{"name":"Novartis AG","slug":"novartis","ticker":"NVS","exchange":"NYSE","domain":"novartis.com","description":"Novartis AG is a Swiss multinational pharmaceutical corporation based in Basel, Switzerland. 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Mutation","Malignant Melanoma with BRAF V600K Mutation","Metastatic malignant melanoma","Metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation"],"catalyst":""},{"name":"Zykadia","genericName":"ceritinib","slug":"ceritinib","phase":"marketed","mechanism":"Zykadia blocks the activity of the ALK protein, which is involved in the growth and spread of cancer cells.","indications":["ALK fusion gene-positive non-small-cell lung cancer","Non-small cell lung cancer"],"catalyst":""},{"name":"Gleevec","genericName":"imatinib","slug":"imatinib","phase":"marketed","mechanism":"Gleevec works by blocking the activity of specific enzymes involved in cancer cell growth and proliferation.","indications":["Blastic phase chronic myeloid leukemia","Chronic Myelocytic Leukemia Accelerated Phase","Chronic eosinophilic leukemia","Chronic phase chronic myeloid leukemia","Dermatofibrosarcoma 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inhibiting the enzyme farnesyl pyrophosphate synthase, which is involved in the mevalonate pathway and ultimately leads to the inhibition of osteoclast activity.","indications":["Hypercalcemia of Malignancy","Multiple Myeloma","Bone Metastases from Solid Tumors"],"catalyst":""},{"name":"telbivudine or lamivudine","genericName":"telbivudine or lamivudine","slug":"telbivudine-or-lamivudine","phase":"phase_3","mechanism":"Telbivudine and lamivudine are nucleoside reverse transcriptase inhibitors (NRTIs) that work by inhibiting the replication of viral DNA.","indications":["Chronic hepatitis B","Hepatitis B virus infection"],"catalyst":""},{"name":"AFQ065","genericName":"AFQ065","slug":"afq065","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"ARNI","genericName":"ARNI","slug":"arni","phase":"marketed","mechanism":"Small 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cells.","indications":["Precursor T-cell lymphoblastic lymphoma","T-cell acute lymphoblastic leukemia"],"catalyst":""},{"name":"BION-1301 Single Dose","genericName":"BION-1301 Single Dose","slug":"bion-1301-single-dose","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"COA566","genericName":"COA566","slug":"coa566","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Cedilanid D","genericName":"DESLANOSIDE","slug":"deslanoside","phase":"marketed","mechanism":"Sodium/potassium-transporting ATPase","indications":[],"catalyst":""},{"name":"Chrft5","genericName":"BASILIXIMAB","slug":"basiliximab","phase":"marketed","mechanism":"Interleukin-2 receptor subunit alpha","indications":["Renal transplant rejection"],"catalyst":""},{"name":"Disease Modifying therapy","genericName":"Disease Modifying therapy","slug":"disease-modifying-therapy","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"ENA713","genericName":"ENA713","slug":"ena713","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Exelon","genericName":"rivastigmine","slug":"rivastigmine","phase":"marketed","mechanism":"Acetylcholinesterase, Cholinesterase, Acetylcholine receptor subunit epsilon","indications":["Alzheimer's disease","Dementia associated with Parkinson's Disease"],"catalyst":""},{"name":"FTY720","genericName":"FTY720","slug":"fty720","phase":"marketed","mechanism":"Sphingosine-1-phosphate receptors (S1P1, S1P3, S1P4, S1P5)","indications":["Treatment of relapsing forms of multiple sclerosis (MS) to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability."],"catalyst":""},{"name":"HRO761","genericName":"HRO761","slug":"hro761","phase":"phase_1","mechanism":"Small 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Disease"],"catalyst":""},{"name":"Lysipressin","genericName":"LYPRESSIN","slug":"lypressin","phase":"marketed","mechanism":"Vasopressin receptor","indications":["Partial Central Diabetes Insipidus"],"catalyst":""},{"name":"MHU650","genericName":"MHU650","slug":"mhu650","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Mesantoin","genericName":"MEPHENYTOIN","slug":"mephenytoin","phase":"marketed","mechanism":"Sodium channel alpha subunit","indications":["Epilepsy","Epilepsy