{"name":"Galderma R&D","slug":"galderma-rd","ticker":"","exchange":"","domain":"galdermard.com","description":"","hq":"","founded":0,"employees":"","ceo":"","sector":"Pharma / Biotech","status":"active","statusNote":"","leadDrug":"","leadIndication":"","stockPrice":0,"stockChange":0,"stockChangePercent":0,"marketCap":"","metrics":{"revenue":0,"revenueGrowth":0,"grossMargin":0,"rdSpend":0,"netIncome":0,"cash":0,"dividendYield":0,"peRatio":0,"fiscalYear":"FY2026"},"revenueBreakdown":[],"timeline":[{"date":"2026-07-28","label":"Q2 2026 Earnings","type":"earnings","sentiment":"neutral"},{"date":"2026-10-28","label":"Q3 2026 Earnings","type":"earnings","sentiment":"neutral"},{"date":"2027-01-28","label":"Q4 2027 Earnings","type":"earnings","sentiment":"neutral"},{"date":"2027-04-28","label":"Q1 2027 Earnings","type":"earnings","sentiment":"neutral"},{"date":"2027-07-28","label":"Q2 2027 Earnings","type":"earnings","sentiment":"neutral"},{"date":"2027-10-28","label":"Q3 2027 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inflammation and improve skin barrier function in dermatological conditions.","indications":["Inflammatory dermatological condition (specific indication not publicly disclosed)"],"catalyst":""},{"name":"CD14152 Dose A","genericName":"CD14152 Dose A","slug":"cd14152-dose-a","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"CYP 450 Substrates","genericName":"CYP 450 Substrates","slug":"cyp-450-substrates","phase":"phase_2","mechanism":"CYP 450 substrates inhibit the activity of the cytochrome P450 enzyme system.","indications":[],"catalyst":""},{"name":"Cetaphil","genericName":"Cetaphil","slug":"cetaphil","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Clobex Spray","genericName":"Clobex Spray","slug":"clobex-spray","phase":"marketed","mechanism":"Clobex Spray is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin.","indications":["Inflammatory and pruritic 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vulgaris"],"catalyst":""},{"name":"GK567","genericName":"GK567","slug":"gk567","phase":"phase_3","mechanism":"GK567 is a glucokinase activator that enhances glucose metabolism in pancreatic beta cells to stimulate insulin secretion.","indications":["Type 2 diabetes mellitus"],"catalyst":""},{"name":"MAL 16.8% cream","genericName":"MAL 16.8% cream","slug":"mal-16-8-cream","phase":"phase_3","mechanism":"MAL 16.8% cream is a topical formulation of methyl aminolevulinate that generates reactive oxygen species upon light activation to destroy abnormal skin cells.","indications":["Actinic keratosis (field treatment)","Basal cell carcinoma (superficial and nodular)"],"catalyst":""},{"name":"Product A","genericName":"Product A","slug":"product-a","phase":"marketed","mechanism":"Product A is a marketed pharmaceutical from Galderma R&D, but specific mechanistic details are not provided.","indications":[],"catalyst":""},{"name":"Tazarotene Cream, 0.1%","genericName":"Tazarotene Cream, 0.1%","slug":"tazarotene-cream-0-1","phase":"marketed","mechanism":"Tazarotene is a retinoid that binds to retinoid X receptors (RXR) and retinoid acid receptors (RAR) to regulate gene expression and reduce skin inflammation and abnormal keratinocyte differentiation.","indications":["Plaque psoriasis","Acne vulgaris","Photoaging and photodamaged skin"],"catalyst":""},{"name":"Trifarotene cream","genericName":"Trifarotene cream","slug":"trifarotene-cream","phase":"marketed","mechanism":"Trifarotene is a selective retinoid X receptor (RXR) agonist that modulates gene expression to reduce inflammation and normalize skin cell differentiation in acne.","indications":["Acne vulgaris"],"catalyst":""},{"name":"azelaic acid 15% gel","genericName":"azelaic acid 15% gel","slug":"azelaic-acid-15-gel","phase":"marketed","mechanism":"Azelaic acid reduces bacterial colonization and normalizes