{"disease":{"id":"acidosis","name":"acidosis"},"drugs":{"marketed":[{"drug_id":"potassium-phosphates","indication_name":"Treatment of potassium deficiency (hypokalemia) in patients with potassium-wasting renal tubular acidosis.","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Potassium Phosphates","generic_name":"Potassium Phosphate, Dibasic","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Phosphorus homeostasis and cellular biochemical functions","drug_class":"Electrolyte replacement","quality_score":65,"revenue":null,"mechanism":"Phosphate replaces deficient phosphorus for nucleic acid structure, energy storage, cell signaling, and bone mineralization."},{"drug_id":"repaglinide","indication_name":"Not for treatment of diabetic ketoacidosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prandin","generic_name":"repaglinide","company_name":"Novo Nordisk","drug_phase":"marketed","molecular_target":"ATP-binding cassette sub-family C member 8","drug_class":"Glinide [EPC]","quality_score":10,"revenue":null,"mechanism":"Repaglinide lowers blood glucose levels by stimulating insulin release from the pancreas through ATP-dependent potassium channel blockade."}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04017221","title":"Safety of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Among Patients With Type 2 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":1249636,"lead_sponsor_name":"Canadian Network for Observational Drug Effect Studies, CNODES","has_results":false},{"nct_id":"NCT06065852","title":"National Registry of Rare Kidney Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":35000,"lead_sponsor_name":"UK Kidney Association","has_results":false},{"nct_id":"NCT04975906","title":"The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis","phase":"","overall_status":"COMPLETED","enrollment_count":16475,"lead_sponsor_name":"Changi General Hospital","has_results":false},{"nct_id":"NCT06881641","title":"A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning","phase":"","overall_status":"RECRUITING","enrollment_count":6120,"lead_sponsor_name":"University of Edinburgh","has_results":false},{"nct_id":"NCT03537898","title":"Balanced Solutions and Plasma Electrolytes","phase":"NA","overall_status":"COMPLETED","enrollment_count":2093,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT03710291","title":"Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":1480,"lead_sponsor_name":"Tricida, Inc.","has_results":false},{"nct_id":"NCT03126890","title":"Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT04953013","title":"Risk Potential for Organ Dysfunction Associated With Sodium Bicarbonate Therapy (SBT) in Critically Ill Patients","phase":"","overall_status":"COMPLETED","enrollment_count":664,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT04010630","title":"Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU","phase":"NA","overall_status":"COMPLETED","enrollment_count":640,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT02862925","title":"Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.","phase":"NA","overall_status":"COMPLETED","enrollment_count":550,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT06908408","title":"Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Following Days","phase":"","overall_status":"COMPLETED","enrollment_count":484,"lead_sponsor_name":"University Medical Centre Ljubljana","has_results":false},{"nct_id":"NCT04940897","title":"Use of Blood Ketone Meters to Improve Ambulance Hyperglycaemia Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":420,"lead_sponsor_name":"East of England Ambulance Service NHS Trust","has_results":false},{"nct_id":"NCT02476253","title":"Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT07274527","title":"Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":320,"lead_sponsor_name":"Medical College of Wisconsin","has_results":false},{"nct_id":"NCT06955416","title":"REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":312,"lead_sponsor_name":"POLYSAN Scientific & Technological Pharmaceutical Company","has_results":false},{"nct_id":"NCT07127406","title":"Postoperative Euglycemic Ketoacidosis Frequency in Sodium-Glucose Cotransporter-2 Inhibitor Users","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Kocaeli City Hospital","has_results":false},{"nct_id":"NCT04231045","title":"The Impact of the pH on Cardiac Function in the Critically Ill Patient","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"King's College Hospital NHS Trust","has_results":false},{"nct_id":"NCT04825639","title":"Identifying Risk Factors for Developing AKI in Sepsis","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Cardiff and Vale University Health Board","has_results":false},{"nct_id":"NCT02950181","title":"Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients","phase":"NA","overall_status":"TERMINATED","enrollment_count":299,"lead_sponsor_name":"Arkansas Children's Hospital Research Institute","has_results":false},{"nct_id":"NCT06251895","title":"Association of Systemic Immune-inflammation Index and Severity of Diabetic Ketoacidosis in Type 1 Diabetes Mellitus","phase":"","overall_status":"COMPLETED","enrollment_count":241,"lead_sponsor_name":"Jahra Hospital","has_results":false},{"nct_id":"NCT03102996","title":"Preserve-Transplant