characterized by intractable complex partial seizures","Localization-related epilepsy","Motor cortex epilepsy"],"catalyst":""},{"name":"Miostat","genericName":"CARBACHOL","slug":"carbachol","phase":"marketed","mechanism":"Miostat works by mimicking the action of the neurotransmitter acetylcholine to increase the outflow of aqueous humor and reduce intraocular pressure.","indications":["Open-angle glaucoma"],"catalyst":""},{"name":"NVA237","genericName":"NVA237","slug":"nva237","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Onasemnogene Abeparvovec-xioi","genericName":"Onasemnogene Abeparvovec-xioi","slug":"onasemnogene-abeparvovec-xioi","phase":"marketed","mechanism":"Onasemnogene abeparvovec-xioi is a gene therapy that delivers a functional copy of the SMN1 gene via an adeno-associated virus vector to restore survival motor neuron protein production in patients with spinal muscular atrophy.","indications":["Spinal muscular atrophy (SMA) in pediatric patients"],"catalyst":""},{"name":"Potassium Alum","genericName":"Alum","slug":"alum","phase":"marketed","mechanism":"Biologic","indications":["Gastric Hypersecretory Conditions","Gastroesophageal reflux disease","Heartburn","Hiatal Hernia with Reflux Esophagitis","Indigestion"],"catalyst":""},{"name":"Profenol","genericName":"SUPROFEN","slug":"suprofen","phase":"marketed","mechanism":"Cytochrome P450 2C9, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2","indications":[],"catalyst":""},{"name":"Protaphane","genericName":"Protaphane","slug":"protaphane","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"RFB002","genericName":"RFB002","slug":"rfb002","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Ribiciclib","genericName":"Ribiciclib","slug":"ribiciclib","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Rivastigmine 5 and 10 cm^2 patch","genericName":"Rivastigmine 5 and 10 cm^2 patch","slug":"rivastigmine-5-and-10-cm-2-patch","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Seasonal influenza vaccine","genericName":"Seasonal influenza 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molecule","indications":[],"catalyst":""},{"name":"fluvastatin, ezetimibe","genericName":"fluvastatin, ezetimibe","slug":"fluvastatin-ezetimibe","phase":"phase_3","mechanism":"This combination reduces LDL cholesterol through dual inhibition of cholesterol synthesis and intestinal absorption.","indications":["Hypercholesterolemia and mixed dyslipidemia"],"catalyst":""},{"name":"iDMT","genericName":"iDMT","slug":"idmt","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"\"Usual Care\"","genericName":"\"Usual Care\"","slug":"usual-care","phase":"marketed","mechanism":"Usual Care is not a drug but rather a control or comparator arm representing standard clinical management without the investigational intervention.","indications":[],"catalyst":""},{"name":"111In-ETN029","genericName":"111In-ETN029","slug":"111in-etn029","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"225Ac-PSMA-R2","genericName":"225Ac-PSMA-R2","slug":"225ac-psma-r2","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"AAA617","genericName":"AAA617","slug":"aaa617","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"ADAKVEO","genericName":"CRIZANLIZUMAB-TMCA","slug":"crizanlizumab-tmca","phase":"marketed","mechanism":"P-selectin","indications":["Vaso-occlusive crisis in sickle cell disease"],"catalyst":""},{"name":"AF056","genericName":"AF056","slug":"af056","phase":"phase_2","mechanism":"AF056 is a small molecule that targets the SGLT2 receptor.","indications":["Type 2 diabetes"],"catalyst":""},{"name":"AFQ056 with L-dopa","genericName":"AFQ056 with L-dopa","slug":"afq056-with-l-dopa","phase":"phase_2","mechanism":"AFQ056 is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator that reduces excessive glutamatergic signaling, combined with L-dopa to enhance dopaminergic activity in Parkinson's disease.","indications":["Parkinson's disease with motor complications (dyskinesias and motor fluctuations)"],"catalyst":""},{"name":"AHT956","genericName":"AHT956","slug":"aht956","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"AMN107","genericName":"AMN107","slug":"amn107","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Actidil","genericName":"TRIPROLIDINE","slug":"triprolidine","phase":"marketed","mechanism":"Histamine