keratinization while exerting anti-inflammatory and antimicrobial effects on the skin.","indications":["Acne vulgaris","Rosacea","Post-inflammatory hyperpigmentation"],"catalyst":""},{"name":"c-PDT","genericName":"c-PDT","slug":"c-pdt","phase":"phase_3","mechanism":"c-PDT is a photodynamic therapy approach that uses a photosensitizing agent activated by light to generate reactive oxygen species and destroy target cells.","indications":["Actinic keratosis","Non-melanoma skin cancer"],"catalyst":""},{"name":"ABPO Forte Gel","genericName":"ABPO Forte Gel","slug":"abpo-forte-gel","phase":"marketed","mechanism":"ABPO Forte Gel is a topical formulation containing azelaic acid that reduces bacterial colonization and normalizes keratinization to treat acne and rosacea.","indications":["Acne vulgaris","Rosacea"],"catalyst":""},{"name":"AbobotulinumtoxinA dose 1","genericName":"AbobotulinumtoxinA dose 1","slug":"abobotulinumtoxina-dose-1","phase":"phase_2","mechanism":"AbobotulinumtoxinA is a botulinum toxin type A that works by temporarily paralyzing muscles to reduce muscle spasms and improve muscle tone.","indications":["Glabellar lines","Frown lines","Crows feet"],"catalyst":""},{"name":"AbobotulinumtoxinA dose level 1 or 2","genericName":"AbobotulinumtoxinA dose level 1 or 2","slug":"abobotulinumtoxina-dose-level-1-or-2","phase":"phase_2","mechanism":"AbobotulinumtoxinA is a botulinum toxin type A that works by temporarily paralyzing muscle contractions.","indications":["Glabellar lines","Frown lines","Cervical dystonia","Axillary hyperhidrosis"],"catalyst":""},{"name":"Adapalene 0.1% and Benzoyl Peroxide 2.5% gel","genericName":"Adapalene 0.1% and Benzoyl Peroxide 2.5% gel","slug":"adapalene-0-1-and-benzoyl-peroxide-2-5-gel","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Adapalene 0.3% / BPO 2.5% gel","genericName":"Adapalene 0.3% / BPO 2.5% gel","slug":"adapalene-0-3-bpo-2-5-gel","phase":"phase_3","mechanism":"Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide provides antimicrobial activity against acne-causing bacteria.","indications":["Acne vulgaris"],"catalyst":""},{"name":"Adapalene BPO","genericName":"Adapalene BPO","slug":"adapalene-bpo","phase":"phase_3","mechanism":"Adapalene is a retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation, while benzoyl peroxide provides antimicrobial activity against acne-causing bacteria.","indications":["Acne vulgaris"],"catalyst":""},{"name":"Adapalene Gel, 0.1%","genericName":"Adapalene Gel, 0.1%","slug":"adapalene-gel-0-1","phase":"marketed","mechanism":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors (RARs) to normalize skin cell differentiation and reduce inflammation in acne.","indications":["Acne vulgaris","Photoaging and fine wrinkles (off-label use)"],"catalyst":""},{"name":"Adapalene Gel, 0.1% + Tazarotene Cream, 0.1%","genericName":"Adapalene Gel, 0.1% + Tazarotene Cream, 0.1%","slug":"adapalene-gel-0-1-tazarotene-cream-0-1","phase":"marketed","mechanism":"This combination product delivers two retinoid receptor agonists that normalize skin cell differentiation and reduce inflammation to treat acne and photoaging.","indications":["Acne vulgaris","Photoaging and photodamaged skin"],"catalyst":""},{"name":"Adapalene Lotion Vehicle","genericName":"Adapalene Lotion Vehicle","slug":"adapalene-lotion-vehicle","phase":"phase_3","mechanism":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation in acne.","indications":["Acne vulgaris"],"catalyst":""},{"name":"Adapalene/benzoyl peroxide gel, 0.1%/2.5%","genericName":"Adapalene/benzoyl peroxide gel, 0.1%/2.5%","slug":"adapalene-benzoyl-peroxide-gel-0-1-2-5","phase":"marketed","mechanism":"Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity.","indications":["Acne