecular_target":"GnRH receptors","drug_class":"Progestin","quality_score":63,"revenue":null,"mechanism":"ORIAHNN combines elagolix, which suppresses LH and FSH to reduce ovarian sex hormones, with estradiol and norethindrone acetate to mitigate side effects."},{"drug_id":"norethindrone-acetate","indication_name":"Secondary physiologic amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aygestin","generic_name":"NORETHINDRONE ACETATE","company_name":"Duramed Res","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"Estrogen [EPC]","quality_score":46,"revenue":null,"mechanism":""},{"drug_id":"medroxyprogesterone","indication_name":"Secondary physiologic amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Depo-Provera","generic_name":"medroxyprogesterone","company_name":"Pfizer","drug_phase":"discontinued","molecular_target":"Progesterone receptor","drug_class":"Progestin","quality_score":null,"revenue":null,"mechanism":"Depo-Provera works by binding to the progesterone receptor in the body, which helps to regulate the menstrual cycle and prevent pregnancy."},{"drug_id":"endometrin","indication_name":"Amenorrhea Secondary to Ovarian Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Endometrin","generic_name":"progesterone","company_name":"Ferring","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin, Sodium/nucleoside cotransporter 1, Cation channel sperm-associated protein 1","drug_class":"Progesterone [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"endometrin","indication_name":"Secondary physiologic amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Endometrin","generic_name":"progesterone","company_name":"Ferring","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin, Sodium/nucleoside cotransporter 1, Cation channel sperm-associated protein 1","drug_class":"Progesterone [EPC]","quality_score":10,"revenue":null,"mechanism":null},{"drug_id":"lisuride","indication_name":"Amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lisurid","generic_name":"LISURIDE","company_name":"","drug_phase":"phase_3","molecular_target":"Alpha-2A adrenergic receptor","drug_class":"lisuride","quality_score":null,"revenue":null,"mechanism":"Lisuride works by binding to and activating the alpha-2A adrenergic receptor, which helps to regulate various physiological processes."},{"drug_id":"gonadorelin","indication_name":"Amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fertagyl","generic_name":"GONADORELIN","company_name":"","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor","drug_class":"gonadorelin","quality_score":25,"revenue":null,"mechanism":""},{"drug_id":"progesteron","indication_name":"Amenorrhea Secondary to Ovarian Dysfunction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Progesteron","company_name":"Minia University","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin, Sodium/nucleoside cotransporter 1, Cation channel sperm-associated protein 1","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"progesteron","indication_name":"Secondary physiologic amenorrhea","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Progesteron","company_name":"Minia University","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin, Sodium/nucleoside cotransporter 1, Cation channel sperm-associated protein 1","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":14,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06583408","title":"The REgistry of Very Early Estrogen and AnovuLation","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT04766203","title":"Relative Energy Deficiency in Sport Multicenter Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Trent Stellingwerff","has_results":false},{"nct_id":"NCT00001275","title":"Ovarian Follicle Function in Patients With Primary Ovarian Failure","phase":"","overall_status":"COMPLETED","enrollment_count":1134,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT01500447","title":"Inherited Reproductive Disorders","phase":"","overall_status":"RECRUITING","enrollment_count":850,"lead_sponsor_name":"National Institute of Environmental Health Sciences (NIEHS)","has_results":false},{"nct_id":"NCT06871618","title":"Retrospective Study of Surgical Induced Abortions Between 14 and 16 Weeks of Amenorrhea At Croix Rousse University Hospital in Lyon","phase":"","overall_status":"COMPLETED","enrollment_count":700,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT03568851","title":"Reproductive Health Outcomes by Method of Breast Milk Feeding","phase":"","overall_status":"COMPLETED","enrollment_count":394,"lead_sponsor_name":"University of California, Davis","has_results":false},{"nct_id":"NCT04135729","title":"Mental