H1 receptor","indications":["Cough relief","Minor aches and pains relief","Sore throat relief","Headache relief","Runny nose relief"],"catalyst":""},{"name":"Acylanid","genericName":"ACETYLDIGITOXIN","slug":"acetyldigitoxin","phase":"marketed","mechanism":"Sodium/potassium-transporting ATPase","indications":["Atrial fibrillation","Congestive heart failure"],"catalyst":""},{"name":"Adjuvant endocrine therapy","genericName":"Adjuvant endocrine therapy","slug":"adjuvant-endocrine-therapy","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Adjuvanted seasonal influenza vaccine","genericName":"Adjuvanted seasonal influenza vaccine","slug":"adjuvanted-seasonal-influenza-vaccine","phase":"phase_3","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Aggripal®","genericName":"Aggripal®","slug":"aggripal","phase":"phase_2","mechanism":"Selective serotonin reuptake inhibitor","indications":["Major depressive disorder","Generalized anxiety disorder"],"catalyst":""},{"name":"Agriflu (TIV)","genericName":"Agriflu (TIV)","slug":"agriflu-tiv","phase":"marketed","mechanism":"Agriflu is a trivalent inactivated influenza vaccine that stimulates the immune system to produce antibodies against three strains of influenza virus.","indications":["Seasonal influenza prevention in adults and children ≥6 months of age"],"catalyst":""},{"name":"Aliskiren 150","genericName":"Aliskiren 150","slug":"aliskiren-150","phase":"phase_3","mechanism":"Aliskiren is a direct renin inhibitor that blocks the first step of the renin-angiotensin-aldosterone system (RAAS) by preventing renin from converting angiotensinogen to angiotensin I.","indications":["Hypertension","Diabetic nephropathy (in combination with losartan)"],"catalyst":""},{"name":"Aliskiren 150 mg","genericName":"Aliskiren 150 mg","slug":"aliskiren-150-mg","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Aliskiren 3.125 mini-tablets","genericName":"Aliskiren 3.125 mini-tablets","slug":"aliskiren-3-125-mini-tablets","phase":"phase_1","mechanism":"Aliskiren is a direct renin inhibitor that blocks the conversion of angiotensinogen to angiotensin I, reducing blood pressure.","indications":["Hypertension"],"catalyst":""},{"name":"Aliskiren Hydrochlorothiazide","genericName":"Aliskiren Hydrochlorothiazide","slug":"aliskiren-hydrochlorothiazide","phase":"marketed","mechanism":"Aliskiren hydrochlorothiazide combines a direct renin inhibitor with a thiazide diuretic to lower blood pressure through dual mechanisms of renin-angiotensin system suppression and sodium/fluid reduction.","indications":["Hypertension"],"catalyst":""},{"name":"Aliskiren and HCTZ","genericName":"Aliskiren and HCTZ","slug":"aliskiren-and-hctz","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Aliskiren+HCTZ - Phase 2","genericName":"Aliskiren+HCTZ - Phase 2","slug":"aliskiren-hctz-phase-2","phase":"phase_3","mechanism":"Aliskiren blocks the renin-angiotensin-aldosterone system (RAAS) by inhibiting renin, while HCTZ reduces blood pressure through diuresis and vasodilation.","indications":["Hypertension"],"catalyst":""},{"name":"Aliskiren+HCTZ+amlodipine - Phase 3","genericName":"Aliskiren+HCTZ+amlodipine - Phase 3","slug":"aliskiren-hctz-amlodipine-phase-3","phase":"phase_3","mechanism":"This triple-combination drug lowers blood pressure by blocking the renin-angiotensin system (aliskiren), reducing fluid volume (HCTZ), and relaxing blood vessels (amlodipine).","indications":["Hypertension (high blood pressure)"],"catalyst":""},{"name":"Aliskiren/HCTZ","genericName":"Aliskiren/HCTZ","slug":"aliskiren-hctz","phase":"phase_3","mechanism":"Aliskiren/HCTZ is a fixed-dose combination that lowers blood pressure by blocking the renin-angiotensin system and promoting sodium and water excretion.","indications":["Hypertension"],"catalyst":""},{"name":"Alomide","genericName":"LODOXAMIDE","slug":"lodoxamide","phase":"marketed","mechanism":"G-protein coupled receptor 35","indications":["Vernal Keratitis","Vernal conjunctivitis","Vernal keratoconjunctivitis"],"catalyst":""},{"name":"Amlodipine + HCTZ","genericName":"Amlodipine + HCTZ","slug":"amlodipine-hctz","phase":"phase_3","mechanism":"Amlodipine relaxes blood