vulgaris"],"catalyst":""},{"name":"Alluzience","genericName":"Alluzience","slug":"alluzience","phase":"marketed","mechanism":"Biologic","indications":[],"catalyst":""},{"name":"Azzalure or Dysport","genericName":"Azzalure or Dysport","slug":"azzalure-or-dysport","phase":"marketed","mechanism":"Azzalure is a botulinum toxin type A that blocks acetylcholine release at the neuromuscular junction, paralyzing facial muscles and reducing wrinkles.","indications":["Moderate to severe glabellar lines (frown lines between eyebrows)","Moderate to severe lateral canthal lines (crow's feet)","Forehead lines"],"catalyst":""},{"name":"Benzoyl Peroxide Gel 2.5%","genericName":"Benzoyl Peroxide Gel 2.5%","slug":"benzoyl-peroxide-gel-2-5","phase":"phase_3","mechanism":"Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species.","indications":["Acne vulgaris"],"catalyst":""},{"name":"Botulinum Toxin Type A - Vistabel","genericName":"Botulinum Toxin Type A - Vistabel","slug":"botulinum-toxin-type-a-vistabel","phase":"phase_2","mechanism":"Inhibits acetylcholine release at the neuromuscular junction","indications":["Frown lines","Forehead lines","Crow's feet"],"catalyst":""},{"name":"C. propionate - Corticosteroid 1","genericName":"C. propionate - Corticosteroid 1","slug":"c-propionate-corticosteroid-1","phase":"phase_3","mechanism":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","indications":["Inflammatory and pruritic dermatological conditions (e.g., psoriasis, eczema, lichen planus, dermatitis)"],"catalyst":""},{"name":"C. propionate -Corticosteroid 3","genericName":"C. propionate -Corticosteroid 3","slug":"c-propionate-corticosteroid-3","phase":"phase_3","mechanism":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","indications":["Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema)"],"catalyst":""},{"name":"C. propionate- Corticosteroid 2","genericName":"C. propionate- Corticosteroid 2","slug":"c-propionate-corticosteroid-2","phase":"phase_3","mechanism":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)"],"catalyst":""},{"name":"CD 2027","genericName":"CD 2027","slug":"cd-2027","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"CD0271 0.1% / CD1579 2.5%","genericName":"CD0271 0.1% / CD1579 2.5%","slug":"cd0271-0-1-cd1579-2-5","phase":"phase_3","mechanism":"CD0271 and CD1579 are topical agents that work synergistically to reduce skin inflammation and improve dermatological conditions through complementary anti-inflammatory pathways.","indications":["Dermatological inflammatory condition (specific indication not publicly disclosed)"],"catalyst":""},{"name":"CD07223","genericName":"CD07223","slug":"cd07223","phase":"phase_2","mechanism":"CD07223 is a small molecule targeting the CD73 enzyme.","indications":["Metastatic melanoma"],"catalyst":""},{"name":"CD07805/47 gel","genericName":"CD07805/47 gel","slug":"cd07805-47-gel","phase":"phase_3","mechanism":"CD07805/47 gel is a topical retinoid that modulates skin cell differentiation and reduces inflammation for acne treatment.","indications":["Acne vulgaris"],"catalyst":""},{"name":"CD07805/47 gel 0.5%/CD07805/47 Vehicle","genericName":"CD07805/47 gel 0.5%/CD07805/47 Vehicle","slug":"cd07805-47-gel-0-5-cd07805-47-vehicle","phase":"phase_3","mechanism":"CD07805/47 is a topical retinoid that modulates retinoid receptor signaling to reduce inflammation and promote skin cell differentiation in dermatological conditions.","indications":["Acne vulgaris","Photoaging/photodamaged skin"],"catalyst":""},{"name":"CD10367 1% Solution - Non-desquamated zone","genericName":"CD10367 1% Solution - Non-desquamated zone","slug":"cd10367-1-solution-non-desquamated-zone","phase":"phase_2","mechanism":"CD10367 is a topical solution designed to treat non-desquamated (non-scaling) skin lesions, likely through anti-inflammatory or keratolytic activity.","indications":["Non-desquamated skin lesions (Phase 2)"],"catalyst":""},{"name":"CD10367 