{"disease":{"id":"absorption","name":"absorption"},"drugs":{"marketed":[{"drug_id":"hyaluronidase","indication_name":"Dispersion and Absorption of Injected Drugs","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Wydase","generic_name":"HYALURONIDASE","company_name":"Baxter","drug_phase":"marketed","molecular_target":"hyaluronic acid","drug_class":"Endoglycosidase","quality_score":10,"revenue":"900","mechanism":"Hyaluronidase increases tissue permeability by breaking down hyaluronic acid, promoting the diffusion and absorption of injected fluids."},{"drug_id":"vitamin-k1","indication_name":"Hypoprothrombinemia due to absorption or synthesis issues","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vitamin K1","generic_name":"Phytonadione","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Vitamin K-dependent carboxylase; vitamin K epoxide reductase complex (indirect antagonism of warfarin effects)","drug_class":"Vitamin K [EPC]","quality_score":55,"revenue":null,"mechanism":""},{"drug_id":"phytonadione","indication_name":"Hypoprothrombinemia due to absorption or synthesis limitations","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PHYTONADIONE","company_name":"","drug_phase":"marketed","molecular_target":"Vitamin K epoxide reductase complex subunit 1 (VKORC1)","drug_class":"Vitamin K [EPC]","quality_score":65,"revenue":null,"mechanism":""},{"drug_id":"ethacrynic-acid","indication_name":"Impaired Gastrointestinal Absorption","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Edecrin","generic_name":"ETHACRYNIC ACID","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"Glutathione S-transferase P","drug_class":"Loop Diuretic [EPC]","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"phytonadione","indication_name":"Hypoprothrombinemia secondary to factors limiting absorption or synthesis of Vitamin K","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PHYTONADIONE","company_name":"","drug_phase":"marketed","molecular_target":"Vitamin K epoxide reductase complex subunit 1 (VKORC1)","drug_class":"Vitamin K [EPC]","quality_score":65,"revenue":null,"mechanism":""},{"drug_id":"recombinant-antithrombin-rhat","indication_name":"Increasing the Dispersion and Absorption of Other Injected Drugs","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Recombinant antithrombin (rhAT)","company_name":"Mayo Clinic","drug_phase":"marketed","molecular_target":"Hyaluronic acid and connective tissue polysaccharides","drug_class":"Dispersion agent; enzyme","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT05266703","title":"Defining the Serum Ferritin Concentration in Kenyan Women at Which the Body Senses Iron Depletion and Begins to Upregulate Iron Absorption","phase":"NA","overall_status":"COMPLETED","enrollment_count":1000,"lead_sponsor_name":"Swiss Federal Institute of Technology","has_results":false},{"nct_id":"NCT05209568","title":"Immune Responses to Gluten","phase":"NA","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT07139821","title":"Dietary Iron Requirements","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Pennington Biomedical Research Center","has_results":false},{"nct_id":"NCT02510560","title":"Study to Assess the Efficacy and Safety of NTRA-2112 on Intestinal Malabsorption in Preterm Infants","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":300,"lead_sponsor_name":"Elgan Pharma Ltd.","has_results":true},{"nct_id":"NCT03876717","title":"Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":255,"lead_sponsor_name":"Lars Kristian Munck","has_results":false},{"nct_id":"NCT05973552","title":"Iron Absorption and Requirements in Pregnancy and Lactation","phase":"","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT03894358","title":"Iron Absorption From a Wheat-based Instant Cereal:Gut and Stable Isotope Studies in Kenyan Infants","phase":"NA","overall_status":"COMPLETED","enrollment_count":195,"lead_sponsor_name":"Swiss Federal Institute of Technology","has_results":false},{"nct_id":"NCT05277376","title":"Pharmacokinetic (PK) Evaluation of Bemotrizinol (6%) in a Sunscreen Maximum Usage Trial","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"dsm-firmenich Switzerland AG","has_results":false},{"nct_id":"NCT06548009","title":"Serum Metabolics-based Method for Diagnosing Bile Acid Diarrhoea","phase":"","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"University Hospital, Gentofte, Copenhagen","has_results":false},{"nct_id":"NCT06042985","title":"Comparison of the Absorption of Calcium Citrate and Calcium Carbonate in Patients With an RYGB, LSG, and OAGB","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"General Committee of Teaching Hospitals and Institutes, Egypt","has_results":false},{"nct_id":"NCT07138326","title":"Impact on the Absorption of Drugs in Ostomy Patients","phase":"","overall_status":"RECRUITING","enrollment_count":128,"lead_sponsor_name":"WiGeV Klinik Ottakring","has_results":false},{"nct_id":"NCT03310203","title":"The Relation Between Adiposity, Inflammation, Glycaemia and Iron Absorption","phase":"NA","overall_status":"COMPLETED","enrollment_count":126,"lead_sponsor_name":"American University of Beirut Medical Center","has_results":false},{"nct_id":"NCT03462979","title":"Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease","phase":"NA","overall_status":"SUSPENDED","enrollment_count":120,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT07338565","title":"Magnesium in Gastrointestinal Disease","phase":"","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT05340465","title":"Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT07322406","title":"Kaempferol Absorption and Pharmacokinetics Evaluation","phase":"NA","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of Pittsburgh","has_results":false},{"nct_id":"NCT04774016","title":"Iron Absorption From an Iron-fortified Follow-up Formula With Added Synbiotic or Human Milk Oligosaccharides","phase":"NA","overall_status":"COMPLETED","enrollment_count":82,"lead_sponsor_name":"Société des Produits Nestlé (SPN)","has_results":false},{"nct_id":"NCT05159115","title":"Sucrase-isomaltase Deficiency as a Cause of Irritable Bowel Syndrome","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"Lovisenberg Diakonale Hospital","has_results":false},{"nct_id":"NCT06076187","title":"Protein Digestion