vessels by blocking calcium channels, while HCTZ reduces blood volume by increasing sodium and water excretion through the kidneys, together lowering blood pressure.","indications":["Hypertension","Angina pectoris"],"catalyst":""},{"name":"Amlodipine 2.5 mg","genericName":"Amlodipine 2.5 mg","slug":"amlodipine-2-5-mg","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Amlodipine 300","genericName":"Amlodipine 300","slug":"amlodipine-300","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Angiomax","genericName":"BIVALIRUDIN","slug":"bivalirudin","phase":"marketed","mechanism":"Bivalirudin directly inhibits thrombin by binding to its catalytic site and anion-binding exosite, preventing thrombus formation.","indications":["Percutaneous coronary intervention","Unstable Angina Pectoris during PTCA"],"catalyst":""},{"name":"Ansastrozole","genericName":"Ansastrozole","slug":"ansastrozole","phase":"phase_3","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Anti Thymocyte Globulin","genericName":"Anti Thymocyte Globulin","slug":"anti-thymocyte-globulin","phase":"marketed","mechanism":"Small molecule","indications":["Prophylaxis and treatment of acute rejection in kidney transplant"],"catalyst":""},{"name":"Antrenyl","genericName":"OXYPHENONIUM","slug":"oxyphenonium","phase":"marketed","mechanism":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4","indications":[],"catalyst":""},{"name":"Aspirin, acetaminophen and caffeine","genericName":"Aspirin, acetaminophen and caffeine","slug":"aspirin-acetaminophen-and-caffeine","phase":"marketed","mechanism":"This combination analgesic and antipyretic works through multiple pathways: aspirin inhibits cyclooxygenase to reduce prostaglandins, acetaminophen inhibits pain and fever centers in the CNS, and caffeine enhances analgesic efficacy while promoting alertness.","indications":["Mild to moderate pain (headache, muscle ache, backache, minor arthritis pain, menstrual cramps, common cold)","Fever"],"catalyst":""},{"name":"Avelox","genericName":"Avelox","slug":"avelox","phase":"marketed","mechanism":"DNA gyrase, DNA gyrase subunit A, DNA topoisomerase 4 subunit A","indications":["Abdominal abscess","Acute bacterial sinusitis","Acute exacerbation of chronic bronchitis","Bacterial conjunctivitis","Bacterial infection due to Klebsiella pneumoniae"],"catalyst":""},{"name":"Azopt","genericName":"BRINZOLAMIDE","slug":"brinzolamide","phase":"marketed","mechanism":"Brinzolamide reduces intraocular pressure by inhibiting carbonic anhydrase II, decreasing aqueous humor secretion.","indications":["Ocular hypertension","Open-angle glaucoma"],"catalyst":""},{"name":"BAF312","genericName":"BAF312","slug":"baf312","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Basiliximab (Simulect)","genericName":"Basiliximab (Simulect)","slug":"basiliximab-simulect","phase":"phase_3","mechanism":"Basiliximab is a chimeric monoclonal antibody that blocks the interleukin-2 (IL-2) receptor on T cells, preventing T cell activation and proliferation.","indications":["Acute rejection prophylaxis in renal transplant recipients (in combination with cyclosporine and corticosteroids)"],"catalyst":""},{"name":"Benazepril plus hydrochlorothiazide","genericName":"Benazepril plus hydrochlorothiazide","slug":"benazepril-plus-hydrochlorothiazide","phase":"phase_3","mechanism":"Benazepril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to promote sodium and water excretion.","indications":["Hypertension"],"catalyst":""},{"name":"Beovu","genericName":"Beovu","slug":"beovu","phase":"marketed","mechanism":"Vascular endothelial growth factor A","indications":["Exudative age-related macular degeneration","Macular edema due to diabetes mellitus"],"catalyst":""},{"name":"Beovu","genericName":"BROLUCIZUMAB","slug":"brolucizumab","phase":"marketed","mechanism":"Beovu works by binding to vascular endothelial growth factor A (VEGF-A), preventing its interaction with its receptor and reducing vascular permeability and inflammation.","indications":["Exudative age-related macular degeneration","Macular edema due to diabetes mellitus"],"catalyst":""},{"name":"Betoptic","genericName":"BETAXOLOL","slug":"betaxolol","phase":"marketed","mechanism":"Betaxolol works by blocking the beta-1 adrenergic receptor