Study","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":240,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT03317444","title":"Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":217,"lead_sponsor_name":"Tricida, Inc.","has_results":true},{"nct_id":"NCT06970002","title":"Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":210,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT06545565","title":"Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Aga Khan University Hospital, Pakistan","has_results":false},{"nct_id":"NCT03390842","title":"Long-term Safety Extension to Study TRCA-301","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":196,"lead_sponsor_name":"Tricida, Inc.","has_results":true},{"nct_id":"NCT04977011","title":"Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient","phase":"NA","overall_status":"COMPLETED","enrollment_count":196,"lead_sponsor_name":"Min-Sheng General Hospital","has_results":false},{"nct_id":"NCT06727318","title":"Comparison of Peripheral Perfusion Indicators and Lactate Levels","phase":"","overall_status":"COMPLETED","enrollment_count":192,"lead_sponsor_name":"Gulhane Training and Research Hospital","has_results":false},{"nct_id":"NCT06516692","title":"Inferior Vena Cava Collapsibility and Distensibility Assessment in Critical Care.","phase":"NA","overall_status":"COMPLETED","enrollment_count":180,"lead_sponsor_name":"Jinnah Postgraduate Medical Centre","has_results":false},{"nct_id":"NCT06114667","title":"Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":174,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT05439928","title":"Remote Glucose Monitoring System in Hospitalized Patients With Diabetic Ketoacidosis (DKA)","phase":"NA","overall_status":"COMPLETED","enrollment_count":163,"lead_sponsor_name":"Columbia University","has_results":true},{"nct_id":"NCT06210087","title":"Open-glottis Pushing Technique Versus the Valsalva Pushing Technique in the Second Stage of Labor","phase":"NA","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"Ataturk University","has_results":false},{"nct_id":"NCT03035812","title":"Alkalinization by Urologists & Nephrologists","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":156,"lead_sponsor_name":"Jean-Philippe Bertocchio","has_results":false},{"nct_id":"NCT06338969","title":"The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis","phase":"NA","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"The Society of Bariatric and Metabolic Surgeons of Kazakhstan","has_results":false},{"nct_id":"NCT04766008","title":"Metformin in Diabetic Patients Undergoing Coronary Angiography","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Humanitas Hospital, Italy","has_results":false},{"nct_id":"NCT05443802","title":"Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications","phase":"NA","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT03897101","title":"Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"University Hospital of Ferrara","has_results":false},{"nct_id":"NCT05147051","title":"Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"POLYSAN Scientific & Technological Pharmaceutical Company","has_results":false},{"nct_id":"NCT06599203","title":"Children with Diabetic Ketoacidosis","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":130,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT03466528","title":"Alcohol: Thiamine and or Magnesium 1","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":127,"lead_sponsor_name":"Glasgow Royal Infirmary","has_results":false},{"nct_id":"NCT05005793","title":"Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT06383624","title":"Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis","phase":"","overall_status":"COMPLETED","enrollment_count":115,"lead_sponsor_name":"Benha University","has_results":false},{"nct_id":"NCT02915601","title":"Bicarbonate Administration in CKD","phase":"NA","overall_status":"COMPLETED","enrollment_count":109,"lead_sponsor_name":"University of Colorado, Denver","has_results":true},{"nct_id":"NCT06921473","title":"Effect of Ephedrine vs. Norepinephrine on Prevention of Fetal Acidosis During Cesarean Section Under Spinal Anesthesia","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":102,"lead_sponsor_name":"mehmet özkılıç","has_results":false},{"nct_id":"NCT05867797","title":"Risk Factors and Outcomes of Acute Kidney Injury in Patients With Diabetic Ketoacidosis at Sohag University Hospital.","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Sohag University","has_results":false},{"nct_id":"NCT05666895","title":"Role of CBC as a Prognostic Marker for DKA Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT05508490","title":"Prevalence of Acute Kidney Injury in Patients With Diabetic Ketoacidosis","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT05259202","title":"Value of Fetal Scalp Lactate Sampling During Labour in Cases of Abnormal Fetal Heart Rate","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT07423559","title":"Relapse Among Diabetic Ketoacidosis Patients Maintained Basal Bolus Insulin Administration in Combination With Continuous Intravenous Insulin Infusion VS Non Maintaining Basal Insulin Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT03717896","title":"Thiamine As Adjunctive Therapy for Diabetic Ketoacidosis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT04728412","title":"High Flow Oxygen Therapy in Patients Undergoing Bronchoscopy Under Sedation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Cardarelli Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}