{"disease":{"id":"adrenal-insufficiency","name":"adrenal insufficiency"},"drugs":{"marketed":[{"drug_id":"hydrocortisone-succinate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Solu-Cortef","generic_name":"hydrocortisone succinate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"hydrocortisone-acetate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortifoam","generic_name":"HYDROCORTISONE ACETATE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"cortisone-acetate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortone","generic_name":"CORTISONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":29,"revenue":null,"mechanism":""},{"drug_id":"betamethasone-acetate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Celestone Soluspan","generic_name":"BETAMETHASONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"dexamethasone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Decadron","generic_name":"dexamethasone","company_name":"Generic (originally Merck)","drug_phase":"marketed","molecular_target":"Annexin A1, Interleukin-4, Androgen receptor","drug_class":"Corticosteroid [EPC]","quality_score":44,"revenue":null,"mechanism":""},{"drug_id":"methylprednisolone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Medrol","generic_name":"methylprednisolone","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor","drug_class":"Glucocorticoid (corticosteroid)","quality_score":62,"revenue":null,"mechanism":"Potent synthetic glucocorticoid with 5x hydrocortisone potency and minimal mineralocorticoid activity, used for severe inflammatory conditions."},{"drug_id":"hydrocortisone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortef","generic_name":"hydrocortisone","company_name":"Generic (originally Merck/Upjohn)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"Corticosteroid [EPC]","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"triamcinolone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rodinolone","generic_name":"TRIAMCINOLONE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":51,"revenue":null,"mechanism":""},{"drug_id":"betamethasone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Betametasone","generic_name":"BETAMETHASONE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":65,"revenue":null,"mechanism":"Betamethasone works by binding to the glucocorticoid receptor, which then triggers a series of downstream effects that reduce inflammation and suppress the immune system."},{"drug_id":"cortisol","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cortisol","company_name":"University of Zurich","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"prednisolone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prelone","generic_name":"prednisolone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"Glucocorticoid (corticosteroid)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"prednisolon","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"prednisolon","company_name":"Hannover Medical School","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"methylprednisolon","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Methylprednisolon","company_name":"Leiden University Medical Center","drug_phase":"marketed","molecular_target":"Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":13,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03575247","title":"The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":111804,"lead_sponsor_name":"University of Leeds","has_results":false},{"nct_id":"NCT02769975","title":"Evaluation of Children With Endocrine and Metabolic-Related Conditions","phase":"","overall_status":"RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT01661387","title":"A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)","phase":"","overall_status":"TERMINATED","enrollment_count":3258,"lead_sponsor_name":"Shire","has_results":false},{"nct_id":"NCT03013166","title":"THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone","phase":"","overall_status":"COMPLETED","enrollment_count":3000,"lead_sponsor_name":"Shire","has_results":false},{"nct_id":"NCT00005664","title":"Evaluation of Patients With Endocrine-Related Conditions","phase":"","overall_status":"TERMINATED","enrollment_count":1588,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT03499990","title":"Study to Investigate Adrenal Crisis (Six-year Follow-up)","phase":"","overall_status":"COMPLETED","enrollment_count":268,"lead_sponsor_name":"Wuerzburg University Hospital","has_results":false},{"nct_id":"NCT05435781","title":"Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Marianne Christina Klose","has_results":false},{"nct_id":"NCT06980753","title":"Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":246,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT02818660","title":"Mass Spectrometry Based Cutoffs for Cortisol After Stimulation Tests","phase":"NA","overall_status":"COMPLETED","enrollment_count":232,"lead_sponsor_name":"Haukeland University Hospital","has_results":false},{"nct_id":"NCT00156767","title":"Adrenal Function in Critical Illness","phase":"","overall_status":"COMPLETED","enrollment_count":225,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT07168122","title":"Establishment and Clinical Application of Reference Intervals of Salivary Cortisol","phase":"","overall_status":"RECRUITING","enrollment_count":220,"lead_sponsor_name":"Shanghai 6th People's Hospital","has_results":false},{"nct_id":"NCT06955286","title":"Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Qifu Li","has_results":false},{"nct_id":"NCT05070091","title":"The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course.","phase":"","overall_status":"COMPLETED","enrollment_count":180,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT06208098","title":"Post-corticosteroid Insufficiency: Search for a Threshold Value for Cortisol at 8 Hours, Prospective Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":170,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05806723","title":"Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":104,"lead_sponsor_name":"Hopital La Rabta","has_results":false},{"nct_id":"NCT03615859","title":"Objective Markers and New Indicators in AI Disease (OMNI-AID Study)","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Imperial College London","has_results":false},{"nct_id":"NCT03368066","title":"Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"University of