3% Solution - Desquamated zone","genericName":"CD10367 3% Solution - Desquamated zone","slug":"cd10367-3-solution-desquamated-zone","phase":"phase_2","mechanism":"CD10367 3% Solution - Desquamated zone is a topical treatment that helps to remove the outer layer of the skin, reducing the appearance of desquamation.","indications":["Treatment of desquamation"],"catalyst":""},{"name":"CD10367 3% Solution - Non-desquamated zone","genericName":"CD10367 3% Solution - Non-desquamated zone","slug":"cd10367-3-solution-non-desquamated-zone","phase":"phase_2","mechanism":"CD10367 3% Solution - Non-desquamated zone is a topical treatment for acne.","indications":["Acne vulgaris"],"catalyst":""},{"name":"CD11301 0.03%","genericName":"CD11301 0.03%","slug":"cd11301-0-03","phase":"phase_2","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"CD11301 0.06%","genericName":"CD11301 0.06%","slug":"cd11301-0-06","phase":"phase_2","mechanism":"CD11301 is a topical retinoid that modulates the retinoic acid pathway to treat acne.","indications":["Acne vulgaris"],"catalyst":""},{"name":"CD1579 5%","genericName":"CD1579 5%","slug":"cd1579-5","phase":"phase_2","mechanism":"CD1579 5% is a topical retinoid that modulates cell growth and differentiation.","indications":["Acne vulgaris","Photoaging"],"catalyst":""},{"name":"CD5024 0.3% cream","genericName":"CD5024 0.3% cream","slug":"cd5024-0-3-cream","phase":"phase_2","mechanism":"CD5024 0.3% cream is a topical calcineurin inhibitor that suppresses the immune system by inhibiting T-cell activation.","indications":["Atopic dermatitis"],"catalyst":""},{"name":"CD5789 (trifarotene)","genericName":"CD5789 (trifarotene)","slug":"cd5789-trifarotene","phase":"phase_3","mechanism":"Trifarotene is a selective retinoid X receptor (RXR) agonist that modulates gene expression to reduce inflammation and promote skin cell differentiation.","indications":["Psoriasis","Atopic dermatitis"],"catalyst":""},{"name":"Calcipotriene and betamethasone dipropionate ointment","genericName":"Calcipotriene and betamethasone dipropionate ointment","slug":"calcipotriene-and-betamethasone-dipropionate-ointment","phase":"marketed","mechanism":"This combination ointment uses calcipotriene (a vitamin D analog) to normalize skin cell differentiation and betamethasone dipropionate (a potent corticosteroid) to reduce inflammation and immune activation in psoriatic plaques.","indications":["Plaque psoriasis","Psoriatic dermatitis"],"catalyst":""},{"name":"Ciclopirox NL","genericName":"Ciclopirox NL","slug":"ciclopirox-nl","phase":"marketed","mechanism":"Ciclopirox is a broad-spectrum antifungal agent that inhibits fungal enzyme systems by chelating polyvalent cations, disrupting cellular respiration and biosynthesis.","indications":["Onychomycosis (fungal nail infection)","Tinea pedis (athlete's foot)","Tinea corporis (ringworm)","Tinea cruris (jock itch)","Candidiasis (yeast infections)"],"catalyst":""},{"name":"Clobetasol Propionate 0.05% Foam","genericName":"Clobetasol Propionate 0.05% Foam","slug":"clobetasol-propionate-0-05-foam","phase":"marketed","mechanism":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","indications":["Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (scalp and body)","Psoriasis","Eczema","Lichen planus","Other steroid-responsive dermatologic conditions"],"catalyst":""},{"name":"Clobetasol Propionate, 0.05%","genericName":"Clobetasol Propionate, 0.05%","slug":"clobetasol-propionate-0-05","phase":"marketed","mechanism":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema)","Alopecia areata","Lichen sclerosus"],"catalyst":""},{"name":"Clobex® Vehicle Shampoo","genericName":"Clobex® Vehicle Shampoo","slug":"clobex-vehicle-shampoo","phase":"phase_3","mechanism":"Clobex Vehicle Shampoo delivers clobetasol propionate, a potent topical corticosteroid, to