{"disease":{"id":"africa","name":"africa"},"drugs":{"marketed":[{"drug_id":"fexinidazole","indication_name":"Human African Trypanosomiasis (HAT)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fexinidazole","generic_name":"FEXINIDAZOLE","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"","drug_class":"Nitroimidazole Antimicrobial [EPC]","quality_score":49,"revenue":null,"mechanism":"Fexinidazole works by releasing free radicals that damage the DNA of Trypanosoma brucei gambiense, ultimately killing the parasite."},{"drug_id":"fexinidazole","indication_name":"Human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fexinidazole","generic_name":"FEXINIDAZOLE","company_name":"Sanofi","drug_phase":"marketed","molecular_target":"","drug_class":"Nitroimidazole Antimicrobial [EPC]","quality_score":49,"revenue":null,"mechanism":"Fexinidazole works by releasing free radicals that damage the DNA of Trypanosoma brucei gambiense, ultimately killing the parasite."},{"drug_id":"pentamidine","indication_name":"African trypanosomiasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pentam","generic_name":"PENTAMIDINE","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M4","drug_class":"Antiprotozoal","quality_score":80,"revenue":null,"mechanism":"Pentamidine works by interfering with the reproduction of certain parasites, such as Pneumocystis jiroveci."},{"drug_id":"eflornithine","indication_name":"African trypanosomiasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vaniqa","generic_name":"EFLORNITHINE","company_name":"","drug_phase":"marketed","molecular_target":"Ornithine decarboxylase (ODC)","drug_class":"Antiprotozoal","quality_score":75,"revenue":null,"mechanism":"Eflornithine inhibits ornithine decarboxylase, reducing polyamine synthesis and affecting cancer cell growth and metabolism."},{"drug_id":"melarsoprol","indication_name":"African trypanosomiasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Arsobal","generic_name":"MELARSOPROL","company_name":"","drug_phase":"phase_3","molecular_target":"","drug_class":"melarsoprol","quality_score":null,"revenue":null,"mechanism":"Arsobal works by inhibiting the enzyme dihydrofolate reductase in the parasite, disrupting its ability to synthesize DNA and ultimately leading to its death."}],"pipeline":[],"offLabel":[],"totalMarketed":5,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04099628","title":"Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring","phase":"NA","overall_status":"COMPLETED","enrollment_count":13747,"lead_sponsor_name":"Institut de Recherche pour le Developpement","has_results":false},{"nct_id":"NCT03356665","title":"Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP2 Passive Case Detection","phase":"NA","overall_status":"COMPLETED","enrollment_count":10700,"lead_sponsor_name":"Institut de Recherche pour le Developpement","has_results":false},{"nct_id":"NCT06356974","title":"Stop Transmission of Gambiense Human African Trypanosomiasis (STROgHAT)","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT06408142","title":"Universal Test and Connect for HIV Service Delivery in South Africa","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT05637632","title":"Assessment of Recombinant HAT-RDT Specificity","phase":"","overall_status":"COMPLETED","enrollment_count":1504,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT05358795","title":"Family Connections Cluster RCT in Zambia","phase":"NA","overall_status":"COMPLETED","enrollment_count":1386,"lead_sponsor_name":"Johns Hopkins Bloomberg School of Public Health","has_results":false},{"nct_id":"NCT05256017","title":"Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":1208,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":true},{"nct_id":"NCT05466630","title":"Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis","phase":"NA","overall_status":"COMPLETED","enrollment_count":1095,"lead_sponsor_name":"Institut de Recherche pour le Developpement","has_results":false},{"nct_id":"NCT03751475","title":"Optimizing Acute Malnutrition Management in Children Aged 6 to 59 Months in Democratic Republic of Congo","phase":"NA","overall_status":"COMPLETED","enrollment_count":896,"lead_sponsor_name":"Alliance for International Medical Action","has_results":false},{"nct_id":"NCT04847817","title":"Important Data on COVID-19 Profile in Africa","phase":"","overall_status":"COMPLETED","enrollment_count":574,"lead_sponsor_name":"Centre de Recherche Médicale de Lambaréné","has_results":false},{"nct_id":"NCT07017803","title":"Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":460,"lead_sponsor_name":"Centre de Recherche Médicale de Lambaréné","has_results":false},{"nct_id":"NCT02169557","title":"Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":230,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT03087955","title":"Efficacy and Safety of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis Due to T.b. Gambiense","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":208,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":true},{"nct_id":"NCT03025789","title":"Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":174,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":true},{"nct_id":"NCT05234125","title":"Better Lifestyle Counseling for African American Women During Pregnancy","phase":"NA","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"University of Illinois at Chicago","has_results":false},{"nct_id":"NCT05511935","title":"Testing Preliminary Effectiveness of a Training to Support CHWs Outreach on Dental to African American Caregivers","phase":"NA","overall_status":"COMPLETED","enrollment_count":143,"lead_sponsor_name":"KDH Research & Communication","has_results":true},{"nct_id":"NCT03861832","title":"SMART Brain Health in African-Americans","phase":"NA","overall_status":"UNKNOWN","enrollment_count":140,"lead_sponsor_name":"Howard University","has_results":false},{"nct_id":"NCT02184689","title":"Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":125,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT04029207","title":"The ASOS-2 Trial Maternal Mortality Sub-study","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"University of Cape Town","has_results":false},{"nct_id":"NCT05907174","title":"Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":91,"lead_sponsor_name":"University of Maryland, College Park","has_results":true},{"nct_id":"NCT03112655","title":"Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: Early Test-of-cure","phase":"NA","overall_status":"COMPLETED","enrollment_count":88,"lead_sponsor_name":"Institut de Recherche pour le Developpement","has_results":false},{"nct_id":"NCT04230928","title":"Giving a Low Carbohydrate Diet to Overcome Hypertension","phase":"NA","overall_status":"COMPLETED","enrollment_count":64,"lead_sponsor_name":"Baylor Research Institute","has_results":false},{"nct_id":"NCT03974178","title":"Fexinidazole in Human African Trypanosomiasis Due to T. b. Rhodesiense","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":true},{"nct_id":"NCT07011017","title":"Sexual Health of Sub-Saharan African Migrant Women Recently Diagnosed With HIV in Île-de-France: Missed Opportunities for Prevention","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":45,"lead_sponsor_name":"Centre Hospitalier de Saint-Denis","has_results":false},{"nct_id":"NCT05433350","title":"Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT05473026","title":"Grateful Strides Toward Physical Activity and Well-Being for Black Breast Cancer Survivors","phase":"NA","overall_status":"COMPLETED","enrollment_count":26,"lead_sponsor_name":"University of Florida","has_results":true},{"nct_id":"NCT05947604","title":"DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT05714280","title":"PA4Health Physical Activity App Open Pilot Study for African American Women","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":15,"lead_sponsor_name":"City University of New York, School of Public Health","has_results":false},{"nct_id":"NCT03726710","title":"Cut Your Blood Pressure 3","phase":"NA","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Cedars-Sinai Medical Center","has_results":false},{"nct_id":"NCT04270981","title":"ADME Study of Acoziborole in Healthy Subjects","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":6,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT05645822","title":"Screen and Treat Implementation for HAT Control","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT02770001","title":"Suitability of Some Data Quality Controls Thresholds for Genetic Association Studies of Admixed Population","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"National Human Genome Research Institute (NHGRI)","has_results":false},{"nct_id":"NCT03394976","title":"Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false}],"total":33},"guidelines":[],"source":"Drug Landscape verified database"}