Health in Fitness Instructors","phase":"","overall_status":"COMPLETED","enrollment_count":304,"lead_sponsor_name":"Norwegian School of Sport Sciences","has_results":false},{"nct_id":"NCT06280807","title":"Observation of Environment and Reproductive-Endocrine Effects","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"National Institute of Environmental Health Sciences (NIEHS)","has_results":false},{"nct_id":"NCT03794895","title":"Prediction of Response to IUCD Associated Menorrhagia Using Doppler","phase":"NA","overall_status":"COMPLETED","enrollment_count":156,"lead_sponsor_name":"Ain Shams University","has_results":false},{"nct_id":"NCT07010146","title":"Role of Estrogen on Skeletal Outcomes in FHA","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT03669731","title":"Evaluation of the Protein Intake of the Pregnant Woman According to the Weight Status and in Pregnant Women Operated on Bariatric Surgery","phase":"NA","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT01511588","title":"Hormonal Regulation of Puberty and Fertility","phase":"","overall_status":"COMPLETED","enrollment_count":111,"lead_sponsor_name":"National Institute of Environmental Health Sciences (NIEHS)","has_results":false},{"nct_id":"NCT03916978","title":"Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Genesis Athens Clinic","has_results":false},{"nct_id":"NCT07164248","title":"Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice","phase":"","overall_status":"COMPLETED","enrollment_count":74,"lead_sponsor_name":"Bagcilar Training and Research Hospital","has_results":false},{"nct_id":"NCT07386223","title":"Health and Lifestyle Support for Functional Hypothalamic Amenorrhea","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":70,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT04424576","title":"Ovarian Morphology in Girls","phase":"","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Cornell University","has_results":false},{"nct_id":"NCT05967819","title":"Effects of Physical and Psychosocial Stress on Functional Hypothalamic Amenorrhea in Exercising Women","phase":"NA","overall_status":"RECRUITING","enrollment_count":54,"lead_sponsor_name":"University of Colorado, Colorado Springs","has_results":false},{"nct_id":"NCT03841981","title":"Body Fat as Determinant of Female Gonadal Dysfunction","phase":"","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal","has_results":false},{"nct_id":"NCT05921877","title":"AMH and Functional Hypothalamic Amenorrhea","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","has_results":false},{"nct_id":"NCT04938622","title":"Bioenergetics of Exercise-Induced Menstrual Disturbances","phase":"NA","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"Penn State University","has_results":false},{"nct_id":"NCT01976728","title":"LutrePulse Hypogonadotropic Hypogonadism","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"Ferring Pharmaceuticals","has_results":true},{"nct_id":"NCT07235917","title":"A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":34,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":false},{"nct_id":"NCT03018366","title":"Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":29,"lead_sponsor_name":"Cedars-Sinai Medical Center","has_results":true},{"nct_id":"NCT05410886","title":"Screening Women for Functional Hypothalamic Amenorrhea (FHA)","phase":"","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Imperial College London","has_results":false},{"nct_id":"NCT05633966","title":"Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":13,"lead_sponsor_name":"Stephanie B. Seminara, MD","has_results":false},{"nct_id":"NCT03732261","title":"Effects of Exercise and Yogurt on Bone Mineral Density and Immunological Factors in Human Milk: The MEEMA Study","phase":"NA","overall_status":"TERMINATED","enrollment_count":13,"lead_sponsor_name":"North Carolina Agriculture & Technical State University","has_results":false},{"nct_id":"NCT02019589","title":"A Phase 3, Randomized, Three-Cycle, Double-Blind, Placebo-Controlled Study to Evaluate Induction of Secretory Conversion of Endometrium and Withdrawal Bleeding for Secondary Amenorrhea","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":6,"lead_sponsor_name":"TherapeuticsMD","has_results":false},{"nct_id":"NCT07152730","title":"A Study to Measure Pharmacokinetic (PK) Concentrations of Gonadotropin-Releasing Hormone Delivered by the OmniPod Pump","phase":"PHASE1","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Ferring Pharmaceuticals","has_results":false}],"total":28},"guidelines":[],"source":"Drug Landscape verified database"}