in the heart and eyes, reducing heart rate and pressure, and decreasing intraocular pressure.","indications":["Hypertensive disorder","Ocular hypertension","Open-angle glaucoma"],"catalyst":""},{"name":"Branded Tacrolimus","genericName":"Branded Tacrolimus","slug":"branded-tacrolimus","phase":"marketed","mechanism":"Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation by blocking the phosphatase calcineurin, preventing IL-2 production and T-cell proliferation.","indications":["Prevention of organ rejection in transplant recipients (kidney, heart, liver, pancreas)","Atopic dermatitis","Severe rheumatoid arthritis","Autoimmune uveitis"],"catalyst":""},{"name":"Calcium/Vitamin D","genericName":"Calcium/Vitamin D","slug":"calcium-vitamin-d","phase":"phase_3","mechanism":"Calcium and vitamin D work together to support bone mineralization and maintain serum calcium levels for skeletal health.","indications":["Osteoporosis prevention and treatment","Calcium and vitamin D deficiency","Bone health maintenance in postmenopausal women"],"catalyst":""},{"name":"Candesartan plus Hydrochlorothiazide","genericName":"Candesartan plus Hydrochlorothiazide","slug":"candesartan-plus-hydrochlorothiazide","phase":"phase_3","mechanism":"Candesartan blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume and sodium reabsorption.","indications":["Hypertension (high blood pressure)","Reduction of cardiovascular events in hypertensive patients"],"catalyst":""},{"name":"Candesartan+HCTZ - Phase 1","genericName":"Candesartan+HCTZ - Phase 1","slug":"candesartan-hctz-phase-1","phase":"phase_3","mechanism":"Candesartan blocks angiotensin II receptors to lower blood pressure, while HCTZ is a thiazide diuretic that reduces fluid volume and sodium reabsorption.","indications":["Hypertension"],"catalyst":""},{"name":"Cell-derived influenza vaccine","genericName":"Cell-derived influenza vaccine","slug":"cell-derived-influenza-vaccine","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Certican®","genericName":"Certican®","slug":"certican","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Chelation","genericName":"Chelation","slug":"chelation","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Cibacalcin","genericName":"CALCITONIN HUMAN","slug":"calcitonin-human","phase":"marketed","mechanism":"Amylin receptor AMY2, Calcitonin receptor, Amylin receptor AMY1","indications":[],"catalyst":""},{"name":"Coartem","genericName":"LUMEFANTRINE","slug":"lumefantrine","phase":"marketed","mechanism":"Coartem Tablets, a combination of artemether and lumefantrine, act as an antimalarial agent.","indications":["Falciparum malaria"],"catalyst":""},{"name":"Coartem","genericName":"Coartem","slug":"coartem","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Crizanlizuamb","genericName":"Crizanlizuamb","slug":"crizanlizuamb","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Cyclosporine (Neoral)","genericName":"Cyclosporine (Neoral)","slug":"cyclosporine-neoral","phase":"marketed","mechanism":"Cyclosporine inhibits T-cell activation by binding to cyclophilin and blocking calcineurin-mediated transcription of interleukin-2 and other cytokines.","indications":["Organ transplant rejection prophylaxis (kidney, heart, liver, pancreas)","Severe active rheumatoid arthritis","Severe psoriasis","Nephrotic syndrome (minimal change disease)","Severe atopic dermatitis"],"catalyst":""},{"name":"Cyclosporine - cyclosporine microemulsion","genericName":"Cyclosporine - cyclosporine microemulsion","slug":"cyclosporine-cyclosporine-microemulsion","phase":"marketed","mechanism":"Cyclosporine inhibits calcineurin phosphatase, blocking T-cell activation and proliferation by preventing IL-2 transcription.","indications":["Organ transplant rejection prophylaxis (kidney, heart, liver, pancreas)","Rheumatoid arthritis","Psoriasis","Atopic dermatitis","Nephrotic syndrome (minimal change 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vomiting","Vomiting"],"catalyst":""},{"name":"Everolimus (Certican)","genericName":"Everolimus (Certican)","slug":"everolimus-certican","phase":"phase_3","mechanism":"Everolimus inhibits mTOR (mammalian target of rapamycin), a key protein kinase that regulates cell growth and proliferation.","indications":["Prevention