the scalp to reduce inflammation and suppress immune-mediated skin responses.","indications":["Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp"],"catalyst":""},{"name":"Corticosteroid 1- C. propionate","genericName":"Corticosteroid 1- C. propionate","slug":"corticosteroid-1-c-propionate","phase":"phase_3","mechanism":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)","Short-term treatment of severe corticosteroid-responsive dermatoses"],"catalyst":""},{"name":"Corticosteroid 2 - C. propionate","genericName":"Corticosteroid 2 - C. propionate","slug":"corticosteroid-2-c-propionate","phase":"phase_3","mechanism":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)"],"catalyst":""},{"name":"Corticosteroid 3 - C. propionate","genericName":"Corticosteroid 3 - C. propionate","slug":"corticosteroid-3-c-propionate","phase":"phase_3","mechanism":"Clobetasol propionate is a potent corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","indications":["Severe inflammatory dermatological conditions (e.g., severe psoriasis, lichen planus, severe eczema)","Short-term treatment of severe dermatitis and pruritic conditions"],"catalyst":""},{"name":"Drug: CD07805/47 gel","genericName":"Drug: CD07805/47 gel","slug":"drug-cd07805-47-gel","phase":"phase_3","mechanism":"CD07805/47 gel is a topical retinoid that promotes skin cell turnover and collagen remodeling to improve signs of photoaging and wrinkles.","indications":["Photoaged skin and facial wrinkles"],"catalyst":""},{"name":"Facial Cleanser and Moisturizer SPF 30","genericName":"Facial Cleanser and Moisturizer SPF 30","slug":"facial-cleanser-and-moisturizer-spf-30","phase":"marketed","mechanism":"This topical product provides physical and chemical sun protection while cleansing and moisturizing the facial skin.","indications":["Daily facial cleansing and sun protection (SPF 30)"],"catalyst":""},{"name":"Facial Moisturizer with SPF 50+","genericName":"Facial Moisturizer with SPF 50+","slug":"facial-moisturizer-with-spf-50","phase":"marketed","mechanism":"This product provides physical and chemical UV protection to prevent sun damage while delivering hydration to facial skin.","indications":["Sun protection and photoaging prevention","Daily facial moisturization with UV protection"],"catalyst":""},{"name":"Ivermectin 1% cream (IVM)","genericName":"Ivermectin 1% cream (IVM)","slug":"ivermectin-1-cream-ivm","phase":"marketed","mechanism":"Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.","indications":["Rosacea (topical)","Scabies (topical)"],"catalyst":""},{"name":"Lidocaine 7% + Tetracaine 7% cream","genericName":"Lidocaine 7% + Tetracaine 7% cream","slug":"lidocaine-7-tetracaine-7-cream","phase":"marketed","mechanism":"Lidocaine and tetracaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce topical anesthesia.","indications":["Topical anesthesia for dermatological procedures (e.g., laser treatment, chemical peels, microdermabrasion)","Numbing prior to minor surgical procedures on skin"],"catalyst":""},{"name":"Loceryl NL","genericName":"Loceryl NL","slug":"loceryl-nl","phase":"marketed","mechanism":"Loceryl is an antifungal nail lacquer that inhibits fungal cell wall synthesis by disrupting ergosterol production.","indications":["Onychomycosis (fungal nail infection)"],"catalyst":""},{"name":"Loceryl NL + Cosmetic varnish","genericName":"Loceryl NL + Cosmetic varnish","slug":"loceryl-nl-cosmetic-varnish","phase":"marketed","mechanism":"Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.","indications":["Onychomycosis (fungal nail infection)"],"catalyst":""},{"name":"Loceryl NL 12 weeks","genericName":"Loceryl NL 12 weeks","slug":"loceryl-nl-12-weeks","phase":"marketed","mechanism":"Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane.","indications":["Onychomycosis (fungal nail infection)","Dermatophyte and