{"disease":{"id":"aldosteronism","name":"Aldosteronism","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":3,"pipeline_drug_count":0,"trial_count":2},"drugs":{"marketed":[{"drug_id":"spironolacton","indication_name":"Aldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Spironolacton","company_name":"ACS Biomarker","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, Multidrug and toxin extrusion protein 1, Nuclear receptor subfamily 1 group I member 2","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"spironolacton","indication_name":"Diagnostic Test for Primary Aldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Spironolacton","company_name":"ACS Biomarker","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, Multidrug and toxin extrusion protein 1, Nuclear receptor subfamily 1 group I member 2","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"potassium-phosphates","indication_name":"Treatment of potassium deficiency (hypokalemia) in patients with hyperaldosteronism.","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Potassium Phosphates","generic_name":"Potassium Phosphate, Dibasic","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Phosphorus homeostasis and cellular biochemical functions","drug_class":"Electrolyte replacement","quality_score":65,"revenue":null,"mechanism":"Phosphate replaces deficient phosphorus for nucleic acid structure, energy storage, cell signaling, and bone mineralization."},{"drug_id":"potassium-phosphates","indication_name":"Treatment of potassium deficiency (hypokalemia) in patients with primary aldosteronism.","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Potassium Phosphates","generic_name":"Potassium Phosphate, Dibasic","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Phosphorus homeostasis and cellular biochemical functions","drug_class":"Electrolyte replacement","quality_score":65,"revenue":null,"mechanism":"Phosphate replaces deficient phosphorus for nucleic acid structure, energy storage, cell signaling, and bone mineralization."},{"drug_id":"aldactone","indication_name":"Short-term preoperative treatment of primary hyperaldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aldactone","generic_name":"Spironolactone","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Aldosterone receptors at aldosterone-dependent sodium-potassium exchange site in distal convoluted renal tubule","drug_class":"Potassium-sparing diuretic, aldosterone antagonist","quality_score":66,"revenue":null,"mechanism":"Aldosterone antagonist causing increased sodium and water excretion while retaining potassium."},{"drug_id":"spironolactone","indication_name":"Aldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aldactone","generic_name":"spironolactone","company_name":"Generic (originally Searle/Pfizer)","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, Multidrug and toxin extrusion protein 1, Nuclear receptor subfamily 1 group I member 2","drug_class":"Aldosterone Antagonist [EPC]","quality_score":56,"revenue":null,"mechanism":"Potassium-sparing diuretic and mineralocorticoid receptor antagonist that blocks aldosterone, reducing fluid retention and lowering blood pressure."},{"drug_id":"spironolactone","indication_name":"Diagnostic Test for Primary Aldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aldactone","generic_name":"spironolactone","company_name":"Generic (originally Searle/Pfizer)","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, Multidrug and toxin extrusion protein 1, Nuclear receptor subfamily 1 group I member 2","drug_class":"Aldosterone Antagonist [EPC]","quality_score":56,"revenue":null,"mechanism":"Potassium-sparing diuretic and mineralocorticoid receptor antagonist that blocks aldosterone, reducing fluid retention and lowering blood pressure."},{"drug_id":"spirolactone","indication_name":"Aldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"spirolactone","company_name":"Second Xiangya Hospital of Central South University","drug_phase":"phase_1","molecular_target":"Cytochrome P450 2C19, Multidrug and toxin extrusion protein 1, Nuclear receptor subfamily 1 group I member 2","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"spirolactone","indication_name":"Diagnostic Test for Primary Aldosteronism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"spirolactone","company_name":"Second Xiangya Hospital of Central South University","drug_phase":"phase_1","molecular_target":"Cytochrome P450 2C19, Multidrug and toxin extrusion protein 1, Nuclear receptor subfamily 1 group I member 2","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":9,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06065852","title":"National Registry of Rare Kidney Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":35000,"lead_sponsor_name":"UK Kidney Association","has_results":false},{"nct_id":"NCT03655223","title":"Early Check: Expanded Screening in Newborns","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":30000,"lead_sponsor_name":"RTI International","has_results":false},{"nct_id":"NCT05925569","title":"Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":12501,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":false},{"nct_id":"NCT06229405","title":"Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World Data","phase":"","overall_status":"UNKNOWN","enrollment_count":8200,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT07252284","title":"CHina Adrenal Venous saMPling InvestigatiON","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false},{"nct_id":"NCT03155139","title":"Primary Aldosteronism In Hypertensive Patients in China","phase":"","overall_status":"COMPLETED","enrollment_count":3500,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT04890444","title":"China Adrenal Disease Registry","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT03224312","title":"Chongqing Primary Aldosteronism Study","phase":"","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT06192238","title":"China National Study of Adrenal Venous Sampling","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false},{"nct_id":"NCT03778645","title":"Adrenal Venous Sampling Via an Antecubital Approach","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false},{"nct_id":"NCT03474237","title":"A Prospective Cohort Study for Patients With Adrenal Diseases","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1500,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT03105531","title":"Screening for Primary Aldosteronism in a Population of Patients With Hypertension","phase":"","overall_status":"COMPLETED","enrollment_count":1183,"lead_sponsor_name":"Uppsala University","has_results":false},{"nct_id":"NCT00001275","title":"Ovarian Follicle Function in Patients With Primary Ovarian Failure","phase":"","overall_status":"COMPLETED","enrollment_count":1134,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT06236698","title":"The Diagnostic Performance of 24-hour Urinary Aldosterone