After Bariatric Surgery in Older Adults","phase":"","overall_status":"RECRUITING","enrollment_count":72,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT03059537","title":"Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":71,"lead_sponsor_name":"Lars Kristian Munck","has_results":false},{"nct_id":"NCT07315295","title":"Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya","phase":"NA","overall_status":"RECRUITING","enrollment_count":68,"lead_sponsor_name":"ETH Zurich","has_results":false},{"nct_id":"NCT02979080","title":"Iron Long-Term Labelling Study Benin","phase":"NA","overall_status":"UNKNOWN","enrollment_count":63,"lead_sponsor_name":"Prof. Michael B. Zimmermann","has_results":false},{"nct_id":"NCT06502704","title":"Bile Acids and Microbiome in Early Colorectal Carcinogenesis","phase":"","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Vilnius University","has_results":false},{"nct_id":"NCT05077397","title":"Is Regional Oxygen Saturation Effective in Predicting Perfusion Parameters and Patient Outcomes in Liver Resection","phase":"NA","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Marmara University","has_results":false},{"nct_id":"NCT02979132","title":"Iron Long-Term Labelling Study Switzerland","phase":"NA","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Prof. Michael B. Zimmermann","has_results":false},{"nct_id":"NCT04981262","title":"Improved Quality of Life in Children With Intestinal Failure","phase":"NA","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT03955575","title":"Treatment of Bile Acid Malabsorption With Liraglutide","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"Filip Krag Knop","has_results":false},{"nct_id":"NCT06629688","title":"Semaglutide and Intestinal Iron Absorption","phase":"NA","overall_status":"COMPLETED","enrollment_count":51,"lead_sponsor_name":"University Hospital Dubrava","has_results":false},{"nct_id":"NCT02977806","title":"Iron Long-Term Labelling Study Malawi","phase":"","overall_status":"UNKNOWN","enrollment_count":48,"lead_sponsor_name":"Prof. Michael B. Zimmermann","has_results":false},{"nct_id":"NCT03492190","title":"Bioavailability of Proteins From Plant Based Diets","phase":"","overall_status":"UNKNOWN","enrollment_count":45,"lead_sponsor_name":"Eduardo Ferriolli","has_results":false},{"nct_id":"NCT03433040","title":"17OHP-C Dosing Among Obese Pregnant Women","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"University of South Florida","has_results":true},{"nct_id":"NCT03453918","title":"Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.","phase":"NA","overall_status":"COMPLETED","enrollment_count":41,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT04615858","title":"Genepro Generation 3 Protein Bioavailability Compared to Whey Protein","phase":"NA","overall_status":"UNKNOWN","enrollment_count":40,"lead_sponsor_name":"Musclegen Research, Inc.","has_results":false},{"nct_id":"NCT07272668","title":"MA of Tryptophan in Cornmeal in Healthy Adults>60y","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":40,"lead_sponsor_name":"The Hospital for Sick Children","has_results":false},{"nct_id":"NCT06721637","title":"Effect of Core Stability Exercise Versus Whole Body Vibration in Improving Vitamin D Absorption in Women","phase":"","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"October 6 University","has_results":false},{"nct_id":"NCT06858631","title":"IMPact of AerobiC Exercise in Addition to Nutritional Treatment on Quality of Life After Pancreatectomy","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":38,"lead_sponsor_name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","has_results":false},{"nct_id":"NCT03438227","title":"Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"Indiana University","has_results":true},{"nct_id":"NCT06524674","title":"Clinical Study to Compare the Effect of an Oral Rehydration Solution on the Rate of Absorption of Functional Ingredients","phase":"NA","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Liquid I.V.","has_results":false},{"nct_id":"NCT03380611","title":"Algae and Cholesterol Absorption","phase":"NA","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"Maastricht University Medical Center","has_results":false},{"nct_id":"NCT03586245","title":"Iron Absorption From Iron Enriched Aspergillus Oryzae in Females Using Stable Isotope Methodology","phase":"NA","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"Iowa State University","has_results":false},{"nct_id":"NCT05572203","title":"Phenotyping of Adult Crohn's Focusing on Sarcopenia","phase":"NA","overall_status":"UNKNOWN","enrollment_count":35,"lead_sponsor_name":"University of Nottingham","has_results":false},{"nct_id":"NCT06236620","title":"Zinc Absorption in Flakes Derived from Sprouted or Hydrothermally Processed Wheat","phase":"NA","overall_status":"COMPLETED","enrollment_count":34,"lead_sponsor_name":"KU Leuven","has_results":false},{"nct_id":"NCT03207763","title":"Microneedle Patch Study in Healthy Infants/Young Children","phase":"NA","overall_status":"COMPLETED","enrollment_count":33,"lead_sponsor_name":"Emory University","has_results":true},{"nct_id":"NCT05635747","title":"A 90 Day Observational Study as an Extension to the Phase 3,Open Labeled Exploratory Study of RELiZORB","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":32,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT03530852","title":"A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB","phase":"NA","overall_status":"RECRUITING","enrollment_count":32,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT03552653","title":"Bioequivalence Study on Vitamin D in Healthy Adults","phase":"NA","overall_status":"COMPLETED","enrollment_count":31,"lead_sponsor_name":"Church & Dwight Company, Inc.","has_results":false},{"nct_id":"NCT06110260","title":"Pharmacokinetic Effect of AstraGin on Whey Protein Absorption and Muscle Function in Healthy Subjects","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Chung Shan Medical University","has_results":false},{"nct_id":"NCT03270085","title":"Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Mayo Clinic","has_results":true},{"nct_id":"NCT05130047","title":"Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Michael Camilleri, MD","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}