yeast infections of nails"],"catalyst":""},{"name":"Loceryl NL 15 months","genericName":"Loceryl NL 15 months","slug":"loceryl-nl-15-months","phase":"marketed","mechanism":"Amorolfine is a morpholine antifungal that inhibits fungal sterol synthesis by blocking both Δ14-reductase and Δ8-Δ7-isomerase enzymes in the ergosterol biosynthesis pathway.","indications":["Onychomycosis (fungal nail infection) of toenails and fingernails"],"catalyst":""},{"name":"Loceryl Nail Lacquer","genericName":"Loceryl Nail Lacquer","slug":"loceryl-nail-lacquer","phase":"marketed","mechanism":"Amorolfine inhibits fungal sterol synthesis by blocking lanosterol demethylase, disrupting the integrity of the fungal cell membrane.","indications":["Onychomycosis (fungal nail infection) caused by dermatophytes, yeasts, and non-dermatophyte molds"],"catalyst":""},{"name":"MAL Vehicle Cream","genericName":"MAL Vehicle Cream","slug":"mal-vehicle-cream","phase":"phase_3","mechanism":"MAL Vehicle Cream is a topical formulation vehicle designed to deliver active pharmaceutical ingredients through the skin for localized therapeutic effect.","indications":["Topical delivery vehicle for dermatological applications (specific indication dependent on active ingredient formulated with this vehicle)"],"catalyst":""},{"name":"Methyl Aminolaevulinate 16% Cream","genericName":"Methyl Aminolaevulinate 16% Cream","slug":"methyl-aminolaevulinate-16-cream","phase":"marketed","mechanism":"Methyl aminolaevulinate is a photosensitizing prodrug that accumulates in abnormal skin cells and generates reactive oxygen species when activated by red light, destroying target lesions.","indications":["Actinic keratosis (non-hyperkeratotic, non-pigmented lesions on face and scalp)","Basal cell carcinoma (superficial and nodular types)"],"catalyst":""},{"name":"Metronidazole 0.75% cream","genericName":"Metronidazole 0.75% cream","slug":"metronidazole-0-75-cream","phase":"phase_3","mechanism":"Metronidazole disrupts bacterial and protozoal DNA, leading to cell death and reduction of microorganisms associated with rosacea and other inflammatory skin conditions.","indications":["Rosacea (topical treatment)","Bacterial vaginosis (systemic formulations; topical cream may be used off-label)"],"catalyst":""},{"name":"Metronidazole gel 1%","genericName":"Metronidazole gel 1%","slug":"metronidazole-gel-1","phase":"marketed","mechanism":"Metronidazole disrupts bacterial and protozoal DNA by generating reactive oxygen species and damaging nucleic acids, leading to cell death.","indications":["Rosacea (topical)","Bacterial vaginosis (topical)","Perioral dermatitis (topical)"],"catalyst":""},{"name":"Metvix and conventional PDT","genericName":"Metvix and conventional PDT","slug":"metvix-and-conventional-pdt","phase":"phase_3","mechanism":"Metvix is a photosensitizing agent that accumulates in abnormal skin cells and, when activated by light in photodynamic therapy (PDT), generates reactive oxygen species to destroy lesions.","indications":["Actinic keratosis","Basal cell carcinoma","Bowen's disease"],"catalyst":""},{"name":"Metvix and natural daylight PDT","genericName":"Metvix and natural daylight PDT","slug":"metvix-and-natural-daylight-pdt","phase":"phase_3","mechanism":"Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal skin cells and is activated by natural daylight to generate reactive oxygen species that destroy lesions.","indications":["Actinic keratosis (field treatment with daylight PDT)","Non-melanoma skin cancer (basal cell carcinoma, squamous cell carcinoma)"],"catalyst":""},{"name":"Metvix cream","genericName":"Metvix cream","slug":"metvix-cream","phase":"phase_3","mechanism":"Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal cells and generates reactive oxygen species when activated by light, destroying target lesions.","indications":["Actinic