for Primary Aldosteronism","phase":"","overall_status":"COMPLETED","enrollment_count":999,"lead_sponsor_name":"Zhiming Zhu","has_results":false},{"nct_id":"NCT04428827","title":"Outcome of Patients With Primary Aldosteronism","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Changi General Hospital","has_results":false},{"nct_id":"NCT06513585","title":"Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy","phase":"NA","overall_status":"RECRUITING","enrollment_count":570,"lead_sponsor_name":"Xinjiang Medical University","has_results":false},{"nct_id":"NCT04761354","title":"Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis","phase":"","overall_status":"COMPLETED","enrollment_count":514,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT06513676","title":"Super Selective Adrenal Artery Embolization for Primary Aldosteronism: a Prospective Cohort Study(SAAE-PA)","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Xinjiang Medical University","has_results":false},{"nct_id":"NCT07298954","title":"Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE)","phase":"NA","overall_status":"RECRUITING","enrollment_count":456,"lead_sponsor_name":"Shumin Yang","has_results":false},{"nct_id":"NCT06941116","title":"Steroids-Based Screening for Primary Aldosteronism","phase":"","overall_status":"RECRUITING","enrollment_count":406,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT05262660","title":"The Long-term Effect of SAAE and Medical Treatment for Primary Aldosteronism","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"First Affiliated Hospital of Chengdu Medical College","has_results":false},{"nct_id":"NCT07111351","title":"Multi-omics Studies of Primary Aldosteronism","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Peking University First Hospital","has_results":false},{"nct_id":"NCT05446779","title":"Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":400,"lead_sponsor_name":"Helsinki University Central Hospital","has_results":false},{"nct_id":"NCT05959863","title":"Primary Aldosteronism LC-MS/MS-specific Cutoffs","phase":"","overall_status":"COMPLETED","enrollment_count":396,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT07137364","title":"Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary Aldosteronism","phase":"","overall_status":"RECRUITING","enrollment_count":350,"lead_sponsor_name":"Third Military Medical University","has_results":false},{"nct_id":"NCT04991961","title":"Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism","phase":"","overall_status":"COMPLETED","enrollment_count":341,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT04328181","title":"Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)","phase":"NA","overall_status":"RECRUITING","enrollment_count":339,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT06238232","title":"Outcome of 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Primary Aldosteronism","phase":"NA","overall_status":"RECRUITING","enrollment_count":320,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT06457074","title":"Finerenone for Patients With Primary Aldosteronism (FAIRY)","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":306,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT03789357","title":"Prevalence of Primary Aldosteronism in Patients With Stroke","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Changi General Hospital","has_results":false},{"nct_id":"NCT04115280","title":"Prevalence of Primary Aldosteronism Among Hypertensive Patients With Atrial Arythmia","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Centre Hospitalier de PAU","has_results":false},{"nct_id":"NCT06068101","title":"Clinical and Genetic Investigation of the Association Between Primary Aldosteronism and Thyroid Cancer","phase":"","overall_status":"COMPLETED","enrollment_count":274,"lead_sponsor_name":"Instituto do Cancer do Estado de São Paulo","has_results":false},{"nct_id":"NCT06980753","title":"Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":246,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT06740838","title":"Overnight Dexamethasone in Primary Aldosteronism Screening","phase":"","overall_status":"RECRUITING","enrollment_count":240,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT04461535","title":"Corticotropin Stimulation in Adrenal Venous Sampling for Patients With Primary Aldosteronism(ADOPA)","phase":"NA","overall_status":"COMPLETED","enrollment_count":228,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT03500120","title":"Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT03449797","title":"Rapid Cortisol Assay in Adrenal Vein Sampling","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"University Hospital Padova","has_results":false},{"nct_id":"NCT05561361","title":"The Effect of SAAE on Vascular Endothelial Function in PA Patients","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Second Affiliated Hospital of Nanchang University","has_results":false},{"nct_id":"NCT06955286","title":"Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT06534268","title":"Study on Postoperative Adrenal Function Assessment in Patients With Primary Aldosteronism","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Ruijin Hospital","has_results":false},{"nct_id":"NCT06250699","title":"A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Zhe Meng","has_results":false},{"nct_id":"NCT04193137","title":"Comparison of Three Confirmatory Tests in the Diagnosis of Primary Aldosteronism","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT06228677","title":"Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization","phase":"","overall_status":"RECRUITING","enrollment_count":196,"lead_sponsor_name":"First Affiliated Hospital of Chengdu Medical College","has_results":false},{"nct_id":"NCT02945904","title":"IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism","phase":"","overall_status":"COMPLETED","enrollment_count":190,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT04422756","title":"Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism","phase":"","overall_status":"COMPLETED","enrollment_count":183,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT07007793","title":"A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT06523465","title":"Statin Combined with Amlodipine Treats Primary Aldosteronism","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"Third Military Medical University","has_results":false},{"nct_id":"NCT06833437","title":"68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)","phase":"NA","overall_status":"RECRUITING","enrollment_count":178,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT07328230","title":"Superselective Adrenal Arterial Embolization Versus Oral Spironolactone for Treatment of Idiopathic Hyperaldosteronism","phase":"NA","overall_status":"RECRUITING","enrollment_count":172,"lead_sponsor_name":"Chinese Academy of Medical Sciences, Fuwai Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}