of organ rejection in heart transplant recipients","Prevention of organ rejection in kidney transplant recipients","Advanced renal cell carcinoma","Pancreatic neuroendocrine tumors","Breast cancer (hormone receptor-positive, HER2-negative)"],"catalyst":""},{"name":"Everolmus","genericName":"Everolmus","slug":"everolmus","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Exjade","genericName":"DEFERASIROX","slug":"deferasirox","phase":"marketed","mechanism":"Exjade works by binding to iron in the body and removing it through the urine.","indications":["Chronic Iron Overload","beta Thalassemia"],"catalyst":""},{"name":"FDC 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inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor.","indications":["Herpes simplex","Herpes zoster","Recurrent Mucocutaneous Herpes Simplex in Human Immunodeficiency Virus Infected Patients","Recurrent genital herpes simplex","Recurrent herpes simplex labialis"],"catalyst":""},{"name":"Farydak","genericName":"Farydak","slug":"farydak","phase":"discontinued","mechanism":"Bromodomain-containing protein 4, Histone deacetylase 1, Histone deacetylase 10","indications":["Multiple myeloma","Primary cutaneous T-cell lymphoma"],"catalyst":""},{"name":"Fingolimod 0.5mg","genericName":"Fingolimod 0.5mg","slug":"fingolimod-0-5mg","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Fixed combination simvastatin/ezetimibe","genericName":"Fixed combination simvastatin/ezetimibe","slug":"fixed-combination-simvastatin-ezetimibe","phase":"marketed","mechanism":"This combination reduces cholesterol by blocking its synthesis in the liver (simvastatin) and inhibiting its absorption in the intestines (ezetimibe).","indications":["Hypercholesterolemia and mixed dyslipidemia","Reduction of cardiovascular risk in patients requiring additional LDL-C lowering"],"catalyst":""},{"name":"Fluad_MF59-adjuvanted trivalent influenza subunit vaccine","genericName":"Fluad_MF59-adjuvanted trivalent influenza subunit vaccine","slug":"fluad-mf59-adjuvanted-trivalent-influenza-subunit-vaccine","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Fluorescite","genericName":"FLUORESCEIN","slug":"fluorescein","phase":"marketed","mechanism":"Cytochrome P450 2C19","indications":["Fluorescein staining of eye"],"catalyst":""},{"name":"Fluticasone propionate 100 mcg","genericName":"Fluticasone propionate 100 mcg","slug":"fluticasone-propionate-100-mcg","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Fluticasone propionate 500 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reducing inflammation in the central nervous system.","indications":["Relapsing remitting multiple sclerosis"],"catalyst":""},{"name":"Glycopyrronium bromide 12.5ug","genericName":"Glycopyrronium bromide 12.5ug","slug":"glycopyrronium-bromide-12-5ug","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"GnRH antagonists","genericName":"GnRH antagonists","slug":"gnrh-antagonists","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Haemophilus influenza type b conjugate vaccine","genericName":"Haemophilus influenza type b conjugate vaccine","slug":"haemophilus-influenza-type-b-conjugate-vaccine","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Hepatitis A Virus","genericName":"Hepatitis A Virus","slug":"hepatitis-a-virus","phase":"marketed","mechanism":"Hepatitis A Virus vaccine stimulates the immune system to produce antibodies against hepatitis A virus, providing protection against infection.","indications":["Prevention of hepatitis A virus infection in children and adults"],"catalyst":""},{"name":"Hydergine","genericName":"ERGOLOID MESYLATES","slug":"ergoloid-mesylates","phase":"marketed","mechanism":"","indications":["Dementia"],"catalyst":""},{"name":"Hydrochlorothiazide (HCTZ)","genericName":"Hydrochlorothiazide (HCTZ)","slug":"hydrochlorothiazide-hctz","phase":"marketed","mechanism":"Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting water and electrolyte excretion to reduce blood volume and blood pressure.","indications":["Hypertension","Edema associated with congestive heart failure","Edema associated with renal disease"],"catalyst":""},{"name":"ICL670","genericName":"ICL670","slug":"icl670","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Indacaterol (QAB149)","genericName":"Indacaterol 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recipients"],"catalyst":""},{"name":"MMR-V","genericName":"MMR-V","slug":"mmr-v","phase":"phase_3","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Matching placebo to Aliskiren","genericName":"Matching placebo to Aliskiren","slug":"matching-placebo-to-aliskiren","phase":"marketed","mechanism":"This is a matching placebo formulation designed to mimic Aliskiren, a direct renin inhibitor that blocks the first step of the renin-angiotensin-aldosterone system.","indications":["Control arm in clinical trials of Aliskiren for hypertension"],"catalyst":""},{"name":"Matching placebo to Ramipril","genericName":"Matching placebo to Ramipril","slug":"matching-placebo-to-ramipril","phase":"marketed","mechanism":"This is a matching placebo formulation designed to mimic Ramipril, an ACE inhibitor that lowers blood pressure by blocking angiotensin-converting enzyme.","indications":["Clinical trial control for Ramipril studies in hypertension","Clinical trial control for Ramipril 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conjugate vaccine that stimulates immune responses against serogroups A, C, W, and Y by conjugating polysaccharide antigens to a carrier protein (CRM197).","indications":["Prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W, and Y"],"catalyst":""},{"name":"MenC","genericName":"MenC","slug":"menc","phase":"marketed","mechanism":"MenC stimulates the immune system to produce antibodies against the capsular polysaccharide of Neisseria meningitidis serogroup C.","indications":[],"catalyst":""},{"name":"Meningococcal B vaccine","genericName":"Meningococcal B vaccine","slug":"meningococcal-b-vaccine","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Meningococcal C conjugate vaccine","genericName":"Meningococcal C conjugate vaccine","slug":"meningococcal-c-conjugate-vaccine","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Metixen","genericName":"metixene","slug":"metixene","phase":"marketed","mechanism":"5-hydroxytryptamine receptor 2C","indications":["Parkinsonism"],"catalyst":""},{"name":"Mycograb","genericName":"Mycograb","slug":"mycograb","phase":"discontinued","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Mycophenolate","genericName":"MYCOPHENOLIC ACID","slug":"mycophenolic-acid","phase":"marketed","mechanism":"Inosine-5'-monophosphate dehydrogenase 2","indications":["Prevention of Cardiac Transplant Rejection","Prevention of Kidney Transplant Rejection","Prevention of Liver Transplant Rejection"],"catalyst":""},{"name":"Mycophenolic Acid (MPA)","genericName":"Mycophenolic Acid (MPA)","slug":"mycophenolic-acid-mpa","phase":"marketed","mechanism":"Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), selectively suppressing T and B lymphocyte proliferation to prevent organ rejection.","indications":["Prevention of organ rejection in patients receiving allogeneic renal, cardiac, or hepatic transplants","Prevention of acute and chronic rejection in heart transplant recipients","Prevention of acute rejection in renal transplant recipients"],"catalyst":""},{"name":"Myfortic","genericName":"Myfortic","slug":"myfortic","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"NJH395","genericName":"NJH395","slug":"njh395","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"NVA237 200 µg","genericName":"NVA237 200 µg","slug":"nva237-200-g","phase":"phase_2","mechanism":"NVA237 is a long-acting muscarinic antagonist that blocks the M3 muscarinic acetylcholine receptor in the airways, leading to bronchodilation.","indications":["Chronic obstructive pulmonary disease (COPD)"],"catalyst":""},{"name":"Naphcon 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protein expression in motor neurons.","indications":["Spinal Muscular Atrophy (SMA)"],"catalyst":""},{"name":"Other treatment","genericName":"Other treatment","slug":"other-treatment","phase":"marketed","mechanism":"Not specified","indications":[],"catalyst":""},{"name":"PKC412","genericName":"PKC412","slug":"pkc412","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Paracetamol (500 mg) tablets","genericName":"Paracetamol (500 mg) tablets","slug":"paracetamol-500-mg-tablets","phase":"phase_3","mechanism":"Paracetamol inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever.","indications":["Mild to moderate pain","Fever reduction"],"catalyst":""},{"name":"Phenazoline","genericName":"ANTAZOLINE","slug":"antazoline","phase":"marketed","mechanism":"Histamine H1 receptor","indications":["Allergic conjunctivitis","Allergic rhinitis","Anaphylaxis Adjunct","Dermatographic urticaria","Itching of skin"],"catalyst":""},{"name":"Phenylbutazon","genericName":"PHENYLBUTAZONE","slug":"phenylbutazone","phase":"marketed","mechanism":"Nicotinate phosphoribosyltransferase, Prostacyclin synthase, Cytochrome P450 2C9","indications":[],"catalyst":""},{"name":"Pimecrolimus Cream 1%","genericName":"Pimecrolimus Cream 1%","slug":"pimecrolimus-cream-1","phase":"marketed","mechanism":"Pimecrolimus inhibits T-cell activation and inflammatory cytokine release by binding to calcineurin, thereby reducing skin inflammation in atopic dermatitis.","indications":["Atopic dermatitis (mild to moderate)","Atopic dermatitis in patients intolerant to or inadequate responders to conventional topical therapies"],"catalyst":""},{"name":"Placebo (PL)","genericName":"Placebo (PL)","slug":"placebo-pl","phase":"marketed","mechanism":"Placebo produces therapeutic effects through patient expectation and the psychobiological placebo response, rather than through a pharmacologically active ingredient.","indications":["Used as control arm in clinical trials across all therapeutic areas"],"catalyst":""},{"name":"Placebo for Valsartan","genericName":"Placebo for Valsartan","slug":"placebo-for-valsartan","phase":"marketed","mechanism":"A placebo contains no active pharmaceutical ingredient and produces no pharmacological effect.","indications":["Control arm in clinical trials for hypertension and related cardiovascular conditions"],"catalyst":""},{"name":"Placebo to Formoterol","genericName":"Placebo to Formoterol","slug":"placebo-to-formoterol","phase":"phase_3","mechanism":"Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.","indications":["Asthma maintenance therapy","Chronic obstructive pulmonary disease (COPD) maintenance therapy"],"catalyst":""},{"name":"Placebo to Salmeterol/fluticasone","genericName":"Placebo to 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angiotensin II, a potent vasoconstrictor, to lower blood pressure. 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rate.","indications":["Hypertension"],"catalyst":""}],"recentEvents":[{"date":"2023-02-01","type":"earnings","headline":"Novartis Reports Strong Q4 and Full-Year 2022 Results","summary":"Novartis reported strong Q4 and full-year 2022 results, driven by the success of its key products, including Cosentyx and Rydapt.","drugName":"","sentiment":"positive"},{"date":"2022-12-15","type":"deal","headline":"Novartis to Acquire Endocyte for $2.1 Billion","summary":"Novartis announced the acquisition of Endocyte, a biopharmaceutical company focused on cancer treatments, for $2.1 billion.","drugName":"","sentiment":"positive"},{"date":"2022-11-04","type":"regulatory","headline":"FDA Approves Novartis' Cosentyx for Psoriatic Arthritis","summary":"The FDA approved Cosentyx, a treatment for psoriatic arthritis, expanding its indication to include this condition.","drugName":"","sentiment":"positive"}],"realNews":[{"url":"https://news.google.com/rss/articles/CBMiogFBVV95cUxQdHA3TFVEeHJ3X1FXS19VeDJBWUhEYlVaV09EYV9KVWVuWWphTDItRTVqT3hEbGVWQjcwZGF2MlRkWW9PQzVxMzdCLWRkLXhndjRuYnQxRU11amJicUN6R3FtRUdQWTlDU2dCRjdRSEtWQ1d0MTBJbTJYZjFIb2NOTE9fZUtyem12OGtkRmlGREtaaFJTNGdUbDBiSU0yZFl5Wnc?oc=5","date":"2026-04-02","type":"trial","source":"Yahoo Finance","summary":"Novartis AG (NVS) Announces Final Two-Year Results From Phase III APPLAUSE‑IgAN Study - Yahoo Finance","headline":"Novartis AG (NVS) Announces Final Two-Year Results From Phase III APPLAUSE‑IgAN Study","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMiXkFVX3lxTE9QQWExZWhlMkJXVElNRS0zbDA5NlJDbmFYdTFJYmNGN1FZaWh5WkpzU1pYMGFXVFBHYlJLZmhuUGwySGszMnVPdmh5anE5ZjNLOEswOENXV2JjOUIzc2c?oc=5","date":"2026-04-02","type":"pipeline","source":"ChartMill","summary":"NVS Stock Price, Quote & Chart | NOVARTIS AG-SPONSORED ADR (NYSE:NVS) - ChartMill","headline":"NVS Stock Price, 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