Virginia","has_results":true},{"nct_id":"NCT03608943","title":"Hydrocortisone Vs Prednisolone in AI (HYPER-AID)","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Imperial College London","has_results":false},{"nct_id":"NCT04519580","title":"Improved Diagnostics and Monitoring of Polymyalgia Rheumatica","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":98,"lead_sponsor_name":"Kresten Krarup Keller","has_results":false},{"nct_id":"NCT05149638","title":"Updated Diagnostic Cortisol Values for Adrenal Insufficiency","phase":"NA","overall_status":"RECRUITING","enrollment_count":90,"lead_sponsor_name":"Montefiore Medical Center","has_results":false},{"nct_id":"NCT06260462","title":"Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiency","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":88,"lead_sponsor_name":"University of Palermo","has_results":false},{"nct_id":"NCT04988269","title":"Assessment of Diurnal Salivary Cortisol Production in COVID-19","phase":"","overall_status":"COMPLETED","enrollment_count":85,"lead_sponsor_name":"National and Kapodistrian University of Athens","has_results":false},{"nct_id":"NCT03140761","title":"The Prevalence of Secondary Adrenal Insufficiency in Patients With Exacerbation of COPD in Glucocorticoid Treatment Related to Differenct Gene Polymorphisms of the Glucocorticoid Receptor Gene","phase":"","overall_status":"COMPLETED","enrollment_count":78,"lead_sponsor_name":"Chronic Obstructive Pulmonary Disease Trial Network, Denmark","has_results":false},{"nct_id":"NCT04642391","title":"Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis","phase":"","overall_status":"COMPLETED","enrollment_count":76,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT00915343","title":"Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":64,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT05827965","title":"Ramadan Fasting in Secondary Adrenal Insufficiency Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":63,"lead_sponsor_name":"Hopital La Rabta","has_results":false},{"nct_id":"NCT03136562","title":"Prevalence of Adrenal Insufficiency in Kidney Transplanted Patients in Glucocorticoid Treatment","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT05222152","title":"Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":58,"lead_sponsor_name":"Neurocrine UK Limited","has_results":false},{"nct_id":"NCT03311932","title":"A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":51,"lead_sponsor_name":"Neurocrine UK Limited","has_results":false},{"nct_id":"NCT03083834","title":"Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients","phase":"NA","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Bnai Zion Medical Center","has_results":false},{"nct_id":"NCT06206655","title":"Diagnosis of Adrenal Insufficiency in Liver Cirrhosis Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT06148090","title":"Screening for Adrenal Insufficiency During Dermocorticoid Reduction in Bullous Pemphigoid (BP)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"University Hospital, Bordeaux","has_results":false},{"nct_id":"NCT06309498","title":"Residual Adrenal Function in Addison's Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT04488432","title":"Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell Transplant","phase":"","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04374721","title":"Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders","phase":"NA","overall_status":"UNKNOWN","enrollment_count":44,"lead_sponsor_name":"University of Roma La Sapienza","has_results":false},{"nct_id":"NCT03936517","title":"Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":44,"lead_sponsor_name":"Imperial College London","has_results":false},{"nct_id":"NCT06861530","title":"A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children","phase":"","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"University Children's Hospital Basel","has_results":false},{"nct_id":"NCT05457296","title":"Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"University Tunis El Manar","has_results":false},{"nct_id":"NCT07367425","title":"Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":35,"lead_sponsor_name":"Hopital La Rabta","has_results":false},{"nct_id":"NCT05806190","title":"Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure","phase":"","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Imperial College Healthcare NHS Trust","has_results":false},{"nct_id":"NCT03505775","title":"Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na MRI in Patients With Chronic Adrenal Insufficiency","phase":"NA","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Wuerzburg University Hospital","has_results":false},{"nct_id":"NCT06299020","title":"Risks of Intermittent Fasting in Patients With Primary Adrenal Insufficiency","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Hopital La Rabta","has_results":false},{"nct_id":"NCT05350982","title":"Neonatal, Infant and Toddler Salivary Study (NITS Study)","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Sheffield Children's NHS Foundation Trust","has_results":false},{"nct_id":"NCT03343327","title":"A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjects","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Neurocrine UK Limited","has_results":false},{"nct_id":"NCT06608433","title":"Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function","phase":"NA","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"University Hospital, Basel, Switzerland","has_results":false},{"nct_id":"NCT04700644","title":"Assessment of CAI in Adults With PWS.","phase":"","overall_status":"COMPLETED","enrollment_count":21,"lead_sponsor_name":"Medical University of Warsaw","has_results":false},{"nct_id":"NCT06832566","title":"Ramadan Fasting Outcomes in Patients With Secondary Adrenal Insufficiency Before and After the Treatment of Hypotension.","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":20,"lead_sponsor_name":"Hopital La Rabta","has_results":false},{"nct_id":"NCT03074123","title":"Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Bnai Zion Medical Center","has_results":false},{"nct_id":"NCT05302726","title":"Impact of Exogenous Estrogens on Cotisol Levels During Synacthen Stimulation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT05931926","title":"Feasibility and Validation of the Fluispotter®, a Novel Intravenous System for Serial Blood Sampling","phase":"","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}