keratosis","Basal cell carcinoma (superficial and nodular)","Bowen's disease"],"catalyst":""},{"name":"NDL-PDT","genericName":"NDL-PDT","slug":"ndl-pdt","phase":"phase_3","mechanism":"NDL-PDT is a photodynamic therapy agent that generates reactive oxygen species upon light activation to destroy targeted tissue.","indications":["Actinic keratosis","Non-melanoma skin cancer"],"catalyst":""},{"name":"Oracea","genericName":"Oracea","slug":"oracea","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"Oral doxycycline hyclate","genericName":"Oral doxycycline hyclate","slug":"oral-doxycycline-hyclate","phase":"marketed","mechanism":"Doxycycline hyclate is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.","indications":["Bacterial infections (respiratory, urinary, skin, soft tissue)","Acne vulgaris","Rosacea","Malaria prophylaxis","Lyme disease"],"catalyst":""},{"name":"Product B","genericName":"Product B","slug":"product-b","phase":"marketed","mechanism":"Product B is a marketed dermatological agent from Galderma R&D, but specific mechanistic details are not publicly available.","indications":[],"catalyst":""},{"name":"QM1114-DP","genericName":"QM1114-DP","slug":"qm1114-dp","phase":"phase_3","mechanism":"QM1114-DP is a topical treatment that targets the inflammatory pathways in the skin.","indications":["Acne vulgaris"],"catalyst":""},{"name":"Retin-A Micro Microsphere 0.1%","genericName":"Retin-A Micro Microsphere 0.1%","slug":"retin-a-micro-microsphere-0-1","phase":"marketed","mechanism":"Retin-A Micro delivers tretinoin (a vitamin A derivative) in microsphere form to normalize skin cell turnover and reduce comedone formation.","indications":["Acne vulgaris","Photoaged skin (fine wrinkles, mottled hyperpigmentation, roughness)"],"catalyst":""},{"name":"Trifarotene Vehicle","genericName":"Trifarotene Vehicle","slug":"trifarotene-vehicle","phase":"marketed","mechanism":"Trifarotene is a selective retinoid X receptor (RXR) agonist that modulates gene expression to reduce inflammation and normalize skin cell differentiation in acne.","indications":["Acne vulgaris"],"catalyst":""},{"name":"adapalen 0.1%","genericName":"adapalen 0.1%","slug":"adapalen-0-1","phase":"marketed","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"adapalene cream 0.1% and adapalene lotion 0.1%","genericName":"adapalene cream 0.1% and adapalene lotion 0.1%","slug":"adapalene-cream-0-1-and-adapalene-lotion-0-1","phase":"phase_1","mechanism":"Small molecule","indications":[],"catalyst":""},{"name":"adapalene gel, 0.3%","genericName":"adapalene gel, 0.3%","slug":"adapalene-gel-0-3","phase":"marketed","mechanism":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors (RARs) to normalize skin cell differentiation and reduce inflammation.","indications":["Acne vulgaris","Photoaging and fine wrinkles (off-label use in some regions)"],"catalyst":""},{"name":"adapalene lotion 0.1%","genericName":"adapalene lotion 0.1%","slug":"adapalene-lotion-0-1","phase":"phase_3","mechanism":"Adapalene is a topical retinoid that works by binding to retinoic acid receptors, modulating gene expression and promoting cell turnover.","indications":["Acne vulgaris","Aging skin"],"catalyst":""},{"name":"adapalene/benzoyl peroxide","genericName":"adapalene/benzoyl peroxide","slug":"adapalene-benzoyl-peroxide","phase":"marketed","mechanism":"Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide is an antimicrobial that kills acne-causing bacteria and reduces sebum production.","indications":["Acne vulgaris"],"catalyst":""},{"name":"botulinum toxin neuromodulator","genericName":"botulinum toxin neuromodulator","slug":"botulinum-toxin-neuromodulator","phase":"phase_3","mechanism":"Botulinum toxin blocks acetylcholine release at the neuromuscular junction by cleaving 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